ATE499934T1 - Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs - Google Patents
Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebsInfo
- Publication number
- ATE499934T1 ATE499934T1 AT04776757T AT04776757T ATE499934T1 AT E499934 T1 ATE499934 T1 AT E499934T1 AT 04776757 T AT04776757 T AT 04776757T AT 04776757 T AT04776757 T AT 04776757T AT E499934 T1 ATE499934 T1 AT E499934T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- analogues
- treatment
- heterocyclic compounds
- animal
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48027003P | 2003-06-20 | 2003-06-20 | |
US56695204P | 2004-04-30 | 2004-04-30 | |
PCT/US2004/019543 WO2005002572A2 (en) | 2003-06-20 | 2004-06-18 | Use of [3.2.0] heterocyclic compounds and analogs thereof for the treatment of cancer, inflammation and infectious diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE499934T1 true ATE499934T1 (de) | 2011-03-15 |
Family
ID=33567612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04776757T ATE499934T1 (de) | 2003-06-20 | 2004-06-18 | Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs |
Country Status (14)
Country | Link |
---|---|
US (2) | US20050049294A1 (de) |
EP (1) | EP1638552B1 (de) |
JP (2) | JP2007523862A (de) |
KR (1) | KR20060026052A (de) |
CN (1) | CN102151261A (de) |
AT (1) | ATE499934T1 (de) |
AU (1) | AU2004253478A1 (de) |
BR (1) | BRPI0411677A (de) |
CA (1) | CA2532066C (de) |
DE (1) | DE602004031614D1 (de) |
IL (1) | IL172705A (de) |
MX (1) | MXPA05013982A (de) |
NZ (1) | NZ544588A (de) |
WO (1) | WO2005002572A2 (de) |
Families Citing this family (46)
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JP4395549B2 (ja) * | 2000-11-16 | 2010-01-13 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬物及び発酵生成物の発見のための海洋放線菌分類群 |
US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US7179834B2 (en) * | 2002-06-24 | 2007-02-20 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US8217072B2 (en) * | 2003-06-20 | 2012-07-10 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US20050049294A1 (en) * | 2003-06-20 | 2005-03-03 | Michael Palladino | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
EP1691812A4 (de) | 2003-11-20 | 2010-01-13 | Childrens Hosp Medical Center | Gtpase-hemmer und anwendungsverfahren |
WO2005099687A2 (en) * | 2004-04-09 | 2005-10-27 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
US7276530B2 (en) * | 2004-04-30 | 2007-10-02 | Nereus Pharmaceuticals, Inc. | [3.2.0] Heterocyclic compounds and methods of using the same |
US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
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CN103230394B (zh) * | 2004-12-03 | 2016-04-20 | 达纳-法伯癌症研究公司 | ***性疾病的化合物及其用途 |
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US7691896B2 (en) | 2005-08-10 | 2010-04-06 | President And Fellows Of Harvard College | Analogs of salinosporamide A |
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US7842814B2 (en) | 2006-04-06 | 2010-11-30 | Nereus Pharmaceuticals, Inc. | Total synthesis of salinosporamide A and analogs thereof |
US20090280130A1 (en) * | 2006-06-14 | 2009-11-12 | Children's Medical Center Corporation | Method for the treatment of anthrax toxicity |
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WO2008137780A2 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Use of [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
EP2088205A1 (de) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: Diagnosemarker und therapeutisches Target für chronische Abstoßung |
BRPI0909661A2 (pt) | 2008-03-07 | 2015-08-11 | Nereus Pharmaceuticals Inc | Composto e métodos de síntese química e de formação ou preparação de compostos |
US20090285836A1 (en) * | 2008-04-14 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Use of salinosporamide a to inhibit metastasis |
WO2009140287A1 (en) * | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Salinosporamide derivatives as proteasome inhibitors |
EP2297347B1 (de) | 2008-05-14 | 2017-03-08 | Millennium Pharmaceuticals, Inc. | Verfahren und kits zur überwachung der wirkung von immunmodulatoren auf die adaptive immunität |
US8073633B2 (en) * | 2008-12-30 | 2011-12-06 | The Invention Science Fund I, Llc | Computational methods and systems for suggesting modulators of CYP450 as treatment options |
US8315815B2 (en) | 2008-12-30 | 2012-11-20 | The Invention Science Fund I, Llc | Computational methods and systems for suggesting modulators of CYP450 as treatment options |
US8321151B2 (en) | 2008-12-30 | 2012-11-27 | The Invention Science Fund I, Llc | Computational methods and systems for treatment in relation to modulation of CYP450 enzyme activity |
EP3021120A1 (de) | 2009-02-20 | 2016-05-18 | Michael P. Lisanti | Verfahren zur diagnose oder prognose eines neoplasmas einschliesslich der bestimmung des expressionsgrads eines proteins in stromazellen neben dem neoplasma |
US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
US9272014B2 (en) | 2011-03-29 | 2016-03-01 | Texas Tech University System | Galectin-3C combination therapy for human cancer |
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JP6286358B2 (ja) | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤に応答するバイオマーカー |
EP2810066B1 (de) | 2012-01-24 | 2019-07-31 | Millennium Pharmaceuticals, Inc. | Verfahren zur behandlung von krebs |
GB2523211B (en) | 2012-01-27 | 2020-03-18 | Univ Jefferson | MCT protein inhibitor-related prognostic and therapeutic methods |
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EP2916656B1 (de) | 2012-11-09 | 2017-10-25 | Cornell University | Kleinmolekülige malt1-hemmer |
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US10703760B2 (en) | 2016-08-19 | 2020-07-07 | Celgene International Ii Sàrl | Morphic forms of marizomib and uses thereof |
KR101953671B1 (ko) * | 2017-08-21 | 2019-03-04 | 충남대학교산학협력단 | 프로테아좀 억제제를 유효성분으로 함유하는 아토피성 피부질환의 예방, 개선 또는 치료용 조성물 |
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CN103230394B (zh) * | 2004-12-03 | 2016-04-20 | 达纳-法伯癌症研究公司 | ***性疾病的化合物及其用途 |
WO2006124902A2 (en) * | 2005-05-16 | 2006-11-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of salinosporamide a and analogues thereof |
US7572606B1 (en) * | 2005-09-09 | 2009-08-11 | Nereus Pharmaceuticals, Inc. | Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs |
DE102005046344A1 (de) * | 2005-09-28 | 2007-03-29 | Saltigo Gmbh | Verfahren zur Kupplung von Benzylaminen mit Halogenaromaten |
CA2628110A1 (en) * | 2005-11-04 | 2007-05-18 | The Regents Of The University Of California | Methods of sensitizing cancer to therapy-induced cytotoxicity |
GB0605217D0 (en) * | 2006-03-15 | 2006-04-26 | Novartis Ag | Method and compositions for assessing acute rejection |
US7842814B2 (en) | 2006-04-06 | 2010-11-30 | Nereus Pharmaceuticals, Inc. | Total synthesis of salinosporamide A and analogs thereof |
US8088923B2 (en) * | 2006-07-07 | 2012-01-03 | The Texas A&M University System | Cyclic-fused beta-lactones and their synthesis |
WO2008137780A2 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Use of [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
EP2088205A1 (de) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: Diagnosemarker und therapeutisches Target für chronische Abstoßung |
BRPI0909661A2 (pt) | 2008-03-07 | 2015-08-11 | Nereus Pharmaceuticals Inc | Composto e métodos de síntese química e de formação ou preparação de compostos |
WO2009140287A1 (en) * | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Salinosporamide derivatives as proteasome inhibitors |
-
2004
- 2004-06-18 US US10/871,368 patent/US20050049294A1/en not_active Abandoned
- 2004-06-18 JP JP2006517404A patent/JP2007523862A/ja not_active Withdrawn
- 2004-06-18 CA CA2532066A patent/CA2532066C/en active Active
- 2004-06-18 WO PCT/US2004/019543 patent/WO2005002572A2/en active Application Filing
- 2004-06-18 AU AU2004253478A patent/AU2004253478A1/en not_active Abandoned
- 2004-06-18 DE DE602004031614T patent/DE602004031614D1/de active Active
- 2004-06-18 AT AT04776757T patent/ATE499934T1/de not_active IP Right Cessation
- 2004-06-18 NZ NZ544588A patent/NZ544588A/en unknown
- 2004-06-18 EP EP04776757A patent/EP1638552B1/de not_active Not-in-force
- 2004-06-18 CN CN2010102534518A patent/CN102151261A/zh active Pending
- 2004-06-18 MX MXPA05013982A patent/MXPA05013982A/es not_active Application Discontinuation
- 2004-06-18 KR KR1020057024503A patent/KR20060026052A/ko not_active Application Discontinuation
- 2004-06-18 BR BRPI0411677-1A patent/BRPI0411677A/pt not_active IP Right Cessation
-
2005
- 2005-12-20 IL IL172705A patent/IL172705A/en active IP Right Grant
-
2008
- 2008-06-10 US US12/136,688 patent/US8168803B2/en active Active
-
2011
- 2011-10-28 JP JP2011238014A patent/JP2012031198A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
BRPI0411677A (pt) | 2006-08-29 |
WO2005002572A3 (en) | 2005-05-12 |
US20090182027A1 (en) | 2009-07-16 |
US20050049294A1 (en) | 2005-03-03 |
US8168803B2 (en) | 2012-05-01 |
MXPA05013982A (es) | 2006-05-25 |
DE602004031614D1 (de) | 2011-04-14 |
WO2005002572A2 (en) | 2005-01-13 |
IL172705A0 (en) | 2006-04-10 |
CA2532066A1 (en) | 2005-01-13 |
NZ544588A (en) | 2010-06-25 |
JP2012031198A (ja) | 2012-02-16 |
KR20060026052A (ko) | 2006-03-22 |
AU2004253478A1 (en) | 2005-01-13 |
IL172705A (en) | 2017-06-29 |
CN102151261A (zh) | 2011-08-17 |
JP2007523862A (ja) | 2007-08-23 |
EP1638552B1 (de) | 2011-03-02 |
CA2532066C (en) | 2015-07-28 |
EP1638552A2 (de) | 2006-03-29 |
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