ATE452140T1 - Verbessertes verfahren zur herstellung von copolymer-1 - Google Patents

Verbessertes verfahren zur herstellung von copolymer-1

Info

Publication number
ATE452140T1
ATE452140T1 AT07799327T AT07799327T ATE452140T1 AT E452140 T1 ATE452140 T1 AT E452140T1 AT 07799327 T AT07799327 T AT 07799327T AT 07799327 T AT07799327 T AT 07799327T AT E452140 T1 ATE452140 T1 AT E452140T1
Authority
AT
Austria
Prior art keywords
copolymer
protected
carboxyanhydrides
treated
mixture
Prior art date
Application number
AT07799327T
Other languages
English (en)
Inventor
Mani Iyer
Corinne Bauer
Pat Oliver-Shaffer
Original Assignee
Momenta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Momenta Pharmaceuticals Inc filed Critical Momenta Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE452140T1 publication Critical patent/ATE452140T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polyamides (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
AT07799327T 2006-07-05 2007-07-05 Verbessertes verfahren zur herstellung von copolymer-1 ATE452140T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80658506P 2006-07-05 2006-07-05
PCT/US2007/072865 WO2008006026A1 (en) 2006-07-05 2007-07-05 Improved process for the preparation of copolymer-1

Publications (1)

Publication Number Publication Date
ATE452140T1 true ATE452140T1 (de) 2010-01-15

Family

ID=38658274

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07799327T ATE452140T1 (de) 2006-07-05 2007-07-05 Verbessertes verfahren zur herstellung von copolymer-1

Country Status (11)

Country Link
US (1) US20080021192A1 (de)
EP (2) EP2143728A1 (de)
JP (1) JP2009542864A (de)
CN (1) CN101511862A (de)
AT (1) ATE452140T1 (de)
AU (1) AU2007269140A1 (de)
CA (1) CA2656573A1 (de)
DE (1) DE602007003848D1 (de)
ES (1) ES2338488T3 (de)
SI (1) SI2046817T1 (de)
WO (1) WO2008006026A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7429374B2 (en) 2001-12-04 2008-09-30 Teva Pharmaceutical Industries, Ltd. Process for the measurement of the potency of glatiramer acetate
WO2006029411A2 (en) 2004-09-09 2006-03-16 Yeda Research And Development Co. Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof
WO2009016643A1 (en) * 2007-07-31 2009-02-05 Natco Pharma Limited Process for the preparation glatiramer acetate (copolymer-1)
US20090035816A1 (en) * 2007-08-02 2009-02-05 Scinopharm Taiwan Ltd. Process for the preparation of a polypeptide
PL2307448T3 (pl) * 2008-08-07 2015-10-30 Sigma Aldrich Co Llc Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością
WO2010065362A1 (en) * 2008-11-25 2010-06-10 Innovative Technologies, L.L.C. Improvements in polypeptide synthesis for drug delivery
US9617313B2 (en) 2008-12-24 2017-04-11 Synthon Bv Process for purifying a polymer mixture
RS52885B (en) 2009-08-20 2014-02-28 Yeda Research And Development Co. Ltd. LOW-FREQUENCY GLATIRAMER ACETATOM THERAPY
BR112012011783A2 (pt) * 2009-11-17 2019-09-24 Ares Trading Sa "métodos para aperfeiçoar o desenho, biodisponibilidade e eficiência de composições de polímero de sequência aleatória via detecção à base de proteína de soro de composições de polímero de sequência aleatória."
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en) 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
AU2011248663A1 (en) * 2010-04-27 2012-11-08 Dr. Reddy's Laboratories Ltd. Preparation of polypeptides and salts thereof
MX347871B (es) 2010-10-11 2017-05-16 Teva Pharmaceutical Ind Ltd * Biomarcadores de citoquina como marcadores predictivos de respuesta clínica para acetato de glatirámero.
WO2012067974A1 (en) * 2010-11-17 2012-05-24 Sigma-Aldrich Co. Llc. A greener method for the production of copolymer 1
WO2013009885A2 (en) 2011-07-11 2013-01-17 Momenta Pharmaceuticals, Inc. Evaluation of copolymer diethylamide
US8575198B1 (en) 2011-09-07 2013-11-05 Momenta Pharmaceuticals, Inc. In-process control for the manufacture of glatiramer acetate
EA201490749A1 (ru) 2011-10-10 2014-09-30 Тева Фармасьютикал Индастриз Лтд. Однонуклеотидные полиморфизмы, полезные для прогнозирования клинической реакции на глатирамера ацетат
CN102617851B (zh) * 2012-03-31 2014-06-11 上海大学 分子量可控聚l-谷氨酸制备方法
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
ES2707500T3 (es) 2015-11-23 2019-04-03 Chemi Spa Análisis mediante RP-HPLC de mezclas de polipéptidos complejos
MX2019010174A (es) 2017-03-26 2019-10-15 Mapi Pharma Ltd Sistemas de deposito de glatiramer para el tratamiento de formas progresivas de esclerosis multiple.
CN116355201B (zh) * 2023-06-01 2023-09-08 苏州大学 一种基于原位纯化的共聚氨基酸的一锅法制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3349550A (en) * 1966-11-08 1967-10-31 Lourenco Anthony L Plant compressing apparatus for mechanical pickers
CA2023176A1 (en) * 1989-08-25 1991-02-26 Margaret M. Bowers-Daines Preparation and use of iodopropargyl esters of a-amino acid derivatives as antimicrobial agents
US5800808A (en) * 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
EP1545462A4 (de) * 2002-07-19 2007-08-08 Univ California Dendrimere als molekulare translokatoren
CA2411786C (en) * 2002-11-13 2009-01-27 Brantford Chemicals Inc. A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids
AU2003283152A1 (en) * 2002-11-13 2004-06-03 Apotex Pharmachem Inc. Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine
AR052321A1 (es) * 2004-10-29 2007-03-14 Sandoz Ag Procesos para la preparacion de un polipeptido
CA2619123A1 (en) * 2005-08-15 2007-02-22 Wai Hong Chan Process for the preparation of copolymer-1

Also Published As

Publication number Publication date
AU2007269140A1 (en) 2008-01-10
EP2046817A1 (de) 2009-04-15
WO2008006026A1 (en) 2008-01-10
CA2656573A1 (en) 2008-01-10
US20080021192A1 (en) 2008-01-24
ES2338488T3 (es) 2010-05-07
JP2009542864A (ja) 2009-12-03
DE602007003848D1 (de) 2010-01-28
EP2046817B1 (de) 2009-12-16
SI2046817T1 (sl) 2010-04-30
EP2143728A1 (de) 2010-01-13
CN101511862A (zh) 2009-08-19

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