ATE434131T1 - System zur handhabung einer fluidmenge - Google Patents

System zur handhabung einer fluidmenge

Info

Publication number
ATE434131T1
ATE434131T1 AT04799095T AT04799095T ATE434131T1 AT E434131 T1 ATE434131 T1 AT E434131T1 AT 04799095 T AT04799095 T AT 04799095T AT 04799095 T AT04799095 T AT 04799095T AT E434131 T1 ATE434131 T1 AT E434131T1
Authority
AT
Austria
Prior art keywords
fluid
droplet
control electrodes
counter electrode
fluid droplet
Prior art date
Application number
AT04799095T
Other languages
English (en)
Inventor
Michel Decre
Thomas Duriez
Stein Kuiper
Original Assignee
Koninkl Philips Electronics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv filed Critical Koninkl Philips Electronics Nv
Application granted granted Critical
Publication of ATE434131T1 publication Critical patent/ATE434131T1/de

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B17/00—Methods preventing fouling
    • B08B17/02—Preventing deposition of fouling or of dust
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0493—Specific techniques used
    • B01L2400/0496—Travelling waves, e.g. in combination with electrical or acoustic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
    • B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
    • B41J2/01—Ink jet
    • B41J2/135—Nozzles
    • B41J2/14—Structure thereof only for on-demand ink jet heads
    • B41J2002/14395—Electrowetting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Fats And Perfumes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Coating Apparatus (AREA)
  • Control Of Non-Electrical Variables (AREA)
AT04799095T 2003-11-17 2004-11-09 System zur handhabung einer fluidmenge ATE434131T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03104229 2003-11-17
PCT/IB2004/052355 WO2005047696A1 (en) 2003-11-17 2004-11-09 System for manipulation of a body of fluid

Publications (1)

Publication Number Publication Date
ATE434131T1 true ATE434131T1 (de) 2009-07-15

Family

ID=34585907

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04799095T ATE434131T1 (de) 2003-11-17 2004-11-09 System zur handhabung einer fluidmenge

Country Status (7)

Country Link
US (1) US7328979B2 (de)
EP (1) EP1687531B1 (de)
JP (1) JP4773360B2 (de)
CN (1) CN100478075C (de)
AT (1) ATE434131T1 (de)
DE (1) DE602004021624D1 (de)
WO (1) WO2005047696A1 (de)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005122672A2 (en) * 2004-06-16 2005-12-29 The University Of British Columbia Microfluidic transport by electrostatic deformation of fluidic interfaces
JP4539213B2 (ja) * 2004-07-27 2010-09-08 ブラザー工業株式会社 液体移送装置
JP5897780B2 (ja) 2005-01-28 2016-03-30 デューク ユニバーシティ プリント回路基板上の液滴操作装置及び方法
CN101208259B (zh) * 2005-04-25 2011-07-06 新加坡科技研究局 用于在微通道中使用疏水性控制部件来泵送连续液柱的***和方法
KR101431775B1 (ko) 2005-05-11 2014-08-20 듀크 유니버서티 복수의 온도에서 생화학적 또는 화학적 반응을 수행하기위한 방법 및 장치
FR2887705B1 (fr) * 2005-06-27 2007-08-10 Commissariat Energie Atomique Dispositif de pompage ou de centrifugation des gouttes deplacees par electromouillage
KR100781739B1 (ko) * 2005-09-28 2007-12-03 삼성전자주식회사 전기습윤에서 액적의 접촉각 변위 및 변화속도 증가방법 및상기 방법에 의해 형성된 액적을 적용한 액적제어장치
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
WO2009140671A2 (en) 2008-05-16 2009-11-19 Advanced Liquid Logic, Inc. Droplet actuator devices and methods for manipulating beads
WO2007123908A2 (en) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US8980198B2 (en) * 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US7727723B2 (en) 2006-04-18 2010-06-01 Advanced Liquid Logic, Inc. Droplet-based pyrosequencing
US8716015B2 (en) * 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US7901947B2 (en) 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
US9675972B2 (en) 2006-05-09 2017-06-13 Advanced Liquid Logic, Inc. Method of concentrating beads in a droplet
EP2084404A4 (de) * 2006-11-07 2017-03-29 WCH Technologies Corporation Fläche zur bewegung eines fluids über elektronische randfelder
US20100024908A1 (en) * 2006-11-27 2010-02-04 Takashi Yasuda Microvolume liquid dispensing device
FR2909293B1 (fr) * 2006-12-05 2011-04-22 Commissariat Energie Atomique Micro-dispositif de traitement d'echantillons liquides
WO2008091848A2 (en) * 2007-01-22 2008-07-31 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
CA2712863C (en) 2007-02-09 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods employing magnetic beads
WO2008101194A2 (en) 2007-02-15 2008-08-21 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
EP2837692A1 (de) 2007-03-22 2015-02-18 Advanced Liquid Logic, Inc. Enzymassays für einen Tropfenaktuator
WO2011084703A2 (en) 2009-12-21 2011-07-14 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
BRPI0809978A2 (pt) * 2007-04-10 2014-10-07 Advanced Liquid Logic Inc Dispositivos e métodos de dispensação de gotículas
WO2009002920A1 (en) 2007-06-22 2008-12-31 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification in a temperature gradient
AU2008293652B2 (en) * 2007-08-24 2013-02-21 Advanced Liquid Logic, Inc. Bead manipulations on a droplet actuator
WO2009032863A2 (en) 2007-09-04 2009-03-12 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
US20100236928A1 (en) * 2007-10-17 2010-09-23 Advanced Liquid Logic, Inc. Multiplexed Detection Schemes for a Droplet Actuator
WO2009052095A1 (en) * 2007-10-17 2009-04-23 Advanced Liquid Logic, Inc. Reagent storage and reconstitution for a droplet actuator
US20100236929A1 (en) * 2007-10-18 2010-09-23 Advanced Liquid Logic, Inc. Droplet Actuators, Systems and Methods
EP2232535A4 (de) * 2007-12-10 2016-04-13 Advanced Liquid Logic Inc Tröpfchenaktorkonfigurationen und verfahren
JP5462183B2 (ja) 2007-12-23 2014-04-02 アドヴァンスト リキッド ロジック インコーポレイテッド 液滴動作を導く液滴アクチュエータ構成及び方法
US8367370B2 (en) * 2008-02-11 2013-02-05 Wheeler Aaron R Droplet-based cell culture and cell assays using digital microfluidics
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
US20110097763A1 (en) * 2008-05-13 2011-04-28 Advanced Liquid Logic, Inc. Thermal Cycling Method
US8187864B2 (en) 2008-10-01 2012-05-29 The Governing Council Of The University Of Toronto Exchangeable sheets pre-loaded with reagent depots for digital microfluidics
US8053239B2 (en) 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
CA2740113C (en) 2008-10-10 2019-12-24 The Governing Council Of The University Of Toronto Hybrid digital and channel microfluidic devices and methods of use thereof
US8877512B2 (en) * 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US8202736B2 (en) * 2009-02-26 2012-06-19 The Governing Council Of The University Of Toronto Method of hormone extraction using digital microfluidics
US9851365B2 (en) 2009-02-26 2017-12-26 The Governing Council Of The University Of Toronto Digital microfluidic liquid-liquid extraction device and method of use thereof
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8846414B2 (en) 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
US9091649B2 (en) 2009-11-06 2015-07-28 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel; electrophoresis and molecular analysis
DK2539450T3 (da) 2010-02-25 2016-05-30 Advanced Liquid Logic Inc Fremgangsmåde til fremstilling af nukleinsyrebiblioteker
EP2553473A4 (de) 2010-03-30 2016-08-10 Advanced Liquid Logic Inc Tröpfchenoperationsplattform
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
DK2556171T3 (en) 2010-04-05 2015-12-14 Prognosys Biosciences Inc Spatially CODED BIOLOGICAL ASSAYS
US10232374B2 (en) 2010-05-05 2019-03-19 Miroculus Inc. Method of processing dried samples using digital microfluidic device
WO2012012090A2 (en) 2010-06-30 2012-01-26 Advanced Liquid Logic, Inc. Droplet actuator assemblies and methods of making same
CA2813090C (en) 2010-10-01 2019-11-12 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase
EP3193180A1 (de) 2010-11-17 2017-07-19 Advanced Liquid Logic, Inc. Kapazitätsdetektion in einem tröpfchenaktuator
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US20140174926A1 (en) 2011-05-02 2014-06-26 Advanced Liquid Logic, Inc. Molecular diagnostics platform
EP2707131B1 (de) 2011-05-09 2019-04-24 Advanced Liquid Logic, Inc. Mikrofluidische rückkopplung mittels impedanzerkennung
WO2012154794A2 (en) 2011-05-10 2012-11-15 Advanced Liquid Logic, Inc. Enzyme concentration and assays
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
EP2729792A4 (de) 2011-07-06 2015-03-18 Advanced Liquid Logic Inc Reagenzienaufbewahrung auf einem tröpfchenaktuator
WO2013009927A2 (en) 2011-07-11 2013-01-17 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based assays
US9446404B2 (en) 2011-07-25 2016-09-20 Advanced Liquid Logic, Inc. Droplet actuator apparatus and system
WO2013070627A2 (en) 2011-11-07 2013-05-16 Illumina, Inc. Integrated sequencing apparatuses and methods of use
WO2013078216A1 (en) 2011-11-21 2013-05-30 Advanced Liquid Logic Inc Glucose-6-phosphate dehydrogenase assays
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
IN2015DN00359A (de) 2012-06-27 2015-06-12 Advanced Liquid Logic Inc
WO2014062551A1 (en) 2012-10-15 2014-04-24 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
LT3013984T (lt) 2013-06-25 2023-06-12 Prognosys Biosciences, Inc. Biologinių taikinių erdvinių modelių mėginyje nustatymo būdai
CN105408728B (zh) 2013-08-13 2020-09-11 先进流体逻辑公司 使用作为流体输入的接通致动器储液器来提高液滴计量的准确度和精度的方法
KR20160081896A (ko) 2013-08-30 2016-07-08 일루미나, 인코포레이티드 친수성 또는 다양한-친수성 표면 상에서의 액적의 조작
SG10201912516SA (en) 2014-04-29 2020-02-27 Illumina Inc Multiplexed single cell gene expression analysis using template switch and tagmentation
KR102241309B1 (ko) * 2014-08-12 2021-04-16 광주과학기술원 전기습윤 구동 방식의 광자극기
JP6668336B2 (ja) 2014-10-09 2020-03-18 イラミーナ インコーポレーテッド 非混和性液体を分離して少なくとも１つの液体を効果的に単離する方法及び装置
CN107110816B (zh) * 2014-10-21 2021-06-01 多伦多大学管理委员会 具有集成的电化学传感器的数字微流体设备
TWI698282B (zh) 2014-12-05 2020-07-11 加州大學董事會 基板、微流體元件、移動微流體元件中的液滴之方法以及用於操控微流體元件中的液滴之程序
WO2016130704A2 (en) 2015-02-10 2016-08-18 Illumina, Inc. Methods and compositions for analyzing cellular components
EP3271073B1 (de) 2015-03-20 2019-06-12 Illumina, Inc. Fluidikkassette zur verwendung in vertikaler oder weitgehend vertikaler position
ES2955488T3 (es) 2015-04-10 2023-12-01 Spatial Transcriptomics Ab Análisis multiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos
AU2016250689B2 (en) 2015-04-22 2021-07-08 Berkeley Lights, Inc. Microfluidic cell culture
RU2724998C2 (ru) 2015-05-11 2020-06-29 Иллюмина, Инк. Платформа для обнаружения и анализа терапевтических агентов
US10464067B2 (en) 2015-06-05 2019-11-05 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
EP3303548A4 (de) 2015-06-05 2019-01-02 Miroculus Inc. Verdampfungsverwaltung in digitalen mikrofluidischen vorrichtungen
GB2556713B (en) 2015-07-06 2021-06-23 Illumina Inc Balanced AC modulation for driving droplet operations electrodes
DK3334839T3 (da) 2015-08-14 2021-04-26 Illumina Inc Systemer og fremgangsmåder under anvendelse af magnetisk reagerende sensorer til bestemmelse af en genetisk egenskab
CA3172078A1 (en) 2015-08-28 2017-03-09 Illumina, Inc. Nucleic acid sequence analysis from single cells
CN107921432A (zh) 2015-09-02 2018-04-17 伊卢米纳剑桥有限公司 改善流控***中的液滴操作的***和方法
US10450598B2 (en) 2015-09-11 2019-10-22 Illumina, Inc. Systems and methods for obtaining a droplet having a designated concentration of a substance-of-interest
CA3002983A1 (en) 2015-10-22 2017-04-27 Illumina, Inc. Filler fluid for fluidic devices
EP3370868B1 (de) * 2015-10-27 2020-12-09 Berkeley Lights, Inc. Mikrofluidische elektrobenetzungsvorrichtung mit einer kovalent gebundenen hydrophoben oberfläche
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
DK3384046T3 (da) 2015-12-01 2021-07-12 Illumina Inc Digitalt mikrofluidisk system til enkeltcelleisolering og karakterisering af analytter
EP3383538B1 (de) 2015-12-01 2022-03-09 Illumina, Inc. Flüssigkeitsspeicherungs- und abgabemechanismus
EP3440220B1 (de) 2016-04-07 2020-03-25 Illumina, Inc. Verfahren und systeme zur herstellung von normalisierten nukleinsäure-bibliotheken
WO2017205830A1 (en) 2016-05-26 2017-11-30 Berkeley Lights, Inc. Covalently modified surfaces, kits, and methods of preparation and use
CA3034064A1 (en) 2016-08-22 2018-03-01 Miroculus Inc. Feedback system for parallel droplet control in a digital microfluidic device
CN110383061A (zh) 2016-12-28 2019-10-25 米罗库鲁斯公司 数字微流控设备和方法
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
US11413617B2 (en) 2017-07-24 2022-08-16 Miroculus Inc. Digital microfluidics systems and methods with integrated plasma collection device
WO2019046860A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. DIGITAL MICROFLUIDIC DEVICES AND METHODS OF USE
CN112041459A (zh) 2018-01-29 2020-12-04 圣祖德儿童研究医院 核酸扩增方法
CA3096855A1 (en) 2018-05-23 2019-11-28 Miroculus Inc. Control of evaporation in digital microfluidics
WO2020210292A1 (en) 2019-04-08 2020-10-15 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US11927740B2 (en) 2019-11-20 2024-03-12 Nuclera Ltd Spatially variable hydrophobic layers for digital microfluidics
CN114945426A (zh) 2020-01-17 2022-08-26 核酸有限公司 用于数字微流体的空间可变介电层
US11946901B2 (en) 2020-01-27 2024-04-02 Nuclera Ltd Method for degassing liquid droplets by electrical actuation at higher temperatures
WO2021168131A1 (en) 2020-02-18 2021-08-26 Nuclear Nucleics Ltd. Adaptive gate driving for high frequency ac driving of ewod arrays
WO2021168162A1 (en) 2020-02-19 2021-08-26 Nuclera Nucleics Ltd. Latched transistor driving for high frequency ac driving of ewod arrays
CN115461152A (zh) 2020-04-27 2022-12-09 核酸有限公司 用于数字微流体的可变驱动和短路保护的分段顶板
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
JP2023540754A (ja) 2020-09-04 2023-09-26 バービーズ インコーポレイテッド 非結合型ビリルビンのためのマイクロ流体に基づく検定評価
WO2022074399A1 (en) 2020-10-08 2022-04-14 Nuclera Nucleics Ltd Electrowetting system and method for reagent-specific driving ewod arrays in microfluidic systems
GB2617917B (en) 2020-11-04 2024-05-22 Nuclera Ltd Dielectric layers for digital microfluidic devices
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0267782A3 (de) * 1986-11-10 1989-09-27 Kabushiki Kaisha Toshiba Tintenstrahlsystem
US6315953B1 (en) * 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
JP3791999B2 (ja) * 1997-03-24 2006-06-28 株式会社アドバンス 液体微粒子ハンドリング装置
FI980874A (fi) * 1998-04-20 1999-10-21 Wallac Oy Menetelmä ja laite pienten nestemäärien kemiallisen analyysin suorittamiseksi
US6565727B1 (en) * 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6939451B2 (en) * 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
DE10124988A1 (de) * 2001-05-22 2002-12-12 Infineon Technologies Ag Dispensier-Anordnung und Verfahren zum Dispensieren einer zu dispensierenden Lösung unter Verwendung der Dispensier-Anordnung
US6538823B2 (en) * 2001-06-19 2003-03-25 Lucent Technologies Inc. Tunable liquid microlens
US20050064423A1 (en) * 2002-01-08 2005-03-24 Toshiro Higuchi Pcr method by electrostatic transportation, hybridization method for electrostatic transportation and devices therefor
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
JP4031322B2 (ja) * 2002-08-26 2008-01-09 独立行政法人科学技術振興機構 液滴操作装置
JP4438044B2 (ja) * 2002-10-15 2010-03-24 キヤノン株式会社 電気泳動表示用粒子分散液およびそれを用いた電気泳動表示装置

Also Published As

Publication number Publication date
EP1687531A1 (de) 2006-08-09
CN1882778A (zh) 2006-12-20
WO2005047696A1 (en) 2005-05-26
JP2007512121A (ja) 2007-05-17
EP1687531B1 (de) 2009-06-17
US20070139486A1 (en) 2007-06-21
JP4773360B2 (ja) 2011-09-14
DE602004021624D1 (de) 2009-07-30
CN100478075C (zh) 2009-04-15
US7328979B2 (en) 2008-02-12

Similar Documents

Publication Publication Date Title
ATE434131T1 (de) System zur handhabung einer fluidmenge
ATE426183T1 (de) Elektrobenetzungseinrichtung
DE60328223D1 (de) Vorrichtung zur bildung von variablen meniskusformen
IL258702B (en) Pump system for use in organ treatment systems
WO2018187587A3 (en) Liquid lens control systems and methods
ATE460135T1 (de) Beschichtungen zur verwendung auf medizinprodukten
ATE505162T1 (de) Fluidik zur regelung von drosselungsvorrichtungen
WO2006091525A3 (en) Electro-blotting devices, systems, and kits, and methods for their use
AU2016368532A8 (en) Dressing for skin care in a moist environment
DE602005021792D1 (de) Flüssigkeitsbehandlungsvorrichtung mit oberflächenmerkmalen an einer dichtung
ATE434983T1 (de) Vorrichtung zur elastischen stabilisierung von wirbelkörpern
BRPI0821734A2 (pt) Configurações de autuador de gotículas e métodos para conduzir operações de gotícula.
DE60303679D1 (de) Elektrophysiologische elektrode mit mehreren energieversorgungsleitungen
MXPA04004305A (es) Materiales electrocromicos con un coeficiente de difusion controlado para usar en medios electrocromicos y dispositivos electrocromicos asociados.
CR8385A (es) Pirimidinas sustituidas con sulfoximina como inhibidores de cdk y/o vegf, su preparacion y sus usos como medicamento
AR052980A1 (es) Preparacion de dispersiones polimericas de etileno - acido acrilico neutralizadas y uso en medios de impresion para mejorar la adhesion de pigmento organico digital
DE602007011620D1 (de) Medizinisches abgabesystem mit asymmetrischen kodiervorrichtungen
BR0308191B1 (pt) fluido de hidrocarboneto, uso do mesmo, composiÇço seladora de silicone e tinta.
ATE542517T1 (de) Haftzusammensetzung für hartes gewebe
ATE282472T1 (de) Pipette mit spitzenbehälter
ATE488847T1 (de) Kontaktelement
WO2006013391A3 (en) Conformable structures
WO2009042509A3 (en) Emulsions of silicone elastomer and silicone organic elastomer gels
AU2003276604A1 (en) Manipulation of objects with fluid droplets
EP2833542A8 (de) Betätigungselement mit kohlenstoffelektrode

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties