ATE55054T1 - Renininhibitoren und verfahren zur anwendung derselben. - Google Patents

Renininhibitoren und verfahren zur anwendung derselben.

Info

Publication number
ATE55054T1
ATE55054T1 AT86308492T AT86308492T ATE55054T1 AT E55054 T1 ATE55054 T1 AT E55054T1 AT 86308492 T AT86308492 T AT 86308492T AT 86308492 T AT86308492 T AT 86308492T AT E55054 T1 ATE55054 T1 AT E55054T1
Authority
AT
Austria
Prior art keywords
administration
methods
renin inhibitors
renin
rise
Prior art date
Application number
AT86308492T
Other languages
English (en)
Inventor
Robert Wayne Watkins
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE55054T1 publication Critical patent/ATE55054T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/553—Renin inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT86308492T 1985-11-05 1986-10-31 Renininhibitoren und verfahren zur anwendung derselben. ATE55054T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/795,282 US4906613A (en) 1985-11-05 1985-11-05 Antiglaucoma compositions and methods
EP86308492A EP0246381B1 (de) 1985-11-05 1986-10-31 Renininhibitoren und Verfahren zur Anwendung derselben

Publications (1)

Publication Number Publication Date
ATE55054T1 true ATE55054T1 (de) 1990-08-15

Family

ID=25165170

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86308492T ATE55054T1 (de) 1985-11-05 1986-10-31 Renininhibitoren und verfahren zur anwendung derselben.

Country Status (8)

Country Link
US (2) US4906613A (de)
EP (2) EP0243477A1 (de)
JP (1) JPS63501287A (de)
AT (1) ATE55054T1 (de)
DE (1) DE3673161D1 (de)
ES (1) ES2031822T3 (de)
GR (1) GR3000993T3 (de)
WO (1) WO1987002581A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927807A (en) * 1987-10-06 1990-05-22 Abbott Laboratories Glaucoma treatment
US5036051A (en) * 1987-10-06 1991-07-30 Abbott Laboratories Glaucoma treatment
US5346887A (en) * 1987-10-06 1994-09-13 Abbott Laboratories Glaucoma treatment
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
GB8728560D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
EP0326364B1 (de) * 1988-01-26 1994-06-22 Sankyo Company Limited Renin inhibierende Polypeptide, ihre Herstellung und Anwendung
US5059589A (en) * 1988-09-08 1991-10-22 Abbott Laboratories Glaucoma treatment
US5268374A (en) * 1988-10-04 1993-12-07 Abbott Laboratories Non-peptide renin inhibitors
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
EP0449943A1 (de) * 1988-12-22 1991-10-09 The Upjohn Company Transdermale und intranasale verabreichung von reninhemmenden peptiden
FR2647675B1 (fr) * 1989-06-05 1994-05-20 Sanofi Utilisation d'un derive de la statine dans le traitement des affections oculaires
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
US5688770A (en) * 1989-12-14 1997-11-18 Schering Corporation Antiglaucoma compositions and methods
US5182266A (en) * 1990-01-31 1993-01-26 Abbott Laboratories Method for treating renal disease
IE911326A1 (en) * 1990-04-23 1991-10-23 Abbott Lab Psoriasis treatment
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
US5332742A (en) * 1990-05-11 1994-07-26 Abbott Laboratories Renin inhibitors
JPH04243835A (ja) * 1990-08-29 1992-08-31 Pfizer Inc 高眼圧症又は緑内障治療用薬剤組成物及び治療方法
GB9127041D0 (en) * 1991-12-20 1992-02-19 Fujisawa Pharmaceutical Co New use
US6165490A (en) * 1996-04-05 2000-12-26 Staar Surgical Ag Biological material, method of preparing such materials, uses thereof and products made therefrom
US8889112B2 (en) * 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US20020082288A1 (en) * 1999-09-16 2002-06-27 Gerald Horn Ophthalmic formulations comprising an imidazoline
WO2001019364A1 (en) 1999-09-16 2001-03-22 Horn Gerald D A method for optimizing pupil size using alpha antagonist
US6730065B1 (en) 2000-09-15 2004-05-04 Ocularis Pharma, Inc. Night vision composition
US6420407B1 (en) 1999-09-16 2002-07-16 Gerald Horn Ophthalmic formulation which modulates dilation
US20060211753A1 (en) * 2000-11-03 2006-09-21 Ocularis Pharma, Inc. Method and composition which reduces stimulation of muscles which dilate the eye
KR20080021782A (ko) 2005-06-17 2008-03-07 리지너크스 바이오 파마소티컬스, 인코포레이티드 엘케이케이티이티 및/또는 엘케이케이티엔티 펩티드조성물들 및 그 방법
PT2950648T (pt) 2013-02-01 2020-01-06 Ocuphire Pharma Inc Soluções oftálmicas aquosas de fentolamina e usos médicos
WO2014121028A1 (en) 2013-02-01 2014-08-07 Ocularis Pharma, Llc Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
KR20210096096A (ko) 2018-10-26 2021-08-04 오큐파이어 파마, 인크. 노안, 산동, 및 기타 안구 장애의 치료를 위한 방법 및 조성물
CA3168400A1 (en) 2020-02-19 2021-08-26 Vestlandets Innovasjonsselskap As Treatment of corneal vascularisation
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985875A (en) * 1974-01-12 1976-10-12 Dainippon Pharmaceutical Co., Ltd. ω-(N-acylamino)alkylphosphoryl ethanolamines, pharmaceutical compositions containing them, and their uses
FR2399409A1 (fr) * 1977-08-04 1979-03-02 Anvar Nouveaux derives de la pepstatine, leur preparation et les compositions pharmaceutiques qui les contiennent
US4269827A (en) * 1980-06-23 1981-05-26 The Massachusetts General Hospital Process and composition for reducing blood pressure
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4384994A (en) * 1981-10-08 1983-05-24 Merck & Co., Inc. Renin inhibitory peptides
US4478826A (en) * 1981-10-08 1984-10-23 Merck & Co., Inc. Renin inhibitory peptides
US4470971A (en) * 1981-10-19 1984-09-11 Merck & Co., Inc. Renin inhibitory peptides having His13
US4479941A (en) * 1981-12-10 1984-10-30 Merck & Co., Inc. Renin inhibitory peptides having PHE13 delection
FR2531951A1 (fr) * 1982-08-17 1984-02-24 Sanofi Sa Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
US4478827A (en) * 1983-05-09 1984-10-23 The General Hospital Corporation Renin inhibitors
US4455303A (en) * 1983-05-24 1984-06-19 The General Hospital Corporation Renin inhibitors
US4485099A (en) * 1983-06-15 1984-11-27 Merck & Co., Inc. Renin inhibitors containing a C-terminal amide cycle
US4477440A (en) * 1983-09-14 1984-10-16 Merck & Co., Inc. Renin inhibitors containing an n-terminal disulfide cycle
US4477441A (en) * 1983-09-14 1984-10-16 Merck & Co., Inc. Renin inhibitors containing a C-terminal disulfide cycle
US4602093A (en) * 1984-02-08 1986-07-22 Merck & Co., Inc. Novel substituted imidazoles, their preparation and use
US4510085A (en) * 1984-04-12 1985-04-09 G.D. Searle & Co. Antihypertensive tetrapeptide amides
US4514332A (en) * 1984-04-16 1985-04-30 G. D. Searle & Co. Tetrapeptide adamantyl amides
US4574127A (en) * 1984-05-07 1986-03-04 Merck & Co., Inc. Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl moiety
US4749698A (en) * 1985-07-08 1988-06-07 Rorer Pharmaceutical Corporation Antihypertensive derivatives

Also Published As

Publication number Publication date
WO1987002581A1 (en) 1987-05-07
EP0243477A1 (de) 1987-11-04
ES2031822T3 (es) 1993-01-01
GR3000993T3 (en) 1991-12-10
EP0246381B1 (de) 1990-08-01
US4906613A (en) 1990-03-06
US5352666A (en) 1994-10-04
JPS63501287A (ja) 1988-05-19
EP0246381A1 (de) 1987-11-25
DE3673161D1 (de) 1990-09-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee