ATE489628T1 - Galk1s als modifikatoren des pten/akt-wegs - Google Patents

Galk1s als modifikatoren des pten/akt-wegs

Info

Publication number
ATE489628T1
ATE489628T1 AT06799955T AT06799955T ATE489628T1 AT E489628 T1 ATE489628 T1 AT E489628T1 AT 06799955 T AT06799955 T AT 06799955T AT 06799955 T AT06799955 T AT 06799955T AT E489628 T1 ATE489628 T1 AT E489628T1
Authority
AT
Austria
Prior art keywords
pten
galk1s
modifiers
akt pathway
akt
Prior art date
Application number
AT06799955T
Other languages
English (en)
Inventor
Arthur Brace
Lynn M Bjerke
Susana Nieto-Bergman
Lori S Friedman
Kevin Ward
Robert A Blake
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Application granted granted Critical
Publication of ATE489628T1 publication Critical patent/ATE489628T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4703Regulators; Modulating activity
    • G01N2333/4704Inhibitors; Supressors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/9121Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00Detection of programmed cell death, i.e. apoptosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06799955T 2005-06-20 2006-06-20 Galk1s als modifikatoren des pten/akt-wegs ATE489628T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69234205P 2005-06-20 2005-06-20
PCT/US2006/024053 WO2007002131A2 (en) 2005-06-20 2006-06-20 Galk1s as modifiers of the pten/akt pathway and methods of use

Publications (1)

Publication Number Publication Date
ATE489628T1 true ATE489628T1 (de) 2010-12-15

Family

ID=37595741

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06799955T ATE489628T1 (de) 2005-06-20 2006-06-20 Galk1s als modifikatoren des pten/akt-wegs

Country Status (8)

Country Link
US (3) US20110135629A1 (de)
EP (1) EP1898950B1 (de)
JP (1) JP2008543337A (de)
AT (1) ATE489628T1 (de)
AU (1) AU2006262324A1 (de)
CA (1) CA2612224A1 (de)
DE (1) DE602006018461D1 (de)
WO (5) WO2007002088A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8357701B2 (en) 2007-08-15 2013-01-22 University Of Miami Galactokinase inhibitors
EP2254603A4 (de) * 2008-02-25 2012-09-19 Univ Colorado Regents Verfahren zur hemmung von six 1- und eya-proteinen
FR2939355B1 (fr) 2008-12-04 2011-01-07 Seb Sa Appareil electromenager de preparation de jus a rendement de pressage ameliore
BE1018802A3 (nl) 2009-06-29 2011-09-06 Flooring Ind Ltd Sarl Paneel, meer speciaal vloerpaneel.
CN105709217B (zh) * 2014-12-03 2020-04-03 中国科学院上海生命科学研究院 Psat1及其产物在制备调节胰岛素敏感性的药物中的用途
WO2023154729A2 (en) * 2022-02-08 2023-08-17 Temple University-Of The Commonwealth System Of Higher Education Compositions and methods for cardiac tissue regeneration

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165461A (en) * 1998-04-14 2000-12-26 Board Of Regents, University Of Texas System Tao protein kinases and methods of use therefor
US20060058516A1 (en) * 2000-04-10 2006-03-16 Burkhard Scharm Novel serine-threonine kinase
US6777439B2 (en) * 2000-05-30 2004-08-17 Advanced Research & Technology Institute, Inc. Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
DE60119524T2 (de) * 2000-07-07 2007-05-03 Eirx Therapeutics Ltd. Screening-verfahren
JP2005507652A (ja) * 2001-08-17 2005-03-24 インサイト・ゲノミックス・インコーポレイテッド 核酸結合タンパク質
US20050095592A1 (en) * 2002-02-13 2005-05-05 Jazaeri Amir A. Identification of ovarian cancer tumor markers and therapeutic targets
GB0305267D0 (en) * 2003-03-07 2003-04-09 Eirx Therapeutics Ltd Proteins involved in apoptosis
EP1633856A4 (de) * 2003-06-19 2007-07-18 Exelixis Inc Marks als modifikatoren des pten-wegs und verwendungsverfahren
US20050279317A1 (en) * 2004-06-18 2005-12-22 Leasure Jeremy D Reservoir seal with fluid level indicator

Also Published As

Publication number Publication date
WO2007002088A3 (en) 2007-03-29
AU2006262324A1 (en) 2007-01-04
EP1898950A4 (de) 2009-02-18
US20100183583A1 (en) 2010-07-22
DE602006018461D1 (de) 2011-01-05
WO2007002080A2 (en) 2007-01-04
JP2008543337A (ja) 2008-12-04
WO2007002087A3 (en) 2009-04-16
WO2007002088A2 (en) 2007-01-04
CA2612224A1 (en) 2007-01-04
WO2007002131A2 (en) 2007-01-04
WO2007002188A3 (en) 2007-05-18
WO2007002131A3 (en) 2007-10-04
EP1898950A2 (de) 2008-03-19
WO2007002087A2 (en) 2007-01-04
US20100122354A1 (en) 2010-05-13
US20110135629A1 (en) 2011-06-09
EP1898950B1 (de) 2010-11-24
WO2007002188A2 (en) 2007-01-04
WO2007002080A3 (en) 2009-04-30

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