ATE533041T1 - Verfahren zur analyse einer probe und vorrichtung dafür - Google Patents

Verfahren zur analyse einer probe und vorrichtung dafür

Info

Publication number
ATE533041T1
ATE533041T1 AT05768147T AT05768147T ATE533041T1 AT E533041 T1 ATE533041 T1 AT E533041T1 AT 05768147 T AT05768147 T AT 05768147T AT 05768147 T AT05768147 T AT 05768147T AT E533041 T1 ATE533041 T1 AT E533041T1
Authority
AT
Austria
Prior art keywords
sample
response
processing means
experiment
analyzing
Prior art date
Application number
AT05768147T
Other languages
English (en)
Inventor
Colin Blackmore
Patrick Courtney
Alistair Fitch
Shab Ladha
Original Assignee
Perkinelmer Singapore Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkinelmer Singapore Pte Ltd filed Critical Perkinelmer Singapore Pte Ltd
Priority claimed from PCT/GB2005/003226 external-priority patent/WO2006024819A2/en
Application granted granted Critical
Publication of ATE533041T1 publication Critical patent/ATE533041T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT05768147T 2004-09-01 2005-08-17 Verfahren zur analyse einer probe und vorrichtung dafür ATE533041T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0419325.6A GB0419325D0 (en) 2004-09-01 2004-09-01 A method of analysing a sample including fluorescent labels and apparatus therefor
GB0512811A GB2418018B (en) 2004-09-01 2005-06-23 A method of analysing a sample including fluorescent labels and apparatus therefor
PCT/GB2005/003226 WO2006024819A2 (en) 2004-09-01 2005-08-17 A method of analysing a sample and apparatus therefor

Publications (1)

Publication Number Publication Date
ATE533041T1 true ATE533041T1 (de) 2011-11-15

Family

ID=33104852

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05768147T ATE533041T1 (de) 2004-09-01 2005-08-17 Verfahren zur analyse einer probe und vorrichtung dafür

Country Status (4)

Country Link
US (1) US7671345B2 (de)
EP (1) EP2375240B1 (de)
AT (1) ATE533041T1 (de)
GB (2) GB0419325D0 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0900526D0 (en) 2009-01-14 2009-02-11 Perkinelmer Ltd Fluorescence microscopy methods and apparatus
US8759792B2 (en) * 2009-07-10 2014-06-24 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Non-contact total emission detection method and system for multi-photon microscopy
WO2012096619A1 (en) * 2011-01-12 2012-07-19 Applied Precision, Inc. Systems and methods for camera-based image processing in microscopy instruments
US9412572B2 (en) 2012-10-28 2016-08-09 Perkinelmer Health Sciences, Inc. Sample holders and methods of using them
US9117641B2 (en) 2012-10-29 2015-08-25 Perkinelmer Health Sciences, Inc. Direct sample analysis device adapters and methods of using them
US9733156B2 (en) 2012-10-29 2017-08-15 Perkinelmer Health Sciences, Inc. Sample platforms and methods of using them
US10597697B2 (en) * 2015-02-05 2020-03-24 Ge Healthcare Bio-Sciences Corp. Method of determining a nucleotide sequence of a nucleic acid segment from a region of interest in a biological sample
DE102015118856B3 (de) * 2015-11-04 2016-08-18 Netzsch-Gerätebau GmbH Verfahren und Vorrichtung zur photothermischen Untersuchung einer Probe
EP3418710B1 (de) * 2016-02-19 2022-08-24 Nikon Corporation Probenzubereitungsverfahren und probenzubereitungsvorrichtung
DE102016109303A1 (de) * 2016-05-20 2017-11-23 Friedrich-Schiller-Universität Jena Lasermikroskop mit Ablationsfunktion
WO2018044919A1 (en) * 2016-09-01 2018-03-08 The George Washington University Enzyme-dependent fluorescence recovery of nadh after photobleaching to assess dehydrogenase activity of living tissues
GB201707239D0 (en) * 2017-05-05 2017-06-21 Univ Edinburgh Optical system and method

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
JPH0660901B2 (ja) * 1985-08-30 1994-08-10 東ソー株式会社 酵素免疫測定法
US4895156A (en) * 1986-07-02 1990-01-23 Schulze John E Sensor system using fluorometric decay measurements
JPH05504263A (ja) * 1991-01-04 1993-07-08 マイクロスキャン、インコーポレイテッド 吸光度に制御された蛍光の変化をモニターすることによる隔離された蛍光団中における細菌性の二酸化炭素産生の測定
FR2671405B1 (fr) * 1991-01-04 1994-07-08 Inst Nat Sante Rech Med Dispositif de mesure du ph d'une cible, procede d'utilisation dudit dispositif et ses applications.
EP0717779B1 (de) * 1992-04-06 2001-10-31 Abbott Laboratories Verfahren und vorrichtung zum nachweis von nukleinsäure oder analysen unter verwendung der internen totalreflexion
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
DE69738605T2 (de) * 1996-06-04 2009-04-30 University Of Utah Research Foundation, Salt Lake City Behälter zum Durchführen und Beobachten biologischer Prozesse
US6259807B1 (en) * 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
WO2000006991A2 (en) * 1998-07-27 2000-02-10 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
US6289229B1 (en) * 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
EP1090073B1 (de) * 1999-04-23 2003-03-05 Molecular Probes Inc. Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen
US20030026762A1 (en) * 1999-05-05 2003-02-06 Malmros Mark K. Bio-spectral imaging system and methods for diagnosing cell disease state
AU779602B2 (en) * 2000-02-02 2005-02-03 Ge Healthcare Uk Limited Detection reagent
EP1146480B1 (de) * 2000-04-06 2003-09-10 European Molecular Biology Laboratory Rechnergesteuertes Mikroskop
US6678398B2 (en) * 2000-09-18 2004-01-13 Sti Medical Systems, Inc. Dual mode real-time screening and rapid full-area, selective-spectral, remote imaging and analysis device and process
CN1348096A (zh) * 2000-10-10 2002-05-08 栾国彦 一种均相特异性检测核酸的探针及应用方法
US20020048811A1 (en) * 2000-10-16 2002-04-25 Devreotes Peter N. Receptor mediated activation of heterotrimeric G-proteins
DE10155053B4 (de) * 2001-11-09 2005-11-24 Friz Biochem Gesellschaft Für Bioanalytik Mbh Reversible Bindung eines Fluorophors an eine Oberfläche zur Detektion von Ligat-Ligand-Assoziationsereignissen durch Fluoreszenz-Quenchen
WO2004038042A1 (fr) * 2002-10-24 2004-05-06 Ben Gao Methode quadridimensionnelle et appareil de detection d'une paire hybride d'acides nucleiques sur une puce a adn

Also Published As

Publication number Publication date
US20080315119A1 (en) 2008-12-25
GB0419325D0 (en) 2004-09-29
GB0512811D0 (en) 2005-08-03
EP2375240A1 (de) 2011-10-12
GB2418018B (en) 2007-09-12
EP2375240B1 (de) 2013-04-24
GB2418018A (en) 2006-03-15
US7671345B2 (en) 2010-03-02

Similar Documents

Publication Publication Date Title
ATE533041T1 (de) Verfahren zur analyse einer probe und vorrichtung dafür
SG126066A1 (en) Inspection method and system using multifrequency phase analysis
ATE390627T1 (de) Verfahren und vorrichtung zur oberflächenplasmonenmikroskopie
DE602009000662D1 (de) Vorrichtung und Verfahren zur Audiosignalverarbeitung
ATE339043T1 (de) Vorrichtung und verfahren zur datenverarbeitung
WO2007120996A3 (en) Method and apparatus for compact spectrometer for detecting hazardous agents
DE60308050D1 (de) Verfahren und vorrichtung zur vorbehandlung von proben durch zentrifugieren
DE59402462D1 (de) Verfahren und vorrichtung zur analyse von glucose in einer biologischen matrix
WO2006122232A3 (en) Methods and apparatus for imaging with magnetic induction
DE602006012964D1 (de) Vorrichtungen und verfahren zur analyse individueller zellen
DE60239940D1 (de) Verfahren, vorrichtungen und computerprogramme zum verifizieren der integrität einer sonde
ATE492801T1 (de) Vorrichtung und verfahren zur röntgenstrahlfluoreszenz-analyse einer mineralprobe
GB2468097A (en) Process and apparatus for testing a component using an omni-directional eddy current probe
WO2007101279A3 (en) Method and apparatus for compact spectrometer with fiber array spectral translator
DE60134844D1 (de) Verfahren zur identifizierung von objekten mittels eines optisches spektrometers und eines transportsystems
WO2006024819A8 (en) A method of analysing a sample and apparatus therefor
WO2006047662A3 (en) Method and apparatus for sediment characterization
ATE443851T1 (de) Verfahren und vorrichtung zur charakterisierung von fs-laserpulsen
ATE512455T1 (de) Vorrichtung und methode zur untersuchung oder modifizierung einer oberfläche mittels ladungsträgerstrahls
DE60311643D1 (de) Verfahren zur analyse von pharmazeutischen proben
DE60022141D1 (de) Verfahren und vorrichtung zur analyse radioaktiver gegenstände unter verwendung von neutronen
GB2439261A (en) Analytical instrumentation apparatus and methods
ATE463733T1 (de) Verfahren und vorrichtung zur messung dynamischer partikelparameter
ATE360205T1 (de) Verfahren und vorrichtung zum in-vitro-nachweis und kennzeichnung psychoaktiver substanzen, unter verwendung einer analyse der repetitiven elektrischen aktivität in einer neuronalen probe
AT501639B8 (de) Verfahren und vorrichtung zur zerstörungsfreien überprüfung von holzbauteilen