ATE431396T1 - Für hcv-infektion geeignete zusammensetzungen und verfahren - Google Patents

Für hcv-infektion geeignete zusammensetzungen und verfahren

Info

Publication number
ATE431396T1
ATE431396T1 AT02753872T AT02753872T ATE431396T1 AT E431396 T1 ATE431396 T1 AT E431396T1 AT 02753872 T AT02753872 T AT 02753872T AT 02753872 T AT02753872 T AT 02753872T AT E431396 T1 ATE431396 T1 AT E431396T1
Authority
AT
Austria
Prior art keywords
compositions
hcv
methods
hcv infection
methods suitable
Prior art date
Application number
AT02753872T
Other languages
English (en)
Inventor
Ann Kwong
Randal Byrn
Lola Reid
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE431396T1 publication Critical patent/ATE431396T1/de

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0031—Serum-free culture media
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/18—Liver cell growth factor (LCGF, Gly-His-Lys)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/335—Glucagon; Glucagon-like peptide [GLP]; Exendin
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/375—Thyroid stimulating hormone [TSH]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Semiconductor Lasers (AREA)
AT02753872T 2001-03-27 2002-03-27 Für hcv-infektion geeignete zusammensetzungen und verfahren ATE431396T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27917401P 2001-03-27 2001-03-27
PCT/US2002/009685 WO2002077206A1 (en) 2001-03-27 2002-03-27 Compositiona and methods useful for hcv infection

Publications (1)

Publication Number Publication Date
ATE431396T1 true ATE431396T1 (de) 2009-05-15

Family

ID=23067944

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02753872T ATE431396T1 (de) 2001-03-27 2002-03-27 Für hcv-infektion geeignete zusammensetzungen und verfahren

Country Status (15)

Country Link
US (3) US7879606B2 (de)
EP (1) EP1381673B1 (de)
JP (2) JP4499990B2 (de)
KR (1) KR100947911B1 (de)
CN (1) CN100362095C (de)
AT (1) ATE431396T1 (de)
CA (1) CA2441688C (de)
DE (1) DE60232322D1 (de)
ES (1) ES2328466T3 (de)
HK (1) HK1063334A1 (de)
MX (1) MXPA03008882A (de)
NO (1) NO20034278L (de)
NZ (1) NZ528462A (de)
WO (1) WO2002077206A1 (de)
ZA (1) ZA200307373B (de)

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UA66767C2 (uk) 1996-10-18 2004-06-15 Вертекс Фармасьютикалс Інкорпорейтед Інгібітори серин-протеаз, фармацевтична композиція, спосіб інгібування активності та спосіб лікування або профілактики вірусної інфекції гепатиту с
SV2003000617A (es) * 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
EP3000899A1 (de) 2002-12-04 2016-03-30 Applied Biosystems, LLC Multiplexverstärkung von polynucleotiden
TWI359147B (en) 2003-09-05 2012-03-01 Vertex Pharma Inhibitors of serine proteases, particularly hcv n
AU2004295702A1 (en) * 2003-12-01 2005-06-16 Vertex Pharmaceuticals Incorporated Compositions comprising fetal liver cells and methods useful for HCV infection
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
US8039475B2 (en) 2006-02-27 2011-10-18 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
WO2007109080A2 (en) 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
CN101903392A (zh) 2007-02-27 2010-12-01 弗特克斯药品有限公司 丝氨酸蛋白酶的抑制剂
JP2010519330A (ja) 2007-02-27 2010-06-03 バーテックス ファーマシューティカルズ インコーポレイテッド 共結晶体およびそれを含む医薬組成物
CN101835774B (zh) 2007-08-30 2014-09-17 弗特克斯药品有限公司 共晶体和包含该共晶体的药物组合物
WO2009073689A1 (en) 2007-12-04 2009-06-11 Miladin Kostovic Kit and method for detecting bovine viral diarrhea virus in tissue samples
CN101906487A (zh) * 2010-08-05 2010-12-08 中国兽医药品监察所 一种猪瘟病毒核酸标准物质的制备方法
ES2651414T3 (es) * 2012-08-31 2018-01-26 The Governors Of The University Of Alberta Métodos para la producción de células que tienen un fenotipo de hepatocitos primarios humanos y composiciones
US10988737B2 (en) 2015-04-28 2021-04-27 Universite De Strasbourg Clinical gene signature-based human cell culture model and uses thereof

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Also Published As

Publication number Publication date
ES2328466T3 (es) 2009-11-13
NO20034278L (no) 2003-11-25
US20130071834A1 (en) 2013-03-21
CA2441688C (en) 2014-01-21
KR100947911B1 (ko) 2010-03-17
CA2441688A1 (en) 2002-10-03
US8211696B2 (en) 2012-07-03
HK1063334A1 (en) 2004-12-24
US7879606B2 (en) 2011-02-01
ZA200307373B (en) 2005-06-29
JP2004529637A (ja) 2004-09-30
CN100362095C (zh) 2008-01-16
NO20034278D0 (no) 2003-09-25
JP2010142249A (ja) 2010-07-01
EP1381673A1 (de) 2004-01-21
WO2002077206A1 (en) 2002-10-03
CN1511190A (zh) 2004-07-07
EP1381673A4 (de) 2004-11-10
WO2002077206A9 (en) 2004-02-19
US20020142449A1 (en) 2002-10-03
NZ528462A (en) 2005-11-25
US20110229874A1 (en) 2011-09-22
DE60232322D1 (de) 2009-06-25
JP4499990B2 (ja) 2010-07-14
KR20040012739A (ko) 2004-02-11
EP1381673B1 (de) 2009-05-13
MXPA03008882A (es) 2003-12-08

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