ATE504648T1 - Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen - Google Patents

Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen

Info

Publication number
ATE504648T1
ATE504648T1 AT04715568T AT04715568T ATE504648T1 AT E504648 T1 ATE504648 T1 AT E504648T1 AT 04715568 T AT04715568 T AT 04715568T AT 04715568 T AT04715568 T AT 04715568T AT E504648 T1 ATE504648 T1 AT E504648T1
Authority
AT
Austria
Prior art keywords
cancer cell
cell growth
rna interference
inhibiting cancer
cell
Prior art date
Application number
AT04715568T
Other languages
English (en)
Inventor
Yusuke Nakamura
Yoichi Furukawa
Original Assignee
Oncotherapy Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Application granted granted Critical
Publication of ATE504648T1 publication Critical patent/ATE504648T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01043—Histone-lysine N-methyltransferase (2.1.1.43)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04715568T 2003-02-28 2004-02-27 Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen ATE504648T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45064403P 2003-02-28 2003-02-28
PCT/JP2004/002446 WO2004076623A2 (en) 2003-02-28 2004-02-27 Rna-interference for znfn3a1-gene as a method for inhibiting cancer cell growth

Publications (1)

Publication Number Publication Date
ATE504648T1 true ATE504648T1 (de) 2011-04-15

Family

ID=32927675

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04715568T ATE504648T1 (de) 2003-02-28 2004-02-27 Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen

Country Status (7)

Country Link
EP (2) EP1599586B9 (de)
JP (1) JP4467559B2 (de)
CN (2) CN1780912B (de)
AT (1) ATE504648T1 (de)
DE (1) DE602004032114D1 (de)
ES (1) ES2363500T3 (de)
WO (1) WO2004076623A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE356223T1 (de) 2001-09-25 2007-03-15 Japan President Univ Tokyo Gen und protein mit bezug zu hepatozellulärem karzinom
TWI350373B (en) 2004-01-23 2011-10-11 Oncotherapy Science Inc Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators
CA2576925C (en) 2004-08-16 2013-12-10 The Cbr Institute For Biomedical Research, Inc. Method of delivering rna interference and uses thereof
US7998695B2 (en) 2005-02-10 2011-08-16 Oncotherapy Science, Inc. Method of diagnosing bladder cancer
US7939254B2 (en) 2005-02-28 2011-05-10 Oncotherapy Science, Inc. Breast cancer related gene ZNFN3A1
WO2006121208A1 (en) * 2005-05-12 2006-11-16 Oncotherapy Science, Inc. Polymorphisms of the e2f-1 binding element and methods of determining cancer susceptibility
TW200741009A (en) 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
JP2009502115A (ja) * 2005-07-27 2009-01-29 オンコセラピー・サイエンス株式会社 小細胞肺癌の診断方法
WO2008152816A1 (en) 2007-06-14 2008-12-18 Oncotherapy Science, Inc. Methods of identifying agents that modulate methylation of vegfr1 by smyd3
WO2011115810A2 (en) * 2010-03-16 2011-09-22 Massachusetts Institute Of Technology Isoform-specific rnai based on codon redundancy/degeneracy
EP2646107A2 (de) 2010-12-01 2013-10-09 Spinal Modulation Inc. Wirkstofffreisetzungssysteme für selektive nervenmodulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
JP2003521231A (ja) * 1999-01-29 2003-07-15 インサイト・ファーマスーティカルズ・インコーポレイテッド 核酸結合タンパク質
US20030153519A1 (en) * 2001-07-23 2003-08-14 Kay Mark A. Methods and compositions for RNAi mediated inhibition of gene expression in mammals
ATE356223T1 (de) * 2001-09-25 2007-03-15 Japan President Univ Tokyo Gen und protein mit bezug zu hepatozellulärem karzinom

Also Published As

Publication number Publication date
DE602004032114D1 (de) 2011-05-19
CN1780912B (zh) 2011-06-15
WO2004076623A3 (en) 2004-12-23
EP1599586B1 (de) 2011-04-06
CN102172408A (zh) 2011-09-07
EP1599586A2 (de) 2005-11-30
JP2006519009A (ja) 2006-08-24
WO2004076623A2 (en) 2004-09-10
EP2311948A1 (de) 2011-04-20
JP4467559B2 (ja) 2010-05-26
ES2363500T3 (es) 2011-08-05
EP1599586B9 (de) 2012-03-14
CN1780912A (zh) 2006-05-31

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Legal Events

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