ATE52498T1 - Amidderivate. - Google Patents

Amidderivate.

Info

Publication number: ATE52498T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; manufacture; derivatives; amide derivatives
Prior art date: 1986-07-23

Application number

AT87306442T

Other languages

English (en)

Inventor

Brian Roy Holloway

Ralph Howe

Balbir Singh Rao

Donald Stribling

Original Assignee

Ici Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-23

Filing date

1987-07-21

Publication date

1990-05-15

1986-07-23 Priority claimed from GB868617986A external-priority patent/GB8617986D0/en

1987-01-28 Priority claimed from GB878701832A external-priority patent/GB8701832D0/en

1987-07-21 Application filed by Ici Plc filed Critical Ici Plc

1990-05-15 Application granted granted Critical

1990-05-15 Publication of ATE52498T1 publication Critical patent/ATE52498T1/de

Links

150000001408 amides Chemical class 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
AOPRXJXHLWYPQR-UHFFFAOYSA-N 2-phenoxyacetamide Chemical class NC(=O)COC1=CC=CC=C1 AOPRXJXHLWYPQR-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
-1 polymethylene Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Obesity (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Child & Adolescent Psychology (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Compounds Of Unknown Constitution (AREA)
Hydrogenated Pyridines (AREA)

AT87306442T 1986-07-23 1987-07-21 Amidderivate. ATE52498T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB868617986A GB8617986D0 (en)	1986-07-23	1986-07-23	Amide derivatives
GB878701832A GB8701832D0 (en)	1987-01-28	1987-01-28	Carboxamides
EP87306442A EP0254532B1 (de)	1986-07-23	1987-07-21	Amidderivate

Publications (1)

Publication Number	Publication Date
ATE52498T1 true ATE52498T1 (de)	1990-05-15

Family

ID=26291076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87306442T ATE52498T1 (de)	1986-07-23	1987-07-21	Amidderivate.

Country Status (24)

Country	Link
US (2)	US4927836A (de)
EP (1)	EP0254532B1 (de)
JP (1)	JPS6393755A (de)
KR (1)	KR880001576A (de)
CN (1)	CN1015707B (de)
AT (1)	ATE52498T1 (de)
AU (1)	AU604027B2 (de)
CA (1)	CA1327576C (de)
CS (1)	CS264145B2 (de)
DE (1)	DE3762618D1 (de)
DK (1)	DK385387A (de)
ES (1)	ES2018832B3 (de)
FI (1)	FI88289C (de)
GB (1)	GB8714901D0 (de)
GR (1)	GR3000571T3 (de)
HU (1)	HU197293B (de)
IE (1)	IE60887B1 (de)
IL (1)	IL83026A0 (de)
MY (1)	MY102866A (de)
NO (1)	NO174044C (de)
NZ (1)	NZ221158A (de)
PH (1)	PH23607A (de)
PT (1)	PT85379B (de)
SU (1)	SU1549476A3 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8801306D0 (en) *	1988-01-21	1988-02-17	Ici Plc	Chemical compounds
IL94466A (en) *	1989-05-25	1995-01-24	Erba Carlo Spa	Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
GB8925032D0 (en) *	1989-11-06	1989-12-28	Ici Plc	Chemical compounds
GB8926083D0 (en) *	1989-11-17	1990-01-10	Ici Plc	Therapeutic agents
GB9003185D0 (en) *	1990-02-13	1990-04-11	Ici Plc	Pharmaceutical compositions
GB9016655D0 (en) *	1990-07-30	1990-09-12	Ici Plc	Therapeutic agents
GB9111426D0 (en) *	1991-05-28	1991-07-17	Ici Plc	Chemical compounds
US5502078A (en) *	1991-05-28	1996-03-26	Zeneca Limited	Chemical compounds
GB9224740D0 (en) *	1992-11-26	1993-01-13	Ici Plc	Therapeutic agents
DK0703911T3 (da) *	1993-06-14	1997-10-06	Pfizer	Sekundære aminer som antidiabetiske og antiobesitetsmidler
US5578638A (en) *	1993-11-05	1996-11-26	American Cyanamid Company	Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5563171A (en) *	1993-11-05	1996-10-08	American Cyanamid Company	Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5627200A (en) *	1994-09-26	1997-05-06	Pfizer Inc	β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia
US6075040A (en) *	1996-09-05	2000-06-13	Eli Lilly And Company	Selective β3 adrenergic agonists
ZA967892B (en) *	1995-09-21	1998-03-18	Lilly Co Eli	Selective β3 adrenergic agonists.
DE69711519T2 (de)	1996-09-05	2002-10-31	Lilly Co Eli	Carbazolanaloge als selektive beta3-adrenergische Agonisten
CO5011072A1 (es) *	1997-12-05	2001-02-28	Lilly Co Eli	Etanolaminas pirazinil substituidas como agfonistas de los receptores
GB9727523D0 (en)	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Alpha-aminoamide derivatives useful as analgesic agents
US6344481B1 (en)	1999-03-01	2002-02-05	Pfizer Inc.	Thyromimetic antiobesity agents
US7504435B2 (en) *	2001-01-31	2009-03-17	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Method for stimulating weight loss and/or for lowering triglycerides in patients
DK1423168T3 (da) *	2001-09-03	2006-05-15	Newron Pharm Spa	Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
US7202222B2 (en) *	2003-01-06	2007-04-10	National Bioscience Corporation	Methods for treatment of obesity and effective fat loss promotion
EP1438956A1 (de) *	2003-01-16	2004-07-21	Newron Pharmaceuticals S.p.A.	Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
EP1809271B9 (de) *	2004-09-10	2010-09-22	Newron Pharmaceuticals S.p.A.	Verwendung von (r)-(halogenbenzyloxy)-benzylamino-propanamiden als natrium- und/oder calciumkanal-selektive modulatoren
AU2008219585A1 (en) *	2007-02-27	2008-09-04	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Administration of 3,5-diiodothyropropionic acid for stimulating weight loss, and/or lowering triglyceride levels, and/or treatment of metabolic syndrome.
US9044606B2 (en)	2010-01-22	2015-06-02	Ethicon Endo-Surgery, Inc.	Methods and devices for activating brown adipose tissue using electrical energy
US8476227B2 (en)	2010-01-22	2013-07-02	Ethicon Endo-Surgery, Inc.	Methods of activating a melanocortin-4 receptor pathway in obese subjects
WO2011115763A1 (en)	2010-03-15	2011-09-22	The Trustees Of The University Of Pennsylvania	Inhibitors of the tumor necrosis factor receptor complex
US9784726B2 (en)	2013-01-08	2017-10-10	Atrogi Ab	Screening method, a kit, a method of treatment and a compound for use in a method of treatment
US10080884B2 (en)	2014-12-29	2018-09-25	Ethicon Llc	Methods and devices for activating brown adipose tissue using electrical energy
US10092738B2 (en)	2014-12-29	2018-10-09	Ethicon Llc	Methods and devices for inhibiting nerves when activating brown adipose tissue
GB201714736D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB201714734D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB201714740D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB201714745D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB202205895D0 (en)	2022-04-22	2022-06-08	Atrogi Ab	New medical uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3903091A (en) *	1970-02-06	1975-09-02	Sumitomo Chemical Co	1,2,3,4-Tetrahydroisoquinoline derivatives
IE35386B1 (en) *	1970-05-27	1976-02-04	Ici Ltd	Alkanolamine derivatives
US4088764A (en) *	1973-12-27	1978-05-09	Cassella Farbwerke Mainkur Aktiengesellschaft	Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol
US4263323A (en) *	1976-10-07	1981-04-21	Aktiebolaget Hassle	β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
DD144050A5 (de) *	1978-06-05	1980-09-24	Ciba Geigy Ag	Verfahren zur herstellung von n-alkylierten aminoalkoholen
DE2965655D1 (en) *	1978-06-28	1983-07-21	Beecham Group Plc	Secondary amines, their preparation, pharmaceutical compositions containing them and their use
JPS57185243A (en) *	1981-05-08	1982-11-15	Ciba Geigy Ag	Substituted 2-aminoethanol
GB8420837D0 (en) *	1984-08-16	1984-09-19	Beecham Group Plc	Compounds
US4697033A (en) *	1985-12-24	1987-09-29	Sandoz Ltd.	Carbamic and carbamothioic acid esters as pesticides
JPS6422898A (en) *	1987-07-17	1989-01-25	Asahi Breweries Ltd	2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative

1987
- 1987-06-24 GB GB878714901A patent/GB8714901D0/en active Pending
- 1987-06-29 IE IE173387A patent/IE60887B1/en not_active IP Right Cessation
- 1987-06-30 IL IL83026A patent/IL83026A0/xx not_active IP Right Cessation
- 1987-07-02 PH PH35488A patent/PH23607A/en unknown
- 1987-07-02 AU AU75030/87A patent/AU604027B2/en not_active Ceased
- 1987-07-07 MY MYPI87000956A patent/MY102866A/en unknown
- 1987-07-16 FI FI873154A patent/FI88289C/fi not_active IP Right Cessation
- 1987-07-20 HU HU873333A patent/HU197293B/hu not_active IP Right Cessation
- 1987-07-21 EP EP87306442A patent/EP0254532B1/de not_active Expired - Lifetime
- 1987-07-21 DE DE8787306442T patent/DE3762618D1/de not_active Expired - Lifetime
- 1987-07-21 AT AT87306442T patent/ATE52498T1/de not_active IP Right Cessation
- 1987-07-21 ES ES87306442T patent/ES2018832B3/es not_active Expired - Lifetime
- 1987-07-22 CA CA000542721A patent/CA1327576C/en not_active Expired - Fee Related
- 1987-07-22 JP JP62181304A patent/JPS6393755A/ja active Granted
- 1987-07-22 SU SU874202958A patent/SU1549476A3/ru active
- 1987-07-22 PT PT85379A patent/PT85379B/pt not_active IP Right Cessation
- 1987-07-22 NZ NZ221158A patent/NZ221158A/xx unknown
- 1987-07-22 NO NO873071A patent/NO174044C/no unknown
- 1987-07-23 KR KR1019870008048A patent/KR880001576A/ko not_active Application Discontinuation
- 1987-07-23 DK DK385387A patent/DK385387A/da not_active Application Discontinuation
- 1987-07-23 CS CS875565A patent/CS264145B2/cs unknown
- 1987-07-23 CN CN87105189A patent/CN1015707B/zh not_active Expired
1988
- 1988-06-29 US US07/213,259 patent/US4927836A/en not_active Expired - Lifetime
1990
- 1990-03-08 US US07/490,406 patent/US4977148A/en not_active Expired - Lifetime
- 1990-06-21 GR GR89400210T patent/GR3000571T3/el unknown

Also Published As

Publication number	Publication date
HUT44001A (en)	1988-01-28
DK385387A (da)	1988-01-24
ES2018832B3 (es)	1991-05-16
AU604027B2 (en)	1990-12-06
DE3762618D1 (de)	1990-06-13
NO174044C (no)	1994-03-09
HU197293B (en)	1989-03-28
NZ221158A (en)	1990-07-26
NO873071L (no)	1988-01-25
US4927836A (en)	1990-05-22
FI873154A (fi)	1988-01-24
FI873154A0 (fi)	1987-07-16
CA1327576C (en)	1994-03-08
DK385387D0 (da)	1987-07-23
IE871733L (en)	1988-01-23
JPH0579057B2 (de)	1993-11-01
PT85379A (en)	1987-08-01
EP0254532A1 (de)	1988-01-27
NO174044B (no)	1993-11-29
JPS6393755A (ja)	1988-04-25
CS264145B2 (en)	1989-06-13
GR3000571T3 (en)	1991-07-31
FI88289C (fi)	1993-04-26
IE60887B1 (en)	1994-08-24
CN87105189A (zh)	1988-04-06
AU7503087A (en)	1988-01-28
MY102866A (en)	1993-03-31
NO873071D0 (no)	1987-07-22
CS556587A2 (en)	1988-08-16
PH23607A (en)	1989-09-11
GB8714901D0 (en)	1987-07-29
KR880001576A (ko)	1988-04-25
PT85379B (pt)	1990-04-30
CN1015707B (zh)	1992-03-04
SU1549476A3 (ru)	1990-03-07
US4977148A (en)	1990-12-11
IL83026A0 (en)	1987-12-20
EP0254532B1 (de)	1990-05-09
FI88289B (fi)	1993-01-15

Legal Events

Date	Code	Title	Description
1990-11-15	UEP	Publication of translation of european patent specification
1997-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE52498T1 (de)	1990-05-15	Amidderivate.
NO159017C (no)	1988-11-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,2,3,4-tetrahydroisokinolin-3-karboksylsyre-derivater.
NO903438L (no)	1991-02-08	Fremgangsmaate for fremstilling av tiazolderivater.
ATE28565T1 (de)	1987-08-15	Spiro(4.(3+n))-2-aza-alkan-3-carbonsaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung.
ATE79257T1 (de)	1992-08-15	Verwendung von tetrahydrobenz(c,d>indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
HUP0003577A2 (hu)	2001-09-28	Tetrahidro-gamma-karbolinok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
ATE123487T1 (de)	1995-06-15	Derivate der kaffeinsäure und sie enthaltende pharmazeutische zusammensetzungen.
ES2027492A6 (es)	1992-06-01	Procedimiento de preparacion de nuevos derivados dihidropirimidotiazinos y de sus sales de adicion acidas farmaceuticamente aceptables.
DE3782619T2 (de)	1993-04-22	1-hydroxyalkylxanthine, verfahren zu ihrer herstellung und sie enthaltende medikamente.
DE3784883T2 (de)	1993-09-02	Fluor enthaltende makrolid-verbindungen, pharmazeutische zusammensetzungen, welche diese enthalten und ihre verwendung fuer die herstellung von arzneimitteln.