ATE554093T1 - Zwischenprodukt und verfahren zur herstellung von ecteinascidinen wie ecteinascidin 583 und 597 unter verwendung eines solchen zwischenprodukts - Google Patents

Zwischenprodukt und verfahren zur herstellung von ecteinascidinen wie ecteinascidin 583 und 597 unter verwendung eines solchen zwischenprodukts

Info

Publication number: ATE554093T1
Authority: AT; Austria
Prior art keywords: group; ecteinascidin; ecteinascidins; producing; alkyl
Prior art date: 2005-10-20

Application number

AT06829917T

Other languages

English (en)

Inventor

Jieping Zhu

Michele Bois-Choussy

Jinchun Chen

Xiaochuan Chen

Original Assignee

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-20

Filing date

2006-10-20

Publication date

2012-05-15

2006-10-20 Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient

2012-05-15 Application granted granted Critical

2012-05-15 Publication of ATE554093T1 publication Critical patent/ATE554093T1/de

Links

PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 2
229960000977 trabectedin Drugs 0.000 title abstract 2
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 1
YMAUZYADYYYPHZ-UHFFFAOYSA-N Ecteinascidin 770 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(C#N)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C YMAUZYADYYYPHZ-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000005098 aryl alkoxy carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
BGFXHQYUWCGGLL-QWIBJBKUSA-N ecteinascidin 770 Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](C#N)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 BGFXHQYUWCGGLL-QWIBJBKUSA-N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT06829917T 2005-10-20 2006-10-20 Zwischenprodukt und verfahren zur herstellung von ecteinascidinen wie ecteinascidin 583 und 597 unter verwendung eines solchen zwischenprodukts ATE554093T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US72829505P	2005-10-20	2005-10-20
EP05292203A EP1792904A1 (de)	2005-10-20	2005-10-20	Zwischenprodukt und Verfahren zur Herstellung von Ecteinascidin aus diesem Zwischenprodukt
PCT/EP2006/067611 WO2007045686A2 (en)	2005-10-20	2006-10-20	Intermediate and process of preparation of ecteinascidin such as ecteinascidines-583, 597 using such intermediate

Publications (1)

Publication Number	Publication Date
ATE554093T1 true ATE554093T1 (de)	2012-05-15

Family

ID=37899253

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06829917T ATE554093T1 (de)	2005-10-20	2006-10-20	Zwischenprodukt und verfahren zur herstellung von ecteinascidinen wie ecteinascidin 583 und 597 unter verwendung eines solchen zwischenprodukts

Country Status (6)

Country	Link
US (1)	US8058435B2 (de)
EP (2)	EP1792904A1 (de)
JP (1)	JP2009512662A (de)
AT (1)	ATE554093T1 (de)
CA (1)	CA2626595A1 (de)
WO (1)	WO2007045686A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9090542B2 (en) *	2009-11-11	2015-07-28	University Of Georgia Research Foundation, Inc.	Methods for labeling a substrate using a hetero-diels-alder reaction
US20110108411A1 (en) *	2009-11-11	2011-05-12	Popik Vladimir V	Methods for labeling a substrate using a hetero-diels-alder reaction
CA2800097C (en)	2010-05-25	2019-01-08	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds and intermediates
CN103304478B (zh) *	2013-06-28	2016-04-20	四川大学	一类合成renieramycins型生物碱的中间体及其制备方法
CN103709101B (zh) *	2013-12-19	2016-06-29	四川大学	一类renieramycin G的合成中间体及其制备方法
CN107739387B (zh) *	2017-10-16	2020-01-03	上海皓元生物医药科技有限公司	一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) *	2017-12-13	2021-12-24	浙江中科创越药业有限公司	天然产物Trabectedin的制备
CN108276408B (zh) *	2018-04-19	2020-09-29	上海皓元医药股份有限公司	一种曲贝替定的中间体及其制备方法和用途
CN111518110B (zh) *	2019-02-01	2023-11-03	博瑞生物医药（苏州）股份有限公司	一种海鞘素化合物及其中间体的制备方法
CN112745327B (zh) *	2019-10-30	2023-08-25	南通诺泰生物医药技术有限公司	一种曲贝替定中间体化合物的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4208469B2 (ja) *	2002-01-29	2009-01-14	独立行政法人科学技術振興機構	エクテナサイジン類の全合成方法、エクテナサイジン類に類縁構造を持つ前記全合成用中間体化合物類、及び該中間体化合物類の合成方法

2005
- 2005-10-20 EP EP05292203A patent/EP1792904A1/de not_active Withdrawn
2006
- 2006-10-20 US US12/083,740 patent/US8058435B2/en not_active Expired - Fee Related
- 2006-10-20 CA CA002626595A patent/CA2626595A1/en not_active Abandoned
- 2006-10-20 EP EP06829917A patent/EP1937689B1/de not_active Not-in-force
- 2006-10-20 AT AT06829917T patent/ATE554093T1/de active
- 2006-10-20 JP JP2008536058A patent/JP2009512662A/ja active Pending
- 2006-10-20 WO PCT/EP2006/067611 patent/WO2007045686A2/en active Application Filing

Also Published As

Publication number	Publication date
EP1937689A2 (de)	2008-07-02
JP2009512662A (ja)	2009-03-26
EP1937689B1 (de)	2012-04-18
US20090171080A1 (en)	2009-07-02
CA2626595A1 (en)	2007-04-26
WO2007045686A3 (en)	2007-07-12
US8058435B2 (en)	2011-11-15
WO2007045686A2 (en)	2007-04-26
EP1792904A1 (de)	2007-06-06

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