ATE469969T1 - Menschlicher anti-mensch-mcp-1-antikorper sowie antikorperfragment davon - Google Patents
Menschlicher anti-mensch-mcp-1-antikorper sowie antikorperfragment davonInfo
- Publication number
- ATE469969T1 ATE469969T1 AT03795363T AT03795363T ATE469969T1 AT E469969 T1 ATE469969 T1 AT E469969T1 AT 03795363 T AT03795363 T AT 03795363T AT 03795363 T AT03795363 T AT 03795363T AT E469969 T1 ATE469969 T1 AT E469969T1
- Authority
- AT
- Austria
- Prior art keywords
- human
- mcp
- antibodies
- fragment
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002267184 | 2002-09-12 | ||
PCT/JP2003/011560 WO2004024921A1 (ja) | 2002-09-12 | 2003-09-10 | ヒト抗ヒトmcp−1抗体及び該抗体フラグメント |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE469969T1 true ATE469969T1 (de) | 2010-06-15 |
Family
ID=31986692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03795363T ATE469969T1 (de) | 2002-09-12 | 2003-09-10 | Menschlicher anti-mensch-mcp-1-antikorper sowie antikorperfragment davon |
Country Status (11)
Country | Link |
---|---|
US (1) | US7342106B2 (de) |
EP (1) | EP1538207B1 (de) |
JP (1) | JP4426449B2 (de) |
KR (1) | KR20050042801A (de) |
CN (1) | CN1681926A (de) |
AT (1) | ATE469969T1 (de) |
AU (1) | AU2003262051B2 (de) |
CA (1) | CA2497804A1 (de) |
DE (1) | DE60332847D1 (de) |
DK (1) | DK1538207T3 (de) |
WO (1) | WO2004024921A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
EP1708684A2 (de) | 2003-09-26 | 2006-10-11 | Alza Corporation | Arzneimittelbeschichtung mit hoher arzneimittelbeladung und verfahren dafür |
US8114964B2 (en) * | 2005-05-19 | 2012-02-14 | Centocor, Inc. | Anti-MCP-1 antibodies, compositions, methods and uses |
PE20110071A1 (es) * | 2005-05-19 | 2011-01-31 | Centocor Inc | Anticuerpos anti-mcp-1, composiciones y metodos |
US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
US8906680B2 (en) | 2006-12-22 | 2014-12-09 | Ablynx N.V. | Amino acid sequences directed against chemokines and polypeptides comprising the same for the treatment of chemokine-related diseases and disorders |
EP2481408A3 (de) | 2007-03-01 | 2013-01-09 | Probiodrug AG | Neue Verwendung von Inhibitoren der Glutaminyl Cyclase |
JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
CA2695237A1 (en) | 2007-08-02 | 2009-04-30 | Novimmune S.A. | Anti-rantes antibodies and methods of use thereof |
SG10201701323TA (en) | 2008-08-18 | 2017-04-27 | Amgen Fremont Inc | Antibodies to ccr2 |
AU2009284092B2 (en) | 2008-08-20 | 2016-05-19 | Vivoryon Therapeutics N.V. | Antibodies directed against pyroglutamate monocyte chemoattractant protein-1 (MCP-1 N1pE) |
SG178953A1 (en) | 2009-09-11 | 2012-04-27 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
ES2481823T3 (es) | 2010-03-10 | 2014-07-31 | Probiodrug Ag | Inhibidores heterocíclicos de glutaminil ciclasa (QC, EC 2.3.2.5) |
JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
EP2686313B1 (de) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazolderivate als glutaminylcyclase-hemmer |
BR112017002980A2 (pt) * | 2014-08-15 | 2017-12-12 | Pixarbio Corp | composição para inibir a inflamação em um indivíduo com um dano na coluna vertebral, método para tratar inflamação em um indivíduo tendo um dano na coluna vertebral e kit para produzir a composição |
JP2020508436A (ja) | 2016-12-07 | 2020-03-19 | プロジェニティ, インコーポレイテッド | 胃腸管の検出方法、装置およびシステム |
US10980739B2 (en) | 2016-12-14 | 2021-04-20 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
CN116726362A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
EP4309722A2 (de) | 2019-12-13 | 2024-01-24 | Biora Therapeutics, Inc. | Einnehmbare vorrichtung zur abgabe eines therapeutischen mittels an den magen-darm-trakt |
CN112358547A (zh) * | 2020-09-30 | 2021-02-12 | 浙江大学 | 抗人cxcl-2单克隆抗体3-d3及其编码基因和应用 |
CN112778414B (zh) * | 2020-12-31 | 2022-04-15 | 中南大学湘雅二医院 | cBIN1抗体及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0967399A (ja) | 1995-08-30 | 1997-03-11 | Mitsui Toatsu Chem Inc | 抗mcp−1ヒトモノクローナル抗体 |
JP4298051B2 (ja) * | 1999-04-13 | 2009-07-15 | 和久 杉村 | 抗mcp−1抗体認識ペプチドミミックス、その製造方法およびその用途 |
AU2001258836A1 (en) | 2000-05-26 | 2001-12-03 | Kensuke Egashira | Preventives and remedies for pulmonary hypertension |
GB0016138D0 (en) * | 2000-06-30 | 2000-08-23 | Novartis Ag | Organic compounds |
-
2003
- 2003-09-10 JP JP2004535928A patent/JP4426449B2/ja not_active Expired - Fee Related
- 2003-09-10 DE DE60332847T patent/DE60332847D1/de not_active Expired - Lifetime
- 2003-09-10 CN CNA038215527A patent/CN1681926A/zh active Pending
- 2003-09-10 AT AT03795363T patent/ATE469969T1/de active
- 2003-09-10 DK DK03795363.5T patent/DK1538207T3/da active
- 2003-09-10 AU AU2003262051A patent/AU2003262051B2/en not_active Ceased
- 2003-09-10 EP EP03795363A patent/EP1538207B1/de not_active Expired - Lifetime
- 2003-09-10 US US10/527,823 patent/US7342106B2/en not_active Expired - Fee Related
- 2003-09-10 WO PCT/JP2003/011560 patent/WO2004024921A1/ja active Application Filing
- 2003-09-10 CA CA002497804A patent/CA2497804A1/en not_active Abandoned
- 2003-09-10 KR KR1020057004050A patent/KR20050042801A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US7342106B2 (en) | 2008-03-11 |
DK1538207T3 (da) | 2010-07-05 |
AU2003262051B2 (en) | 2008-09-25 |
KR20050042801A (ko) | 2005-05-10 |
AU2003262051A1 (en) | 2004-04-30 |
DE60332847D1 (de) | 2010-07-15 |
JPWO2004024921A1 (ja) | 2006-01-12 |
EP1538207A1 (de) | 2005-06-08 |
US20060246069A1 (en) | 2006-11-02 |
CA2497804A1 (en) | 2004-03-25 |
CN1681926A (zh) | 2005-10-12 |
WO2004024921A1 (ja) | 2004-03-25 |
EP1538207A4 (de) | 2006-05-24 |
JP4426449B2 (ja) | 2010-03-03 |
EP1538207B1 (de) | 2010-06-02 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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