ATE440865T1 - Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region - Google Patents

Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region

Info

Publication number
ATE440865T1
ATE440865T1 AT99914138T AT99914138T ATE440865T1 AT E440865 T1 ATE440865 T1 AT E440865T1 AT 99914138 T AT99914138 T AT 99914138T AT 99914138 T AT99914138 T AT 99914138T AT E440865 T1 ATE440865 T1 AT E440865T1
Authority
AT
Austria
Prior art keywords
protein
receptors
mammal
coupled
new
Prior art date
Application number
AT99914138T
Other languages
English (en)
Inventor
Aaron Hsueh
Sheau Hsu
Shan-Guang Liang
Der Spek Petrus Van
Original Assignee
Univ Leland Stanford Junior
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Akzo Nobel Nv filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE440865T1 publication Critical patent/ATE440865T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99914138T 1998-03-26 1999-03-25 Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region ATE440865T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7950198P 1998-03-26 1998-03-26
PCT/US1999/006573 WO1999048921A1 (en) 1998-03-26 1999-03-25 Novel mammalian g-protein coupled receptors having extracellular leucine rich repeat regions

Publications (1)

Publication Number Publication Date
ATE440865T1 true ATE440865T1 (de) 2009-09-15

Family

ID=22150958

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99914138T ATE440865T1 (de) 1998-03-26 1999-03-25 Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region

Country Status (6)

Country Link
EP (1) EP1066324B1 (de)
JP (2) JP2002507406A (de)
AT (1) ATE440865T1 (de)
DE (1) DE69941330D1 (de)
ES (1) ES2332025T3 (de)
WO (1) WO1999048921A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
US20020061556A1 (en) * 2000-04-27 2002-05-23 Walke D. Wade Novel membrane proteins and polynucleotides encoding the same
WO2001009323A1 (fr) * 1999-07-29 2001-02-08 Helix Research Institute Recepteurs couples a des proteines de liaison guanosine triphosphate, genes correspondants et production et utilisation de ceux-ci
WO2001014548A2 (en) * 1999-08-19 2001-03-01 Merck Patent Gmbh New g-protein coupled receptor and dna sequences thereof
WO2001027275A1 (en) * 1999-10-13 2001-04-19 Lexicon Genetics Incorporated Novel human membrane proteins
GB9924956D0 (en) * 1999-10-21 1999-12-22 Pfizer Ltd Novel polypeptide
NZ518662A (en) * 1999-11-17 2004-10-29 Arena Pharm Inc Endogenous and non-endogenous versions of human G protein-coupled receptors
AU2001239756A1 (en) * 2000-02-08 2001-08-20 Curagen Corporation Novel proteins and nucleic acids encoding same
EP1290030A2 (de) * 2000-05-30 2003-03-12 Bayer Aktiengesellschaft Regulation eines menschlichen lgr4-ähnlichen g protein-gekoppelten rezeptors
WO2002000689A2 (en) * 2000-06-30 2002-01-03 Ingenium Pharmaceuticals Ag HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR11, AND USES THEREOF
AU2001269462A1 (en) * 2000-07-07 2002-01-21 Takeda Chemical Industries Ltd. Novel g protein-coupled receptor protein and dna thereof
AU2001283254A1 (en) * 2000-08-10 2002-02-25 Amgen Inc. Leucine-rich repeat-containing G-protein coupled receptor-8 molecules and uses thereof
WO2002016600A2 (en) * 2000-08-25 2002-02-28 Curagen Corporation Novel proteins and nucleic acids encoding same
AU2001294841A1 (en) * 2000-09-27 2002-04-08 Bristol-Myers Squibb Company A novel human g-protein coupled receptor, hgprbmy5, expressed highly in brain and ovarian tissues
CA2437717A1 (en) * 2001-02-07 2002-08-15 Incyte Genomics, Inc. G-protein coupled receptors
CA2456753A1 (en) 2001-08-17 2003-02-27 The Board Of Trustees Of The Leland Stanford Junior University Mammalian relaxin receptors
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
WO2003093827A2 (en) * 2002-05-02 2003-11-13 Bayer Healthcare Ag Diagnostics and drug screening for diseases associated with leucine-rich repeat-containing g-protein coupled receptor 7 (lgr7)
EP1380644A1 (de) * 2002-07-08 2004-01-14 Kylix B.V. Verwendung spezifischer TCF Zielgene zur Identifizierung von Medikamenten zur Behandlung von Krebsarten, insbesondere Colorectalkrebs, bei denen TCF/beta-catenin/WNT Signaltransduktion eine zentrale Rolle spielt
CA2511907A1 (en) * 2003-01-06 2004-07-22 Wyeth Compositions and methods for diagnosing and treating colon cancers
DE10339820A1 (de) * 2003-08-22 2005-03-17 Hinzmann, Bernd, Dr. Verwendung von an GPR49 bindenden Substanzen zur Diagnose und Behandlung von Krebs
WO2005040828A2 (en) * 2003-10-24 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 49 (gpr49)
US7189539B2 (en) 2003-11-25 2007-03-13 Bristol-Myers Squibb Company Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1
US8158757B2 (en) 2007-07-02 2012-04-17 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
AU2008321840B2 (en) 2007-11-14 2014-02-06 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-GPR49 antibody
WO2010074192A1 (ja) * 2008-12-26 2010-07-01 国立大学法人東京大学 抗lgr7抗体を用いる癌の診断および治療
WO2010113988A1 (ja) * 2009-03-31 2010-10-07 国立大学法人三重大学 抗ｇｐｃｒ抗体の製造方法および抗ｇｐｃｒ抗体
CN106167526A (zh) 2011-07-15 2016-11-30 昂考梅德药品有限公司 Rspo结合剂和其应用
MX2015000565A (es) 2012-07-13 2015-04-10 Oncomed Pharm Inc Agentes de union de proteina de r-espondina humana (rspo3) y usos de los mismos.
CA2961374A1 (en) 2014-09-16 2016-03-24 Oncomed Pharmaceuticals, Inc. Treatment of fibrotic diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614363A (en) 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
US5858716A (en) * 1997-05-30 1999-01-12 Smithkline Beecham Corporation H2CAA71 polynucleotides
WO1999015545A1 (en) * 1997-09-24 1999-04-01 Merck & Co., Inc. G-protein coupled glycoprotein hormone receptor aomf05

Also Published As

Publication number Publication date
EP1066324A1 (de) 2001-01-10
EP1066324A4 (de) 2005-06-15
ES2332025T3 (es) 2010-01-22
WO1999048921A1 (en) 1999-09-30
DE69941330D1 (de) 2009-10-08
JP2002507406A (ja) 2002-03-12
EP1066324B1 (de) 2009-08-26
JP2010166923A (ja) 2010-08-05

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