ATE485818T1 - Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren - Google Patents

Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren

Info

Publication number
ATE485818T1
ATE485818T1 AT03772067T AT03772067T ATE485818T1 AT E485818 T1 ATE485818 T1 AT E485818T1 AT 03772067 T AT03772067 T AT 03772067T AT 03772067 T AT03772067 T AT 03772067T AT E485818 T1 ATE485818 T1 AT E485818T1
Authority
AT
Austria
Prior art keywords
cholesterol
ezetimibe
associated tumor
methods
malignant tumors
Prior art date
Application number
AT03772067T
Other languages
English (en)
Inventor
Carl Schaffner
Keith Solomon
Michael Freeman
Original Assignee
Karykion Inc
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karykion Inc, Childrens Medical Center filed Critical Karykion Inc
Application granted granted Critical
Publication of ATE485818T1 publication Critical patent/ATE485818T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03772067T 2002-07-30 2003-07-30 Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren ATE485818T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39969002P 2002-07-30 2002-07-30
US10/630,578 US6933292B2 (en) 2002-07-30 2003-07-30 Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors
PCT/US2003/023764 WO2004010948A2 (en) 2002-07-30 2003-07-30 Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors

Publications (1)

Publication Number Publication Date
ATE485818T1 true ATE485818T1 (de) 2010-11-15

Family

ID=32511171

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03772067T ATE485818T1 (de) 2002-07-30 2003-07-30 Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren

Country Status (10)

Country Link
US (3) US6933292B2 (de)
EP (1) EP1545479B1 (de)
JP (1) JP2006501205A (de)
CN (1) CN1678296A (de)
AT (1) ATE485818T1 (de)
AU (1) AU2003254261B2 (de)
CA (1) CA2493614C (de)
DE (1) DE60334711D1 (de)
NZ (1) NZ538498A (de)
WO (1) WO2004010948A2 (de)

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EP2011802A3 (de) 2001-04-27 2009-04-15 Kyowa Hakko Kirin Co., Ltd. Monoklonaler Antikörper gegen CD40
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
ATE485818T1 (de) * 2002-07-30 2010-11-15 Karykion Inc Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren
EP1677803A2 (de) * 2003-09-26 2006-07-12 Forbes Medi-Tech Inc. Verfahren zur hemmung der expression von genen mit multi-arzneimittel-resistenz und hemmung der produktion von proteinen, die sich aus der expression dieser gene ergeben, und so verstärkung der wirksamkeit von chemotherapeutika zur behandlung von krebs
WO2005061452A1 (en) 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
US8361999B2 (en) 2005-04-04 2013-01-29 Pontificia Universidad Catolica De Chile Methods of treating cholesterol gallstone disease with ezetimibe
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
US20070275052A1 (en) * 2006-05-24 2007-11-29 Glenmark Pharmaceuticals Limited Pharmaceutical compositions containing sterol inhibitors
US20090208448A1 (en) * 2008-02-15 2009-08-20 Solomon Keith R Inhibition of angiogenesis
US9034863B2 (en) 2008-09-02 2015-05-19 The Board Of Trustees Of The University Of Illinois Compositions and methods for inhibiting entry of a hepatic virus
US8673288B2 (en) * 2008-09-02 2014-03-18 The Board Of Trustees Of The University Of Illinois Compositions and methods for inhibiting entry of a hepatic virus
WO2015065505A1 (en) * 2013-10-29 2015-05-07 Duke University Use of cyp27a1 inhibitors, statin, or lxr antagonists alone or in combination with conventional therapy for the treatment of breast cancer
BR112022009066A2 (pt) * 2019-11-12 2022-08-09 Univ South Africa Ezetimiba para uso em tratamento de câncer
WO2022087437A1 (en) * 2020-10-22 2022-04-28 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Methods of treatment
CN115364094A (zh) * 2021-05-19 2022-11-22 南京大学 伊折麦布在制备抗肿瘤药物中的应用

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Also Published As

Publication number Publication date
JP2006501205A (ja) 2006-01-12
US7449453B2 (en) 2008-11-11
AU2003254261A1 (en) 2004-02-16
CA2493614C (en) 2011-09-13
US20070037755A1 (en) 2007-02-15
US20050209167A1 (en) 2005-09-22
US20040116358A1 (en) 2004-06-17
WO2004010948A3 (en) 2004-07-01
DE60334711D1 (de) 2010-12-09
AU2003254261B2 (en) 2008-04-17
EP1545479A2 (de) 2005-06-29
NZ538498A (en) 2009-02-28
WO2004010948A2 (en) 2004-02-05
EP1545479A4 (de) 2007-10-24
US7098198B2 (en) 2006-08-29
EP1545479B1 (de) 2010-10-27
US6933292B2 (en) 2005-08-23
CA2493614A1 (en) 2004-02-05
CN1678296A (zh) 2005-10-05

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