ATE554764T1 - Wirkungsvolle vereinfachte derivate von immunosuppressiva - Google Patents

Wirkungsvolle vereinfachte derivate von immunosuppressiva

Info

Publication number
ATE554764T1
ATE554764T1 AT03714131T AT03714131T ATE554764T1 AT E554764 T1 ATE554764 T1 AT E554764T1 AT 03714131 T AT03714131 T AT 03714131T AT 03714131 T AT03714131 T AT 03714131T AT E554764 T1 ATE554764 T1 AT E554764T1
Authority
AT
Austria
Prior art keywords
immunosuppressants
effective simplified
derivatives
present
simplified derivatives
Prior art date
Application number
AT03714131T
Other languages
English (en)
Inventor
Daniel Romo
Jun Liu
Nam Choi
Jong Shi
Original Assignee
Texas A & M Univ Sys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A & M Univ Sys filed Critical Texas A & M Univ Sys
Application granted granted Critical
Publication of ATE554764T1 publication Critical patent/ATE554764T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT03714131T 2002-03-13 2003-03-13 Wirkungsvolle vereinfachte derivate von immunosuppressiva ATE554764T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36434702P 2002-03-13 2002-03-13
PCT/US2003/007759 WO2003077862A2 (en) 2002-03-13 2003-03-13 Potent, simplified derivatives of immunosuppressive agents

Publications (1)

Publication Number Publication Date
ATE554764T1 true ATE554764T1 (de) 2012-05-15

Family

ID=28041903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03714131T ATE554764T1 (de) 2002-03-13 2003-03-13 Wirkungsvolle vereinfachte derivate von immunosuppressiva

Country Status (6)

Country Link
US (1) US7230021B2 (de)
EP (1) EP1482933B1 (de)
JP (1) JP2005531514A (de)
AT (1) ATE554764T1 (de)
AU (1) AU2003218141A1 (de)
WO (1) WO2003077862A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7737134B2 (en) * 2002-03-13 2010-06-15 The Texas A & M University System Anticancer agents and use
UY33827A (es) * 2010-12-22 2012-07-31 Abbott Lab Proteínas de unión a media-inmunoglobulina y sus usos
US10407444B2 (en) * 2015-03-31 2019-09-10 The Texas A&M University System Alpha-amino pateamine A derivatives and methods for treating chronic lymphocytic leukemia
WO2017173313A1 (en) 2016-03-31 2017-10-05 The Texas A&M University System Beta-amimo pateamine a derivatives and methods for treating chronic lymphocytic leukemia
JP7030115B2 (ja) * 2017-05-19 2022-03-04 昭和電工株式会社 電気化学的にゲルマンを製造する方法
JP7158416B2 (ja) 2017-05-24 2022-10-21 イーフェクター セラピューティクス， インコーポレイテッド 抗腫瘍免疫応答を改善するための組成物および方法
WO2021001743A1 (en) 2019-07-02 2021-01-07 Effector Therapeutics, Inc. Translation inhibitors and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548481A (en) * 1983-11-07 1985-10-22 Nippon Kogaku K.K. Variable magnification observation optical device
US4729996A (en) * 1986-05-29 1988-03-08 Harbor Branch Oceanographic Institution, Inc. Antitumor compositions and their methods of use
US4737510A (en) * 1986-09-30 1988-04-12 The Board Of Trustees Of The University Of Illinois Bioactive metabolites from the caribbean sponge agelas coniferin
US4808590A (en) * 1987-07-17 1989-02-28 Harbor Branch Oceanographic Institution, Inc. Antiviral, antitumor and antifungal compositions and their methods of use
GB9026658D0 (en) * 1990-12-07 1991-01-23 Pharma Mar Sa Novel antitumoral and antiviral compound
EP0647645A1 (de) 1993-10-12 1995-04-12 Pharma Mar, S.A. Antitumor- und antivirale Verbindung
US6057333A (en) * 1997-07-25 2000-05-02 Harbor Branch Oceanographic Institution, Inc. Discorhabdin compounds and methods of use

Also Published As

Publication number Publication date
AU2003218141A8 (en) 2003-09-29
US7230021B2 (en) 2007-06-12
WO2003077862A2 (en) 2003-09-25
AU2003218141A1 (en) 2003-09-29
EP1482933A2 (de) 2004-12-08
EP1482933B1 (de) 2012-04-25
WO2003077862A3 (en) 2004-03-25
EP1482933A4 (de) 2006-04-12
US20030216436A1 (en) 2003-11-20
JP2005531514A (ja) 2005-10-20

Similar Documents

Publication Publication Date Title
GEP20053600B (en) 3-(4-Amidopyrrol-2-Ylmethlidene)-2- Indolinone Derivatives as Protein Kinase Inhibitors
CY1111693T1 (el) Αντιιικοι παραγοντες
ATE371656T1 (de) Heteroaryl-pyrimidinderivate als jak-inhibitoren
MY139446A (en) Novel quinoline derivatives
ATE453636T1 (de) Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren
BR0113838A (pt) Derivados de n-fenil-2-pirimidina-amina
TR200302242T2 (tr) Protein kinaz önleyicileri olarak pirolopirimidinler
DE602004024375D1 (de) Carboxamidderivate
IS8502A (is) Azatvíhringja heteróhringir sem kannabínóíð-viðtakastillar
ATE454378T1 (de) Verbindungen, die sich als inhibitoren vonjak und anderen proteinkinasen eignen
ATE375341T1 (de) Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen
BR0212042A (pt) Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, e, uso de um composto
EA200401114A3 (ru) Замещённые гидроксиэтиламины
MXPA04005156A (es) Antagonistas del receptor de adenosina a2a.
DK1689721T3 (da) Aminopyrazolderivater som GSK-3-ihibitorer
BRPI0508107A (pt) derivados de indazol e composições farmacêuticas contendo os mesmos
NO20052182L (no) Nye forbindelser
SE0101932D0 (sv) Pharmaceutical combinations
PE20030061A1 (es) 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4
DK1641454T3 (da) Pyrazolo[3,4-B]pyridin-6-oner som GSK-3-hæmmere
ATE372995T1 (de) Benzo(b)(1,4)dioxepinderivate
GEP20074058B (en) 4-(7-halo-2-quino(xa) linyloxy-phenoxy-propionic acid derivatives as antineoplastic agents
ATE424200T1 (de) Solubilisierte topoisomerase-gift-mittel
ATE390923T1 (de) Topoisomerase-giftmittel
ATE554764T1 (de) Wirkungsvolle vereinfachte derivate von immunosuppressiva