ATE496941T1 - Herstellung von insulinkonjugaten - Google Patents
Herstellung von insulinkonjugatenInfo
- Publication number
- ATE496941T1 ATE496941T1 AT05784019T AT05784019T ATE496941T1 AT E496941 T1 ATE496941 T1 AT E496941T1 AT 05784019 T AT05784019 T AT 05784019T AT 05784019 T AT05784019 T AT 05784019T AT E496941 T1 ATE496941 T1 AT E496941T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- insulin
- insulin conjugates
- conjugation
- oligomer
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 230000021615 conjugation Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2005/000234 WO2007007345A1 (en) | 2005-07-08 | 2005-07-08 | Preparation of insulin conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE496941T1 true ATE496941T1 (de) | 2011-02-15 |
Family
ID=37636774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05784019T ATE496941T1 (de) | 2005-07-08 | 2005-07-08 | Herstellung von insulinkonjugaten |
Country Status (16)
Country | Link |
---|---|
US (1) | US7977454B2 (de) |
EP (1) | EP1907419B1 (de) |
JP (1) | JP4818361B2 (de) |
KR (1) | KR101225679B1 (de) |
CN (1) | CN101223190B (de) |
AT (1) | ATE496941T1 (de) |
BR (1) | BRPI0520362B1 (de) |
CY (1) | CY1112009T1 (de) |
DE (1) | DE602005026182D1 (de) |
DK (1) | DK1907419T3 (de) |
ES (1) | ES2361166T3 (de) |
IL (1) | IL188603A (de) |
PL (1) | PL1907419T3 (de) |
PT (1) | PT1907419E (de) |
SI (1) | SI1907419T1 (de) |
WO (1) | WO2007007345A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1934252T3 (en) * | 2005-10-13 | 2015-08-31 | Biocon Ltd | METHOD FOR PRODUCING insulin conjugates |
WO2008049711A1 (en) | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
CA2766571A1 (en) * | 2009-07-09 | 2011-02-24 | Biocon Limited | A preparative non-linear gradient based chromatographic method and purified products thereof |
AR080884A1 (es) | 2010-04-14 | 2012-05-16 | Sanofi Aventis | Conjugados de insulina-sirna |
CN102675452B (zh) * | 2011-03-17 | 2015-09-16 | 重庆富进生物医药有限公司 | 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物 |
SG195192A1 (en) * | 2011-06-02 | 2013-12-30 | Hanmi Science Co Ltd | Non-peptidyl polymer-insulin multimer and method for producing the same |
US9457096B2 (en) | 2012-07-06 | 2016-10-04 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) | Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery |
CN102816819B (zh) * | 2012-08-13 | 2014-10-29 | 山东阿华生物药业有限公司 | 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法 |
GB2567646B8 (en) | 2017-10-18 | 2020-07-08 | Leonardo Mw Ltd | Apparatus and method for reducing distortion of an optical signal |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
IE50892B1 (en) * | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
US6309633B1 (en) * | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
JP2002217457A (ja) * | 2001-01-12 | 2002-08-02 | Nec Corp | 携帯電話機、それに備えられた拡散体及び照明装置 |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
-
2005
- 2005-07-08 BR BRPI0520362-7A patent/BRPI0520362B1/pt not_active IP Right Cessation
- 2005-07-08 SI SI200531254T patent/SI1907419T1/sl unknown
- 2005-07-08 ES ES05784019T patent/ES2361166T3/es active Active
- 2005-07-08 US US11/995,059 patent/US7977454B2/en active Active
- 2005-07-08 DE DE602005026182T patent/DE602005026182D1/de active Active
- 2005-07-08 DK DK05784019.1T patent/DK1907419T3/da active
- 2005-07-08 EP EP05784019A patent/EP1907419B1/de active Active
- 2005-07-08 KR KR1020087002705A patent/KR101225679B1/ko active IP Right Grant
- 2005-07-08 CN CN2005800510183A patent/CN101223190B/zh not_active Expired - Fee Related
- 2005-07-08 AT AT05784019T patent/ATE496941T1/de active
- 2005-07-08 JP JP2008520064A patent/JP4818361B2/ja not_active Expired - Fee Related
- 2005-07-08 PL PL05784019T patent/PL1907419T3/pl unknown
- 2005-07-08 WO PCT/IN2005/000234 patent/WO2007007345A1/en active Application Filing
- 2005-07-08 PT PT05784019T patent/PT1907419E/pt unknown
-
2008
- 2008-01-06 IL IL188603A patent/IL188603A/en active IP Right Grant
-
2011
- 2011-04-18 CY CY20111100398T patent/CY1112009T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1112009T1 (el) | 2015-11-04 |
US7977454B2 (en) | 2011-07-12 |
SI1907419T1 (sl) | 2011-06-30 |
EP1907419A1 (de) | 2008-04-09 |
IL188603A (en) | 2012-12-31 |
EP1907419B1 (de) | 2011-01-26 |
PT1907419E (pt) | 2011-04-06 |
US20080139784A1 (en) | 2008-06-12 |
DE602005026182D1 (de) | 2011-03-10 |
ES2361166T3 (es) | 2011-06-14 |
BRPI0520362B1 (pt) | 2017-10-17 |
PL1907419T3 (pl) | 2011-08-31 |
BRPI0520362A2 (pt) | 2009-05-05 |
WO2007007345A1 (en) | 2007-01-18 |
DK1907419T3 (da) | 2011-04-26 |
CN101223190A (zh) | 2008-07-16 |
KR101225679B1 (ko) | 2013-01-23 |
JP4818361B2 (ja) | 2011-11-16 |
KR20080033334A (ko) | 2008-04-16 |
JP2009500396A (ja) | 2009-01-08 |
IL188603A0 (en) | 2008-04-13 |
CN101223190B (zh) | 2012-06-20 |
EP1907419A4 (de) | 2008-07-23 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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