ATE536548T1 - Mikrowell-array-chip zum nachweis eines antigenspezifischen lymphozyten, verfahren zum nachweis eines antigenspezifischen lymphozyten und verfahren zur klonierung eines antigenrezeptorgens eines antigenspezifischen lymphozyten - Google Patents

Mikrowell-array-chip zum nachweis eines antigenspezifischen lymphozyten, verfahren zum nachweis eines antigenspezifischen lymphozyten und verfahren zur klonierung eines antigenrezeptorgens eines antigenspezifischen lymphozyten

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Publication number
ATE536548T1
ATE536548T1 AT03812277T AT03812277T ATE536548T1 AT E536548 T1 ATE536548 T1 AT E536548T1 AT 03812277 T AT03812277 T AT 03812277T AT 03812277 T AT03812277 T AT 03812277T AT E536548 T1 ATE536548 T1 AT E536548T1
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Prior art keywords
antigen
detecting
specific lymphocyte
lymphocyte
array chip
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AT03812277T
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English (en)
Inventor
Atsushi Muraguchi
Hiroyuki Kishi
Eiichi Tamiya
Masayasu Susuki
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Vivalis
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082Hepadnaviridae, e.g. hepatitis B virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/0074Biological products
    • B01J2219/00743Cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT03812277T 2002-11-14 2003-09-30 Mikrowell-array-chip zum nachweis eines antigenspezifischen lymphozyten, verfahren zum nachweis eines antigenspezifischen lymphozyten und verfahren zur klonierung eines antigenrezeptorgens eines antigenspezifischen lymphozyten ATE536548T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002331031 2002-11-14
JP2002346728 2002-11-29
PCT/JP2003/012500 WO2004051266A1 (ja) 2002-11-14 2003-09-30 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法、並びに抗原特異的リンパ球抗原受容体遺伝子のクローニング方法

Publications (1)

Publication Number Publication Date
ATE536548T1 true ATE536548T1 (de) 2011-12-15

Family

ID=32473638

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03812277T ATE536548T1 (de) 2002-11-14 2003-09-30 Mikrowell-array-chip zum nachweis eines antigenspezifischen lymphozyten, verfahren zum nachweis eines antigenspezifischen lymphozyten und verfahren zur klonierung eines antigenrezeptorgens eines antigenspezifischen lymphozyten

Country Status (6)

Country Link
US (2) US20060134704A1 (de)
EP (2) EP2365331B1 (de)
AT (1) ATE536548T1 (de)
AU (1) AU2003266712A1 (de)
DK (1) DK1566635T3 (de)
WO (1) WO2004051266A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2365331B1 (de) * 2002-11-14 2015-11-04 Valneva Vefahren zur Klonierung eines Antigenspezifischen Lymphozyten zu klonen.
IL154677A0 (en) 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
WO2004087911A1 (ja) * 2003-03-28 2004-10-14 Toyama New Industry Organization 1個の抗原特異的bリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US7888110B2 (en) 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US8597597B2 (en) 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
EP1691196B1 (de) * 2003-09-25 2012-12-26 Toyama Prefecture Microwell-array-chip und verfahren zu dessen herstellung
JP2006061023A (ja) * 2004-08-24 2006-03-09 Suntory Ltd マイクロチャンバーアレイを用いたスクリーニング方法およびスクリーニング装置
JP3927978B2 (ja) * 2004-11-02 2007-06-13 キヤノン株式会社 生化学反応カートリッジおよび生化学処理装置システム
WO2006080000A1 (en) 2005-01-25 2006-08-03 Seng Enterprises Ltd. Device for the studying individual cells
WO2007035633A2 (en) 2005-09-16 2007-03-29 President & Fellows Of Harvard College Screening assays and methods
JP4025916B2 (ja) 2005-09-30 2007-12-26 富山県 感熱応答性高分子を用いた穴パタン付き膜を有するチップ及びその製造方法
US8288120B2 (en) 2005-11-03 2012-10-16 Seng Enterprises Ltd. Method for studying floating, living cells
JP2009520188A (ja) * 2005-12-16 2009-05-21 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション サブミクロン表面プラズモン共鳴センサシステム
US8355136B2 (en) 2005-12-16 2013-01-15 Indiana University Research And Technology Corporation Sub-micron surface plasmon resonance sensor systems
US20080227664A1 (en) * 2007-03-16 2008-09-18 Canon Kabushiki Kaisha Cell array structural body and cell array
JP4148367B1 (ja) 2007-08-02 2008-09-10 富山県 細胞のスクリーニング方法
WO2009045898A2 (en) * 2007-09-28 2009-04-09 Mayo Foundation For Medical Education And Research Assessing t cell repertoires
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
EP2237887A2 (de) 2007-12-26 2010-10-13 Seng Enterprises Ltd. Vorrichtung zur untersuchung von lebenden zellen
EP2098536A1 (de) 2008-03-05 2009-09-09 4-Antibody AG Isolation und Identifikation antigen- oder ligandenspezifischer Bindungsproteine
US8309035B2 (en) * 2008-04-05 2012-11-13 Single Cell Technology, Inc. Multi-well system
US9249445B2 (en) 2008-09-02 2016-02-02 National Institute Of Advanced Industrial Science And Technology Cell detection method, and microarray chip for use in the method
CN104195227B (zh) 2008-11-07 2017-04-12 适应生物技术公司 通过序列分析监测状况的方法
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8691510B2 (en) * 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US8748103B2 (en) * 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8685898B2 (en) 2009-01-15 2014-04-01 Imdaptive, Inc. Adaptive immunity profiling and methods for generation of monoclonal antibodies
CA2765949C (en) 2009-06-25 2016-03-29 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US20130115606A1 (en) 2010-07-07 2013-05-09 The University Of British Columbia System and method for microfluidic cell culture
US10087408B2 (en) 2010-07-07 2018-10-02 The University Of British Columbia System and method for microfluidic cell culture
EP2724157B1 (de) 2011-06-27 2017-03-08 Valneva Screening-verfahren für zellen
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
AU2012325791B2 (en) 2011-10-21 2018-04-05 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
ES2683037T3 (es) 2011-12-09 2018-09-24 Adaptive Biotechnologies Corporation Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US8790907B2 (en) 2012-01-27 2014-07-29 Japan Agency For Marine-Earth Science And Technology Method for detachment and preparation of living microorganisms
US10077478B2 (en) 2012-03-05 2018-09-18 Adaptive Biotechnologies Corp. Determining paired immune receptor chains from frequency matched subunits
JP6327734B2 (ja) * 2012-03-07 2018-05-23 国立大学法人富山大学 T細胞の刺激方法およびその利用
SG10201507700VA (en) 2012-05-08 2015-10-29 Adaptive Biotechnologies Corp Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions
AU2013327423B2 (en) 2012-10-01 2017-06-22 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
US10150996B2 (en) 2012-10-19 2018-12-11 Adaptive Biotechnologies Corp. Quantification of adaptive immune cell genomes in a complex mixture of cells
JP6210004B2 (ja) * 2013-04-09 2017-10-11 株式会社Jvcケンウッド 試料分析用デバイス及びエクソソームの捕捉方法
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
ES2741740T3 (es) 2014-03-05 2020-02-12 Adaptive Biotechnologies Corp Métodos que usan moléculas sintéticas que contienen segmentos de nucleótidos aleatorios
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US10533204B2 (en) 2014-05-30 2020-01-14 National University Corporatlon University of Toyama Method for amplifying a T cell receptor (TCR) cDNA
ES2784343T3 (es) 2014-10-29 2020-09-24 Adaptive Biotechnologies Corp Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras
EP3216852A4 (de) * 2014-11-04 2018-09-26 Toppan Printing Co., Ltd. Verfahren zum einbringen von nukleinsäure, verfahren zur erkennung von nukleinsäure, verfahren zur analyse eines biologischen bestandteils, arrayvorrichtung zum testen eines biologischen bestandteils und kit zur analyse eines biologischen bestandteils
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
CA2968543C (en) 2014-11-25 2024-04-02 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
WO2016138122A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
WO2016149639A1 (en) 2015-03-19 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip
EP3277294B1 (de) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Verfahren zur identifizierung von menschlichen kompatiblen t-zell-rezeptoren spezifisch für ein antigen-ziel
WO2017132627A2 (en) 2016-01-29 2017-08-03 Achaogen, Inc. Screening methods for identifying antibodies that bind cell surface epitopes
CN109563539A (zh) 2016-06-15 2019-04-02 慕尼黑路德维希马克西米利安斯大学 使用dna纳米技术的单分子检测或定量
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US10724089B2 (en) 2016-10-06 2020-07-28 The Board Of Trustees Of The University Of Illinois Spatial molecular analysis of tissue
WO2018140827A1 (en) 2017-01-27 2018-08-02 Achaogen, Inc. Reporter microorganisms and uses thereof
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2020120442A2 (en) 2018-12-13 2020-06-18 Dna Script Direct oligonucleotide synthesis on cells and biomolecules
JP2024500268A (ja) * 2020-10-22 2024-01-09 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ テキサス システム 高スループットマイクロウェルアレイプレートおよび製造方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272081A (en) * 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
IL68507A (en) * 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US5310674A (en) 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
US6410252B1 (en) * 1995-12-22 2002-06-25 Case Western Reserve University Methods for measuring T cell cytokines
EP0937251B1 (de) * 1996-09-06 2006-11-29 Ortho-McNeil Pharmaceutical, Inc. Reinigung von antigenspezifischen t-zellen
US6548263B1 (en) * 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
CA2318881A1 (en) 1998-02-04 1999-08-12 Tina Garyantes Virtual wells for use in high throughput screening assays
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6087103A (en) * 1998-03-04 2000-07-11 Lifespan Biosciences, Inc. Tagged ligand arrays for identifying target-ligand interactions
US20030027214A1 (en) * 1999-02-17 2003-02-06 Kamb Carl Alexander Methods for substrate-ligand interaction screening
DE10082052T1 (de) * 1999-07-02 2001-09-27 Thomson Licensing Sa Fernseh-Projektionsschirm
US7211209B2 (en) * 2000-11-08 2007-05-01 Surface Logix, Inc. Method of making device for arraying biomolecules and for monitoring cell motility in real-time
US20020141906A1 (en) 2001-03-30 2002-10-03 American Type Culture Collection Microtiter plate sealing cover with well identifiers
US6777187B2 (en) * 2001-05-02 2004-08-17 Rubicon Genomics, Inc. Genome walking by selective amplification of nick-translate DNA library and amplification from complex mixtures of templates
JP4754746B2 (ja) 2001-09-28 2011-08-24 オリンパス株式会社 棒状担体およびこれを具備するシリンダー反応容器
EP2365331B1 (de) * 2002-11-14 2015-11-04 Valneva Vefahren zur Klonierung eines Antigenspezifischen Lymphozyten zu klonen.
WO2004087911A1 (ja) 2003-03-28 2004-10-14 Toyama New Industry Organization 1個の抗原特異的bリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法

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Publication number Publication date
US8445193B2 (en) 2013-05-21
US20090181859A1 (en) 2009-07-16
EP1566635B1 (de) 2011-12-07
EP1566635A1 (de) 2005-08-24
AU2003266712A1 (en) 2004-06-23
WO2004051266A1 (ja) 2004-06-17
EP1566635A4 (de) 2006-12-27
EP2365331A2 (de) 2011-09-14
DK1566635T3 (da) 2012-03-19
EP2365331B1 (de) 2015-11-04
US20060134704A1 (en) 2006-06-22
EP2365331A3 (de) 2011-11-23

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