ATE494290T1 - Substituierte 2,5-dihydro-3h-pyrazol-ä4,3-cü- pyridazin-3-on-derivate, ihre herstellung und ihre verwendung als cannibinoid-cb1- rezeptorliganden - Google Patents
Substituierte 2,5-dihydro-3h-pyrazol-ä4,3-cü- pyridazin-3-on-derivate, ihre herstellung und ihre verwendung als cannibinoid-cb1- rezeptorligandenInfo
- Publication number
- ATE494290T1 ATE494290T1 AT07870295T AT07870295T ATE494290T1 AT E494290 T1 ATE494290 T1 AT E494290T1 AT 07870295 T AT07870295 T AT 07870295T AT 07870295 T AT07870295 T AT 07870295T AT E494290 T1 ATE494290 T1 AT E494290T1
- Authority
- AT
- Austria
- Prior art keywords
- cannibinoid
- pyridazine
- pyrazole
- dihydro
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0610371A FR2909090B1 (fr) | 2006-11-23 | 2006-11-23 | Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique. |
PCT/FR2007/001889 WO2008068424A2 (fr) | 2006-11-23 | 2007-11-19 | Derives de 2, 5-dihydro-3h-pyrazolo [4, 3-c] pyridazin-3-one substitues, leur preparation et leur utilisation comme ligands des recepteurs cb1 des cannabinoides |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE494290T1 true ATE494290T1 (de) | 2011-01-15 |
Family
ID=38229329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07870295T ATE494290T1 (de) | 2006-11-23 | 2007-11-19 | Substituierte 2,5-dihydro-3h-pyrazol-ä4,3-cü- pyridazin-3-on-derivate, ihre herstellung und ihre verwendung als cannibinoid-cb1- rezeptorliganden |
Country Status (20)
Country | Link |
---|---|
US (1) | US7915258B2 (de) |
EP (1) | EP2094706B1 (de) |
JP (1) | JP2010510297A (de) |
KR (1) | KR20090092774A (de) |
CN (1) | CN101541802A (de) |
AR (1) | AR063898A1 (de) |
AT (1) | ATE494290T1 (de) |
AU (1) | AU2007330652A1 (de) |
BR (1) | BRPI0719291A2 (de) |
CA (1) | CA2668196A1 (de) |
CL (1) | CL2007003346A1 (de) |
DE (1) | DE602007011815D1 (de) |
FR (1) | FR2909090B1 (de) |
IL (1) | IL198523A0 (de) |
MX (1) | MX2009005447A (de) |
PE (1) | PE20081496A1 (de) |
RU (1) | RU2009123841A (de) |
TW (1) | TW200836739A (de) |
UY (1) | UY30742A1 (de) |
WO (1) | WO2008068424A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200920372A (en) * | 2007-07-13 | 2009-05-16 | Genelabs Tech Inc | Anti-viral compounds, compositions, and methods of use |
WO2010123716A1 (en) * | 2009-04-20 | 2010-10-28 | Merck Sharp & Dohme Corp. | Heterocyclic fused cinnoline m1 receptor positive allosteric modulators |
WO2012018059A1 (ja) * | 2010-08-04 | 2012-02-09 | 武田薬品工業株式会社 | 複素環化合物 |
EA026393B1 (ru) | 2012-05-22 | 2017-04-28 | Дженентек, Инк. | N-замещенные бензамиды и их применение в лечении боли |
HUE043349T2 (hu) * | 2013-09-12 | 2019-08-28 | Janssen Biopharma Inc | Piridazinon vegyületek és ezek alkalmazása |
BR112016005270B1 (pt) | 2013-09-12 | 2022-11-01 | Alios Biopharma, Inc | Compostos de aza-piridona, composições farmacêuticas e seus usos |
WO2015099107A1 (ja) | 2013-12-26 | 2015-07-02 | 塩野義製薬株式会社 | 含窒素6員環誘導体およびそれらを含有する医薬組成物 |
WO2016145103A1 (en) | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
PL3287443T3 (pl) | 2015-04-24 | 2022-02-21 | Shionogi & Co., Ltd | 6-członowa pochodna heterocykliczna i kompozycja farmaceutyczna ją zawierająca |
BR112019006675A2 (pt) | 2016-10-17 | 2019-06-25 | Shionogi & Co | derivado heterocíclico nitrogenado bicíclico e composição farmacêutica contendo o mesmo |
TW202321229A (zh) | 2021-08-18 | 2023-06-01 | 美商富曼西公司 | 殺真菌的取代的雜環化合物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4345934A (en) | 1977-03-10 | 1982-08-24 | Rohm And Haas Company | Method of producing hybrid cereal grain seeds by application of 1-aryl-1,4-dihydro-4-oxo(thio)-pyridazines |
FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2713225B1 (fr) | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
US6005103A (en) | 1993-11-19 | 1999-12-21 | Warner-Lambert Company | Pyrone derivatives as protease inhibitors and antiviral agents |
US5808082A (en) * | 1996-05-08 | 1998-09-15 | Merck & Co., Inc. | Method of preparing phosphodiesterase IV inhibitors |
FR2789079B3 (fr) | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
US7601718B2 (en) * | 2003-02-06 | 2009-10-13 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
US7232823B2 (en) * | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
WO2005061504A1 (en) * | 2003-12-16 | 2005-07-07 | Pfizer Products Inc. | Bicyclic pyridazinone cannabinoid receptor ligands and uses thereof |
JP2010539218A (ja) * | 2007-09-20 | 2010-12-16 | グラクソ グループ リミテッド | M1受容体にて活性を有する化合物および医薬としてのそれらの使用 |
-
2006
- 2006-11-23 FR FR0610371A patent/FR2909090B1/fr not_active Expired - Fee Related
-
2007
- 2007-11-19 KR KR1020097010476A patent/KR20090092774A/ko not_active Application Discontinuation
- 2007-11-19 EP EP07870295A patent/EP2094706B1/de active Active
- 2007-11-19 JP JP2009537670A patent/JP2010510297A/ja not_active Withdrawn
- 2007-11-19 RU RU2009123841/04A patent/RU2009123841A/ru not_active Application Discontinuation
- 2007-11-19 DE DE602007011815T patent/DE602007011815D1/de active Active
- 2007-11-19 CA CA002668196A patent/CA2668196A1/fr not_active Abandoned
- 2007-11-19 BR BRPI0719291-6A patent/BRPI0719291A2/pt not_active Application Discontinuation
- 2007-11-19 AU AU2007330652A patent/AU2007330652A1/en not_active Abandoned
- 2007-11-19 CN CNA2007800431890A patent/CN101541802A/zh active Pending
- 2007-11-19 WO PCT/FR2007/001889 patent/WO2008068424A2/fr active Application Filing
- 2007-11-19 MX MX2009005447A patent/MX2009005447A/es not_active Application Discontinuation
- 2007-11-19 AT AT07870295T patent/ATE494290T1/de not_active IP Right Cessation
- 2007-11-20 PE PE2007001610A patent/PE20081496A1/es not_active Application Discontinuation
- 2007-11-20 TW TW096143951A patent/TW200836739A/zh unknown
- 2007-11-22 AR ARP070105186A patent/AR063898A1/es unknown
- 2007-11-22 CL CL200703346A patent/CL2007003346A1/es unknown
- 2007-11-23 UY UY30742A patent/UY30742A1/es not_active Application Discontinuation
-
2009
- 2009-05-03 IL IL198523A patent/IL198523A0/en unknown
- 2009-05-19 US US12/468,294 patent/US7915258B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CL2007003346A1 (es) | 2008-07-04 |
UY30742A1 (es) | 2008-07-03 |
US7915258B2 (en) | 2011-03-29 |
FR2909090B1 (fr) | 2009-01-09 |
WO2008068424A3 (fr) | 2008-07-24 |
RU2009123841A (ru) | 2010-12-27 |
EP2094706A2 (de) | 2009-09-02 |
TW200836739A (en) | 2008-09-16 |
IL198523A0 (en) | 2010-02-17 |
EP2094706B1 (de) | 2011-01-05 |
WO2008068424A8 (fr) | 2009-07-02 |
CN101541802A (zh) | 2009-09-23 |
KR20090092774A (ko) | 2009-09-01 |
FR2909090A1 (fr) | 2008-05-30 |
PE20081496A1 (es) | 2009-01-04 |
AR063898A1 (es) | 2009-02-25 |
US20090281107A1 (en) | 2009-11-12 |
BRPI0719291A2 (pt) | 2014-02-25 |
CA2668196A1 (fr) | 2008-06-12 |
WO2008068424A2 (fr) | 2008-06-12 |
DE602007011815D1 (de) | 2011-02-17 |
AU2007330652A1 (en) | 2008-06-12 |
JP2010510297A (ja) | 2010-04-02 |
MX2009005447A (es) | 2009-08-07 |
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