ATE443136T1 - Methode für dna synthese - Google Patents
Methode für dna syntheseInfo
- Publication number
- ATE443136T1 ATE443136T1 AT07104945T AT07104945T ATE443136T1 AT E443136 T1 ATE443136 T1 AT E443136T1 AT 07104945 T AT07104945 T AT 07104945T AT 07104945 T AT07104945 T AT 07104945T AT E443136 T1 ATE443136 T1 AT E443136T1
- Authority
- AT
- Austria
- Prior art keywords
- dna synthesis
- dna
- synthesis reaction
- enhancer
- reaction
- Prior art date
Links
- 230000006820 DNA synthesis Effects 0.000 title abstract 13
- 238000000034 method Methods 0.000 title 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 abstract 5
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 abstract 5
- 238000003786 synthesis reaction Methods 0.000 abstract 5
- 239000003623 enhancer Substances 0.000 abstract 4
- 108010010677 Phosphodiesterase I Proteins 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 238000000338 in vitro Methods 0.000 abstract 2
- 238000001308 synthesis method Methods 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11400598 | 1998-04-23 | ||
JP31524398 | 1998-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE443136T1 true ATE443136T1 (de) | 2009-10-15 |
Family
ID=26452869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07104945T ATE443136T1 (de) | 1998-04-23 | 1999-04-21 | Methode für dna synthese |
Country Status (10)
Country | Link |
---|---|
US (2) | US7521178B1 (de) |
EP (3) | EP1816197B1 (de) |
JP (2) | JP3748378B2 (de) |
KR (1) | KR100519895B1 (de) |
CN (2) | CN1177931C (de) |
AT (1) | ATE443136T1 (de) |
AU (1) | AU3534199A (de) |
CA (1) | CA2326725A1 (de) |
DE (1) | DE69941441D1 (de) |
WO (1) | WO1999054455A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3724321B2 (ja) * | 2000-03-21 | 2005-12-07 | 株式会社島津製作所 | 核酸合成法 |
TW201037080A (en) | 2003-12-25 | 2010-10-16 | Danform Kk | Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same |
US7462475B2 (en) * | 2004-05-20 | 2008-12-09 | Dna Poleymerase Technology, Inc. | Use of whole blood in PCR reactions |
JP2008151771A (ja) | 2006-11-22 | 2008-07-03 | Fujifilm Corp | マイクロ流体チップ |
CA2622649C (en) | 2007-03-09 | 2018-04-24 | Riken | Nucleic acid amplification method using primer exhibiting exciton effect |
US20100221787A1 (en) | 2007-10-25 | 2010-09-02 | Riken | Isothermal amplification method and dna polymerase used in the same |
EP2256188B1 (de) * | 2008-02-29 | 2014-06-18 | Riken | Verfahren zur erhöhung der enzymatischen reaktivität |
WO2010061922A1 (ja) | 2008-11-27 | 2010-06-03 | 独立行政法人理化学研究所 | 新規MutSタンパク質およびそれを用いた変異の判定方法 |
WO2010080910A1 (en) * | 2009-01-08 | 2010-07-15 | Bio-Rad Laboratories, Inc. | Methods and compositions for improving efficiency of nucleic acids amplification reactions |
EP3502272A1 (de) * | 2010-06-21 | 2019-06-26 | Life Technologies Corporation | Zusammensetzungen, kits und verfahren zur synthese und/oder zum nachweis von nukleinsäuren |
EP2600901B1 (de) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | Pharmazeutische zusammensetzungen enthaltenbearbeitete nukleinsäuren und ihre medizinische verwendung |
CA2821992A1 (en) | 2010-10-01 | 2012-04-05 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
US9458498B2 (en) | 2011-01-24 | 2016-10-04 | Takara Bio Inc. | Method for modifying nucleic acids |
JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
US9586987B2 (en) | 2011-09-08 | 2017-03-07 | Kabushiki Kaisha Dnaform | Primer set for isothermal amplication of a target nucleic acid sequence |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
US9428535B2 (en) | 2011-10-03 | 2016-08-30 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
HRP20220717T1 (hr) | 2011-12-16 | 2022-07-22 | Modernatx, Inc. | Modificirani pripravci mrna |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
JP2015513912A (ja) | 2012-04-02 | 2015-05-18 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | タンパク質の産生のための修飾ポリヌクレオチド |
US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
CN104812901B (zh) | 2012-09-13 | 2018-08-10 | 美国印第安纳大学研究和技术公司 | 赋予植物抗病性的组合物和***及其使用方法 |
EP2922554B1 (de) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminal modifizierte rns |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
US20160194625A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
AU2014329452B2 (en) | 2013-10-03 | 2019-06-20 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
US20150259743A1 (en) | 2013-12-31 | 2015-09-17 | Roche Nimblegen, Inc. | Methods of assessing epigenetic regulation of genome function via dna methylation status and systems and kits therefor |
WO2015114469A2 (en) | 2014-01-15 | 2015-08-06 | Abbott Japan Co., Ltd | Covered sequence conversion dna and detection methods |
WO2016011226A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
CN108064312B (zh) | 2014-12-24 | 2022-04-08 | 雅培实验室 | 基于具有靶扩增的信号放大dna级联反应的检测方法 |
KR101785074B1 (ko) | 2015-01-28 | 2017-10-12 | 고려대학교 산학협력단 | Dna 합성용 마이크로 칩 및 이를 이용한 dna 합성방법 |
SI3394093T1 (sl) | 2015-12-23 | 2022-05-31 | Modernatx, Inc. | Metode uporabe liganda OX40, ki kodira polinukleotid |
US20190241658A1 (en) | 2016-01-10 | 2019-08-08 | Modernatx, Inc. | Therapeutic mRNAs encoding anti CTLA-4 antibodies |
AU2017268397B2 (en) | 2016-05-18 | 2023-07-06 | Modernatx, Inc. | Polynucleotides encoding interleukin-12 (IL12) and uses thereof |
WO2017201325A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Combinations of mrnas encoding immune modulating polypeptides and uses thereof |
CN106916909B (zh) * | 2017-05-09 | 2018-09-11 | 广州海力特生物科技有限公司 | 一种HBV pgRNA的实时荧光定量RT-PCR检测引物组、探针组、试剂盒及方法 |
WO2018231990A2 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
US11905518B2 (en) | 2018-02-12 | 2024-02-20 | Curators Of The University Of Missouri | Small auxin upregulated (SAUR) gene for the improvement of root system architecture, waterlogging tolerance, drought resistance and yield in plants and methods of uses |
WO2020185312A2 (en) | 2019-01-25 | 2020-09-17 | President And Fellows Of Harvard College | Compositions and method for synthesizing nucleic acids |
JP2023506176A (ja) | 2019-12-12 | 2023-02-15 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 光誘導型生体分子バーコーディングのための組成物および方法 |
CA3176545A1 (en) | 2020-04-22 | 2021-10-28 | President And Fellows Of Harvard College | Isothermal methods, compositions, kits, and systems for detecting nucleic acids |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4072574A (en) * | 1976-07-30 | 1978-02-07 | The Institute For Cancer Research | System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents |
US5225556A (en) * | 1985-01-18 | 1993-07-06 | The Trustees Of Columbia University In The City Of New York | Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers |
DE3601136A1 (de) * | 1986-01-16 | 1987-07-23 | Max Planck Gesellschaft | Hemmstoffe der reversen transkriptase fuer prophylaxe und therapie von retrovirus-infektionen in saeugetieren |
CA2065719A1 (en) | 1991-04-30 | 1992-10-31 | John B. Findlay | Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle |
DE69231178T2 (de) * | 1991-08-30 | 2000-11-23 | Syngenix Ltd., Cambridge | Nukleinsäure-amplifikation durch polymerase-reaktion |
US5418162A (en) * | 1991-10-22 | 1995-05-23 | Duke University | Serotonin transporter CDNA |
AU4248593A (en) * | 1992-05-14 | 1993-12-13 | Mark Holodniy | Polymerase chain reaction assays for monitoring antiviral therapy |
DK0590327T3 (da) * | 1992-09-11 | 2003-07-28 | Hoffmann La Roche | Påvisning af nukleinsyrer i blod |
RU2048522C1 (ru) * | 1992-10-14 | 1995-11-20 | Институт белка РАН | Способ размножения нуклеиновых кислот, способ их экспрессии и среда для их осуществления |
US6410277B1 (en) * | 1993-02-19 | 2002-06-25 | Takara Shuzo Co., Ltd. | DNA polymersases with enhanced length of primer extension |
US5436149A (en) * | 1993-02-19 | 1995-07-25 | Barnes; Wayne M. | Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension |
US5556772A (en) * | 1993-12-08 | 1996-09-17 | Stratagene | Polymerase compositions and uses thereof |
US6087097A (en) * | 1994-05-12 | 2000-07-11 | Mayo Foundation For Medical Education And Research | PCR detection of Borrelia burgdorferi |
EP0745687A1 (de) | 1995-04-08 | 1996-12-04 | Roche Diagnostics GmbH | Verfahren zur spezifischen Vervielfältigung und zum Nachweis von DNA bzw. RNA |
US5789206A (en) * | 1995-07-07 | 1998-08-04 | Myriad Genetics, Inc. | Method for ligating adaptors to nucleic acids which methods are useful for obtaining the ends of genes |
US5795722A (en) * | 1997-03-18 | 1998-08-18 | Visible Genetics Inc. | Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample |
CN1137266C (zh) | 1995-12-27 | 2004-02-04 | 宝酒造株式会社 | 新型dna聚合酶 |
CA2243543A1 (en) * | 1996-01-26 | 1997-07-31 | Research Institute For Glycotechnology | Apoptosis inducers |
CA2248981C (en) * | 1996-03-15 | 2009-11-24 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
US5917031A (en) * | 1996-04-19 | 1999-06-29 | Taiko Pharmaceutical Co., Ltd. | Method of synthesizing polydeoxyribonucleotides |
US5928906A (en) * | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
DE69736110T2 (de) | 1996-06-12 | 2007-01-18 | Takara Bio Inc., Otsu | Verwendung von Fucoidin |
JP3463780B2 (ja) | 1996-07-30 | 2003-11-05 | 東洋紡績株式会社 | 核酸増幅用dnaポリメラーゼ組成物 |
DE69725076T2 (de) | 1996-07-29 | 2004-04-15 | Toyo Boseki K.K. | Modifizierte thermostabile DNA Polymerase und eine DNA Polymerasezusammensetzung zur Amplifikation von Nukleinsäuren |
EP1705253B1 (de) * | 1997-04-03 | 2010-11-03 | Life Technologies Corporation | Verfahren und Produkte zur reversen Transkription gekoppelt mit Polymerasekettenreaktion (RT-PCR) |
US5939259A (en) * | 1997-04-09 | 1999-08-17 | Schleicher & Schuell, Inc. | Methods and devices for collecting and storing clinical samples for genetic analysis |
US6348336B1 (en) * | 1997-07-01 | 2002-02-19 | Alpha Therapeutic Corporation | Process for purification of PCR test samples |
KR100559098B1 (ko) * | 1998-09-08 | 2006-03-15 | 다카라 바이오 가부시키가이샤 | Dna 의 합성방법 |
EP0989192A3 (de) | 1998-09-21 | 2004-02-25 | Shimadzu Corporation | Verfahren zur Nucleinsäuresynthese |
JP2001029078A (ja) | 1999-07-16 | 2001-02-06 | Shimadzu Corp | Rna増幅法 |
GB0001450D0 (en) * | 2000-01-21 | 2000-03-08 | Genpoint As | Cell isolation method |
DE10006662A1 (de) * | 2000-02-15 | 2001-08-23 | Antigen Produktions Gmbh | Gefäß zur Nukleinsäureanalytik |
US6350580B1 (en) * | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
US6667165B2 (en) * | 2001-11-13 | 2003-12-23 | Eppendorf Ag | Method and compositions for reversible inhibition of thermostable polymerases |
-
1999
- 1999-04-21 DE DE69941441T patent/DE69941441D1/de not_active Expired - Lifetime
- 1999-04-21 CN CNB998077097A patent/CN1177931C/zh not_active Expired - Lifetime
- 1999-04-21 CA CA002326725A patent/CA2326725A1/en not_active Abandoned
- 1999-04-21 AT AT07104945T patent/ATE443136T1/de not_active IP Right Cessation
- 1999-04-21 JP JP2000544787A patent/JP3748378B2/ja not_active Expired - Lifetime
- 1999-04-21 EP EP07104945A patent/EP1816197B1/de not_active Expired - Lifetime
- 1999-04-21 AU AU35341/99A patent/AU3534199A/en not_active Abandoned
- 1999-04-21 KR KR10-2000-7011784A patent/KR100519895B1/ko not_active IP Right Cessation
- 1999-04-21 US US09/673,884 patent/US7521178B1/en not_active Expired - Fee Related
- 1999-04-21 EP EP09167571.0A patent/EP2116600B1/de not_active Expired - Lifetime
- 1999-04-21 EP EP99917081A patent/EP1072678A4/de not_active Withdrawn
- 1999-04-21 WO PCT/JP1999/002121 patent/WO1999054455A1/ja not_active Application Discontinuation
- 1999-04-21 CN CNA2004100825674A patent/CN1637146A/zh active Pending
-
2005
- 2005-10-14 JP JP2005300626A patent/JP4214142B2/ja not_active Expired - Fee Related
-
2008
- 2008-10-15 US US12/285,866 patent/US8367328B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2326725A1 (en) | 1999-10-28 |
WO1999054455A1 (en) | 1999-10-28 |
EP1072678A4 (de) | 2006-09-27 |
EP1072678A1 (de) | 2001-01-31 |
EP1816197A3 (de) | 2007-11-28 |
KR20010042958A (ko) | 2001-05-25 |
EP2116600B1 (de) | 2013-09-18 |
EP1816197B1 (de) | 2009-09-16 |
EP2116600A3 (de) | 2010-01-13 |
JP3748378B2 (ja) | 2006-02-22 |
CN1306570A (zh) | 2001-08-01 |
EP2116600A2 (de) | 2009-11-11 |
CN1637146A (zh) | 2005-07-13 |
US8367328B2 (en) | 2013-02-05 |
JP4214142B2 (ja) | 2009-01-28 |
AU3534199A (en) | 1999-11-08 |
US20090098613A1 (en) | 2009-04-16 |
JP2006061164A (ja) | 2006-03-09 |
DE69941441D1 (de) | 2009-10-29 |
CN1177931C (zh) | 2004-12-01 |
KR100519895B1 (ko) | 2005-10-13 |
EP1816197A2 (de) | 2007-08-08 |
US7521178B1 (en) | 2009-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |