ATE537183T1 - Hiv-fusionshemmerpeptide mit verbesserten biologischen eigenschaften - Google Patents

Hiv-fusionshemmerpeptide mit verbesserten biologischen eigenschaften

Info

Publication number
ATE537183T1
ATE537183T1 AT07749903T AT07749903T ATE537183T1 AT E537183 T1 ATE537183 T1 AT E537183T1 AT 07749903 T AT07749903 T AT 07749903T AT 07749903 T AT07749903 T AT 07749903T AT E537183 T1 ATE537183 T1 AT E537183T1
Authority
AT
Austria
Prior art keywords
biological properties
fusion inhibitor
improved biological
hiv fusion
inhibitor peptides
Prior art date
Application number
AT07749903T
Other languages
English (en)
Inventor
John Dwyer
Brian Bray
Stephen Schneider
Huyi Zhang
Nicolai Tvermoes
Barbara Johnston
Paul Friedrich
Original Assignee
Trimeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trimeris Inc filed Critical Trimeris Inc
Application granted granted Critical
Publication of ATE537183T1 publication Critical patent/ATE537183T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT07749903T 2006-02-02 2007-02-02 Hiv-fusionshemmerpeptide mit verbesserten biologischen eigenschaften ATE537183T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76467406P 2006-02-02 2006-02-02
PCT/US2007/002990 WO2007097903A2 (en) 2006-02-02 2007-02-02 Hiv fusion inhibitor peptides with improved biological properties

Publications (1)

Publication Number Publication Date
ATE537183T1 true ATE537183T1 (de) 2011-12-15

Family

ID=38437849

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07749903T ATE537183T1 (de) 2006-02-02 2007-02-02 Hiv-fusionshemmerpeptide mit verbesserten biologischen eigenschaften

Country Status (15)

Country Link
US (3) US7456251B2 (de)
EP (1) EP1989220B1 (de)
JP (1) JP4682251B2 (de)
CN (1) CN101415723B (de)
AR (2) AR059300A1 (de)
AT (1) ATE537183T1 (de)
AU (1) AU2007218025A1 (de)
CA (1) CA2651793C (de)
CY (1) CY1113115T1 (de)
DK (1) DK1989220T3 (de)
ES (1) ES2381631T3 (de)
NZ (1) NZ570300A (de)
PT (1) PT1989220E (de)
TW (1) TWI341844B (de)
WO (1) WO2007097903A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI341844B (en) 2006-02-02 2011-05-11 Trimeris Inc Hiv fusion inhibitor peptides with improved biological properties
EP2201028A2 (de) * 2007-09-25 2010-06-30 Trimeris, Inc. Neues verfahren zur synthese therapeutischer antiviraler peptide
US8828931B2 (en) * 2008-05-28 2014-09-09 New York Blood Center, Inc. Bifunctional molecules for inhibiting HIV entry
AU2009281992A1 (en) * 2008-08-13 2010-02-18 New York Blood Center Combination therapy of HIV fusion/entry inhibitors targeting gp41
CA2739288A1 (en) * 2008-10-16 2010-04-22 Shibo Jiang Immunoenhancer-linked oligomeric hiv vaccines
WO2010047826A2 (en) * 2008-10-24 2010-04-29 Trimeris, Inc. Dosing regimens and dosage formulations of an antiviral peptide therapeutic
CA2751865A1 (en) * 2009-02-09 2010-08-12 New York Blood Center, Inc. Trimeric hiv fusion inhibitors for treating or preventing hiv infection
CN102883740B (zh) 2010-05-03 2015-10-14 纽约血库公司 用于使hiv失活并阻断hiv的双功能分子
CN104159914A (zh) * 2011-12-19 2014-11-19 爱尔兰詹森研发公司 Hiv膜融合抑制剂
WO2013150532A1 (en) 2012-04-04 2013-10-10 Yeda Research And Development Co. Ltd. Lipopeptide conjugates comprising sphingolipid and hiv gp41 derived peptides
CN103724404B (zh) * 2013-12-08 2016-11-02 北京工业大学 抑制hiv病毒与宿主细胞融合的非对映体多肽及其用途
GB201509782D0 (en) * 2015-06-05 2015-07-22 Isis Innovation Methods and products for fusion protein synthesis
CN109320593A (zh) * 2018-11-05 2019-02-12 中国人民解放军军事科学院军事医学研究院 抑制hiv感染的螺旋多肽及其用途

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CN1030256A (zh) * 1987-06-29 1989-01-11 日清食品株式会社 检测和治疗人类免疫缺陷病毒的方法和物质
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NZ254640A (en) 1992-07-20 1997-04-24 Univ Duke Hiv protein fragments of transmembrane glycoprotein gp41 (dp-107) with antiviral activity and their use
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Also Published As

Publication number Publication date
CN101415723A (zh) 2009-04-22
US8034899B2 (en) 2011-10-11
EP1989220B1 (de) 2011-12-14
EP1989220A4 (de) 2009-05-06
ES2381631T3 (es) 2012-05-30
US20090105143A1 (en) 2009-04-23
TWI341844B (en) 2011-05-11
NZ570300A (en) 2011-08-26
DK1989220T3 (da) 2012-04-02
US20120040891A1 (en) 2012-02-16
CA2651793A1 (en) 2007-08-30
CY1113115T1 (el) 2016-04-13
EP1989220A2 (de) 2008-11-12
WO2007097903A2 (en) 2007-08-30
AR059300A1 (es) 2008-03-26
US7456251B2 (en) 2008-11-25
JP2009525051A (ja) 2009-07-09
JP4682251B2 (ja) 2011-05-11
AR108277A2 (es) 2018-08-01
CN101415723B (zh) 2014-06-25
WO2007097903A3 (en) 2008-05-22
AU2007218025A1 (en) 2007-08-30
PT1989220E (pt) 2012-03-23
TW200806687A (en) 2008-02-01
CA2651793C (en) 2015-07-07
US20070179278A1 (en) 2007-08-02

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