ATE522580T1 - Cyaninfarbstoffe als markieragenzien - Google Patents

Cyaninfarbstoffe als markieragenzien

Info

Publication number
ATE522580T1
ATE522580T1 AT04791610T AT04791610T ATE522580T1 AT E522580 T1 ATE522580 T1 AT E522580T1 AT 04791610 T AT04791610 T AT 04791610T AT 04791610 T AT04791610 T AT 04791610T AT E522580 T1 ATE522580 T1 AT E522580T1
Authority
AT
Austria
Prior art keywords
groups
dye
attached
group
ring
Prior art date
Application number
AT04791610T
Other languages
English (en)
Inventor
R M West
N Bosworth
Ratnakar Mujumdar
Original Assignee
Ge Healthcare Ltd
Univ Carnegie Mellon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Univ Carnegie Mellon filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE522580T1 publication Critical patent/ATE522580T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Laminated Bodies (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04791610T 2003-10-31 2004-10-29 Cyaninfarbstoffe als markieragenzien ATE522580T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51642803P 2003-10-31 2003-10-31
PCT/GB2004/004573 WO2005044923A1 (en) 2003-10-31 2004-10-29 Cyanine dye labelling reagents

Publications (1)

Publication Number Publication Date
ATE522580T1 true ATE522580T1 (de) 2011-09-15

Family

ID=34572883

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04791610T ATE522580T1 (de) 2003-10-31 2004-10-29 Cyaninfarbstoffe als markieragenzien

Country Status (8)

Country Link
US (2) US7750163B2 (de)
EP (2) EP1678258B1 (de)
JP (1) JP4943156B2 (de)
CN (1) CN100577742C (de)
AT (1) ATE522580T1 (de)
ES (1) ES2372395T3 (de)
HK (1) HK1093520A1 (de)
WO (1) WO2005044923A1 (de)

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EP1678258B1 (de) * 2003-10-31 2011-08-31 GE Healthcare Limited Cyaninfarbstoffe als markieragenzien
ES2461858T3 (es) 2004-08-13 2014-05-21 Epoch Biosciences, Inc. Colorantes fluorescentes de fosfonato y conjugados
US7767834B2 (en) * 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
ATE480596T1 (de) 2005-12-05 2010-09-15 Dyomics Gmbh Hydrophile marker auf der basis von diastereomeren cyaninen
DE102006029454A1 (de) 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophile Marker auf Basis von diasteromeren
WO2007100711A2 (en) * 2006-02-24 2007-09-07 Investigen, Inc. Methods and compositions for detecting polynucleotides
US7771947B2 (en) 2007-02-23 2010-08-10 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
KR101578225B1 (ko) * 2007-05-16 2015-12-17 지이 헬스케어 에이에스 영상화를 위한 표지된 ｈｇｆ 결합성 펩티드
JP2010527922A (ja) * 2007-05-16 2010-08-19 ジーイー・ヘルスケア・アクスイェ・セルスカプ 光学造影剤
US7951959B2 (en) 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
CN101723874B (zh) * 2008-10-31 2013-09-11 深圳迈瑞生物医疗电子股份有限公司 花菁类化合物及其在生物样品染色中的用途
WO2010054330A2 (en) * 2008-11-07 2010-05-14 The General Hospital Corporation Monofunctional carbocyanine dyes for in vivo and in vitro imaging
CN101750476B (zh) * 2008-12-08 2015-06-03 深圳迈瑞生物医疗电子股份有限公司 血液分析试剂及其使用方法
KR101149535B1 (ko) * 2009-04-17 2012-05-25 한국과학기술연구원 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
US20100291706A1 (en) * 2009-05-15 2010-11-18 Millipore Corporation Dye conjugates and methods of use
GB2478359B (en) * 2010-03-05 2018-09-12 Innova Biosciences Ltd Conjugation reactions
EP2588541A1 (de) 2010-06-29 2013-05-08 GE Healthcare AS Farbstoffzusammensetzungen und farbstoffsynthesen
GB201010878D0 (en) * 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
US9012242B2 (en) * 2010-09-20 2015-04-21 Caliper Life Sciences Multivalent fluorescent probes
WO2012048063A2 (en) * 2010-10-06 2012-04-12 Emd Millipore Corporation Cyanine compounds, conjugates and method of use
EP2655327B1 (de) 2010-12-21 2016-02-24 Pierce Biotechnology, Inc. Fluoreszierende verbindungen
US8877892B2 (en) 2011-03-15 2014-11-04 Innova Biosciences Limited Conjugation reactions
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
WO2013041117A1 (en) 2011-09-23 2013-03-28 Illumina Cambrigde Ltd. Dyes for labelling molecular ligands
US9631096B2 (en) * 2012-01-20 2017-04-25 Cornell University Dye compositions, methods of preparation, conjugates thereof, and methods of use
CN102608051B (zh) * 2012-02-21 2015-04-08 中国科学院化学研究所 用于诊断白血病的试剂盒
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
EP3081564B1 (de) 2012-03-02 2019-07-10 Pierce Biotechnology, Inc. Indolderivate als markierungsfarbstoff für biomoleküle
US9676787B2 (en) 2012-08-28 2017-06-13 Pierce Biotechnology, Inc. Benzopyrylium compounds
US8809551B1 (en) 2013-03-08 2014-08-19 Illumina Cambridge Limited Polymethine compounds and their use as fluorescent labels
WO2014165216A1 (en) * 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
GB201408077D0 (en) 2014-05-07 2014-06-18 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
US20160176819A1 (en) * 2014-12-19 2016-06-23 Washington University Asymmetrically charged nir fluorophores
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
GB201516987D0 (en) * 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
KR101953819B1 (ko) * 2017-12-22 2019-03-06 (주)바이오액츠 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
CN108752406A (zh) * 2018-05-29 2018-11-06 苏州百源基因技术有限公司 一种荧光标记的核苷酸及其制备方法和用途
WO2021125295A1 (ja) * 2019-12-19 2021-06-24 富士フイルム株式会社 化合物及びこれを用いた蛍光標識生体物質
US20230098702A1 (en) * 2020-02-10 2023-03-30 C-Biomex Co., Ltd. Amphoteric fluorescent substance capable of being attached to biomaterials
US11964965B2 (en) 2020-05-08 2024-04-23 On Target Laboratories, LLC Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof
JP2023525139A (ja) * 2020-05-12 2023-06-14 ユニヴェルシテ・ドゥ・ストラスブール 内因性受容体の検出のためのプローブとして有用な蛍光発生性ダイマー化合物

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US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
JPH04186342A (ja) * 1990-11-21 1992-07-03 Fuji Photo Film Co Ltd 写真感光材料を用いるカラープルーフの作成方法
JPH0531330A (ja) * 1991-07-31 1993-02-09 Riken Corp 排ガス浄化方法
JPH05313304A (ja) 1992-05-11 1993-11-26 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
WO2004039894A2 (en) * 2002-05-10 2004-05-13 Carnegie Mellon University Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
ATE352586T2 (de) * 2000-09-29 2007-02-15 Molecular Probes Inc Modifizierte carbocyaninfarbstoffe und deren konjugate
EP1678258B1 (de) * 2003-10-31 2011-08-31 GE Healthcare Limited Cyaninfarbstoffe als markieragenzien

Also Published As

Publication number Publication date
US7750163B2 (en) 2010-07-06
JP4943156B2 (ja) 2012-05-30
EP2360211A1 (de) 2011-08-24
ES2372395T3 (es) 2012-01-19
WO2005044923A1 (en) 2005-05-19
US20070203343A1 (en) 2007-08-30
US20100267937A1 (en) 2010-10-21
EP1678258A1 (de) 2006-07-12
EP1678258B1 (de) 2011-08-31
HK1093520A1 (en) 2007-03-02
CN1875073A (zh) 2006-12-06
US8148539B2 (en) 2012-04-03
JP2007510031A (ja) 2007-04-19
CN100577742C (zh) 2010-01-06

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