ATE511538T1 - Thermostabile mutanten pyrrolochinolin-chinon- abhängiger glucose-dehydrogenase - Google Patents

Thermostabile mutanten pyrrolochinolin-chinon- abhängiger glucose-dehydrogenase

Info

Publication number
ATE511538T1
ATE511538T1 AT05792997T AT05792997T ATE511538T1 AT E511538 T1 ATE511538 T1 AT E511538T1 AT 05792997 T AT05792997 T AT 05792997T AT 05792997 T AT05792997 T AT 05792997T AT E511538 T1 ATE511538 T1 AT E511538T1
Authority
AT
Austria
Prior art keywords
gdh
pyrrolocinoline
quinone
glucose dehydrogenase
dependent glucose
Prior art date
Application number
AT05792997T
Other languages
English (en)
Inventor
Mara Boenitz-Dulat
Peter Kratzsch
Rainer Schmuck
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE511538T1 publication Critical patent/ATE511538T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT05792997T 2004-10-15 2005-10-14 Thermostabile mutanten pyrrolochinolin-chinon- abhängiger glucose-dehydrogenase ATE511538T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04024593 2004-10-15
PCT/EP2005/011077 WO2006040172A1 (en) 2004-10-15 2005-10-14 Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase

Publications (1)

Publication Number Publication Date
ATE511538T1 true ATE511538T1 (de) 2011-06-15

Family

ID=34926995

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05792997T ATE511538T1 (de) 2004-10-15 2005-10-14 Thermostabile mutanten pyrrolochinolin-chinon- abhängiger glucose-dehydrogenase

Country Status (10)

Country Link
US (1) US7781196B2 (de)
EP (2) EP2251420B1 (de)
JP (1) JP4782138B2 (de)
CN (1) CN101040044B (de)
AT (1) ATE511538T1 (de)
CA (1) CA2581226C (de)
ES (2) ES2366479T3 (de)
HK (1) HK1111723A1 (de)
PL (2) PL2251420T3 (de)
WO (1) WO2006040172A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040044B (zh) 2004-10-15 2014-06-11 霍夫曼-拉罗奇有限公司 吡咯并喹啉醌依赖性葡糖脱氢酶的热稳定突变体
FR2948680B1 (fr) * 2009-07-28 2013-10-04 Centre Nat Rech Scient Nouveaux mutants de la pqq s-gdh
CA2822331A1 (en) 2010-12-20 2012-07-19 Lek Pharmaceuticals D.D. Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof
EP2465936A1 (de) 2010-12-20 2012-06-20 LEK Pharmaceuticals d.d. Enzymatische Synthese von Statinen und deren Zwischenprodukte
CN102559624B (zh) * 2012-03-05 2013-10-16 浙江德清汇宁生物科技有限公司 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法
WO2015063025A1 (en) 2013-10-29 2015-05-07 F. Hoffmann-La Roche Ag Nano-enzyme containers for test elements
CN111073866B (zh) 2015-10-29 2024-03-19 英科隆生物技术（杭州）有限公司 PQQ-sGDH突变体、聚核苷酸及其在葡萄糖检测中的应用
EP3394252B1 (de) 2015-12-21 2020-04-29 F. Hoffmann-La Roche AG Mutante 3-hydroxybutyratdehydrogenase von alcaligenes faecalis sowie verfahren und verwendungen damit
ES2782199T3 (es) 2016-02-09 2020-09-11 Hoffmann La Roche 3-Hidroxibutirato deshidrogenasa mutante de Rhodobacter sphaeroides, así como procedimientos y usos que implican la misma
KR20190135508A (ko) * 2017-03-31 2019-12-06 기꼬만 가부시키가이샤 Fad-의존형 글루코오스 탈수소효소를 이용하는 연속적인 글루코오스 모니터링 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3716957A1 (de) 1987-05-20 1988-12-01 Boehringer Mannheim Gmbh Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten
DE4311464A1 (de) 1993-04-08 1994-10-13 Boehringer Mannheim Gmbh Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase
DE19639169A1 (de) 1996-09-24 1998-04-02 Boehringer Mannheim Gmbh Redoxaktive Verbindungen und deren Anwendung
JPH10243786A (ja) 1997-03-03 1998-09-14 Koji Hayade 改変型グルコース脱水素酵素
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
JPH11243949A (ja) 1998-03-03 1999-09-14 Toyobo Co Ltd Ｐｑｑを補欠分子族とするグルコースデヒドロゲナーゼおよびその製造方法
JP2000350588A (ja) 1999-04-08 2000-12-19 Koji Hayade グルコース脱水素酵素
TWI224136B (en) 1999-04-30 2004-11-21 Koji Sode Glucose dehydrogenase
ATE520777T1 (de) 2000-10-27 2011-09-15 Hoffmann La Roche Varianten der löslichen pyrroloquinolin quinon- abhängigen glukose dehydrogenase
EP1367120A3 (de) 2002-05-27 2004-06-02 Toyo Boseki Kabushiki Kaisha Modifizierte pyrroloquinolin quinon-abhängigen glukose Dehydrogenase mit höher Substratspezifität und Stabilität
JP2004173538A (ja) 2002-11-25 2004-06-24 Amano Enzyme Inc ピロロキノリンキノン依存性グルコース脱水素酵素
CN101040044B (zh) 2004-10-15 2014-06-11 霍夫曼-拉罗奇有限公司 吡咯并喹啉醌依赖性葡糖脱氢酶的热稳定突变体

Also Published As

Publication number Publication date
WO2006040172A1 (en) 2006-04-20
HK1111723A1 (en) 2008-08-15
CA2581226C (en) 2011-06-14
JP4782138B2 (ja) 2011-09-28
US20090305316A1 (en) 2009-12-10
JP2008515400A (ja) 2008-05-15
CN101040044A (zh) 2007-09-19
EP2251420A1 (de) 2010-11-17
CN101040044B (zh) 2014-06-11
CA2581226A1 (en) 2006-04-20
US7781196B2 (en) 2010-08-24
EP1802748A1 (de) 2007-07-04
ES2537106T3 (es) 2015-06-02
ES2366479T3 (es) 2011-10-20
EP2251420B1 (de) 2015-03-04
PL1802748T3 (pl) 2011-11-30
PL2251420T3 (pl) 2015-08-31
EP1802748B1 (de) 2011-06-01

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