ATE440888T1 - Verfahren zur herstellung von glatiramer - Google Patents
Verfahren zur herstellung von glatiramerInfo
- Publication number
- ATE440888T1 ATE440888T1 AT05824006T AT05824006T ATE440888T1 AT E440888 T1 ATE440888 T1 AT E440888T1 AT 05824006 T AT05824006 T AT 05824006T AT 05824006 T AT05824006 T AT 05824006T AT E440888 T1 ATE440888 T1 AT E440888T1
- Authority
- AT
- Austria
- Prior art keywords
- glatiramer
- producing
- producing glatiramer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62334604P | 2004-10-29 | 2004-10-29 | |
US65153505P | 2005-02-09 | 2005-02-09 | |
US65137205P | 2005-02-09 | 2005-02-09 | |
US72390105P | 2005-10-05 | 2005-10-05 | |
PCT/US2005/039003 WO2006050122A1 (en) | 2004-10-29 | 2005-10-27 | Processes for preparing glatiramer |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE440888T1 true ATE440888T1 (de) | 2009-09-15 |
Family
ID=36046637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05824006T ATE440888T1 (de) | 2004-10-29 | 2005-10-27 | Verfahren zur herstellung von glatiramer |
Country Status (14)
Country | Link |
---|---|
US (5) | US20060154862A1 (de) |
EP (1) | EP1807467B1 (de) |
JP (1) | JP5297653B2 (de) |
CN (1) | CN101044188B (de) |
AR (1) | AR052321A1 (de) |
AT (1) | ATE440888T1 (de) |
AU (1) | AU2005302500B2 (de) |
CA (1) | CA2583589C (de) |
DE (1) | DE602005016292D1 (de) |
ES (1) | ES2331015T3 (de) |
IL (2) | IL182581A (de) |
SI (1) | SI1807467T1 (de) |
TW (1) | TWI307349B (de) |
WO (1) | WO2006050122A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1459065T1 (sl) | 2001-12-04 | 2010-11-30 | Teva Pharma | Postopki za merjenje potentnosti glatiramer acetata |
EP1797109B1 (de) | 2004-09-09 | 2016-02-24 | Yeda Research And Development Co., Ltd. | Mischungen von polypeptiden, zusammensetzungen, die diese enthalten, und verfahren zu deren herstellung, und deren anwendungen |
JP5297653B2 (ja) * | 2004-10-29 | 2013-09-25 | サンド・アクチエンゲゼルシヤフト | グラチラマーの製造法 |
WO2007081975A2 (en) * | 2006-01-11 | 2007-07-19 | Teva Pharmaceutical Industries, Ltd. | Method of treating multiple sclerosis |
JP2009542864A (ja) * | 2006-07-05 | 2009-12-03 | モメンタ ファーマシューティカルズ インコーポレイテッド | コポリマー1の調製のための改良法 |
EP2381254B2 (de) | 2007-06-21 | 2017-07-19 | Momenta Pharmaceuticals, Inc. | Copolymeranalyse |
US20090035816A1 (en) * | 2007-08-02 | 2009-02-05 | Scinopharm Taiwan Ltd. | Process for the preparation of a polypeptide |
EP2277050B2 (de) | 2008-04-16 | 2022-09-28 | Momenta Pharmaceuticals, Inc. | Analyse von aminosäurecopolymerzusammensetzungen |
PL2307448T3 (pl) | 2008-08-07 | 2015-10-30 | Sigma Aldrich Co Llc | Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością |
JP2011530523A (ja) * | 2008-08-07 | 2011-12-22 | サイノファーム タイワン リミテッド | 酢酸グラチラマーの合成 |
US9617313B2 (en) | 2008-12-24 | 2017-04-11 | Synthon Bv | Process for purifying a polymer mixture |
WO2010115175A1 (en) * | 2009-04-03 | 2010-10-07 | Momenta Pharmaceticals, Inc. | Control of copolymer compositions |
DK2275086T3 (da) | 2009-07-15 | 2012-07-09 | Teva Pharma | Reduceret volumenformulering af glatirameracetat og fremgangsmåder til administration heraf |
US8920373B2 (en) | 2009-07-15 | 2014-12-30 | Teva Pharmaceutical Industries, Ltd. | Reduced volume formulation of glatiramer acetate and methods of administration |
EP2405749B1 (de) | 2009-08-20 | 2013-05-08 | Yeda Research and Development Co., Ltd. | Niedrigfrequente glatiramerazetattherapie |
US8790665B2 (en) * | 2009-11-17 | 2014-07-29 | Ares Trading Sa | Serum protein-based detection of random sequence polymer compositions |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
MX2012012489A (es) * | 2010-04-27 | 2012-12-17 | Reddys Lab Ltd Dr | Preparacion de polipeptidos y sales de los mismos. |
WO2012016042A2 (en) * | 2010-07-29 | 2012-02-02 | Dr. Reddy's Laboratories Ltd. | Glatiramer acetate molecular weight markers |
NZ609938A (en) | 2010-10-11 | 2015-11-27 | Teva Pharma | Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate |
US9029507B2 (en) | 2011-02-14 | 2015-05-12 | Usv Limited | Copolymer-1, process for preparation and analytical methods thereof |
WO2012114167A1 (en) * | 2011-02-24 | 2012-08-30 | Biocon Limited | Processes for the preparation of glatiramer acetate |
WO2013009864A1 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Structure assessment of heterogeneous polypeptide mixtures |
WO2013009885A2 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation of copolymer diethylamide |
US8575198B1 (en) | 2011-09-07 | 2013-11-05 | Momenta Pharmaceuticals, Inc. | In-process control for the manufacture of glatiramer acetate |
TW201326399A (zh) | 2011-10-10 | 2013-07-01 | Teva Pharma | 用於預測對格拉替雷(glatiramer)醋酸鹽之臨床反應之單核苷酸多型性之判定 |
AU2012330728A1 (en) * | 2011-11-03 | 2014-06-26 | Biocon Limited | Process for the preparation of random polypeptides and employing circular dichroism as a guidance tool for the manufacture of glatiramer acetate |
US20140045740A1 (en) * | 2012-08-13 | 2014-02-13 | Momenta Pharmaceuticals, Inc. | Analysis of glatiramer acetate |
US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
EP3433430B1 (de) | 2016-03-23 | 2022-08-17 | A.L.M. Holding Company | Chargenasphaltmischanlage |
EP3600553A4 (de) | 2017-03-26 | 2020-09-02 | Mapi Pharma Ltd. | Glatiramerdepotsysteme zur behandlung progressiver formen von multipler sklerose |
CN107082796B (zh) * | 2017-05-02 | 2020-06-09 | 江苏大学 | 一种提纯蛋白酶解物中小分子多肽的方法 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2657972A (en) * | 1952-09-06 | 1953-11-03 | Robert B Woodward | Copolymer of l-leucine and dl-phenylalanine |
US3704282A (en) * | 1971-04-09 | 1972-11-28 | Sidney Spector | Catecholamine antigens and antibodies specific therefor |
IL36670A (en) * | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
HU174500B (hu) * | 1976-05-05 | 1980-01-28 | Richter Gedeon Vegyeszet | Sposob poluchenija slozhnogo oktapeptidamid-sul'fatnogo ehfira kholecistokhinin-pankreozimina |
JPS6053535A (ja) * | 1983-09-02 | 1985-03-27 | Nitto Boseki Co Ltd | 規則性ポリアミノ酸樹脂の製造方法 |
SU1182051A1 (ru) | 1984-04-28 | 1985-09-30 | Таджикский государственный университет им.В.И.Ленина | Политрипептиды,обладающие энантовой селективностью в реакци х гидролиза @ -нитрофениловых эфиров карбобензокси - @ - и @ -аланина |
AR247097A1 (es) | 1985-06-18 | 1994-11-30 | Univ Emory | Procedimiento para preparar composiciones farmaceuticas que incluyen copolimeros biologicamente activos como agente activo. |
DD257174A3 (de) | 1985-12-20 | 1988-06-08 | Ve Forschungszentrum Biotechno | Verfahren zur herstellung der peptide z-ala-ala-lon-p-nitranilid oder z-asp-phe-ome mit metalloprotease |
CA2009996A1 (en) | 1989-02-17 | 1990-08-17 | Kathleen S. Cook | Process for making genes encoding random polymers of amino acids |
DE3930733A1 (de) | 1989-09-14 | 1991-03-28 | Roehm Gmbh | Verfahren zur herstellung eines komplexierten arzneimittels |
US5800808A (en) * | 1994-05-24 | 1998-09-01 | Veda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
GB9411292D0 (en) | 1994-06-06 | 1994-07-27 | Teva Pharma | Pharmaceuticals compositions |
CA2213317C (en) * | 1996-01-16 | 2001-07-03 | Lumigen, Inc. | Chemiluminescent compositions for reaction with phosphatase enzymes, and methods of use |
US6271198B1 (en) * | 1996-11-06 | 2001-08-07 | Genentech, Inc. | Constrained helical peptides and methods of making same |
US6214791B1 (en) * | 1997-01-10 | 2001-04-10 | Yeda Research And Development Co. Ltd. | Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1 |
US6514935B1 (en) * | 1997-03-14 | 2003-02-04 | President And Fellows Of Harvard | Methods of treating hypertension |
US6632541B2 (en) * | 1998-02-10 | 2003-10-14 | Sumitomo Chemical Company, Limited | Olefin-based copolymer composition |
US7906153B2 (en) * | 1998-04-08 | 2011-03-15 | Theta Biomedical Consulting & Development Co., Inc. | Anti-inflammatory compositions for treating multiple sclerosis |
IL141423A (en) * | 1998-08-27 | 2005-09-25 | Teva Pharma | Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
US6800287B2 (en) * | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
US6514938B1 (en) | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
WO2000027417A1 (en) | 1998-11-12 | 2000-05-18 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd |
JP2000256395A (ja) * | 1999-01-07 | 2000-09-19 | Takeda Chem Ind Ltd | ポリオール類、その製造法および用途 |
DE60041365D1 (de) * | 1999-06-04 | 2009-02-26 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Verwendung von Riluzol zur Behandlung Multipler Sklerose |
US6531130B1 (en) * | 1999-07-06 | 2003-03-11 | The Board Of Trustees Of The Leland Stanford University | Treatment of demyelinating autoimmune disease with ordered peptides |
US6963008B2 (en) * | 1999-07-19 | 2005-11-08 | Teva Pharmaceutical Industries Ltd. | Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
US6995237B1 (en) * | 1999-10-27 | 2006-02-07 | Cel-Sci Corporation | Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions |
AU780188B2 (en) * | 2000-01-20 | 2005-03-03 | Yeda Research And Development Co. Ltd. | The use of copolymer 1 and related peptides and polypeptides and T cells treated therewith for neuroprotective therapy |
US20020077278A1 (en) * | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
IL157073A0 (en) * | 2001-01-24 | 2004-02-08 | Harvard College | Therapeutic peptides for demyelinating conditions |
US6936599B2 (en) * | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
PE20030701A1 (es) * | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
CA2411786C (en) * | 2002-11-13 | 2009-01-27 | Brantford Chemicals Inc. | A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids |
EP1565486A2 (de) * | 2002-11-13 | 2005-08-24 | Apotex Pharmachem Inc. | Verfahren zur herstellung von glatirameracetat durch polymerisierung von n-carbonsäureanhydriden vonl-alanin, l-tyrosin, benzyl-l-glutamat und benzyloxycarbonyl-l-lysin |
US6936539B2 (en) * | 2003-09-24 | 2005-08-30 | Micron Technology, Inc. | Antireflective coating for use during the manufacture of a semiconductor device |
DE602005018800D1 (de) * | 2004-09-09 | 2010-02-25 | Teva Pharma | Verfahren zur herstellung von polypeptidmischungen unter anwendung von aufgereinigter bromwasserstoffsäure |
JP5297653B2 (ja) * | 2004-10-29 | 2013-09-25 | サンド・アクチエンゲゼルシヤフト | グラチラマーの製造法 |
US8420605B2 (en) * | 2005-09-07 | 2013-04-16 | The University Of Strathclyde | Hydrogel compositions |
-
2005
- 2005-10-27 JP JP2007539184A patent/JP5297653B2/ja not_active Expired - Fee Related
- 2005-10-27 WO PCT/US2005/039003 patent/WO2006050122A1/en active Application Filing
- 2005-10-27 AU AU2005302500A patent/AU2005302500B2/en not_active Ceased
- 2005-10-27 EP EP05824006A patent/EP1807467B1/de active Active
- 2005-10-27 AT AT05824006T patent/ATE440888T1/de active
- 2005-10-27 AR ARP050104513A patent/AR052321A1/es not_active Application Discontinuation
- 2005-10-27 ES ES05824006T patent/ES2331015T3/es active Active
- 2005-10-27 DE DE602005016292T patent/DE602005016292D1/de active Active
- 2005-10-27 SI SI200530809T patent/SI1807467T1/sl unknown
- 2005-10-27 CA CA2583589A patent/CA2583589C/en not_active Expired - Fee Related
- 2005-10-27 CN CN2005800357997A patent/CN101044188B/zh not_active Expired - Fee Related
- 2005-10-28 US US11/262,122 patent/US20060154862A1/en not_active Abandoned
- 2005-10-28 TW TW094137997A patent/TWI307349B/zh not_active IP Right Cessation
-
2007
- 2007-04-16 IL IL182581A patent/IL182581A/en not_active IP Right Cessation
- 2007-09-27 US US11/904,422 patent/US8536305B2/en not_active Expired - Fee Related
-
2010
- 2010-03-18 US US12/726,571 patent/US8729229B2/en not_active Expired - Fee Related
- 2010-03-19 US US12/727,758 patent/US20100174048A1/en not_active Abandoned
- 2010-03-19 US US12/727,653 patent/US20100234566A1/en not_active Abandoned
-
2014
- 2014-07-10 IL IL233618A patent/IL233618A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2583589A1 (en) | 2006-05-11 |
US20100234272A1 (en) | 2010-09-16 |
AR052321A1 (es) | 2007-03-14 |
US20100234566A1 (en) | 2010-09-16 |
CN101044188A (zh) | 2007-09-26 |
US8536305B2 (en) | 2013-09-17 |
SI1807467T1 (sl) | 2009-12-31 |
WO2006050122A1 (en) | 2006-05-11 |
DE602005016292D1 (de) | 2009-10-08 |
CN101044188B (zh) | 2010-08-04 |
US20080021200A1 (en) | 2008-01-24 |
ES2331015T3 (es) | 2009-12-18 |
EP1807467A1 (de) | 2007-07-18 |
IL182581A (en) | 2015-09-24 |
EP1807467B1 (de) | 2009-08-26 |
US20100174048A1 (en) | 2010-07-08 |
US8729229B2 (en) | 2014-05-20 |
JP5297653B2 (ja) | 2013-09-25 |
AU2005302500B2 (en) | 2008-11-27 |
CA2583589C (en) | 2012-04-24 |
TWI307349B (en) | 2009-03-11 |
IL233618A (en) | 2016-05-31 |
JP2008518930A (ja) | 2008-06-05 |
IL182581A0 (en) | 2007-07-24 |
US20060154862A1 (en) | 2006-07-13 |
TW200634051A (en) | 2006-10-01 |
IL233618A0 (en) | 2014-08-31 |
AU2005302500A1 (en) | 2006-05-11 |
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Legal Events
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