ATE442354T1 - Pyrrolidinderivate als oxytocin antagonisten - Google Patents
Pyrrolidinderivate als oxytocin antagonistenInfo
- Publication number
- ATE442354T1 ATE442354T1 AT03762692T AT03762692T ATE442354T1 AT E442354 T1 ATE442354 T1 AT E442354T1 AT 03762692 T AT03762692 T AT 03762692T AT 03762692 T AT03762692 T AT 03762692T AT E442354 T1 ATE442354 T1 AT E442354T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- pyrrolidine derivatives
- oxytocin antagonists
- sup
- forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02100784 | 2002-07-05 | ||
| PCT/EP2003/050286 WO2004005249A1 (en) | 2002-07-05 | 2003-07-04 | Pyrrolidine derivatives as oxytocin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442354T1 true ATE442354T1 (de) | 2009-09-15 |
Family
ID=30011225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03762692T ATE442354T1 (de) | 2002-07-05 | 2003-07-04 | Pyrrolidinderivate als oxytocin antagonisten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7115754B2 (de) |
| EP (1) | EP1532109B1 (de) |
| JP (1) | JP4851085B2 (de) |
| CN (1) | CN1330633C (de) |
| AT (1) | ATE442354T1 (de) |
| BR (1) | BR0312586A (de) |
| CA (1) | CA2487532C (de) |
| DE (1) | DE60329189D1 (de) |
| EA (1) | EA008479B1 (de) |
| ES (1) | ES2330841T3 (de) |
| HK (1) | HK1076107A1 (de) |
| HR (1) | HRP20041208A2 (de) |
| IL (1) | IL166103A0 (de) |
| MX (1) | MXPA05000326A (de) |
| NO (1) | NO20050612L (de) |
| PL (1) | PL374666A1 (de) |
| RS (1) | RS115804A (de) |
| UA (1) | UA78058C2 (de) |
| WO (1) | WO2004005249A1 (de) |
| ZA (1) | ZA200409820B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS99503A (en) * | 2001-06-18 | 2006-12-15 | Applied Research Systems Ars Holding N.V. | Pyrrolidine oxadiazole- and thiadiazole derivatives |
| US10722645B2 (en) | 2011-12-21 | 2020-07-28 | Deka Products Limited Partnership | Syringe pump, and related method and system |
| EP2845850A1 (de) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidinderivate als Oxytocin/Vasopressin-V1a-Rezeptorantagonisten |
| EP2886107A1 (de) * | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Orale Formulierungen von Pyrrolydinderivaten |
| CN114105851A (zh) * | 2014-07-02 | 2022-03-01 | 奥布赛瓦股份公司 | 治疗ot-r活性相关的病症的方法中可用的晶体 |
| PL3037101T3 (pl) * | 2014-12-22 | 2019-06-28 | Ferring B.V. | Terapia antagonistą receptora oksytocyny w fazie lutealnej w celu implantacji i uzyskania ciąży u kobiet poddawanych technikom wspomaganego rozrodu |
| AU2017205254B2 (en) | 2016-01-04 | 2021-05-20 | Xoma (Us) Lcc | Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof |
| EP4056178A1 (de) | 2016-07-21 | 2022-09-14 | ObsEva S.A. | Oxytocinantagonistdosierungsschemen zur förderung der embryoimplantation und zur vorbeugung von fehlgeburt |
| EP4025207A1 (de) | 2019-09-03 | 2022-07-13 | ObsEva S.A. | Oxytocinantagonistdosierungsschemen zur förderung der embryoimplantation und zur vorbeugung von fehlgeburt |
| CN115380122A (zh) | 2020-02-10 | 2022-11-22 | 奥布赛瓦股份公司 | 用于催产素受体拮抗剂疗法的生物标志物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329418B1 (en) * | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
| KR100714585B1 (ko) * | 2000-03-27 | 2007-05-07 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 약학적인 활성 피롤리딘 유도체 |
-
2003
- 2003-04-07 UA UA20041210895A patent/UA78058C2/uk unknown
- 2003-07-04 JP JP2004518783A patent/JP4851085B2/ja not_active Expired - Fee Related
- 2003-07-04 EP EP03762692A patent/EP1532109B1/de not_active Expired - Lifetime
- 2003-07-04 CA CA2487532A patent/CA2487532C/en not_active Expired - Fee Related
- 2003-07-04 ES ES03762692T patent/ES2330841T3/es not_active Expired - Lifetime
- 2003-07-04 PL PL03374666A patent/PL374666A1/xx not_active Application Discontinuation
- 2003-07-04 CN CNB038204010A patent/CN1330633C/zh not_active Expired - Fee Related
- 2003-07-04 DE DE60329189T patent/DE60329189D1/de not_active Expired - Lifetime
- 2003-07-04 AT AT03762692T patent/ATE442354T1/de not_active IP Right Cessation
- 2003-07-04 RS YUP-1158/04A patent/RS115804A/sr unknown
- 2003-07-04 WO PCT/EP2003/050286 patent/WO2004005249A1/en active Application Filing
- 2003-07-04 MX MXPA05000326A patent/MXPA05000326A/es active IP Right Grant
- 2003-07-04 US US10/518,543 patent/US7115754B2/en not_active Expired - Lifetime
- 2003-07-04 EA EA200500133A patent/EA008479B1/ru not_active IP Right Cessation
- 2003-07-04 BR BR0312586-6A patent/BR0312586A/pt not_active IP Right Cessation
-
2004
- 2004-12-03 ZA ZA200409820A patent/ZA200409820B/en unknown
- 2004-12-23 HR HR20041208A patent/HRP20041208A2/xx not_active Application Discontinuation
-
2005
- 2005-01-03 IL IL16610305A patent/IL166103A0/xx unknown
- 2005-02-03 NO NO20050612A patent/NO20050612L/no not_active Application Discontinuation
- 2005-11-17 HK HK05110274A patent/HK1076107A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL166103A0 (en) | 2006-01-15 |
| DE60329189D1 (de) | 2009-10-22 |
| BR0312586A (pt) | 2005-04-12 |
| HK1076107A1 (en) | 2006-01-06 |
| CA2487532C (en) | 2011-03-08 |
| JP4851085B2 (ja) | 2012-01-11 |
| EP1532109A1 (de) | 2005-05-25 |
| PL374666A1 (en) | 2005-10-31 |
| US7115754B2 (en) | 2006-10-03 |
| CA2487532A1 (en) | 2004-01-15 |
| ES2330841T3 (es) | 2009-12-16 |
| CN1330633C (zh) | 2007-08-08 |
| US20060004020A1 (en) | 2006-01-05 |
| AU2003254498A1 (en) | 2004-01-23 |
| MXPA05000326A (es) | 2005-03-31 |
| EP1532109B1 (de) | 2009-09-09 |
| EA008479B1 (ru) | 2007-06-29 |
| UA78058C2 (en) | 2007-02-15 |
| WO2004005249A1 (en) | 2004-01-15 |
| ZA200409820B (en) | 2006-07-26 |
| CN1678576A (zh) | 2005-10-05 |
| NO20050612L (no) | 2005-02-03 |
| HRP20041208A2 (en) | 2005-06-30 |
| JP2005533828A (ja) | 2005-11-10 |
| EA200500133A1 (ru) | 2005-08-25 |
| RS115804A (en) | 2007-02-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20050612L (no) | Pyrrolidinderivater som oksytocinantagonister | |
| EA200301216A1 (ru) | Замещенные хинуклидинами мультициклические гетероарилы для лечения заболевания | |
| ATE253545T1 (de) | Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren | |
| ATE368656T1 (de) | Piperidinderivate zur verwendung bei der behandlung von durch chemokins vermittelten leiden | |
| NO20053794L (no) | N-(1-benzyl-2-oxo-2-(1-piperazinyl) etyl)-1-piperidinkarboksamid-derivater og relaterte forbindelsers bruk som CGRP-antagonister for behandling av hodepine. | |
| ATE357434T1 (de) | Disubstituierte thiazolylcarboxanilide und ihre verwendung als mikrobizide | |
| NO20050134L (no) | Difenylazetidioner substituert med syregrupper, fremgangsmate for fremstilling av disse, medikamenter inneholdende disse forbindelser og deres anvendelse | |
| NO20072605L (no) | Nytt antranilinsyrederivat eller et salt derav | |
| ATE440087T1 (de) | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen | |
| NO20055977L (no) | Nye benzimidazolderivater | |
| ATE384061T1 (de) | Imidazo- und thiazolopyridine als jak3-kinase- inhibitoren | |
| NO20062950L (no) | 5,7-diaminopyrazolo `43-Dlpyrimidiner med PDE-5 inhiberende aktivitet | |
| PE20021002A1 (es) | Compuestos heterociclicos condensados | |
| EA200500342A1 (ru) | Гетероциклические замещённые пиперазины для лечения шизофрении | |
| AR041298A1 (es) | Derivados de pirrolidona como inhibidores de maob | |
| NO20053762L (no) | Kondensert furanforbindelse. | |
| NO20062021L (no) | Omleirede pentanoler, fremgangsmpte for fremstilling av dette, og deres anvendelse som antiflogistika | |
| ATE540928T1 (de) | Isochinolinverbindungen und ihre medizinische verwendung | |
| NO20060718L (no) | Substituerte tiofoner og deres anvendelse | |
| NO20050270L (no) | Nye forbindelser, deres anvendelse og fremstilling | |
| DE60335404D1 (de) | Verwendung von 4-aminochinolin-verbindungen zur behandlung entzündlicher erkrankungen des auges | |
| CO5680420A2 (es) | Compuestos de 6-amino-1h-indazol y 4-aminobenzenofurano como inhibidores de la fosfodiesterasa 4 | |
| EA200301203A1 (ru) | Новые соединения и композиции как ингибиторы катепсина | |
| NO20054418L (no) | Substituert benzoylureidopyridylpiperidin- og -pyrrolidinkarboksylsyrederivater, deres fremstilling og anvendelse | |
| DE50304891D1 (de) | N-aryl-4,5-diaminopyrazole und diese verbindungen enthaltende färbemittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |