ATE448242T1 - Gamma-sekretase-inhibitoren - Google Patents
Gamma-sekretase-inhibitorenInfo
- Publication number
- ATE448242T1 ATE448242T1 AT03720938T AT03720938T ATE448242T1 AT E448242 T1 ATE448242 T1 AT E448242T1 AT 03720938 T AT03720938 T AT 03720938T AT 03720938 T AT03720938 T AT 03720938T AT E448242 T1 ATE448242 T1 AT E448242T1
- Authority
- AT
- Austria
- Prior art keywords
- val
- group
- leu
- alkyl
- ile
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002121983 | 2002-04-24 | ||
PCT/JP2003/005017 WO2003091278A1 (fr) | 2002-04-24 | 2003-04-18 | Inhibiteurs de gamma secretase |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE448242T1 true ATE448242T1 (de) | 2009-11-15 |
Family
ID=29267426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03720938T ATE448242T1 (de) | 2002-04-24 | 2003-04-18 | Gamma-sekretase-inhibitoren |
Country Status (11)
Country | Link |
---|---|
US (1) | US7585938B2 (de) |
EP (1) | EP1498421B1 (de) |
JP (1) | JP4404643B2 (de) |
KR (1) | KR101051249B1 (de) |
CN (1) | CN1319987C (de) |
AT (1) | ATE448242T1 (de) |
AU (1) | AU2003235283A1 (de) |
BR (1) | BR0304562A (de) |
DE (1) | DE60329995D1 (de) |
NO (1) | NO329184B1 (de) |
WO (1) | WO2003091278A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
AU2007316597B2 (en) * | 2006-11-07 | 2013-01-31 | Katholieke Universiteit Leuven, K. U. Leuven R & D | Diagnosis and treatment of T-cell acute lymphoblastic leukemia |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
EP2177529B1 (de) * | 2007-08-09 | 2013-03-27 | Kabushiki Kaisha Yakult Honsha | Gamma-sekretasehemmer |
ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
WO2012144972A2 (en) * | 2010-01-19 | 2012-10-26 | The General Hospital Corporation | Methods to inhibit neurodegeneration |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
JP5688745B2 (ja) | 2010-03-10 | 2015-03-25 | プロビオドルグ エージー | グルタミニルシクラーゼ(qc、ec2.3.2.5)の複素環阻害剤 |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
CN102344485A (zh) * | 2010-08-05 | 2012-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 用于治疗阿尔茨海默病的肽类β分泌酶抑制剂及其用途 |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
EP3461819B1 (de) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Hemmer der glutaminylcyclase |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI870474A (fi) | 1986-02-07 | 1987-08-08 | Ciba Geigy Ag | Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat. |
EP1254108A1 (de) | 2000-01-24 | 2002-11-06 | MERCK SHARP & DOHME LTD. | Gamma-sekretase-inhibitoren |
US6753410B2 (en) * | 2000-03-02 | 2004-06-22 | Merck & Co., Inc. | Investigational compounds |
AU2001261368A1 (en) * | 2000-05-11 | 2001-11-20 | Scios Inc. | Modulation of gamma-secretase activity |
US20030022251A1 (en) * | 2001-07-04 | 2003-01-30 | Boehringer Ingelheim Pharma Kg | Gamma-secretase in vitro screening assay |
-
2003
- 2003-04-18 CN CNB038118963A patent/CN1319987C/zh not_active Expired - Fee Related
- 2003-04-18 EP EP03720938A patent/EP1498421B1/de not_active Expired - Lifetime
- 2003-04-18 BR BR0304562-5A patent/BR0304562A/pt active Pending
- 2003-04-18 JP JP2003587836A patent/JP4404643B2/ja not_active Expired - Fee Related
- 2003-04-18 US US10/511,269 patent/US7585938B2/en not_active Expired - Fee Related
- 2003-04-18 AT AT03720938T patent/ATE448242T1/de not_active IP Right Cessation
- 2003-04-18 DE DE60329995T patent/DE60329995D1/de not_active Expired - Lifetime
- 2003-04-18 KR KR1020047016996A patent/KR101051249B1/ko not_active IP Right Cessation
- 2003-04-18 AU AU2003235283A patent/AU2003235283A1/en not_active Abandoned
- 2003-04-18 WO PCT/JP2003/005017 patent/WO2003091278A1/ja active Application Filing
- 2003-12-11 NO NO20035535A patent/NO329184B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US7585938B2 (en) | 2009-09-08 |
WO2003091278A1 (fr) | 2003-11-06 |
KR101051249B1 (ko) | 2011-07-21 |
NO20035535D0 (no) | 2003-12-11 |
EP1498421A1 (de) | 2005-01-19 |
NO20035535L (no) | 2004-02-19 |
EP1498421A4 (de) | 2006-05-17 |
AU2003235283A1 (en) | 2003-11-10 |
KR20040106370A (ko) | 2004-12-17 |
CN1656115A (zh) | 2005-08-17 |
EP1498421B1 (de) | 2009-11-11 |
JP4404643B2 (ja) | 2010-01-27 |
JPWO2003091278A1 (ja) | 2005-09-02 |
CN1319987C (zh) | 2007-06-06 |
BR0304562A (pt) | 2004-07-20 |
US20060205666A1 (en) | 2006-09-14 |
NO329184B1 (no) | 2010-09-06 |
DE60329995D1 (de) | 2009-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60329995D1 (de) | Gamma-sekretase-inhibitoren | |
SE9203825D0 (sv) | Dual inhibitors of no synthase and cyclooxygenase, process for their preparation and therapeutical compositions containing them | |
BR0114147A (pt) | Uso de tensoativos catiÈnicos em preparações cosméticas | |
RS54847B1 (sr) | Inhibitori kristalne peptid epoksi keton proteaze i sinteza aminokiselinskih keto-epoksida | |
AR038383A1 (es) | Compuesto inhibidor de la hepatitis c | |
UY28674A1 (es) | Inhibidores heterociclil amino de 11-beta-hidroxiesteroide deshidrogenasa tipo 1 | |
PE107299A1 (es) | Composiciones farmaceuticas que comprenden un analogo de gaba y un antiinflamatorio no esteroideo | |
ATE331708T1 (de) | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren | |
SG50602A1 (en) | Novel heterocyclic compound | |
ES2421447T3 (es) | Métodos para proteger frente a apoptosis usando lipopéptidos | |
ATE289590T1 (de) | Beta-sulfonyl-hydroxamsäuren als matrix- metalloproteinaseinhibitoren | |
BR0307060A (pt) | ésteres hidroxamato do ácido n-(fenil 4-substituìdo)-antranìlico | |
IS7482A (is) | Fjölhringa efnasambönd sem sterk alfa2-adrenóviðtakamótlyf | |
MX9705559A (es) | Derivados de acido neuraminico, su preparacion y su uso en medicina. | |
HRP20080330T3 (en) | Antitumoral compounds based on kahalalide f | |
WO2001072263A3 (de) | Verwendung von ectoin oder ectoin-derivaten zum schutz der stressprotein in der haut | |
CY1107990T1 (el) | Τριπεπτιδια και παραγωγα τριπεπτιδιων για τη θepαπεια νευροεκφυλιστικων ασθενειων | |
PT1226160E (pt) | Novos peptidos antiarritmicos | |
DK0624586T3 (da) | Substituerede pyrroler | |
EP2266971A3 (de) | HIV-Protease inhibierende Verbindungen | |
DE59900730D1 (de) | Korrosionsinhibitoren enthaltender Injektionszement | |
DK1309535T3 (da) | Fremgangsmåder til fremstilling af alfa'-chlorketoner | |
DK1474439T3 (da) | Dipeptider og tripeptider med anti-inflammatorisk virkning | |
HRP20050242B1 (en) | Synthetic peptides containing unnatural adamantane related amino acids for use as antitumour drugs | |
AU2003245979A1 (en) | Amides of cyclic amino acids used as pde 4 inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |