ATE464913T1 - Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden - Google Patents
Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotidenInfo
- Publication number
- ATE464913T1 ATE464913T1 AT04788783T AT04788783T ATE464913T1 AT E464913 T1 ATE464913 T1 AT E464913T1 AT 04788783 T AT04788783 T AT 04788783T AT 04788783 T AT04788783 T AT 04788783T AT E464913 T1 ATE464913 T1 AT E464913T1
- Authority
- AT
- Austria
- Prior art keywords
- polynucleotids
- vivo delivery
- polyacetals
- biodegradable
- biodegradable polyacetals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50716103P | 2003-09-29 | 2003-09-29 | |
PCT/US2004/030323 WO2005032597A1 (en) | 2003-09-29 | 2004-09-16 | Biodegradable polyacetals for in vivo polynucleotide delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE464913T1 true ATE464913T1 (de) | 2010-05-15 |
Family
ID=34421587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04788783T ATE464913T1 (de) | 2003-09-29 | 2004-09-16 | Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden |
Country Status (7)
Country | Link |
---|---|
US (2) | US7794696B2 (de) |
EP (1) | EP1667732B1 (de) |
JP (1) | JP4586022B2 (de) |
AT (1) | ATE464913T1 (de) |
DE (1) | DE602004026747D1 (de) |
HK (1) | HK1092727A1 (de) |
WO (1) | WO2005032597A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7332477B2 (en) * | 2003-07-10 | 2008-02-19 | Nitto Denko Corporation | Photocleavable DNA transfer agent |
ATE464913T1 (de) | 2003-09-29 | 2010-05-15 | Nitto Denko Corp | Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden |
US7446099B2 (en) * | 2004-02-27 | 2008-11-04 | Nitto Denko Corporation | Compositions and methods for biodegradable polymer-peptide mediated transfection |
DE102004023117A1 (de) * | 2004-05-11 | 2005-12-08 | A. u. K. Müller GmbH & Co KG | Elektromagnetventil für flüssige Medien, insbesondere Heißwasser |
US7358223B2 (en) * | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
US7674452B2 (en) | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
US7588754B2 (en) * | 2005-05-10 | 2009-09-15 | Nitto Denko Corporation | Biodegradable polyacetals and methods |
US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
US7700541B2 (en) | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
WO2008127532A1 (en) * | 2007-04-12 | 2008-10-23 | Emory University | Novel strategies for delivery of active agents using micelles and particles |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS254355B1 (en) * | 1985-04-10 | 1988-01-15 | Vladimir Saudek | Soluble and biodegradatable copolymeres activated for bond of biologicaly active substances |
US4713441A (en) * | 1986-08-01 | 1987-12-15 | Sandoz Pharmaceuticals Corp. | Polyacetal hydrogels formed from divinyl ethers and polyols |
US6258354B1 (en) * | 1989-09-29 | 2001-07-10 | Joel S. Greenberger | Method for homing hematopoietic stem cells to bone marrow stromal cells |
US5206325A (en) * | 1990-02-27 | 1993-04-27 | Asahi Kasei Kogyo Kabushiki Kaisha | Thermoplastic graft copolymer and process for producing the same |
US20030087985A1 (en) * | 1990-10-15 | 2003-05-08 | Hubbell Jeffrey A. | Gels for encapsulation of biological materials |
CA2099376A1 (en) | 1991-01-03 | 1992-07-04 | Henry E. Auer | Stabilization of proteins by cationic biopolymers |
DE4142130A1 (de) * | 1991-12-20 | 1993-06-24 | Basf Ag | Verwendung von polyacetalen auf basis von vinylethern und dihydroxyverbindungen in wasch- und reinigungsmitteln und polyacetale |
JPH07309943A (ja) | 1994-05-16 | 1995-11-28 | Mitsubishi Chem Corp | 酸性アミノ酸系樹脂 |
NO180167C (no) * | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
US5811510A (en) * | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
US5902246A (en) * | 1996-03-26 | 1999-05-11 | Lifespex, Incorporated | Method and apparatus for calibrating an optical probe |
TW371617B (en) * | 1996-10-09 | 1999-10-11 | Of Animal And Plant Health Inspection And Quarantine Council Of Agriculture Executive Yuan Bureau | Method to transplant GFP into autographa californica multiple nuclear polyhedrosis virus for inflicting pest in an attempt to detect and flow up it existence and to improve life span against UV |
US6258351B1 (en) | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
CA2591581C (en) * | 1996-12-20 | 2013-01-29 | Alza Corporation | Gel composition and methods |
ES2213899T3 (es) * | 1997-04-29 | 2004-09-01 | Amersham Health As | Agentes de contraste utilizados en tecnicas de formacion de imagen en base a la luz. |
EP0999855A1 (de) | 1997-07-25 | 2000-05-17 | SDG, Inc. | Arzneizubereitungen auf polymerbasis zur gezielten abgabe biologisch aktiver wirkstoffe |
US6383811B2 (en) * | 1997-12-30 | 2002-05-07 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
US20030113303A1 (en) * | 1998-02-05 | 2003-06-19 | Yitzhack Schwartz | Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances |
US6866842B1 (en) * | 1998-05-01 | 2005-03-15 | University Of Pittsburgh | Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction |
JPH11335269A (ja) * | 1998-05-19 | 1999-12-07 | Hisamitsu Pharmaceut Co Inc | 遺伝子関連医薬の経口投与固形製剤 |
US7396919B1 (en) | 1998-07-17 | 2008-07-08 | Mirus Bio Corporation | Charge reversal of polyion complexes |
US7018654B2 (en) * | 1999-03-05 | 2006-03-28 | New River Pharmaceuticals Inc. | Pharmaceutical composition containing an active agent in an amino acid copolymer structure |
EP1209971A4 (de) | 1999-08-20 | 2004-04-14 | Mirus Corp | Ladungswechsel von polyion-komplexen |
WO2001032720A1 (en) | 1999-11-02 | 2001-05-10 | Canadian Space Agency | Photosolubilizable layers |
US20020052335A1 (en) * | 1999-11-29 | 2002-05-02 | Rozema David B. | Charge reversal of polyion complexes |
US7033607B2 (en) * | 1999-12-31 | 2006-04-25 | Mirus Bio Corporation | pH-titratable polyampholytes for delivering polyions to a cell |
WO2001049841A1 (en) | 1999-12-31 | 2001-07-12 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
US6881576B2 (en) * | 1999-12-31 | 2005-04-19 | Mirus Bio Corporation | Formation of polyampholytes in the presence of a polyion |
AU2001281758A1 (en) | 2000-08-23 | 2002-03-04 | Surfarc Aps | Biocompatible materials |
WO2002020663A2 (en) | 2000-09-06 | 2002-03-14 | Ap Pharma, Inc. | Degradable polyacetal polymers |
US6534243B1 (en) * | 2000-10-23 | 2003-03-18 | Advanced Micro Devices, Inc. | Chemical feature doubling process |
US20030049320A1 (en) | 2000-12-18 | 2003-03-13 | Wockhardt Limited | Novel in-situ forming controlled release microcarrier delivery system |
US20030120355A1 (en) * | 2001-06-08 | 2003-06-26 | Urs Hafeli | Biocompatible and biodegradable polymers for diagnostic and therapeutic radioisotope delivery |
WO2003016091A1 (en) * | 2001-08-15 | 2003-02-27 | Dow Global Technologies Inc. | Improved seating system |
JP3493608B2 (ja) * | 2001-11-28 | 2004-02-03 | 学校法人慶應義塾 | 医用高分子及びその用途 |
JP3969109B2 (ja) * | 2002-02-08 | 2007-09-05 | コニカミノルタホールディングス株式会社 | 感光性平版印刷版及びその記録方法 |
AU2003220161A1 (en) * | 2002-03-12 | 2003-09-29 | Nitto Denko Corporation | Vector for transfection of eukaryotic cells |
US20030191458A1 (en) * | 2002-04-03 | 2003-10-09 | Cornelius Diamond | Light-activated drug delivery method and device |
US20030215395A1 (en) * | 2002-05-14 | 2003-11-20 | Lei Yu | Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier |
JP4800614B2 (ja) | 2002-07-19 | 2011-10-26 | ザ ジェネラル ホスピタル コーポレイション | オキシム結合体、およびそれらの形成および使用のための方法 |
WO2004009774A2 (en) | 2002-07-19 | 2004-01-29 | Amgen Inc. | Protein conjugates with a water-soluble biocompatible, biogradable polymer |
CA2505251A1 (en) * | 2002-11-05 | 2004-05-27 | Brigham And Women's Hospital, Inc. | Mesenchymal stem cells and methods of use thereof |
US6878374B2 (en) * | 2003-02-25 | 2005-04-12 | Nitto Denko Corporation | Biodegradable polyacetals |
US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
US7332477B2 (en) * | 2003-07-10 | 2008-02-19 | Nitto Denko Corporation | Photocleavable DNA transfer agent |
US7048925B2 (en) * | 2003-08-28 | 2006-05-23 | Nitto Denko Corporation | Acid-sensitive polyacetals and methods |
ATE464913T1 (de) | 2003-09-29 | 2010-05-15 | Nitto Denko Corp | Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden |
US7163677B2 (en) * | 2003-10-24 | 2007-01-16 | Nitto Denko Corporation | Cationic polymers having degradable crosslinks |
US7368240B2 (en) * | 2003-11-11 | 2008-05-06 | Nitto Denko Corporation | Microscope system and methods for intracellular studies |
US7446099B2 (en) * | 2004-02-27 | 2008-11-04 | Nitto Denko Corporation | Compositions and methods for biodegradable polymer-peptide mediated transfection |
US7358223B2 (en) * | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
US7674452B2 (en) * | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
US7588754B2 (en) * | 2005-05-10 | 2009-09-15 | Nitto Denko Corporation | Biodegradable polyacetals and methods |
US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
-
2004
- 2004-09-16 AT AT04788783T patent/ATE464913T1/de not_active IP Right Cessation
- 2004-09-16 WO PCT/US2004/030323 patent/WO2005032597A1/en active Application Filing
- 2004-09-16 JP JP2006528062A patent/JP4586022B2/ja not_active Expired - Fee Related
- 2004-09-16 DE DE602004026747T patent/DE602004026747D1/de active Active
- 2004-09-16 EP EP04788783A patent/EP1667732B1/de not_active Not-in-force
- 2004-09-21 US US10/946,383 patent/US7794696B2/en not_active Expired - Fee Related
-
2006
- 2006-12-13 HK HK06113696.4A patent/HK1092727A1/xx not_active IP Right Cessation
-
2010
- 2010-09-10 US US12/879,948 patent/US8383091B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7794696B2 (en) | 2010-09-14 |
WO2005032597A1 (en) | 2005-04-14 |
US20050080033A1 (en) | 2005-04-14 |
JP2007511465A (ja) | 2007-05-10 |
HK1092727A1 (en) | 2007-02-16 |
DE602004026747D1 (de) | 2010-06-02 |
JP4586022B2 (ja) | 2010-11-24 |
US8383091B2 (en) | 2013-02-26 |
EP1667732B1 (de) | 2010-04-21 |
EP1667732A1 (de) | 2006-06-14 |
US20110015344A1 (en) | 2011-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |