ATE533486T1 - Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzung - Google Patents
Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzungInfo
- Publication number
- ATE533486T1 ATE533486T1 AT06791093T AT06791093T ATE533486T1 AT E533486 T1 ATE533486 T1 AT E533486T1 AT 06791093 T AT06791093 T AT 06791093T AT 06791093 T AT06791093 T AT 06791093T AT E533486 T1 ATE533486 T1 AT E533486T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridone derivatives
- preventing
- lung injury
- radiotherapy
- related lung
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80491406P | 2006-06-15 | 2006-06-15 | |
PCT/CN2006/002504 WO2007147297A1 (en) | 2006-06-15 | 2006-09-25 | The use of derviate of pyridone for preventing and treating radioactive injury of lungs |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE533486T1 true ATE533486T1 (de) | 2011-12-15 |
Family
ID=38833053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06791093T ATE533486T1 (de) | 2006-06-15 | 2006-09-25 | Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzung |
Country Status (7)
Country | Link |
---|---|
US (2) | US8765726B2 (de) |
EP (1) | EP2036555B1 (de) |
JP (1) | JP5213852B2 (de) |
CN (1) | CN101484167B (de) |
AT (1) | ATE533486T1 (de) |
CA (1) | CA2656017C (de) |
WO (1) | WO2007147297A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2395396T3 (es) | 2006-12-18 | 2013-02-12 | Intermune, Inc. | Método para proporcionar una terapia de pirfenidona a un paciente |
CA3034994A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders |
US20100190731A1 (en) * | 2009-01-26 | 2010-07-29 | Jeff Olgin | Methods for treating acute myocardial infarctions and associated disorders |
MX2011007675A (es) * | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
WO2014151517A1 (en) | 2013-03-15 | 2014-09-25 | Intermune, Inc. | Methods of improving microvascular integrity |
US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
KR102373700B1 (ko) | 2014-04-02 | 2022-03-11 | 인터뮨, 인크. | 항섬유성 피리디논 |
JP6704403B2 (ja) * | 2015-02-05 | 2020-06-03 | メモリアル スローン ケタリング キャンサー センター | 浮腫の治療のための組成物及び方法 |
EP3969114A4 (de) * | 2019-05-13 | 2023-04-05 | Bio Med Sciences, Inc. | Wirkstoffhaltige produkte zur wund- und narbenpflege, verfahren zur herstellung und nützliche artikel daraus |
CN115429802A (zh) * | 2021-06-04 | 2022-12-06 | 北京康蒂尼药业股份有限公司 | 包含羟尼酮与右美沙芬的药物组合物及其治疗肺纤维化的应用 |
CN113274389B (zh) * | 2021-07-09 | 2022-11-08 | 中南大学 | 氟非尼酮在制备治疗急性肺损伤药物中的应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1049411A (en) | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
AU5427080A (en) | 1979-01-08 | 1980-07-17 | Margolin, B. | Pirfenidone in the treatment of pulmonary interstitial fibrosis |
JPH02215719A (ja) | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
ES2183839T3 (es) | 1993-05-07 | 2003-04-01 | Solomon B Margolin | Composiciones y procedimiento de reparacion y de prevencion de lesiones del tipo de fibrosis. |
US5789426A (en) | 1995-01-20 | 1998-08-04 | Cornell Research Foundation, Inc. | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation |
US6114353A (en) * | 1995-03-03 | 2000-09-05 | Margolin; Solomon B. | Compositions and method for treatment of lymphomas, leukemias, and leiomyomas |
US6090822A (en) | 1995-03-03 | 2000-07-18 | Margolin; Solomon B. | Treatment of cytokine growth factor caused disorders |
EP1242084B1 (de) * | 2000-01-24 | 2006-07-05 | MARGOLIN, Solomon B. | Behandlung von brustkarzinomen, astrozytomen, melanomen und verwandten tumoren |
WO2001058448A1 (fr) * | 2000-02-09 | 2001-08-16 | Shionogi & Co., Ltd. | Inhibiteur d'apoptose |
WO2004019863A2 (en) * | 2002-08-28 | 2004-03-11 | Intermune, Inc. | Combination therapy for treatment of fibrotic disorders |
WO2005000227A2 (en) * | 2003-06-06 | 2005-01-06 | Intermune, Inc. | Methods of treating tnf-mediated disorders |
US7407973B2 (en) * | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
US7825133B2 (en) * | 2003-11-14 | 2010-11-02 | Shanghai Genomics, Inc. | Derivatives of pyridone and the use of them |
CN100542532C (zh) * | 2004-05-24 | 2009-09-23 | 上海睿星基因技术有限公司 | 吡非尼酮在制备治疗肝损伤坏死和急性肺损伤的药物中的用途 |
-
2006
- 2006-09-25 EP EP06791093A patent/EP2036555B1/de active Active
- 2006-09-25 WO PCT/CN2006/002504 patent/WO2007147297A1/zh active Application Filing
- 2006-09-25 AT AT06791093T patent/ATE533486T1/de active
- 2006-09-25 JP JP2009514614A patent/JP5213852B2/ja active Active
- 2006-09-25 CN CN2006800549309A patent/CN101484167B/zh active Active
- 2006-09-25 CA CA2656017A patent/CA2656017C/en active Active
-
2007
- 2007-12-17 US US11/958,353 patent/US8765726B2/en active Active
-
2014
- 2014-05-12 US US14/275,562 patent/US20140249347A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101484167B (zh) | 2012-07-04 |
JP5213852B2 (ja) | 2013-06-19 |
CN101484167A (zh) | 2009-07-15 |
CA2656017A1 (en) | 2007-12-27 |
WO2007147297A1 (en) | 2007-12-27 |
EP2036555A4 (de) | 2009-11-11 |
US20080161361A1 (en) | 2008-07-03 |
EP2036555B1 (de) | 2011-11-16 |
US8765726B2 (en) | 2014-07-01 |
EP2036555A1 (de) | 2009-03-18 |
CA2656017C (en) | 2014-02-04 |
JP2009539887A (ja) | 2009-11-19 |
US20140249347A1 (en) | 2014-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE533486T1 (de) | Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzung | |
ATE376828T1 (de) | Verwendung von rotigotin zur behandlung und prävention des parkinson-plus-syndroms | |
MY148985A (en) | 2-aminopyridine analogs as glucokinase activators | |
BRPI0506736A (pt) | composto estereoisoméricos e métodos para o tratamento de distúrbios gastrointestinais e no sistema nervoso central | |
EA201590353A1 (ru) | Способы лечения болезни альцгеймера и фармацевтические композиции | |
ATE521608T1 (de) | Glucokinaseaktivatoren | |
BRPI0607017A2 (pt) | métodos e composições para o tratamento de condições relacionadas ao snc | |
ATE480255T1 (de) | Zusammensetzungen und verfahren zur kontrolle, prävention und behandlung von essstörungen | |
ATE427759T1 (de) | Behandlung von fettsucht und verbundenen erkrankungen | |
MY174018A (en) | Heterocyclic derivates | |
MY145077A (en) | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | |
MX2012000034A (es) | Metodos para el tratamiento o la prevencion de la fatiga. | |
SG195383A1 (en) | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection | |
TW200510334A (en) | Preraration and use of aryl alkyl acid derivatives for the treatment of obesity | |
EA201000603A1 (ru) | ПРИМЕНЕНИЕ АНТИТЕЛ К TrkB ДЛЯ ЛЕЧЕНИЯ РЕСПИРАТОРНЫХ НАРУШЕНИЙ | |
WO2008090287A3 (fr) | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida | |
DE602005008241D1 (de) | Zusammensetzung mit einem survivin-antisense-oligonucleotid und gemcitabin zur behandlung von krebs | |
DE602005009162D1 (de) | Alpha-aminoamidderivate zur behandlung des restless-leg-syndroms | |
ATE424208T1 (de) | Proteinkinaseinhibitoren | |
EA201492279A1 (ru) | Лекарственное средство для предупреждения и/или лечения поликистозной болезни почек | |
IL200410A0 (en) | Novel derivatives of psammaplin a, a method for their synthesis and their use for the prevention or treatment of cancer | |
MX2008002456A (es) | Uso de ambroxol para el tratamiento de infecciones por rinovirus. | |
DE602005007471D1 (de) | Satraplatin zur behandlung von resistenten oder refrkatären tumoren | |
ATE428470T1 (de) | Heilmittel zur behandlung von erkrankungen des sehnervs | |
DE602006020838D1 (de) | Medikamente zur prävention oder behandlung von herzversagen mit einem anticholinergikum |