ATE491789T1 - METHOD FOR PRODUCING GAMMA-CARBOXYLATED PROTEINS - Google Patents

METHOD FOR PRODUCING GAMMA-CARBOXYLATED PROTEINS

Info

Publication number: ATE491789T1
Authority: AT; Austria
Prior art keywords: producing gamma; carboxylated proteins; carboxylated; proteins; gamma
Prior art date: 2003-10-14

Application number

AT04775534T

Other languages

German (de)

Inventor

Christel Fenge

Ann Loevgren

Anders Thelin

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-14

Filing date

2004-10-12

Publication date

2011-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29559260&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE491789(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-10-12 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE491789T1 publication Critical patent/ATE491789T1/en

Links

108091005606 gamma-carboxylated proteins Proteins 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

AT04775534T 2003-10-14 2004-10-12 METHOD FOR PRODUCING GAMMA-CARBOXYLATED PROTEINS ATE491789T1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0324044.7A GB0324044D0 (en)	2003-10-14	2003-10-14	Protein
PCT/SE2004/001453 WO2005038019A1 (en)	2003-10-14	2004-10-12	Method for producing gamma-carboxylated proteins

Publications (1)

Publication Number	Publication Date
ATE491789T1 true ATE491789T1 (en)	2011-01-15

Family

ID=29559260

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04775534T ATE491789T1 (en)	2003-10-14	2004-10-12	METHOD FOR PRODUCING GAMMA-CARBOXYLATED PROTEINS

Country Status (29)

Country	Link
US (2)	US7842477B2 (en)
EP (2)	EP1678297B1 (en)
JP (1)	JP4658946B2 (en)
KR (1)	KR101201020B1 (en)
CN (2)	CN102443548B (en)
AR (1)	AR046180A1 (en)
AT (1)	ATE491789T1 (en)
AU (2)	AU2004281350B2 (en)
BR (1)	BRPI0415277A (en)
CA (1)	CA2541764C (en)
CO (1)	CO5690657A2 (en)
DE (1)	DE602004030603D1 (en)
DK (1)	DK1678297T3 (en)
ES (2)	ES2357603T3 (en)
GB (1)	GB0324044D0 (en)
HK (1)	HK1155475A1 (en)
IL (2)	IL174633A (en)
IS (1)	IS8447A (en)
MX (1)	MXPA06004060A (en)
MY (1)	MY141859A (en)
NO (1)	NO339740B1 (en)
NZ (2)	NZ546584A (en)
PL (1)	PL1678297T3 (en)
PT (1)	PT1678297E (en)
RU (2)	RU2372401C2 (en)
TW (1)	TWI355419B (en)
UY (1)	UY28558A1 (en)
WO (1)	WO2005038019A1 (en)
ZA (1)	ZA200603038B (en)

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EP1842920B2 (en) *	2003-09-23	2017-06-21	University Of North Carolina At Chapel Hill	Cells coexpressing vitamin K reductase and vitamin K dependent protein and use thereof to improve the productivity of said vitamin K dependent protein
WO2006101474A1 (en) *	2005-03-15	2006-09-28	University Of North Carolina At Chapel Hill	Methods and compositions for producing active vitamin k-dependent proteins
GB0324044D0 (en)	2003-10-14	2003-11-19	Astrazeneca Ab	Protein
KR101599062B1 (en)	2005-04-13	2016-03-02	아스트라제네카 아베	A host cell comprising a vector for production of proteins requiring gamma-carboxylation
CA2624072A1 (en) *	2005-09-30	2007-04-12	Juridical Foundation The Chemo-Sero-Therapeutic Research Institute	Process for producing recombinant human thrombin by cultured cell
US7745484B2 (en)	2005-11-21	2010-06-29	Amgen Inc.	Beta-secretase modulators and methods of use
SI1969127T2 (en) *	2005-12-21	2017-10-30	Cnj Holdings, Inc	Method of producing biologically active vitamin k dependent proteins by recombinant methods
EP1996186A4 (en) *	2006-03-06	2009-07-22	Humagene Inc	A method for the preparation of recombinant human thrombin and fibrinogen
JP6050927B2 (en) *	2007-04-26	2016-12-21	シーエヌジェイホールディングス，インコーポレイテッド	Recombinant vitamin K-dependent protein having high sialic acid content and method for preparing the same
US8206967B2 (en) *	2007-07-06	2012-06-26	Medimmune Limited	Method for production of recombinant human thrombin
EP2624859B1 (en)	2010-10-06	2017-03-01	Medimmune Limited	Factor ii alone or in combination with further factors for treatment of impaired haemostasis associated with dilutional coagulopathy
WO2012088222A2 (en)	2010-12-21	2012-06-28	The University Of North Carolina At Chapel Hill	Methods and compositions for producing active vitamin k-dependent proteins
AU2012304763A1 (en)	2011-09-06	2014-03-06	Medimmune Llc	Methods for processing coagulation factors
RU2500816C1 (en) *	2012-07-19	2013-12-10	Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум")	RECOMBINANT PLASMID DNA pAK380 CODING POLYPEPTIDE OF RECOMBINANT FACTOR IX OF HUMAN BLOOD COAGULABILITY, LINE OF CELLS Cricetulus griseus CHO, 1E6-PRODUCER OF RECOMBINANT FACTOR IX OF HUMAN BLOOD COAGULABILITY, AND METHOD FOR OBTAINING POLYPEPTIDE HAVING ACTIVITY OF RECOMBINANT FACTOR IX
JP5830486B2 (en)	2013-03-29	2015-12-09	シスメックス株式会社	Recombinant baculovirus and use thereof
BR112016013420A2 (en) *	2013-12-20	2017-09-26	Novartis Ag	eukaryotic cells and methods for recombinantly expressing a product of interest
CN109207462B (en) *	2018-08-01	2021-05-11	深圳市新产业生物医学工程股份有限公司	Abnormal prothrombin, preparation method thereof, detection agent containing abnormal prothrombin, kit and application

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KR101599062B1 (en)	2005-04-13	2016-03-02	아스트라제네카 아베	A host cell comprising a vector for production of proteins requiring gamma-carboxylation
US8647868B2 (en)	2005-12-02	2014-02-11	Wake Forest University Health Sciences	Compositions and methods for increasing production of recombinant gamma-carboxylated proteins
SI1969127T2 (en)	2005-12-21	2017-10-30	Cnj Holdings, Inc	Method of producing biologically active vitamin k dependent proteins by recombinant methods
US8206967B2 (en)	2007-07-06	2012-06-26	Medimmune Limited	Method for production of recombinant human thrombin

2003
- 2003-10-14 GB GBGB0324044.7A patent/GB0324044D0/en not_active Ceased
2004
- 2004-10-12 EP EP04775534A patent/EP1678297B1/en active Active
- 2004-10-12 KR KR1020067009338A patent/KR101201020B1/en not_active IP Right Cessation
- 2004-10-12 NZ NZ546584A patent/NZ546584A/en not_active IP Right Cessation
- 2004-10-12 DE DE602004030603T patent/DE602004030603D1/en active Active
- 2004-10-12 WO PCT/SE2004/001453 patent/WO2005038019A1/en active Application Filing
- 2004-10-12 ES ES04775534T patent/ES2357603T3/en active Active
- 2004-10-12 CA CA2541764A patent/CA2541764C/en not_active Expired - Fee Related
- 2004-10-12 CN CN201110241382.3A patent/CN102443548B/en not_active Expired - Fee Related
- 2004-10-12 EP EP10185166.5A patent/EP2292748B1/en active Active
- 2004-10-12 PT PT04775534T patent/PT1678297E/en unknown
- 2004-10-12 MY MYPI20044176A patent/MY141859A/en unknown
- 2004-10-12 RU RU2006110147/13A patent/RU2372401C2/en not_active IP Right Cessation
- 2004-10-12 AT AT04775534T patent/ATE491789T1/en active
- 2004-10-12 ES ES10185166.5T patent/ES2532470T3/en active Active
- 2004-10-12 CN CN2004800300373A patent/CN1867669B/en not_active Expired - Fee Related
- 2004-10-12 PL PL04775534T patent/PL1678297T3/en unknown
- 2004-10-12 DK DK04775534.3T patent/DK1678297T3/en active
- 2004-10-12 AU AU2004281350A patent/AU2004281350B2/en not_active Ceased
- 2004-10-12 MX MXPA06004060A patent/MXPA06004060A/en active IP Right Grant
- 2004-10-12 JP JP2006535301A patent/JP4658946B2/en not_active Expired - Fee Related
- 2004-10-12 NZ NZ578306A patent/NZ578306A/en not_active IP Right Cessation
- 2004-10-12 BR BRPI0415277-8A patent/BRPI0415277A/en not_active IP Right Cessation
- 2004-10-13 UY UY28558A patent/UY28558A1/en not_active Application Discontinuation
- 2004-10-14 US US10/964,888 patent/US7842477B2/en not_active Expired - Fee Related
- 2004-10-14 AR ARP040103723A patent/AR046180A1/en unknown
- 2004-10-14 TW TW093131237A patent/TWI355419B/en not_active IP Right Cessation
2006
- 2006-03-29 IL IL174633A patent/IL174633A/en not_active IP Right Cessation
- 2006-03-31 NO NO20061470A patent/NO339740B1/en not_active IP Right Cessation
- 2006-04-12 CO CO06035799A patent/CO5690657A2/en not_active Application Discontinuation
- 2006-04-13 ZA ZA200603038A patent/ZA200603038B/en unknown
- 2006-05-10 IS IS8447A patent/IS8447A/en unknown
2008
- 2008-08-14 AU AU2008205445A patent/AU2008205445A1/en not_active Abandoned
2009
- 2009-06-24 RU RU2009123931/10A patent/RU2009123931A/en not_active Application Discontinuation
2010
- 2010-11-19 US US12/950,713 patent/US8697440B2/en not_active Expired - Fee Related
2011
- 2011-09-09 HK HK11109595.7A patent/HK1155475A1/en not_active IP Right Cessation
2013
- 2013-05-12 IL IL226313A patent/IL226313A0/en unknown

Also Published As

Publication number	Publication date
EP1678297B1 (en)	2010-12-15
EP2292748A1 (en)	2011-03-09
PT1678297E (en)	2011-03-15
PL1678297T3 (en)	2011-11-30
CN102443548A (en)	2012-05-09
BRPI0415277A (en)	2006-12-19
UY28558A1 (en)	2005-05-31
RU2372401C2 (en)	2009-11-10
JP4658946B2 (en)	2011-03-23
CN102443548B (en)	2014-03-12
WO2005038019A1 (en)	2005-04-28
DE602004030603D1 (en)	2011-01-27
AU2004281350B2 (en)	2008-05-15
AR046180A1 (en)	2005-11-30
MY141859A (en)	2010-07-16
NO339740B1 (en)	2017-01-30
US20050164367A1 (en)	2005-07-28
CA2541764C (en)	2015-03-31
MXPA06004060A (en)	2006-06-28
TWI355419B (en)	2012-01-01
JP2007508820A (en)	2007-04-12
RU2009123931A (en)	2010-12-27
US8697440B2 (en)	2014-04-15
IL226313A0 (en)	2013-06-27
RU2006110147A (en)	2007-11-20
AU2004281350A1 (en)	2005-04-28
IL174633A0 (en)	2006-08-20
HK1155475A1 (en)	2012-05-18
ES2357603T3 (en)	2011-04-28
GB0324044D0 (en)	2003-11-19
EP2292748B1 (en)	2014-12-17
IS8447A (en)	2006-05-10
DK1678297T3 (en)	2011-03-14
CN1867669A (en)	2006-11-22
AU2008205445A1 (en)	2008-09-04
CN1867669B (en)	2011-10-19
KR20060123152A (en)	2006-12-01
IL174633A (en)	2013-06-27
KR101201020B1 (en)	2012-11-14
NZ578306A (en)	2011-02-25
CA2541764A1 (en)	2005-04-28
NZ546584A (en)	2009-08-28
NO20061470L (en)	2006-05-12
US20110092429A1 (en)	2011-04-21
TW200523365A (en)	2005-07-16
US7842477B2 (en)	2010-11-30
ES2532470T3 (en)	2015-03-27
EP1678297A1 (en)	2006-07-12
CO5690657A2 (en)	2006-10-31
ZA200603038B (en)	2007-09-26

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