ATE529752T1 - Antikörperquantifizierung - Google Patents

Antikörperquantifizierung

Info

Publication number
ATE529752T1
ATE529752T1 AT07865898T AT07865898T ATE529752T1 AT E529752 T1 ATE529752 T1 AT E529752T1 AT 07865898 T AT07865898 T AT 07865898T AT 07865898 T AT07865898 T AT 07865898T AT E529752 T1 ATE529752 T1 AT E529752T1
Authority
AT
Austria
Prior art keywords
antibody
interest
biological sample
antibodies quantification
ore
Prior art date
Application number
AT07865898T
Other languages
English (en)
Inventor
Brian Walter Granda
Daniel B Wall
Yingqi Karen Wang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE529752T1 publication Critical patent/ATE529752T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT07865898T 2006-12-21 2007-12-20 Antikörperquantifizierung ATE529752T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87137806P 2006-12-21 2006-12-21
PCT/US2007/088258 WO2008079914A1 (en) 2006-12-21 2007-12-20 Antibody quantitation

Publications (1)

Publication Number Publication Date
ATE529752T1 true ATE529752T1 (de) 2011-11-15

Family

ID=39247371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07865898T ATE529752T1 (de) 2006-12-21 2007-12-20 Antikörperquantifizierung

Country Status (6)

Country Link
US (1) US20100015652A1 (de)
EP (1) EP2097756B1 (de)
JP (1) JP2010515020A (de)
AT (1) ATE529752T1 (de)
ES (1) ES2374403T3 (de)
WO (1) WO2008079914A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009029231A2 (en) 2007-08-24 2009-03-05 Millipore Corporation Method of detecting filter extractables in biopharmaceutical products by liquid chromatography-mass spectrometry
US8436297B2 (en) * 2007-08-24 2013-05-07 Emd Millipore Corporation System and method for diversion of a liquid chromatography eluant
WO2010086386A1 (en) * 2009-01-30 2010-08-05 Pronota N.V. Protein quantification methods and use thereof for candidate biomarker validation
EP2398918B1 (de) * 2009-02-20 2018-06-20 Onconome, Inc. Verfahren für die diagnose und prognose von kolorektalkarzinom
EP2572203B1 (de) 2010-05-17 2017-10-25 The Board of Regents of The University of Texas System Bestimmung von Antigen-spezifischen Antikörpersequenzen im Blutkreislauf
CA2829606C (en) 2011-03-09 2020-06-02 Cell Signaling Technology, Inc. Methods and reagents for creating monoclonal antibodies
WO2012155019A1 (en) 2011-05-12 2012-11-15 Genentech, Inc. Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides
GB201110371D0 (en) * 2011-06-17 2011-08-03 Proteome Sciences R & D Gmbh & Co Kg Materials and methods for determining sensitivity potential of compounds
EP2783214A2 (de) 2011-11-23 2014-10-01 The Board of Regents of The University of Texas System Proteomischer nachweis von antikörpern
EP2861760B1 (de) 2012-06-15 2020-01-01 The Board of Regents of The University of Texas System Sequenzierung von mehreren transkripten aus einer einzelnen zelle mit hohem durchsatz
CA2922372C (en) * 2013-09-09 2018-05-15 Shimadzu Corporation Method for preparing peptide fragments, kit for preparing peptide fragments to be used therein, and analysis method
EP3109630B1 (de) * 2014-02-18 2020-02-12 Shimadzu Corporation Proteinnachweis mittels massenspektrometrie
AU2015240454B2 (en) 2014-04-04 2019-08-22 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
US10338039B2 (en) 2015-03-09 2019-07-02 Shimadzu Corporation Method for detecting monoclonal antibody using mass spectrometry
CN115932065A (zh) * 2015-03-10 2023-04-07 株式会社岛津制作所 用于检测单克隆抗体的样品调制用试剂盒
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
JP6968058B2 (ja) 2015-09-24 2021-11-17 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 質量分析法による免疫グロブリン遊離軽鎖の同定
GB201603291D0 (en) * 2016-02-25 2016-04-13 Binding Site Group The Ltd Antibodies
WO2017205741A1 (en) 2016-05-27 2017-11-30 Genentech, Inc. Bioanalytical method for the characterization of site-specific antibody-drug conjugates
CA3031742A1 (en) 2016-08-16 2018-02-22 Regeneron Pharmaceuticals, Inc. Methods for quantitating individual antibodies from a mixture
AU2017325022B2 (en) 2016-09-07 2022-10-13 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
WO2019055634A1 (en) 2017-09-13 2019-03-21 Mayo Foundation For Medical Education And Research IDENTIFICATION AND MONITORING OF A MACROPHAGE APOPTOSIS INHIBITOR
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF
GB2607739B (en) * 2018-06-06 2023-04-05 Bruker Daltonics Gmbh & Co Kg Targeted protein characterization by mass spectrometry

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3491748B2 (ja) * 1999-07-22 2004-01-26 株式会社いかがく 血液中の低比重リポ蛋白（ｌｄｌ）もしくは変性低比重リポ蛋白の検出方法
JP4604345B2 (ja) * 2000-12-21 2011-01-05 住友化学株式会社 タンパク質のｎ末端のアミノ酸配列決定方法
EP1457499A1 (de) * 2003-03-12 2004-09-15 Tufts University School Of Medicine Inhibitoren des extrazellulären Hitzeschockproteins Hsp90
US7662936B2 (en) * 2004-04-07 2010-02-16 Genentech, Inc. Mass spectrometry of antibody conjugates

Also Published As

Publication number Publication date
WO2008079914A1 (en) 2008-07-03
ES2374403T3 (es) 2012-02-16
EP2097756B1 (de) 2011-10-19
EP2097756A1 (de) 2009-09-09
US20100015652A1 (en) 2010-01-21
JP2010515020A (ja) 2010-05-06

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