ATE482922T1 - Aloe-emodinderivate und deren verwendung in der behandlung von neoplasien - Google Patents

Aloe-emodinderivate und deren verwendung in der behandlung von neoplasien

Info

Publication number
ATE482922T1
ATE482922T1 AT02727865T AT02727865T ATE482922T1 AT E482922 T1 ATE482922 T1 AT E482922T1 AT 02727865 T AT02727865 T AT 02727865T AT 02727865 T AT02727865 T AT 02727865T AT E482922 T1 ATE482922 T1 AT E482922T1
Authority
AT
Austria
Prior art keywords
aloe
derivatives
treatment
emodin
neoplasias
Prior art date
Application number
AT02727865T
Other languages
English (en)
Inventor
Giorgio Palu
Modesto Carli
Teresa Pecere
Giuseppe Zagotto
Original Assignee
Univ Padova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Padova filed Critical Univ Padova
Application granted granted Critical
Publication of ATE482922T1 publication Critical patent/ATE482922T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/40—Succinic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/80—Phthalic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02727865T 2001-05-10 2002-05-10 Aloe-emodinderivate und deren verwendung in der behandlung von neoplasien ATE482922T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI000957A ITMI20010957A1 (it) 2001-05-10 2001-05-10 Derivati dell'aoe-emodina e loro impiego nel trattamento di patologieneoplastiche
PCT/IB2002/001604 WO2002090313A1 (en) 2001-05-10 2002-05-10 Aloe-emodin derivatives and their use in the treatment of neoplastic pathologies

Publications (1)

Publication Number Publication Date
ATE482922T1 true ATE482922T1 (de) 2010-10-15

Family

ID=11447624

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02727865T ATE482922T1 (de) 2001-05-10 2002-05-10 Aloe-emodinderivate und deren verwendung in der behandlung von neoplasien

Country Status (11)

Country Link
US (1) US7268162B2 (de)
EP (1) EP1399411B1 (de)
JP (1) JP4467888B2 (de)
AT (1) ATE482922T1 (de)
AU (1) AU2002258050B2 (de)
CA (1) CA2446429C (de)
DE (1) DE60237818D1 (de)
DK (1) DK1399411T3 (de)
ES (1) ES2353203T3 (de)
IT (1) ITMI20010957A1 (de)
WO (1) WO2002090313A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2007132784A1 (ja) * 2006-05-15 2009-09-24 国立大学法人 新潟大学 アントラキノン誘導体を有効成分として含有する抗精神病薬、認知異常の治療薬
US20130045933A1 (en) 2010-01-21 2013-02-21 Ramot At Tel-Aviv University Ltd. Aloe-emodin derivatives and use thereof for the treatment of cancer
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US8541382B2 (en) 2010-11-13 2013-09-24 Sirbal Ltd. Cardiac glycoside analogs in combination with emodin for cancer therapy
US8597695B1 (en) 2010-11-13 2013-12-03 Sirbal Ltd. Herbal combinations for treatment of a skin condition
CN102838530A (zh) * 2012-09-19 2012-12-26 陕西师范大学 芦荟大黄素衍生物及其制备方法
EP3498288A1 (de) 2013-12-02 2019-06-19 Sirbal Ltd. Kräuterkombinationen zur behandlung einer hauterkrankung
CN104356014B (zh) * 2014-11-07 2016-03-30 福州大学 具有抗癌活性的大黄素单链双季铵盐及其制备方法
WO2017019651A1 (en) 2015-07-29 2017-02-02 Sirbal Ltd. Herbal combinations for treating psoriasis
EP3725761B1 (de) * 2017-12-07 2024-01-03 Jiangsu Kanion Pharmaceutical Co., Ltd. Emodin-succinyl-ester-verbindung, herstellungsverfahren dafür und verwendung davon
IT202000004939A1 (it) 2020-03-09 2021-09-09 Palu Giorgio Impieghi di 1,8-diidrossi-3-[idrossimetil]-antrachinone e suoi derivati
CN114315884B (zh) * 2020-10-30 2024-03-22 天津科技大学 两个大黄素衍生物的合成及其在抗人***药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318547B1 (it) 2000-05-31 2003-08-27 Giorgio Palu Impiego dell'aloe-emodin nel trattamento di patologie neoplastiche diorigine neuroectodermica.

Also Published As

Publication number Publication date
DK1399411T3 (da) 2011-01-24
ITMI20010957A1 (it) 2002-11-10
EP1399411B1 (de) 2010-09-29
CA2446429C (en) 2011-06-21
DE60237818D1 (de) 2010-11-11
JP2004528372A (ja) 2004-09-16
CA2446429A1 (en) 2002-11-14
US20040192623A1 (en) 2004-09-30
WO2002090313A1 (en) 2002-11-14
US7268162B2 (en) 2007-09-11
ES2353203T3 (es) 2011-02-28
ITMI20010957A0 (it) 2001-05-10
AU2002258050B2 (en) 2007-03-22
EP1399411A1 (de) 2004-03-24
JP4467888B2 (ja) 2010-05-26
WO2002090313A8 (en) 2002-12-12

Similar Documents

Publication Publication Date Title
IL162214A (en) Pyridine derivatives and pharmaceutical compositions containing the same
PT1902037E (pt) 2,4-diamino-pirimidinas como inibidores de aurora
PL366198A1 (en) Novel compounds
HK1048990A1 (en) Novel compounds.
MY142109A (en) Pyrimidine derivatives for the treatment of abnormal cell growth
GEP20043180B (en) Polymorphous Crystal Forms of Celecoxib, Methods for Their Production and Pharmaceutical Composition Comprising the Same for Treatment or Prevention of Diseases Caused by Cyclooxygenase-2
ATE482922T1 (de) Aloe-emodinderivate und deren verwendung in der behandlung von neoplasien
DE602005008065D1 (de) Von phosphatidylinosit-(pi-)3-kinase und deren verwendung bei der behandlung von krebs
IL172773A (en) Formulations for the treatment of arthritis conditions
TW200510367A (en) Novel lapachone compounds, their preparation, and the use thereof
PT1492773E (pt) Compostos de 4-(heterociclilo)-benzenossulfoximinapara o tratamento da inflamação
HK1090354A1 (en) Novel dibenzo [b,f]oxepine-10-carboxamides and pharmaceutical uses thereof
TW200719903A (en) Compositions for the treatment of neoplasms
GB0120461D0 (en) Novel compounds
TW200637823A (en) Novel benzamide derivatives
IL163608A (en) Sulfonanilides are conserved in their amino / amino acids and derivatives, their process, their pharmaceutical preparations, and their conjugated antibodies and their use in the preparation of drugs for the treatment of culture disorders
MXPA02004441A (es) Derivados de isoxazol como inhibidores de la fosfodiesterasa.
TNSN06233A1 (en) 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, methods for production and use thereof as medicaments
AU6749401A (en) Use of aloe-emodin in the treatment of neuroectodermal tumors
AUPS234402A0 (en) Anti-tumour polycyclic carboxamides
TNSN07300A1 (en) 1,3-thiazole-5-carboxamides useful as cancer chemotherapeutic agents
WO2003103567A3 (en) NITROSODIPHENYLAMINIC DERIVATIVES, COMPOSITIONS COMPRISING SAME, AND THEIR USE AS ANTIOXIDANTS AND AS SPONTANEOUS NITROGEN MONOXIDE DONORS
GEP20064009B (en) Cetylpyridinium salt of an anti-inflammatory agent and armaceutical compositions containing it
AU2002339199A8 (en) Solvates of 3.beta., 28-diacetoxy-18-oxo-19, 20, 21, 29, 30-pentanorlupan-22-oic acid, processes for their preparation and pharmaceutical compositions thereof
MXPA04007895A (es) Compuestos n-acilo triciclicos.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1399411

Country of ref document: EP