ATE444295T1 - Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen - Google Patents

Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen

Info

Publication number
ATE444295T1
ATE444295T1 AT03783211T AT03783211T ATE444295T1 AT E444295 T1 ATE444295 T1 AT E444295T1 AT 03783211 T AT03783211 T AT 03783211T AT 03783211 T AT03783211 T AT 03783211T AT E444295 T1 ATE444295 T1 AT E444295T1
Authority
AT
Austria
Prior art keywords
alkyl
producing quaternary
alkaloid salts
morphinane alkaloid
solvent system
Prior art date
Application number
AT03783211T
Other languages
English (en)
Inventor
Gary Cantrell
Robert Halvachs
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE444295T1 publication Critical patent/ATE444295T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT03783211T 2002-11-08 2003-11-05 Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen ATE444295T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42474802P 2002-11-08 2002-11-08
US42558002P 2002-11-12 2002-11-12
PCT/US2003/035463 WO2004043964A2 (en) 2002-11-08 2003-11-05 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts

Publications (1)

Publication Number Publication Date
ATE444295T1 true ATE444295T1 (de) 2009-10-15

Family

ID=32314554

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03783211T ATE444295T1 (de) 2002-11-08 2003-11-05 Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen

Country Status (11)

Country Link
US (1) US7285665B2 (de)
EP (1) EP1562953B1 (de)
JP (1) JP2006509745A (de)
AT (1) ATE444295T1 (de)
AU (1) AU2003290630B2 (de)
CA (1) CA2504262C (de)
DE (1) DE60329520D1 (de)
ES (1) ES2332453T3 (de)
MX (1) MXPA05004759A (de)
PT (1) PT1562953E (de)
WO (1) WO2004043964A2 (de)

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US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
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US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
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ES2540551T3 (es) 2007-03-29 2015-07-10 Wyeth Llc Antagonistas de receptores opioides periféricos y usos de los mismos
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WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US8383649B2 (en) 2007-07-11 2013-02-26 Mallinckrodt Llc Crystalline forms of naltrexone methobromide
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KR101519682B1 (ko) * 2007-08-09 2015-05-19 렌슬러 폴리테크닉 인스티튜트 4급 오피오이드 카르복스아미드
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WO2009099411A1 (en) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
AU2009214500B2 (en) * 2008-02-14 2014-10-23 Alkermes, Inc. Selective opioid compounds
EP2278966B1 (de) 2008-03-21 2019-10-09 The University of Chicago Behandlung mit opioid-antagonisten und mtor-inhibitoren
PL2285780T3 (pl) 2008-05-27 2016-02-29 SpecGx LLC Sposoby i związki do wytwarzania normorfinanów
CN101607963B (zh) 2008-06-20 2013-04-03 重庆医药工业研究院有限责任公司 ***喃衍生物及其制备方法
EP2331508B1 (de) 2008-09-03 2014-11-12 Mallinckrodt LLC Substituierte berbine und verfahren zu ihrer synthese
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8563724B2 (en) 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398806A1 (de) 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium-n-oxide und verfahren zu ihrer herstellung
CN102459275A (zh) 2009-04-24 2012-05-16 布鲁克大学 制备***烷和***酮化合物的方法
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
WO2011154827A2 (en) 2010-06-11 2011-12-15 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses

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Also Published As

Publication number Publication date
EP1562953B1 (de) 2009-09-30
MXPA05004759A (es) 2005-08-02
ES2332453T3 (es) 2010-02-05
US7285665B2 (en) 2007-10-23
WO2004043964A2 (en) 2004-05-27
CA2504262C (en) 2012-01-10
PT1562953E (pt) 2009-11-19
AU2003290630A1 (en) 2004-06-03
DE60329520D1 (de) 2009-11-12
EP1562953A2 (de) 2005-08-17
JP2006509745A (ja) 2006-03-23
US20060014771A1 (en) 2006-01-19
CA2504262A1 (en) 2004-05-27
AU2003290630B2 (en) 2009-01-29
WO2004043964A3 (en) 2004-08-26

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