ATE496045T1 - PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - Google Patents
PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASEInfo
- Publication number
- ATE496045T1 ATE496045T1 AT08736964T AT08736964T ATE496045T1 AT E496045 T1 ATE496045 T1 AT E496045T1 AT 08736964 T AT08736964 T AT 08736964T AT 08736964 T AT08736964 T AT 08736964T AT E496045 T1 ATE496045 T1 AT E496045T1
- Authority
- AT
- Austria
- Prior art keywords
- disorders
- kinase
- inhibitors
- phosphatidylinositol
- pyrimidine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dental Preparations (AREA)
Abstract
The invention provides a pyrimidine compound of formula (I): wherein R1, R2, and Y have any of the values defined herein; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0707088A GB0707088D0 (en) | 2007-04-12 | 2007-04-12 | Pharmaceutical compounds |
GB0707611A GB0707611D0 (en) | 2007-04-19 | 2007-04-19 | Pharmaceutical compounds |
PCT/GB2008/001301 WO2008125839A2 (en) | 2007-04-12 | 2008-04-14 | Pyrimidine derivatives as inhibitors of phosphatidylinositol-3-kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE496045T1 true ATE496045T1 (en) | 2011-02-15 |
Family
ID=39832798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08736964T ATE496045T1 (en) | 2007-04-12 | 2008-04-14 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE |
Country Status (13)
Country | Link |
---|---|
US (1) | US20100130496A1 (en) |
EP (1) | EP2150546B1 (en) |
JP (1) | JP2010523639A (en) |
KR (1) | KR20100016433A (en) |
CN (1) | CN101765597A (en) |
AT (1) | ATE496045T1 (en) |
AU (1) | AU2008237721A1 (en) |
BR (1) | BRPI0810641A2 (en) |
CA (1) | CA2683624A1 (en) |
DE (1) | DE602008004650D1 (en) |
IL (1) | IL201365A0 (en) |
MX (1) | MX2009010886A (en) |
WO (1) | WO2008125839A2 (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008237715A1 (en) * | 2007-04-12 | 2008-10-23 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
WO2010014939A1 (en) | 2008-07-31 | 2010-02-04 | Genentech, Inc. | Pyrimidine compounds, compositions and methods of use |
US8507491B2 (en) * | 2008-08-25 | 2013-08-13 | Irm Llc | Compounds and compositions as hedgehog pathway inhibitors |
TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
RU2011137399A (en) | 2009-02-12 | 2013-03-20 | Астеллас Фарма Инк. | HETEROCYCLIC DERIVATIVE |
RU2515541C2 (en) | 2009-11-12 | 2014-05-10 | Ф.Хоффманн-Ля Рош Аг | N-7 substituted purines and pyrazolopyrimidines, compositions thereof and methods for use |
EP2498780B1 (en) | 2009-11-12 | 2016-09-07 | F.Hoffmann-La Roche Ag | N-9-substituted purine compounds, compositions and methods of use |
WO2011107494A1 (en) | 2010-03-03 | 2011-09-09 | Sanofi | Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof |
EP2582709B1 (en) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
AU2011290189B8 (en) | 2010-08-10 | 2015-02-19 | Astellas Pharma Inc. | Heterocyclic compound |
BR112013006030B1 (en) | 2010-09-29 | 2020-03-17 | Intervet International B.V. | COMPOUND AND PHARMACEUTICALLY ACCEPTABLE SALES OR N-OXIDES AND USE OF THE COMPOUND |
TW201500358A (en) | 2010-12-16 | 2015-01-01 | Hoffmann La Roche | Tricyclic PI3k inhibitor compounds and methods of use |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
KR102038462B1 (en) | 2011-12-15 | 2019-10-31 | 노파르티스 아게 | Use of inhibitors of the activity or function of PI3K |
AR090545A1 (en) | 2012-03-28 | 2014-11-19 | Intervet Int Bv | HETEROARILO COMPOUND WITH AN ACICLIC BRIDGE UNIT |
KR20160027218A (en) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | Compositions and methods of obtaining and using endoderm and hepatocyte cells |
EP2914260A1 (en) | 2012-10-31 | 2015-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
BR112016010568B1 (en) | 2013-11-15 | 2021-09-21 | Bayer Cropscience Aktiengesellschaft | PROCESS FOR PREPARATION OF A SUBSTITUTED 2-ETHYLAMINOPYRIDINE DERIVATIVE |
RU2713179C2 (en) * | 2014-02-21 | 2020-02-04 | Фрост Биолоджик, Инк. | Antimitotic amides for treating cancer and proliferative diseases |
WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
GB201602527D0 (en) * | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
CN110291069A (en) | 2016-12-21 | 2019-09-27 | 拜耳农作物科学股份公司 | The catalytic hydrogenation of nitrile |
JP7352284B2 (en) * | 2017-05-15 | 2023-09-28 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | Pyrrolo[2,3-c]pyridine and related analogs as LSD-1 inhibitors |
WO2019046316A1 (en) * | 2017-08-28 | 2019-03-07 | Acurastem Inc. | Pikfyve kinase inhibitors |
GB201810669D0 (en) * | 2018-06-28 | 2018-08-15 | Stiftelsen Alzecure | New compounds |
JP7485701B2 (en) * | 2019-06-06 | 2024-05-16 | 北京泰徳製薬股▲フン▼有限公司 | 2,4,6-trisubstituted pyrimidine compounds as ATR kinase inhibitors |
WO2021113506A1 (en) | 2019-12-04 | 2021-06-10 | Chdi Foundation, Inc. | Atm kinase inhibitors and compositions and methods of use thereof |
CA3171187A1 (en) * | 2020-02-14 | 2021-08-19 | Salk Institute For Biological Studies | Inhibitors of ulk1/2 and methods of using same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1186324C (en) * | 2000-04-27 | 2005-01-26 | 山之内制药株式会社 | Condensed heteroaryl derivatives |
CA2507100C (en) * | 2002-11-21 | 2012-10-09 | Chiron Corporation | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer |
CA2527079A1 (en) * | 2003-05-29 | 2005-01-06 | Synta Pharmaceuticals, Corp. | Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss |
JP4906715B2 (en) * | 2004-05-08 | 2012-03-28 | ニューロジェン・コーポレーション | 4,5-disubstituted-2-arylpyrimidines |
US7851466B2 (en) * | 2004-11-19 | 2010-12-14 | Synta Pharmaceuticals Corp. | Pyrimidine compounds and uses thereof |
GB0520657D0 (en) * | 2005-10-11 | 2005-11-16 | Ludwig Inst Cancer Res | Pharmaceutical compounds |
-
2008
- 2008-04-14 CN CN200880019513A patent/CN101765597A/en active Pending
- 2008-04-14 CA CA002683624A patent/CA2683624A1/en not_active Abandoned
- 2008-04-14 US US12/594,529 patent/US20100130496A1/en not_active Abandoned
- 2008-04-14 AU AU2008237721A patent/AU2008237721A1/en not_active Abandoned
- 2008-04-14 MX MX2009010886A patent/MX2009010886A/en not_active Application Discontinuation
- 2008-04-14 BR BRPI0810641A patent/BRPI0810641A2/en not_active IP Right Cessation
- 2008-04-14 AT AT08736964T patent/ATE496045T1/en not_active IP Right Cessation
- 2008-04-14 EP EP08736964A patent/EP2150546B1/en not_active Not-in-force
- 2008-04-14 WO PCT/GB2008/001301 patent/WO2008125839A2/en active Application Filing
- 2008-04-14 DE DE602008004650T patent/DE602008004650D1/en active Active
- 2008-04-14 KR KR1020097023504A patent/KR20100016433A/en not_active Application Discontinuation
- 2008-04-14 JP JP2010502577A patent/JP2010523639A/en active Pending
-
2009
- 2009-10-11 IL IL201365A patent/IL201365A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20100016433A (en) | 2010-02-12 |
JP2010523639A (en) | 2010-07-15 |
US20100130496A1 (en) | 2010-05-27 |
WO2008125839A3 (en) | 2008-12-24 |
AU2008237721A1 (en) | 2008-10-23 |
BRPI0810641A2 (en) | 2019-09-24 |
EP2150546A2 (en) | 2010-02-10 |
CA2683624A1 (en) | 2008-10-23 |
DE602008004650D1 (en) | 2011-03-03 |
EP2150546B1 (en) | 2011-01-19 |
MX2009010886A (en) | 2009-12-14 |
WO2008125839A2 (en) | 2008-10-23 |
CN101765597A (en) | 2010-06-30 |
IL201365A0 (en) | 2010-05-31 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |