ATE49969T1 - Verfahren zur herstellung von pteridinderivaten. - Google Patents

Verfahren zur herstellung von pteridinderivaten.

Info

Publication number
ATE49969T1
ATE49969T1 AT86402544T AT86402544T ATE49969T1 AT E49969 T1 ATE49969 T1 AT E49969T1 AT 86402544 T AT86402544 T AT 86402544T AT 86402544 T AT86402544 T AT 86402544T AT E49969 T1 ATE49969 T1 AT E49969T1
Authority
AT
Austria
Prior art keywords
production
image
pteridine derivatives
pteridine
derivatives
Prior art date
Application number
AT86402544T
Other languages
English (en)
Inventor
Pierre Zimmermann
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Application granted granted Critical
Publication of ATE49969T1 publication Critical patent/ATE49969T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT86402544T 1985-11-19 1986-11-17 Verfahren zur herstellung von pteridinderivaten. ATE49969T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8517057A FR2590255B1 (fr) 1985-11-19 1985-11-19 Procede de preparation de derives de la pteridine
EP86402544A EP0225823B1 (de) 1985-11-19 1986-11-17 Verfahren zur Herstellung von Pteridinderivaten

Publications (1)

Publication Number Publication Date
ATE49969T1 true ATE49969T1 (de) 1990-02-15

Family

ID=9324943

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86402544T ATE49969T1 (de) 1985-11-19 1986-11-17 Verfahren zur herstellung von pteridinderivaten.

Country Status (7)

Country Link
US (1) US4767859A (de)
EP (1) EP0225823B1 (de)
JP (1) JPS62120386A (de)
AT (1) ATE49969T1 (de)
CA (1) CA1261324A (de)
DE (1) DE3668621D1 (de)
FR (1) FR2590255B1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382582A (en) * 1993-03-26 1995-01-17 Chan; Carcy L. Methotrexate analogs and methods of using same
US5698556A (en) * 1995-06-07 1997-12-16 Chan; Carcy L. Methotrexate analogs and methods of using same
DE69738948D1 (de) 1996-12-06 2008-10-09 Amgen Inc Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten
WO1999020626A1 (en) * 1997-10-17 1999-04-29 Purdue Research Foundation Folic acid derivatives
JP2006517191A (ja) * 2002-12-30 2006-07-20 アムジエン・インコーポレーテツド 共刺激因子を用いた併用療法
US6921667B2 (en) 2003-03-07 2005-07-26 Prometheus Laboratories, Inc. Methods for direct detection of individual methotrexate metabolites
US7582282B2 (en) 2003-08-29 2009-09-01 Prometheus Laboratories Inc. Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics
US7612071B2 (en) 2004-03-12 2009-11-03 Syntrix Biosystems, Inc. Compositions and methods employing aminopterin
US20080312201A1 (en) * 2004-09-10 2008-12-18 Patrick Fogarty Reduced Toxicity Methotrexate Formulations and Methods for Using the Same
US7312217B2 (en) 2005-03-11 2007-12-25 Syntrix Biosystems, Inc. Aminopterin dosage forms and methods for inflammatory disorders
US20060286571A1 (en) 2005-04-28 2006-12-21 Prometheus Laboratories, Inc. Methods of predicting methotrexate efficacy and toxicity
CN101355952B (zh) 2005-11-28 2012-03-21 韦罗制药有限公司 用于减少肾毒性的组合物及其使用方法
US7235660B1 (en) 2007-01-02 2007-06-26 Zebala John A Facile process for the preparation of high-purity aminopterin
JP5504179B2 (ja) 2008-03-03 2014-05-28 トスク インコーポレーティッド 毒性を低減するためのメトトレキセートアジュバントおよびその使用法
WO2012037068A1 (en) 2010-09-13 2012-03-22 De Novo Diagnostics, Inc. Methods for monitoring methotrexate therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2122991C2 (de) * 1971-05-04 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden
BE792914A (fr) * 1971-12-18 1973-06-18 Schering Ag Derives amino de n-heterocycles et leur procede de preparation
DE2621645C3 (de) * 1976-05-13 1981-08-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von Aminoderivaten von N-Heterocyclen
FI68400C (fi) * 1980-09-12 1985-09-10 Farmos Oy Foerfarande foer framstaellning av n-(4-(((2,4-diamino-6-pteridinyl)-metyl)metylamino)bensoyl)glutaminsyra

Also Published As

Publication number Publication date
US4767859A (en) 1988-08-30
FR2590255A1 (fr) 1987-05-22
FR2590255B1 (fr) 1987-12-24
CA1261324A (fr) 1989-09-26
EP0225823A1 (de) 1987-06-16
EP0225823B1 (de) 1990-01-31
DE3668621D1 (de) 1990-03-08
JPS62120386A (ja) 1987-06-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee