ATE444295T1 - Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen - Google Patents
Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzenInfo
- Publication number
- ATE444295T1 ATE444295T1 AT03783211T AT03783211T ATE444295T1 AT E444295 T1 ATE444295 T1 AT E444295T1 AT 03783211 T AT03783211 T AT 03783211T AT 03783211 T AT03783211 T AT 03783211T AT E444295 T1 ATE444295 T1 AT E444295T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- producing quaternary
- alkaloid salts
- morphinane alkaloid
- solvent system
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42474802P | 2002-11-08 | 2002-11-08 | |
US42558002P | 2002-11-12 | 2002-11-12 | |
PCT/US2003/035463 WO2004043964A2 (en) | 2002-11-08 | 2003-11-05 | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE444295T1 true ATE444295T1 (de) | 2009-10-15 |
Family
ID=32314554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03783211T ATE444295T1 (de) | 2002-11-08 | 2003-11-05 | Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen |
Country Status (11)
Country | Link |
---|---|
US (1) | US7285665B2 (de) |
EP (1) | EP1562953B1 (de) |
JP (1) | JP2006509745A (de) |
AT (1) | ATE444295T1 (de) |
AU (1) | AU2003290630B2 (de) |
CA (1) | CA2504262C (de) |
DE (1) | DE60329520D1 (de) |
ES (1) | ES2332453T3 (de) |
MX (1) | MXPA05004759A (de) |
PT (1) | PT1562953E (de) |
WO (1) | WO2004043964A2 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2368554T3 (pl) | 2003-04-08 | 2015-05-29 | Progenics Pharm Inc | Preparaty farmaceutyczne zawierające metylonaltrekson |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
ES2714198T3 (es) | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
AU2013200437B2 (en) * | 2005-05-25 | 2015-01-15 | Progenics Pharmaceuticals, Inc. | (S)-N-methylnaltrexone, process for its synthesis and its pharmaceutical use |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
TW200815451A (en) * | 2006-08-04 | 2008-04-01 | Wyeth Corp | 6-carboxy-normorphinan derivatives, synthesis and uses thereof |
EP2099764B1 (de) | 2006-09-20 | 2011-07-27 | Mallinckrodt Inc. | Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon |
FR2906252B1 (fr) | 2006-09-21 | 2008-11-28 | Sanofi Aventis Sa | Procede de preparation d'halogenures de n-aklyl naltrexone |
MX2009005463A (es) * | 2006-11-22 | 2009-08-28 | Progenics Pharm Inc | Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros. |
BRPI0719305A2 (pt) * | 2006-11-22 | 2014-02-04 | Progenics Pharm Inc | (r)-n-estereoisômeros de análogos de 7,8-saturados-4,5-epóxi-morfinano |
US9040726B2 (en) * | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
WO2008109156A2 (en) * | 2007-03-06 | 2008-09-12 | Mallinckrodt Inc. | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
ES2765811T5 (es) * | 2007-03-29 | 2024-02-27 | Progenics Pharm Inc | Forma cristalina de bromuro de (R)-n-metilnaltrexona y sus usos |
ES2540551T3 (es) | 2007-03-29 | 2015-07-10 | Wyeth Llc | Antagonistas de receptores opioides periféricos y usos de los mismos |
PE20090700A1 (es) | 2007-03-29 | 2009-07-13 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
WO2008138383A1 (de) * | 2007-05-16 | 2008-11-20 | Cilag Ag | Verfahren zur herstellung von n-methylnaltrexonbromid |
US8383649B2 (en) | 2007-07-11 | 2013-02-26 | Mallinckrodt Llc | Crystalline forms of naltrexone methobromide |
EP2019105A1 (de) | 2007-07-19 | 2009-01-28 | Siegfried Ltd. | Verfahren zur Herstellung von quaternären N-Alkyl-Morphin- oder Morphinan- Alkaloidderivaten |
KR101519682B1 (ko) * | 2007-08-09 | 2015-05-19 | 렌슬러 폴리테크닉 인스티튜트 | 4급 오피오이드 카르복스아미드 |
WO2009070733A1 (en) * | 2007-11-26 | 2009-06-04 | Pharmacofore, Inc. | Peripheral phenolic opioid antagonist |
WO2009099411A1 (en) | 2008-02-06 | 2009-08-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
AU2009214500B2 (en) * | 2008-02-14 | 2014-10-23 | Alkermes, Inc. | Selective opioid compounds |
EP2278966B1 (de) | 2008-03-21 | 2019-10-09 | The University of Chicago | Behandlung mit opioid-antagonisten und mtor-inhibitoren |
PL2285780T3 (pl) | 2008-05-27 | 2016-02-29 | SpecGx LLC | Sposoby i związki do wytwarzania normorfinanów |
CN101607963B (zh) | 2008-06-20 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | ***喃衍生物及其制备方法 |
EP2331508B1 (de) | 2008-09-03 | 2014-11-12 | Mallinckrodt LLC | Substituierte berbine und verfahren zu ihrer synthese |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
US8563724B2 (en) | 2009-02-23 | 2013-10-22 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
EP2398806A1 (de) | 2009-02-23 | 2011-12-28 | Mallinckrodt LLC | (+)-morphinanium-n-oxide und verfahren zu ihrer herstellung |
CN102459275A (zh) | 2009-04-24 | 2012-05-16 | 布鲁克大学 | 制备***烷和***酮化合物的方法 |
WO2011009020A2 (en) | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第3級アミンのn−脱アルキル化方法 |
WO2011154827A2 (en) | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
CN103917543A (zh) | 2011-09-08 | 2014-07-09 | 马林克罗特有限公司 | 在不分离中间体的情况下制备生物碱 |
WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US3101339A (en) | 1958-10-30 | 1963-08-20 | Boehringer Sohn Ingelheim | Quaternary salts of normorphine and its acylated derivatives |
US4141897A (en) | 1976-12-20 | 1979-02-27 | Research Corporation | N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof |
US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
PL124001B1 (en) | 1980-01-25 | 1982-12-31 | Inst Przemyslu Zielarskiego | Process for preparing quaternary halides of n-alkylor n-aralkyl- derivatives of tropanic and isoquinolylic alkaloids |
US4322426A (en) | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
US4535157A (en) | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
US5668285A (en) | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
DE4132159A1 (de) | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
US5352680A (en) | 1992-07-15 | 1994-10-04 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists to block opioid agonist tolerance and dependence |
WO1994008599A1 (en) | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
SE9401728D0 (sv) | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds II |
US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
US5756851A (en) | 1996-10-21 | 1998-05-26 | Albemarle Corporation | Production of nabumetone or precursors thereof |
GB9713703D0 (en) | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
WO2001014382A1 (fr) * | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif |
DE10229842A1 (de) | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
-
2003
- 2003-11-05 DE DE60329520T patent/DE60329520D1/de not_active Expired - Lifetime
- 2003-11-05 WO PCT/US2003/035463 patent/WO2004043964A2/en active Application Filing
- 2003-11-05 CA CA2504262A patent/CA2504262C/en not_active Expired - Lifetime
- 2003-11-05 MX MXPA05004759A patent/MXPA05004759A/es active IP Right Grant
- 2003-11-05 US US10/530,446 patent/US7285665B2/en not_active Expired - Lifetime
- 2003-11-05 ES ES03783211T patent/ES2332453T3/es not_active Expired - Lifetime
- 2003-11-05 EP EP03783211A patent/EP1562953B1/de not_active Expired - Lifetime
- 2003-11-05 AT AT03783211T patent/ATE444295T1/de active
- 2003-11-05 JP JP2004551830A patent/JP2006509745A/ja active Pending
- 2003-11-05 PT PT03783211T patent/PT1562953E/pt unknown
- 2003-11-05 AU AU2003290630A patent/AU2003290630B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP1562953B1 (de) | 2009-09-30 |
MXPA05004759A (es) | 2005-08-02 |
ES2332453T3 (es) | 2010-02-05 |
US7285665B2 (en) | 2007-10-23 |
WO2004043964A2 (en) | 2004-05-27 |
CA2504262C (en) | 2012-01-10 |
PT1562953E (pt) | 2009-11-19 |
AU2003290630A1 (en) | 2004-06-03 |
DE60329520D1 (de) | 2009-11-12 |
EP1562953A2 (de) | 2005-08-17 |
JP2006509745A (ja) | 2006-03-23 |
US20060014771A1 (en) | 2006-01-19 |
CA2504262A1 (en) | 2004-05-27 |
AU2003290630B2 (en) | 2009-01-29 |
WO2004043964A3 (en) | 2004-08-26 |
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