ATE469912T1 - Gegenionenaustauschverfahren für peptide - Google Patents
Gegenionenaustauschverfahren für peptideInfo
- Publication number
- ATE469912T1 ATE469912T1 AT05811089T AT05811089T ATE469912T1 AT E469912 T1 ATE469912 T1 AT E469912T1 AT 05811089 T AT05811089 T AT 05811089T AT 05811089 T AT05811089 T AT 05811089T AT E469912 T1 ATE469912 T1 AT E469912T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- exchange process
- peptide
- column
- counterion exchange
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61601004P | 2004-10-04 | 2004-10-04 | |
US63052804P | 2004-11-22 | 2004-11-22 | |
PCT/US2005/035868 WO2006041945A2 (en) | 2004-10-04 | 2005-10-04 | A counterion exchange process for peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE469912T1 true ATE469912T1 (de) | 2010-06-15 |
Family
ID=36096369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05811089T ATE469912T1 (de) | 2004-10-04 | 2005-10-04 | Gegenionenaustauschverfahren für peptide |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060148699A1 (de) |
EP (2) | EP1709065B1 (de) |
JP (1) | JP2007513192A (de) |
AT (1) | ATE469912T1 (de) |
CA (1) | CA2582083A1 (de) |
DE (1) | DE602005021614D1 (de) |
DK (1) | DK1709065T3 (de) |
ES (1) | ES2344657T3 (de) |
IL (1) | IL182157A0 (de) |
WO (1) | WO2006041945A2 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2000126C2 (nl) * | 2005-07-15 | 2008-01-29 | Solvay | Werkwijze voor de vervaardiging van eptifibatide. |
US20080287650A1 (en) * | 2007-03-01 | 2008-11-20 | Avi Tovi | High purity peptides |
EP2181118A1 (de) * | 2007-06-29 | 2010-05-05 | Lonza Ag | Verfahren zur herstellung von pramlintid |
EP2062909A1 (de) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Herstellung von Peptiden und Reinigungsverfahren |
US9051349B2 (en) | 2007-11-21 | 2015-06-09 | Alba Therapeutics Corporation | Larazotide acetate compositions |
US20100317827A1 (en) * | 2008-02-06 | 2010-12-16 | Biocon Limited | Method of Purifying a Peptide |
CN101314613B (zh) * | 2008-05-08 | 2012-04-25 | 吉尔生化(上海)有限公司 | 一种阿托西班的固相合成方法 |
WO2009150657A1 (en) * | 2008-06-09 | 2009-12-17 | Natco Pharma Limited | Improved process for preparation of eptifibatide by fmoc solid phase synthesis |
CN101463080B (zh) * | 2009-01-09 | 2011-09-14 | 深圳翰宇药业股份有限公司 | 一种纯化奈西利肽的方法 |
CN101696236B (zh) * | 2009-02-11 | 2012-02-15 | 海南中和药业有限公司 | 一种固相合成阿托西班方法 |
US20120094910A1 (en) | 2009-04-06 | 2012-04-19 | Ananda Kuppanna | Improved process for the preparation of desmopressin or its pharmaceutically acceptable salts |
WO2011011342A1 (en) * | 2009-07-20 | 2011-01-27 | Mallinckrodt Inc. | Synthesis of desmopressin |
MX346473B (es) * | 2009-08-11 | 2017-03-22 | Biocon Ltd | Procesos cromatograficos y compuestos purificados de los mismos. |
CN101787071B (zh) * | 2010-02-26 | 2012-11-07 | 深圳翰宇药业股份有限公司 | 一种伐普肽的纯化方法 |
CN101780267A (zh) * | 2010-03-12 | 2010-07-21 | 深圳翰宇药业股份有限公司 | 一种抗血小板凝集的制剂及其制备方法 |
CN102146121A (zh) * | 2010-11-19 | 2011-08-10 | 深圳市健元医药科技有限公司 | 一种含有oxt拮抗剂药物的生产工艺 |
RU2494105C2 (ru) * | 2010-12-29 | 2013-09-27 | Общество с ограниченной ответственностью "Химфармресурс" | Способ получения циклического пептида |
US9388212B2 (en) | 2013-02-21 | 2016-07-12 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | Solid phase peptide synthesis via side chain attachment |
CN102875663B (zh) * | 2012-09-26 | 2014-06-11 | 深圳翰宇药业股份有限公司 | 利西拉来的纯化方法 |
JP6382488B2 (ja) * | 2013-02-21 | 2018-08-29 | ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス.エー. | 側鎖結合を介する固相ペプチド合成 |
CN103965291B (zh) * | 2014-05-27 | 2016-09-21 | 上海第一生化药业有限公司 | 奥曲肽、奥曲肽醋酸盐的制备方法 |
CN106699847B (zh) * | 2017-01-04 | 2020-08-14 | 陕西慧康生物科技有限责任公司 | 一种低成本纯化六胜肽的方法 |
JP6707576B2 (ja) * | 2018-04-03 | 2020-06-10 | ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス.エー. | 側鎖結合を介する固相ペプチド合成 |
JP7423070B2 (ja) | 2018-04-06 | 2024-01-29 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 増加した溶解度および改善された薬物動態特性を有するコンプスタチンアナログ |
WO2020170185A1 (en) * | 2019-02-21 | 2020-08-27 | Dr. Reddy’S Laboratories Limited | Substantially pure lanreotide or its salt & process thereof |
CN109942686B (zh) * | 2019-05-06 | 2021-06-25 | 上海上药第一生化药业有限公司 | 一种加压素乙酰化杂质的精制方法 |
CN109929011B (zh) * | 2019-05-06 | 2021-04-06 | 上海上药第一生化药业有限公司 | 一种加压素[5-Asp]杂质的精制方法 |
US20220031800A1 (en) * | 2019-07-26 | 2022-02-03 | Allegro Pharmaceuticals, LLC | Peptides for treating non-exudative macular degeneration and other disorders of the eye |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4310518A (en) * | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4235886A (en) * | 1979-10-31 | 1980-11-25 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
DE19375086I2 (de) * | 1979-11-27 | 2003-01-09 | Novartis Ag | Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung |
GB8813160D0 (en) * | 1988-06-03 | 1988-07-06 | Soc D Etudes Prod Chimique | Therapeutic methods |
WO1995001368A1 (en) * | 1993-06-29 | 1995-01-12 | Ferring B.V. | Improved synthesis of cyclic peptides |
EP0763061B1 (de) * | 1994-06-02 | 2002-10-30 | Forssmann, Wolf-Georg, Prof. Dr. med. | Verfahren zur herstellung von cardiodilatin-fragmenten, hochgereinigte cardiodilatin-fragmente und zwischenprodukte zu deren herstellung |
US5889146A (en) * | 1997-11-26 | 1999-03-30 | Institute Of Nuclear Energy Research | Method for synthesis of bifunctional chelating agents-peptides |
EP2305815B1 (de) * | 1998-07-10 | 2014-11-05 | Scios, Inc. | Verfahren zur Herstellung eines natriuretischen Peptids mit einem pI grösser als 8 oder kleiner als 5 |
KR100808149B1 (ko) * | 2000-02-22 | 2008-02-29 | 라보라토리스 세로노 에스.에이. | 정제된 lh |
ME00296B (me) * | 2000-02-22 | 2011-05-10 | Applied Res Systems Ars Holding N V | PROCES PREČIŠĆAVANJA hCG I REKOMBINANTNOG hCG PREČIŠĆENOG TOM METODOM |
ATE334998T1 (de) * | 2003-04-07 | 2006-08-15 | Novetide Ltd | Verfahren zur herstellung cyclischer peptide |
SI2204383T1 (sl) * | 2004-04-08 | 2011-11-30 | Millennium Pharm Inc | Postopek za pripravo eptifibatida in dotičnih vmesnih spojin |
-
2005
- 2005-10-04 EP EP05811089A patent/EP1709065B1/de not_active Not-in-force
- 2005-10-04 ES ES05811089T patent/ES2344657T3/es active Active
- 2005-10-04 CA CA002582083A patent/CA2582083A1/en not_active Abandoned
- 2005-10-04 DE DE602005021614T patent/DE602005021614D1/de active Active
- 2005-10-04 EP EP09178401A patent/EP2163558A3/de not_active Withdrawn
- 2005-10-04 US US11/244,135 patent/US20060148699A1/en not_active Abandoned
- 2005-10-04 AT AT05811089T patent/ATE469912T1/de active
- 2005-10-04 WO PCT/US2005/035868 patent/WO2006041945A2/en active Application Filing
- 2005-10-04 DK DK05811089.1T patent/DK1709065T3/da active
- 2005-10-04 JP JP2006542906A patent/JP2007513192A/ja active Pending
-
2007
- 2007-03-25 IL IL182157A patent/IL182157A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2163558A2 (de) | 2010-03-17 |
DE602005021614D1 (de) | 2010-07-15 |
ES2344657T3 (es) | 2010-09-02 |
EP1709065A2 (de) | 2006-10-11 |
IL182157A0 (en) | 2007-07-24 |
JP2007513192A (ja) | 2007-05-24 |
CA2582083A1 (en) | 2006-04-20 |
EP1709065B1 (de) | 2010-06-02 |
EP2163558A3 (de) | 2010-10-27 |
WO2006041945A3 (en) | 2006-08-24 |
US20060148699A1 (en) | 2006-07-06 |
DK1709065T3 (da) | 2010-08-23 |
WO2006041945A2 (en) | 2006-04-20 |
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