ATE536548T1 - Mikrowell-array-chip zum nachweis eines antigenspezifischen lymphozyten, verfahren zum nachweis eines antigenspezifischen lymphozyten und verfahren zur klonierung eines antigenrezeptorgens eines antigenspezifischen lymphozyten - Google Patents
Mikrowell-array-chip zum nachweis eines antigenspezifischen lymphozyten, verfahren zum nachweis eines antigenspezifischen lymphozyten und verfahren zur klonierung eines antigenrezeptorgens eines antigenspezifischen lymphozytenInfo
- Publication number
- ATE536548T1 ATE536548T1 AT03812277T AT03812277T ATE536548T1 AT E536548 T1 ATE536548 T1 AT E536548T1 AT 03812277 T AT03812277 T AT 03812277T AT 03812277 T AT03812277 T AT 03812277T AT E536548 T1 ATE536548 T1 AT E536548T1
- Authority
- AT
- Austria
- Prior art keywords
- antigen
- detecting
- specific lymphocyte
- lymphocyte
- array chip
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/0074—Biological products
- B01J2219/00743—Cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002331031 | 2002-11-14 | ||
JP2002346728 | 2002-11-29 | ||
PCT/JP2003/012500 WO2004051266A1 (ja) | 2002-11-14 | 2003-09-30 | 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法、並びに抗原特異的リンパ球抗原受容体遺伝子のクローニング方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE536548T1 true ATE536548T1 (de) | 2011-12-15 |
Family
ID=32473638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03812277T ATE536548T1 (de) | 2002-11-14 | 2003-09-30 | Mikrowell-array-chip zum nachweis eines antigenspezifischen lymphozyten, verfahren zum nachweis eines antigenspezifischen lymphozyten und verfahren zur klonierung eines antigenrezeptorgens eines antigenspezifischen lymphozyten |
Country Status (6)
Country | Link |
---|---|
US (2) | US20060134704A1 (de) |
EP (2) | EP2365331B1 (de) |
AT (1) | ATE536548T1 (de) |
AU (1) | AU2003266712A1 (de) |
DK (1) | DK1566635T3 (de) |
WO (1) | WO2004051266A1 (de) |
Families Citing this family (67)
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EP2365331B1 (de) * | 2002-11-14 | 2015-11-04 | Valneva | Vefahren zur Klonierung eines Antigenspezifischen Lymphozyten zu klonen. |
IL154677A0 (en) | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
WO2004087911A1 (ja) * | 2003-03-28 | 2004-10-14 | Toyama New Industry Organization | 1個の抗原特異的bリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法 |
US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
US7888110B2 (en) | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
US8597597B2 (en) | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
EP1691196B1 (de) * | 2003-09-25 | 2012-12-26 | Toyama Prefecture | Microwell-array-chip und verfahren zu dessen herstellung |
JP2006061023A (ja) * | 2004-08-24 | 2006-03-09 | Suntory Ltd | マイクロチャンバーアレイを用いたスクリーニング方法およびスクリーニング装置 |
JP3927978B2 (ja) * | 2004-11-02 | 2007-06-13 | キヤノン株式会社 | 生化学反応カートリッジおよび生化学処理装置システム |
WO2006080000A1 (en) | 2005-01-25 | 2006-08-03 | Seng Enterprises Ltd. | Device for the studying individual cells |
WO2007035633A2 (en) | 2005-09-16 | 2007-03-29 | President & Fellows Of Harvard College | Screening assays and methods |
JP4025916B2 (ja) | 2005-09-30 | 2007-12-26 | 富山県 | 感熱応答性高分子を用いた穴パタン付き膜を有するチップ及びその製造方法 |
US8288120B2 (en) | 2005-11-03 | 2012-10-16 | Seng Enterprises Ltd. | Method for studying floating, living cells |
JP2009520188A (ja) * | 2005-12-16 | 2009-05-21 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | サブミクロン表面プラズモン共鳴センサシステム |
US8355136B2 (en) | 2005-12-16 | 2013-01-15 | Indiana University Research And Technology Corporation | Sub-micron surface plasmon resonance sensor systems |
US20080227664A1 (en) * | 2007-03-16 | 2008-09-18 | Canon Kabushiki Kaisha | Cell array structural body and cell array |
JP4148367B1 (ja) | 2007-08-02 | 2008-09-10 | 富山県 | 細胞のスクリーニング方法 |
WO2009045898A2 (en) * | 2007-09-28 | 2009-04-09 | Mayo Foundation For Medical Education And Research | Assessing t cell repertoires |
US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
EP2237887A2 (de) | 2007-12-26 | 2010-10-13 | Seng Enterprises Ltd. | Vorrichtung zur untersuchung von lebenden zellen |
EP2098536A1 (de) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation und Identifikation antigen- oder ligandenspezifischer Bindungsproteine |
US8309035B2 (en) * | 2008-04-05 | 2012-11-13 | Single Cell Technology, Inc. | Multi-well system |
US9249445B2 (en) | 2008-09-02 | 2016-02-02 | National Institute Of Advanced Industrial Science And Technology | Cell detection method, and microarray chip for use in the method |
CN104195227B (zh) | 2008-11-07 | 2017-04-12 | 适应生物技术公司 | 通过序列分析监测状况的方法 |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US8691510B2 (en) * | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US8748103B2 (en) * | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
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US10087408B2 (en) | 2010-07-07 | 2018-10-02 | The University Of British Columbia | System and method for microfluidic cell culture |
EP2724157B1 (de) | 2011-06-27 | 2017-03-08 | Valneva | Screening-verfahren für zellen |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
AU2012325791B2 (en) | 2011-10-21 | 2018-04-05 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
ES2683037T3 (es) | 2011-12-09 | 2018-09-24 | Adaptive Biotechnologies Corporation | Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima |
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US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
JP6327734B2 (ja) * | 2012-03-07 | 2018-05-23 | 国立大学法人富山大学 | T細胞の刺激方法およびその利用 |
SG10201507700VA (en) | 2012-05-08 | 2015-10-29 | Adaptive Biotechnologies Corp | Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions |
AU2013327423B2 (en) | 2012-10-01 | 2017-06-22 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
JP6210004B2 (ja) * | 2013-04-09 | 2017-10-11 | 株式会社Jvcケンウッド | 試料分析用デバイス及びエクソソームの捕捉方法 |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
ES2741740T3 (es) | 2014-03-05 | 2020-02-12 | Adaptive Biotechnologies Corp | Métodos que usan moléculas sintéticas que contienen segmentos de nucleótidos aleatorios |
US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
US10533204B2 (en) | 2014-05-30 | 2020-01-14 | National University Corporatlon University of Toyama | Method for amplifying a T cell receptor (TCR) cDNA |
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US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
CA2968543C (en) | 2014-11-25 | 2024-04-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
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EP3277294B1 (de) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Verfahren zur identifizierung von menschlichen kompatiblen t-zell-rezeptoren spezifisch für ein antigen-ziel |
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CN109563539A (zh) | 2016-06-15 | 2019-04-02 | 慕尼黑路德维希马克西米利安斯大学 | 使用dna纳米技术的单分子检测或定量 |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
US10724089B2 (en) | 2016-10-06 | 2020-07-28 | The Board Of Trustees Of The University Of Illinois | Spatial molecular analysis of tissue |
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US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
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US20030027214A1 (en) * | 1999-02-17 | 2003-02-06 | Kamb Carl Alexander | Methods for substrate-ligand interaction screening |
DE10082052T1 (de) * | 1999-07-02 | 2001-09-27 | Thomson Licensing Sa | Fernseh-Projektionsschirm |
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US20020141906A1 (en) | 2001-03-30 | 2002-10-03 | American Type Culture Collection | Microtiter plate sealing cover with well identifiers |
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JP4754746B2 (ja) | 2001-09-28 | 2011-08-24 | オリンパス株式会社 | 棒状担体およびこれを具備するシリンダー反応容器 |
EP2365331B1 (de) * | 2002-11-14 | 2015-11-04 | Valneva | Vefahren zur Klonierung eines Antigenspezifischen Lymphozyten zu klonen. |
WO2004087911A1 (ja) | 2003-03-28 | 2004-10-14 | Toyama New Industry Organization | 1個の抗原特異的bリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法 |
-
2003
- 2003-09-30 EP EP10184204.5A patent/EP2365331B1/de not_active Expired - Lifetime
- 2003-09-30 US US10/534,800 patent/US20060134704A1/en not_active Abandoned
- 2003-09-30 DK DK03812277.6T patent/DK1566635T3/da active
- 2003-09-30 EP EP03812277A patent/EP1566635B1/de not_active Revoked
- 2003-09-30 WO PCT/JP2003/012500 patent/WO2004051266A1/ja active Application Filing
- 2003-09-30 AT AT03812277T patent/ATE536548T1/de active
- 2003-09-30 AU AU2003266712A patent/AU2003266712A1/en not_active Abandoned
-
2008
- 2008-12-17 US US12/337,481 patent/US8445193B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8445193B2 (en) | 2013-05-21 |
US20090181859A1 (en) | 2009-07-16 |
EP1566635B1 (de) | 2011-12-07 |
EP1566635A1 (de) | 2005-08-24 |
AU2003266712A1 (en) | 2004-06-23 |
WO2004051266A1 (ja) | 2004-06-17 |
EP1566635A4 (de) | 2006-12-27 |
EP2365331A2 (de) | 2011-09-14 |
DK1566635T3 (da) | 2012-03-19 |
EP2365331B1 (de) | 2015-11-04 |
US20060134704A1 (en) | 2006-06-22 |
EP2365331A3 (de) | 2011-11-23 |
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