ATE470439T1 - Verwendung von hif 1alfa modulatoren zur behandlung von krebs - Google Patents
Verwendung von hif 1alfa modulatoren zur behandlung von krebsInfo
- Publication number
- ATE470439T1 ATE470439T1 AT06784964T AT06784964T ATE470439T1 AT E470439 T1 ATE470439 T1 AT E470439T1 AT 06784964 T AT06784964 T AT 06784964T AT 06784964 T AT06784964 T AT 06784964T AT E470439 T1 ATE470439 T1 AT E470439T1
- Authority
- AT
- Austria
- Prior art keywords
- 1alfa
- hif
- modulators
- treat cancer
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69100605P | 2005-06-15 | 2005-06-15 | |
PCT/US2006/023399 WO2006138511A2 (en) | 2005-06-15 | 2006-06-15 | Use of hif 1alfa modulators for treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE470439T1 true ATE470439T1 (de) | 2010-06-15 |
Family
ID=37571192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06784964T ATE470439T1 (de) | 2005-06-15 | 2006-06-15 | Verwendung von hif 1alfa modulatoren zur behandlung von krebs |
Country Status (14)
Country | Link |
---|---|
US (1) | US8530404B2 (de) |
EP (1) | EP1919463B9 (de) |
JP (2) | JP5410751B2 (de) |
KR (1) | KR20080028918A (de) |
CN (1) | CN101242817B (de) |
AT (1) | ATE470439T1 (de) |
AU (1) | AU2006259352A1 (de) |
BR (1) | BRPI0611670A2 (de) |
CA (1) | CA2611785A1 (de) |
DE (1) | DE602006014843D1 (de) |
HK (1) | HK1117422A1 (de) |
IL (1) | IL188101A (de) |
MX (1) | MX2007016160A (de) |
WO (1) | WO2006138511A2 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1644336T3 (da) | 2003-06-06 | 2011-05-09 | Fibrogen Inc | Nitrogenholdige heteroarylforbindelser og deres anvendelse til forøgelse af endogent erythropoietin |
WO2006133391A2 (en) * | 2005-06-06 | 2006-12-14 | Fibrogen, Inc. | Improved treatment for anemia using a hif-alpha stabilising agent |
EP2476669A1 (de) | 2006-01-27 | 2012-07-18 | Fibrogen, Inc. | Cyanoisochinolinverbindungen und Verfahren zu deren Verwendung |
EP1991269A1 (de) | 2006-02-16 | 2008-11-19 | Fibrogen, Inc. | Verbindungen und verfahren zur behandlung von apoplexie |
JP5111491B2 (ja) * | 2006-04-04 | 2013-01-09 | フィブロジェン, インコーポレイテッド | ピロロ−およびピラゾロ−ピリミジン化合物、およびそれらの使用方法 |
US20070293575A1 (en) * | 2006-06-15 | 2007-12-20 | Fibrogen, Inc. | Compounds and methods for treatment of cancer-related anemia |
US7713986B2 (en) * | 2006-06-15 | 2010-05-11 | Fibrogen, Inc. | Compounds and methods for treatment of chemotherapy-induced anemia |
LT3357911T (lt) | 2006-06-26 | 2022-08-10 | Akebia Therapeutics Inc. | Prolilo hidroksilazės inhibitoriai ir naudojimo būdai |
AU2007334323B2 (en) * | 2006-12-18 | 2011-03-10 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
AU2007334321B2 (en) | 2006-12-18 | 2012-03-08 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
ES2442847T3 (es) * | 2007-04-18 | 2014-02-13 | Amgen, Inc | Quinolonas y azaquinolonas que inhiben la prolil hidroxilasa |
US7569726B2 (en) * | 2007-04-18 | 2009-08-04 | Amgen Inc. | Indanone derivatives that inhibit prolyl hydroxylase |
EP2155746A2 (de) * | 2007-05-04 | 2010-02-24 | Amgen, Inc | Diazachinolone zur hemmung der prolylhydroxylaseaktivität |
EP2150251B9 (de) * | 2007-05-04 | 2013-02-27 | Amgen, Inc | Thienopyridin- und thiazolopyridin-derivate zur hemmung der aktivität von prolylhydroxylase |
WO2008157177A1 (en) * | 2007-06-13 | 2008-12-24 | The Uab Research Foundation | Methods for modulating osteoblast cell differentiation and bone generation through inhibition of a prolyl hydroxylase |
WO2009073669A1 (en) | 2007-12-03 | 2009-06-11 | Fibrogen, Inc. | Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions |
EP2231156A1 (de) * | 2007-12-07 | 2010-09-29 | Fibrogen, Inc. | Verfahren zur vermehrung von weissen blutkörperchen |
EP2252619B1 (de) | 2008-01-11 | 2013-10-09 | Fibrogen, Inc. | Isothiazolpyridinderivate als modulatoren der hif-(hypoxia-inducible-factor-)aktivität |
WO2009100250A1 (en) | 2008-02-05 | 2009-08-13 | Fibrogen, Inc. | Chromene derivatives and use thereof as hif hydroxylase activity inhibitors |
CN102264740B (zh) | 2008-08-20 | 2014-10-15 | 菲布罗根有限公司 | 一种吡咯[1,2-b]哒嗪衍生物及其作为hif调节剂的用途 |
WO2010056767A1 (en) | 2008-11-14 | 2010-05-20 | Fibrogen, Inc. | Thiochromene derivatives as hip hydroxylase inhibitors |
GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
AU2012268400C1 (en) * | 2011-06-06 | 2016-12-22 | Akebia Therapeutics Inc. | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
NO2686520T3 (de) | 2011-06-06 | 2018-03-17 | ||
GB201113101D0 (en) | 2011-07-28 | 2011-09-14 | Isis Innovation | Assay |
EP2785872A4 (de) * | 2011-12-01 | 2015-12-09 | Univ Ohio State | Materialien und verfahren im zusammenhang mit nsaid-chemoprävention bei kolorektalkrebs |
WO2013134660A1 (en) | 2012-03-09 | 2013-09-12 | Fibrogen, Inc. | 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors |
WO2014014834A1 (en) | 2012-07-16 | 2014-01-23 | Fibrogen, Inc. | Process for making isoquinoline compounds |
US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
EP3470397B1 (de) | 2012-07-16 | 2021-12-29 | Fibrogen, Inc. | Kristalline formen eines prolylhydroxylaseinhibitors |
DK2951159T3 (en) | 2013-01-24 | 2018-11-19 | Fibrogen Inc | CRYSTALLIC FORMS OF {[1-CYANO-5- (4-CHLORPHENOXY) -4-HYDROXY-ISOQUINOLIN-3-CARBONYL] -AMINO} ACETIC ACID |
ES2786924T3 (es) | 2013-06-06 | 2020-10-14 | Fibrogen Inc | Formulaciones farmacéuticas que comprenden un inhibidor de hidroxilasa del HIF |
CA3151685A1 (en) | 2013-06-13 | 2014-12-18 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
KR102495018B1 (ko) | 2013-11-15 | 2023-02-06 | 아케비아 테라퓨틱스 인코포레이티드 | {[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노}아세트산의 고체형, 이의 조성물 및 용도 |
WO2016118858A1 (en) | 2015-01-23 | 2016-07-28 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
SI3277270T1 (sl) | 2015-04-01 | 2022-04-29 | Akebia Therapeutics, Inc. | Sestavki in postopki za zdravljenje anemije |
US11124483B2 (en) | 2015-09-02 | 2021-09-21 | The Regents Of The University Of California | HER3 ligands and uses thereof |
WO2017110791A1 (ja) | 2015-12-21 | 2017-06-29 | 株式会社東京精密 | 切断用ブレードの製造方法、及び切断用ブレード |
CN107115355B (zh) * | 2017-05-26 | 2020-01-17 | 昆明医科大学 | 一种含有无机砷化合物的药物组合物及其应用 |
WO2019138084A1 (en) * | 2018-01-11 | 2019-07-18 | Institut Pasteur | Phenanthrolinone derivatives for use in the treatment of bacterial infections |
CA3097219A1 (en) | 2018-05-09 | 2019-11-14 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
WO2021216530A1 (en) | 2020-04-20 | 2021-10-28 | Akebia Therapeutics, Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
TW202313072A (zh) | 2021-05-27 | 2023-04-01 | 美商凱立克斯生物製藥股份有限公司 | 檸檬酸鐵之兒科調配物 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW352384B (en) | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
DE59401923D1 (de) | 1993-11-02 | 1997-04-10 | Hoechst Ag | Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
EP0650961B1 (de) | 1993-11-02 | 1997-03-05 | Hoechst Aktiengesellschaft | Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
TW406076B (en) | 1993-12-30 | 2000-09-21 | Hoechst Ag | Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals |
GB9402857D0 (en) | 1994-02-15 | 1994-04-06 | Isis Innovation | Targeting gene therapy |
DE4410423A1 (de) | 1994-03-25 | 1995-09-28 | Hoechst Ag | Sulfonamidocarbonylpyridin-2-carbonsäureamide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE4410480A1 (de) | 1994-03-25 | 1995-09-28 | Hoechst Ag | Sulfonamidocarbonylpyridin-2-carbonsäureesteramide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
IL135495A (en) | 1995-09-28 | 2002-12-01 | Hoechst Ag | Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid |
DE19650215A1 (de) | 1996-12-04 | 1998-06-10 | Hoechst Ag | 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE19746287A1 (de) | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
US5916898A (en) | 1997-10-24 | 1999-06-29 | Zeneca Limited | Phenanthroline derivatives |
US6200974B1 (en) | 1997-10-24 | 2001-03-13 | Zeneca Limited | Phenanthroline derivatives |
EP1027351B1 (de) | 1997-10-24 | 2003-12-03 | Fibrogen, Inc. | Phenanthrolin-derivate |
EP1034267A1 (de) * | 1997-12-04 | 2000-09-13 | Genzyme Corporation | Verbindungen und methoden zur induktion der genexpression |
US6124131A (en) * | 1998-08-25 | 2000-09-26 | The Johns Hopkins University School Of Medicine | Mutant hypoxia inducible factor-1 HIF-1 |
US6506936B1 (en) | 1999-02-25 | 2003-01-14 | Fibrogen, Inc. | N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production |
GB9911047D0 (en) | 1999-05-12 | 1999-07-14 | Isis Innovation | Assay method and means |
US6855510B2 (en) * | 2001-03-20 | 2005-02-15 | Dana Farber Cancer Institute, Inc. | Pharmaceuticals and methods for treating hypoxia and screening methods therefor |
US20040146964A1 (en) | 2001-03-21 | 2004-07-29 | Maxwell Patrick Henry | Assays, methods and means |
US7396922B2 (en) | 2001-11-28 | 2008-07-08 | Angiogenetics Sweden Ab | Regulation of hypoxia-inducible gene expression with antisense Inhibitory PAS domain protein |
EP2324834B1 (de) * | 2001-12-06 | 2019-05-08 | Fibrogen, Inc. | Verfahren zur Steigerung des endogenen Erythropoietins |
HUP0500103A3 (en) | 2001-12-19 | 2009-01-28 | Ortho Mcneil Pharm Inc | Tetracyclic compounds containing oxygen and/or sulfur atom, process for the preparation of some of them, their use and pharmaceutical compositions containing them |
GB0211920D0 (en) * | 2002-05-23 | 2002-07-03 | Isis Innovations Ltd | Assay |
KR20050083855A (ko) * | 2002-11-01 | 2005-08-26 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | HIF-1 알파의 siRNA 억제를 위한 조성물 및 방법 |
JP2006515885A (ja) * | 2003-01-17 | 2006-06-08 | スレッシュオールド ファーマシューティカルズ, インコーポレイテッド | 癌の処置のための併用療法 |
US20060251638A1 (en) * | 2003-06-06 | 2006-11-09 | Volkmar Guenzler-Pukall | Cytoprotection through the use of hif hydroxylase inhibitors |
US8614204B2 (en) * | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
DK1644336T3 (da) | 2003-06-06 | 2011-05-09 | Fibrogen Inc | Nitrogenholdige heteroarylforbindelser og deres anvendelse til forøgelse af endogent erythropoietin |
WO2006010920A1 (en) | 2004-07-30 | 2006-02-02 | Isis Innovation Limited | Soluble polypeptide |
-
2006
- 2006-06-15 US US11/455,199 patent/US8530404B2/en active Active
- 2006-06-15 KR KR1020087000680A patent/KR20080028918A/ko not_active Application Discontinuation
- 2006-06-15 JP JP2008517119A patent/JP5410751B2/ja active Active
- 2006-06-15 BR BRPI0611670A patent/BRPI0611670A2/pt not_active IP Right Cessation
- 2006-06-15 CN CN200680029935.6A patent/CN101242817B/zh active Active
- 2006-06-15 AU AU2006259352A patent/AU2006259352A1/en not_active Abandoned
- 2006-06-15 AT AT06784964T patent/ATE470439T1/de not_active IP Right Cessation
- 2006-06-15 MX MX2007016160A patent/MX2007016160A/es not_active Application Discontinuation
- 2006-06-15 DE DE602006014843T patent/DE602006014843D1/de active Active
- 2006-06-15 EP EP06784964A patent/EP1919463B9/de active Active
- 2006-06-15 WO PCT/US2006/023399 patent/WO2006138511A2/en active Application Filing
- 2006-06-15 CA CA002611785A patent/CA2611785A1/en not_active Abandoned
-
2007
- 2007-12-13 IL IL188101A patent/IL188101A/en active IP Right Grant
-
2008
- 2008-11-07 HK HK08112223.6A patent/HK1117422A1/xx unknown
-
2013
- 2013-08-15 JP JP2013168758A patent/JP2014012690A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2611785A1 (en) | 2006-12-28 |
MX2007016160A (es) | 2008-03-07 |
CN101242817A (zh) | 2008-08-13 |
US8530404B2 (en) | 2013-09-10 |
JP2008543864A (ja) | 2008-12-04 |
DE602006014843D1 (de) | 2010-07-22 |
JP2014012690A (ja) | 2014-01-23 |
EP1919463A2 (de) | 2008-05-14 |
AU2006259352A1 (en) | 2006-12-28 |
HK1117422A1 (en) | 2009-02-13 |
WO2006138511A3 (en) | 2007-03-29 |
US20070004627A1 (en) | 2007-01-04 |
EP1919463B9 (de) | 2011-02-02 |
IL188101A (en) | 2012-10-31 |
WO2006138511A2 (en) | 2006-12-28 |
EP1919463B1 (de) | 2010-06-09 |
IL188101A0 (en) | 2008-04-13 |
JP5410751B2 (ja) | 2014-02-05 |
KR20080028918A (ko) | 2008-04-02 |
BRPI0611670A2 (pt) | 2016-11-16 |
CN101242817B (zh) | 2016-08-31 |
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