ATE514694T1 - 2-amino-7,8-dihydro-6h-pyrido(4,3-d)pyrimidin-5 one, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

2-amino-7,8-dihydro-6h-pyrido(4,3-d)pyrimidin-5 one, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE514694T1
ATE514694T1 AT06825272T AT06825272T ATE514694T1 AT E514694 T1 ATE514694 T1 AT E514694T1 AT 06825272 T AT06825272 T AT 06825272T AT 06825272 T AT06825272 T AT 06825272T AT E514694 T1 ATE514694 T1 AT E514694T1
Authority
AT
Austria
Prior art keywords
pyrido
pyrimidine
dihydro
amino
production
Prior art date
Application number
AT06825272T
Other languages
English (en)
Inventor
Timothy Machajewski
Cynthia Shafer
Christopher Mcbride
William Antonios-Mccrea
Brandon Doughan
Barry Levine
Yi Xia
Maureen Mckenna
X Michael Wang
Kris Mendenhall
Yasheen Zhou
Baoqing Gong
Dan Gu
John Dolan
John Tulinsky
Kristin Brinner
Zhenhai Gao
Paul Renhowe
Daniel Poon
Paul Barsanti
Xiaodong Lin
Teresa Pick
Abran Costales
Nathan Brammeier
Alice Rico
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE514694T1 publication Critical patent/ATE514694T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT06825272T 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6h-pyrido(4,3-d)pyrimidin-5 one, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen ATE514694T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72279605P 2005-09-30 2005-09-30
US83688606P 2006-08-09 2006-08-09
PCT/US2006/038181 WO2007041362A1 (en) 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones

Publications (1)

Publication Number Publication Date
ATE514694T1 true ATE514694T1 (de) 2011-07-15

Family

ID=37661234

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06825272T ATE514694T1 (de) 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6h-pyrido(4,3-d)pyrimidin-5 one, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen

Country Status (32)

Country Link
US (2) US7671059B2 (de)
EP (1) EP1928875B1 (de)
JP (2) JP5036002B2 (de)
KR (1) KR101311757B1 (de)
AR (1) AR058072A1 (de)
AT (1) ATE514694T1 (de)
AU (1) AU2006297124B2 (de)
BR (1) BRPI0616701A2 (de)
CA (1) CA2624253C (de)
CR (1) CR9846A (de)
CY (1) CY1112028T1 (de)
DK (1) DK1928875T3 (de)
EA (1) EA016152B1 (de)
EC (1) ECSP088324A (de)
GE (1) GEP20115231B (de)
HK (1) HK1118823A1 (de)
HR (1) HRP20110655T1 (de)
IL (1) IL190446A0 (de)
JO (1) JO2783B1 (de)
MA (1) MA29885B1 (de)
ME (1) ME01952B (de)
MY (1) MY143604A (de)
NO (1) NO342258B1 (de)
NZ (1) NZ566914A (de)
PE (1) PE20070621A1 (de)
PL (1) PL1928875T3 (de)
PT (1) PT1928875E (de)
RS (1) RS51795B (de)
SM (1) SMP200800029B (de)
TN (1) TNSN08143A1 (de)
TW (1) TWI373471B (de)
WO (1) WO2007041362A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007002994A1 (es) * 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
CN101225083A (zh) * 2007-01-16 2008-07-23 北京摩力克科技有限公司 四氢喹唑啉酮类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
GB2449293A (en) 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
MX2010008269A (es) * 2008-02-01 2011-02-21 Takeda Pharmaceutical Inhibidores de hsp90.
CN102227237A (zh) * 2008-09-26 2011-10-26 国家健康与医学研究院 作为针对hcv感染的抗病毒治疗的靶标的宿主细胞激酶
PT2370076T (pt) * 2008-11-28 2017-03-31 Novartis Ag Combinações de inibidor hsp90
US20110230499A1 (en) * 2008-11-28 2011-09-22 Novartis Ag Hsp90 inhibitors for therapeutic treatment
KR20110103980A (ko) * 2008-11-28 2011-09-21 노파르티스 아게 피리도〔4,3-ｄ〕피리미딘 유래의 ｈｓｐ90-억제제 및 ｈｅｒ2 억제제를 포함하는 제약 조합물
AR075180A1 (es) * 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
EP2493313B1 (de) * 2009-10-29 2017-12-13 Genosco Kinase-inhibitoren
WO2012104823A2 (en) 2011-02-04 2012-08-09 Novartis Ag Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
RU2624493C2 (ru) 2011-10-14 2017-07-04 Новартис Аг 2-КАРБОКСАМИД ЦИКЛОАМИНО ПРОИЗВОДНЫЕ МОЧЕВИНЫ В КОМБИНАЦИИ С ИНГИБИТОРАМИ Hsp90 ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ
ITTO20111013A1 (it) 2011-11-03 2013-05-04 Dac Srl Composti farmaceutici
CN103664938A (zh) * 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 含有嘧啶并环的syk抑制剂
WO2014074580A1 (en) 2012-11-07 2014-05-15 Novartis Ag Combination therapy
US9677907B2 (en) * 2013-03-14 2017-06-13 Itron Inc Intelligent receptacle
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
US9694001B2 (en) * 2013-09-30 2017-07-04 Taiho Pharmaceutical Co., Ltd. Combination therapy using azabicyclo compound for cancer
BR112017003651A2 (pt) * 2014-09-02 2017-12-05 Pf Medicament derivados de isoquinolinona úteis no tratamento de câncer
KR20160035411A (ko) * 2014-09-23 2016-03-31 주식회사 오스코텍 LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물
KR101653560B1 (ko) * 2016-02-02 2016-09-12 한국화학연구원 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 인플루엔자 바이러스 감염으로 인한 질환의 예방 또는 치료용 약학적 조성물
RU2629599C1 (ru) * 2016-09-28 2017-08-30 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ химиолучевого лечения опухолей прямой кишки и анального канала
WO2021261562A1 (ja) * 2020-06-26 2021-12-30 日本農薬株式会社 アリールテトラヒドロピリジン誘導体又はその塩類及び該化合物を含有する殺虫剤並びにその使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6165873A (ja) * 1984-09-07 1986-04-04 Mitsui Petrochem Ind Ltd ２−ピペラジノピリミジン誘導体
US4734418A (en) * 1984-12-14 1988-03-29 Mitsui Petrochemical Industries, Ltd. Quinazoline compounds and antihypertensives
IL85347A0 (en) * 1987-02-11 1988-07-31 May & Baker Ltd Cyclic diones
ATE305303T1 (de) * 2001-02-12 2005-10-15 Hoffmann La Roche 6-substituierte pyridopyrimidine
DE102004018198A1 (de) * 2004-04-15 2005-11-03 Merck Patent Gmbh Sulfonamide
WO2006045096A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
US20100152206A1 (en) * 2005-01-07 2010-06-17 Ralph Mazitschek Bicyclic Dihydropyrimidines and Uses Thereof
CN101198596A (zh) * 2005-04-14 2008-06-11 诺华疫苗和诊断公司 作为hsp90抑制剂用于治疗增殖疾病的2-氨基-喹唑啉-5-酮

Also Published As

Publication number Publication date
PT1928875E (pt) 2011-09-06
CY1112028T1 (el) 2015-11-04
US7671059B2 (en) 2010-03-02
GEP20115231B (en) 2011-06-10
CR9846A (es) 2008-08-01
ME01952B (en) 2011-12-31
EA200800992A1 (ru) 2008-10-30
RS51795B (en) 2011-12-31
US20100004237A1 (en) 2010-01-07
CA2624253A1 (en) 2007-04-12
AU2006297124A1 (en) 2007-04-12
CA2624253C (en) 2015-06-16
MY143604A (en) 2011-06-15
SMAP200800029A (it) 2008-05-07
TNSN08143A1 (en) 2009-07-14
JP5036002B2 (ja) 2012-09-26
WO2007041362A1 (en) 2007-04-12
HRP20110655T1 (hr) 2011-10-31
JO2783B1 (en) 2014-03-15
PL1928875T3 (pl) 2011-11-30
IL190446A0 (en) 2008-11-03
ECSP088324A (es) 2008-04-28
NO342258B1 (no) 2018-04-30
MA29885B1 (fr) 2008-10-03
JP2012158611A (ja) 2012-08-23
US20070123546A1 (en) 2007-05-31
KR101311757B1 (ko) 2013-09-26
AR058072A1 (es) 2008-01-23
KR20080057318A (ko) 2008-06-24
HK1118823A1 (de) 2009-02-20
EP1928875B1 (de) 2011-06-29
EA016152B1 (ru) 2012-02-28
NO20082069L (no) 2008-06-09
NZ566914A (en) 2011-09-30
DK1928875T3 (da) 2011-10-03
AU2006297124B2 (en) 2011-12-08
SMP200800029B (it) 2008-05-07
JP2009510108A (ja) 2009-03-12
TWI373471B (en) 2012-10-01
BRPI0616701A2 (pt) 2011-06-28
EP1928875A1 (de) 2008-06-11
TW200728304A (en) 2007-08-01
PE20070621A1 (es) 2007-09-06

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