ATE453119T1 - Verfahren und vorrichtung zur messung der membranpermeabilität - Google Patents
Verfahren und vorrichtung zur messung der membranpermeabilitätInfo
- Publication number
- ATE453119T1 ATE453119T1 AT03713278T AT03713278T ATE453119T1 AT E453119 T1 ATE453119 T1 AT E453119T1 AT 03713278 T AT03713278 T AT 03713278T AT 03713278 T AT03713278 T AT 03713278T AT E453119 T1 ATE453119 T1 AT E453119T1
- Authority
- AT
- Austria
- Prior art keywords
- sink
- permeability
- membrane retention
- double
- membrane
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 230000035699 permeability Effects 0.000 title abstract 3
- 230000014759 maintenance of location Effects 0.000 abstract 3
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 abstract 2
- 238000005259 measurement Methods 0.000 abstract 2
- 238000013149 parallel artificial membrane permeability assay Methods 0.000 abstract 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000003905 agrochemical Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 229940083466 soybean lecithin Drugs 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N13/04—Investigating osmotic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N15/082—Investigating permeability by forcing a fluid through a sample
- G01N15/0826—Investigating permeability by forcing a fluid through a sample and measuring fluid flow rate, i.e. permeation rate or pressure change
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
- G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/003—Diffusion; diffusivity between liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/115831—Condition or time responsive
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Fluid Mechanics (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35391402P | 2002-01-31 | 2002-01-31 | |
| PCT/US2003/002095 WO2003065037A2 (en) | 2002-01-31 | 2003-01-23 | Method and apparatus for measuring membrane permeability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453119T1 true ATE453119T1 (de) | 2010-01-15 |
Family
ID=27663266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03713278T ATE453119T1 (de) | 2002-01-31 | 2003-01-23 | Verfahren und vorrichtung zur messung der membranpermeabilität |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7022528B2 (de) |
| EP (1) | EP1521962B1 (de) |
| AT (1) | ATE453119T1 (de) |
| DE (1) | DE60330669D1 (de) |
| WO (1) | WO2003065037A2 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893877B2 (en) | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
| US20020151040A1 (en) | 2000-02-18 | 2002-10-17 | Matthew O' Keefe | Apparatus and methods for parallel processing of microvolume liquid reactions |
| US7332271B2 (en) | 2000-02-18 | 2008-02-19 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
| AU2001264880A1 (en) * | 2000-05-24 | 2001-12-03 | The Texas A And M University System | Degumming of edible oils by ultrafiltration |
| CA2425476C (en) * | 2000-10-10 | 2011-02-01 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| US20100261159A1 (en) | 2000-10-10 | 2010-10-14 | Robert Hess | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
| US7112443B2 (en) * | 2002-10-18 | 2006-09-26 | Symyx Technologies, Inc. | High throughput permeability testing of materials libraries |
| EP1608952B1 (de) | 2002-12-20 | 2016-08-10 | Life Technologies Corporation | Assay vorrichtung und verfahren unter verwendung von mikrofluiden matrixstrukturen |
| US20050106745A1 (en) * | 2003-09-19 | 2005-05-19 | Agy Therapeutics, Inc. | Combination of solubility and membrane permeability measurement methods for profiling of chemical compounds |
| CA2559171A1 (en) | 2004-03-12 | 2005-09-29 | Biotrove, Inc. | Nanoliter array loading |
| WO2005095950A1 (en) * | 2004-03-30 | 2005-10-13 | Pfizer Products Inc. | Method and device for evaluation of pharmaceutical compositions |
| US8840849B2 (en) * | 2004-06-01 | 2014-09-23 | Pion, Inc. | Permeation device and method for reducing aqueous boundary layer thicknesses |
| US20060105453A1 (en) | 2004-09-09 | 2006-05-18 | Brenan Colin J | Coating process for microfluidic sample arrays |
| WO2007022026A2 (en) * | 2005-08-11 | 2007-02-22 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| DE102005044071A1 (de) * | 2005-09-07 | 2007-03-08 | Nimbus Biotechnologie Gmbh | Verfahren zur Messung der Permeation einer Substanz durch eine Barriere |
| US8986781B2 (en) | 2005-10-27 | 2015-03-24 | Corning Incorporated | Immobilized multi-layer artificial membrane for permeability measurements (PAMPA) |
| US8616072B2 (en) * | 2006-02-13 | 2013-12-31 | The Johns Hopkins University | System and methods for sampling materials |
| CN102662038B (zh) * | 2006-02-28 | 2015-09-30 | 霍夫曼-拉罗奇有限公司 | 评价低溶解度化合物吸收特性的方法 |
| US8685749B2 (en) * | 2009-12-02 | 2014-04-01 | Whatman International Limited | Methods and systems for processing samples on porous substrates |
| CN101907549B (zh) * | 2010-07-06 | 2013-03-13 | 南京工业大学 | 一种同时获取固体溶质在液相中饱和溶解度和扩散系数的测试方法及测试装置 |
| CN102183393A (zh) * | 2011-03-07 | 2011-09-14 | 中国海洋大学 | 一种阴离子表面活性剂土壤提取与测定方法 |
| WO2013093954A1 (ja) * | 2011-12-19 | 2013-06-27 | ヤマハ発動機株式会社 | 対象物選別装置および対象物選別方法 |
| US9423234B2 (en) | 2012-11-05 | 2016-08-23 | The Regents Of The University Of California | Mechanical phenotyping of single cells: high throughput quantitative detection and sorting |
| US20170138969A1 (en) * | 2014-05-23 | 2017-05-18 | Indian Institute Of Technology Madras | System And Method For Measuring Permeability Of Drugs/Toxic/Chemical Compounds |
| GB2528096A (en) * | 2014-07-09 | 2016-01-13 | Paraytec Ltd | Method |
| EP3221687B1 (de) * | 2014-11-17 | 2019-05-01 | Syddansk Universitet | Anordnung zur beurteilung der wirkstoffpermeabilität mit einstellbaren biomimetischen eigenschaften |
| WO2016168445A1 (en) | 2015-04-17 | 2016-10-20 | Pion Inc. | Apparatus and method for the assessment of concentration profiling and permeability rates |
| US10883978B2 (en) * | 2017-01-31 | 2021-01-05 | Agilent Technologies, Inc. | Method and device for calibration of biological flux |
| US11293911B2 (en) | 2017-12-28 | 2022-04-05 | Korea Advanced Institute Of Science And Technology | Multi-phase liquid composition, device for measuring permeability of drugs, and method for measuring permeability of drugs |
| US12038433B2 (en) | 2019-09-09 | 2024-07-16 | Board Of Regents, The University Of Texas System | Methods and apparatus for high-throughput screening for testing permeability and retention of compounds across biological barriers |
| CN114279929B (zh) * | 2021-12-23 | 2024-01-12 | 上海交通大学 | 几何未知微尺度矩形槽内气溶胶穿透效率确定方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0242326A3 (de) | 1986-04-15 | 1990-04-18 | Pharmatronic AG | Einrichtung zur Untersuchung der Diffusion einer Substanz und Verfahren zum Betrieb der Einrichtung |
| EP1250587A1 (de) | 2000-01-28 | 2002-10-23 | Pion, Inc. | MESSUNG VON LÖSLICHKEITS-pH-PROFILEN |
| DE10118725C2 (de) | 2001-04-12 | 2003-04-10 | Pharmacelsus Gmbh | Verfahren zum Testen von Arzneimittelwirkstoffen |
| BR0210697A (pt) | 2001-06-29 | 2004-09-21 | Wyeth Corp | Métodos e composições úteis para a previsão da permeação da barreira sangue-cérebro |
-
2003
- 2003-01-23 WO PCT/US2003/002095 patent/WO2003065037A2/en not_active Application Discontinuation
- 2003-01-23 EP EP03713278A patent/EP1521962B1/de not_active Expired - Lifetime
- 2003-01-23 AT AT03713278T patent/ATE453119T1/de not_active IP Right Cessation
- 2003-01-23 DE DE60330669T patent/DE60330669D1/de not_active Expired - Fee Related
- 2003-01-23 US US10/351,263 patent/US7022528B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1521962A2 (de) | 2005-04-13 |
| WO2003065037A3 (en) | 2003-12-18 |
| EP1521962B1 (de) | 2009-12-23 |
| US7022528B2 (en) | 2006-04-04 |
| DE60330669D1 (de) | 2010-02-04 |
| US20030219716A1 (en) | 2003-11-27 |
| WO2003065037A2 (en) | 2003-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |