ATE452140T1 - Verbessertes verfahren zur herstellung von copolymer-1 - Google Patents
Verbessertes verfahren zur herstellung von copolymer-1Info
- Publication number
- ATE452140T1 ATE452140T1 AT07799327T AT07799327T ATE452140T1 AT E452140 T1 ATE452140 T1 AT E452140T1 AT 07799327 T AT07799327 T AT 07799327T AT 07799327 T AT07799327 T AT 07799327T AT E452140 T1 ATE452140 T1 AT E452140T1
- Authority
- AT
- Austria
- Prior art keywords
- copolymer
- protected
- carboxyanhydrides
- treated
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polyamides (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80658506P | 2006-07-05 | 2006-07-05 | |
PCT/US2007/072865 WO2008006026A1 (en) | 2006-07-05 | 2007-07-05 | Improved process for the preparation of copolymer-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE452140T1 true ATE452140T1 (de) | 2010-01-15 |
Family
ID=38658274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07799327T ATE452140T1 (de) | 2006-07-05 | 2007-07-05 | Verbessertes verfahren zur herstellung von copolymer-1 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20080021192A1 (de) |
EP (2) | EP2143728A1 (de) |
JP (1) | JP2009542864A (de) |
CN (1) | CN101511862A (de) |
AT (1) | ATE452140T1 (de) |
AU (1) | AU2007269140A1 (de) |
CA (1) | CA2656573A1 (de) |
DE (1) | DE602007003848D1 (de) |
ES (1) | ES2338488T3 (de) |
SI (1) | SI2046817T1 (de) |
WO (1) | WO2008006026A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7429374B2 (en) | 2001-12-04 | 2008-09-30 | Teva Pharmaceutical Industries, Ltd. | Process for the measurement of the potency of glatiramer acetate |
WO2006029411A2 (en) | 2004-09-09 | 2006-03-16 | Yeda Research And Development Co. Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof |
WO2009016643A1 (en) * | 2007-07-31 | 2009-02-05 | Natco Pharma Limited | Process for the preparation glatiramer acetate (copolymer-1) |
US20090035816A1 (en) * | 2007-08-02 | 2009-02-05 | Scinopharm Taiwan Ltd. | Process for the preparation of a polypeptide |
PL2307448T3 (pl) * | 2008-08-07 | 2015-10-30 | Sigma Aldrich Co Llc | Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością |
WO2010065362A1 (en) * | 2008-11-25 | 2010-06-10 | Innovative Technologies, L.L.C. | Improvements in polypeptide synthesis for drug delivery |
US9617313B2 (en) | 2008-12-24 | 2017-04-11 | Synthon Bv | Process for purifying a polymer mixture |
RS52885B (en) | 2009-08-20 | 2014-02-28 | Yeda Research And Development Co. Ltd. | LOW-FREQUENCY GLATIRAMER ACETATOM THERAPY |
BR112012011783A2 (pt) * | 2009-11-17 | 2019-09-24 | Ares Trading Sa | "métodos para aperfeiçoar o desenho, biodisponibilidade e eficiência de composições de polímero de sequência aleatória via detecção à base de proteína de soro de composições de polímero de sequência aleatória." |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
AU2011248663A1 (en) * | 2010-04-27 | 2012-11-08 | Dr. Reddy's Laboratories Ltd. | Preparation of polypeptides and salts thereof |
MX347871B (es) | 2010-10-11 | 2017-05-16 | Teva Pharmaceutical Ind Ltd * | Biomarcadores de citoquina como marcadores predictivos de respuesta clínica para acetato de glatirámero. |
WO2012067974A1 (en) * | 2010-11-17 | 2012-05-24 | Sigma-Aldrich Co. Llc. | A greener method for the production of copolymer 1 |
WO2013009885A2 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation of copolymer diethylamide |
US8575198B1 (en) | 2011-09-07 | 2013-11-05 | Momenta Pharmaceuticals, Inc. | In-process control for the manufacture of glatiramer acetate |
EA201490749A1 (ru) | 2011-10-10 | 2014-09-30 | Тева Фармасьютикал Индастриз Лтд. | Однонуклеотидные полиморфизмы, полезные для прогнозирования клинической реакции на глатирамера ацетат |
CN102617851B (zh) * | 2012-03-31 | 2014-06-11 | 上海大学 | 分子量可控聚l-谷氨酸制备方法 |
US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
ES2707500T3 (es) | 2015-11-23 | 2019-04-03 | Chemi Spa | Análisis mediante RP-HPLC de mezclas de polipéptidos complejos |
MX2019010174A (es) | 2017-03-26 | 2019-10-15 | Mapi Pharma Ltd | Sistemas de deposito de glatiramer para el tratamiento de formas progresivas de esclerosis multiple. |
CN116355201B (zh) * | 2023-06-01 | 2023-09-08 | 苏州大学 | 一种基于原位纯化的共聚氨基酸的一锅法制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3349550A (en) * | 1966-11-08 | 1967-10-31 | Lourenco Anthony L | Plant compressing apparatus for mechanical pickers |
CA2023176A1 (en) * | 1989-08-25 | 1991-02-26 | Margaret M. Bowers-Daines | Preparation and use of iodopropargyl esters of a-amino acid derivatives as antimicrobial agents |
US5800808A (en) * | 1994-05-24 | 1998-09-01 | Veda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
EP1545462A4 (de) * | 2002-07-19 | 2007-08-08 | Univ California | Dendrimere als molekulare translokatoren |
CA2411786C (en) * | 2002-11-13 | 2009-01-27 | Brantford Chemicals Inc. | A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids |
AU2003283152A1 (en) * | 2002-11-13 | 2004-06-03 | Apotex Pharmachem Inc. | Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine |
AR052321A1 (es) * | 2004-10-29 | 2007-03-14 | Sandoz Ag | Procesos para la preparacion de un polipeptido |
CA2619123A1 (en) * | 2005-08-15 | 2007-02-22 | Wai Hong Chan | Process for the preparation of copolymer-1 |
-
2007
- 2007-07-05 AU AU2007269140A patent/AU2007269140A1/en not_active Abandoned
- 2007-07-05 JP JP2009518630A patent/JP2009542864A/ja active Pending
- 2007-07-05 CA CA002656573A patent/CA2656573A1/en not_active Abandoned
- 2007-07-05 DE DE602007003848T patent/DE602007003848D1/de active Active
- 2007-07-05 ES ES07799327T patent/ES2338488T3/es active Active
- 2007-07-05 CN CNA2007800328809A patent/CN101511862A/zh active Pending
- 2007-07-05 EP EP09174515A patent/EP2143728A1/de not_active Withdrawn
- 2007-07-05 SI SI200730190T patent/SI2046817T1/sl unknown
- 2007-07-05 WO PCT/US2007/072865 patent/WO2008006026A1/en active Application Filing
- 2007-07-05 AT AT07799327T patent/ATE452140T1/de active
- 2007-07-05 EP EP07799327A patent/EP2046817B1/de active Active
- 2007-07-05 US US11/773,864 patent/US20080021192A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2007269140A1 (en) | 2008-01-10 |
EP2046817A1 (de) | 2009-04-15 |
WO2008006026A1 (en) | 2008-01-10 |
CA2656573A1 (en) | 2008-01-10 |
US20080021192A1 (en) | 2008-01-24 |
ES2338488T3 (es) | 2010-05-07 |
JP2009542864A (ja) | 2009-12-03 |
DE602007003848D1 (de) | 2010-01-28 |
EP2046817B1 (de) | 2009-12-16 |
SI2046817T1 (sl) | 2010-04-30 |
EP2143728A1 (de) | 2010-01-13 |
CN101511862A (zh) | 2009-08-19 |
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