ATE420640T1 - Fab-i-inhibitoren - Google Patents
Fab-i-inhibitorenInfo
- Publication number
- ATE420640T1 ATE420640T1 AT02807262T AT02807262T ATE420640T1 AT E420640 T1 ATE420640 T1 AT E420640T1 AT 02807262 T AT02807262 T AT 02807262T AT 02807262 T AT02807262 T AT 02807262T AT E420640 T1 ATE420640 T1 AT E420640T1
- Authority
- AT
- Austria
- Prior art keywords
- fab
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28222501P | 2001-04-06 | 2001-04-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE420640T1 true ATE420640T1 (de) | 2009-01-15 |
Family
ID=29250372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02807262T ATE420640T1 (de) | 2001-04-06 | 2002-04-03 | Fab-i-inhibitoren |
Country Status (12)
Country | Link |
---|---|
US (4) | US7049310B2 (de) |
EP (1) | EP1560584B1 (de) |
JP (1) | JP4387804B2 (de) |
AR (1) | AR035812A1 (de) |
AT (1) | ATE420640T1 (de) |
AU (1) | AU2002367773A1 (de) |
CA (1) | CA2444597A1 (de) |
DE (1) | DE60230934D1 (de) |
DK (1) | DK1560584T3 (de) |
ES (1) | ES2320984T3 (de) |
MY (1) | MY138285A (de) |
WO (1) | WO2003088897A2 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6846819B1 (en) * | 1999-10-08 | 2005-01-25 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
US7048926B2 (en) | 2000-10-06 | 2006-05-23 | Affinium Pharmaceuticals, Inc. | Methods of agonizing and antagonizing FabK |
US7496368B2 (en) * | 2001-04-03 | 2009-02-24 | Sharp Kabushiki Kaisha | Method and device for controlling frequency selection within a wireless communication system |
US7049310B2 (en) | 2001-04-06 | 2006-05-23 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
ES2518316T3 (es) | 2002-12-06 | 2014-11-05 | Debiopharm International Sa | Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia |
DE602004016831D1 (de) * | 2003-03-17 | 2008-11-13 | Affinium Pharm Inc | Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend |
WO2007053131A2 (en) * | 2004-06-04 | 2007-05-10 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as antibiotic agents |
GB0522715D0 (en) | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
JP2009518399A (ja) * | 2005-12-05 | 2009-05-07 | アフィニウム ファーマシューティカルズ, インク. | Fabi阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物 |
CA2658506C (en) | 2006-07-20 | 2016-01-26 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as fab 1 inhibitors |
GB0709513D0 (en) * | 2007-05-17 | 2007-06-27 | Helperby Therapeutics Ltd | Topical formulations |
FR2912133B1 (fr) * | 2007-02-01 | 2009-04-24 | Univ Grenoble 1 | Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens |
US8263613B2 (en) * | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
DK2501693T3 (en) | 2009-11-18 | 2014-12-08 | Fab Pharma Sas | Aza-heterocyclic acrylamides and their use as bactericides |
WO2011156811A2 (en) * | 2010-06-11 | 2011-12-15 | Affinium Pharmaceuticals, Inc. | Compounds for treatment of bovine mastitis |
WO2013021052A1 (en) | 2011-08-10 | 2013-02-14 | Janssen R&D Ireland | Antibacterial piperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones |
JO3611B1 (ar) | 2011-08-10 | 2020-08-27 | Janssen Sciences Ireland Uc | سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم |
EP2742044B1 (de) | 2011-08-10 | 2019-12-04 | Janssen Sciences Ireland Unlimited Company | Antibakterielle homopiperidinyl-substituierte 3,4-dihydro-1h-[1,8]naphthyridinone |
EP2758376A4 (de) * | 2011-09-19 | 2015-04-29 | Vitas Pharma Res Private Ltd | Heterocyclische verbindungen als fettsäurebiosynthese-hemmer bei bakteriellen infektionen |
SG11201402409UA (en) | 2011-12-02 | 2014-10-30 | Aurigene Discovery Tech Ltd | Substituted pyridine derivatives as fabi inhibitors |
US9062075B2 (en) | 2011-12-02 | 2015-06-23 | Aurigene Discovery Technologies Limited | Tetrahydropyridine derivatives as FabI inhibitors |
RS58898B1 (sr) | 2012-06-19 | 2019-08-30 | Debiopharm Int Sa | Prolek derivati (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida |
EA201590331A1 (ru) | 2012-08-10 | 2016-05-31 | Янссен Сайенсиз Айрлэнд Юси | Новые антибактериальные соединения |
EP2882738B1 (de) | 2012-08-10 | 2017-05-31 | Janssen Sciences Ireland UC | Neue antibakterielle verbindungen |
WO2014072930A2 (en) * | 2012-11-09 | 2014-05-15 | Aurigene Discovery Technologies Limited | Fused pyridine derivatives as antibacterial agents |
KR101432078B1 (ko) | 2013-04-22 | 2014-08-21 | 영남대학교 산학협력단 | 항병원성 활성을 갖는 7-벤질옥시인돌 화합물의 신규한 용도 |
WO2014195844A1 (en) | 2013-06-04 | 2014-12-11 | Aurigene Discovery Technologies Limited | TETRAHYDROPYRIDINE DERIVATIVES AS FabI INHIBITORS |
TN2018000293A1 (en) * | 2016-02-26 | 2020-01-16 | Debiopharm Int Sa | Medicament for treatment of diabetic foot infections |
AU2017355603A1 (en) | 2016-11-04 | 2019-06-20 | Auckland Uniservices Limited | Tricyclic heterocyclic derivatives and uses thereof |
MX2020006587A (es) | 2017-12-22 | 2020-12-10 | Ravenna Pharmaceuticals Inc | Derivados de aminopiridina como inhibidores de fosfatidilinositol fosfato cinasa. |
US11691967B2 (en) | 2018-03-12 | 2023-07-04 | The Board Of Trustees Of The University Of Illinois | Antibiotics effective for gram-negative pathogens |
BR112021009106A2 (pt) | 2018-11-12 | 2021-08-10 | Debiopharm International S.A. | compostos antibióticos, métodos de fabricação dos mesmos, composições farmacêuticas que os contêm e seus usos |
LT3923914T (lt) * | 2019-02-14 | 2023-07-25 | Debiopharm International S.A. | Afabicino kompozicija, jos gamybos būdas |
EP4359079A1 (de) * | 2021-06-23 | 2024-05-01 | Debiopharm International S.A. | Neue verbindungen und ihre verwendung |
Family Cites Families (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3828068A (en) * | 1971-05-10 | 1974-08-06 | Tenneco Chem | ((substituted indazolyl)-n1-methyl)carbamates |
US4154943A (en) * | 1977-12-29 | 1979-05-15 | University Of Vermont | Preparation of vincadifformine |
FR2619111B1 (fr) * | 1987-08-07 | 1991-01-11 | Synthelabo | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique |
CA2020437A1 (en) | 1989-07-05 | 1991-01-06 | Yoshihide Fuse | Cinnamamide derivative |
HU210679B (en) | 1991-11-21 | 1995-06-28 | Richter Gedeon Vegyeszet | Process for producing new tetrahydro-pyrido/3,4-b/indol derivatives and pharmaceutical compositions containing the same |
FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
US5416193A (en) | 1993-04-30 | 1995-05-16 | Pfizer Inc. | Coupling reagent and method |
MA23420A1 (fr) | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
US5614551A (en) * | 1994-01-24 | 1997-03-25 | The Johns Hopkins University | Inhibitors of fatty acid synthesis as antimicrobial agents |
CN1156995A (zh) | 1994-06-29 | 1997-08-13 | 史密丝克莱恩比彻姆公司 | 玻璃体结合蛋白受体拮抗剂 |
US6176842B1 (en) | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
US5989832A (en) | 1995-04-21 | 1999-11-23 | Microcide Pharmaceuticals, Inc. | Method for screening for non-tetracycline efflux pump inhibitors |
EP0824535B1 (de) | 1995-05-11 | 2003-02-26 | Biochemie Gesellschaft M.B.H. | Antibakterielle cephalosporinverbindungen |
US6057291A (en) | 1995-06-02 | 2000-05-02 | University Of British Columbia | Antimicrobial cationic peptides |
ES2173420T3 (es) | 1996-02-29 | 2002-10-16 | Fujisawa Pharmaceutical Co | Comprimidos que contienen un antibiotico de beta-lactamico y procedimiento para su produccion. |
US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US6367985B1 (en) | 1996-03-12 | 2002-04-09 | Intellectual Property Company | Optical connector using large diameter alignment features |
US6451816B1 (en) * | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
US6503881B2 (en) | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
US6995254B1 (en) | 1996-08-28 | 2006-02-07 | Affinium Pharmaceuticals, Inc. | Polynucleotide encoding the enoyl-acyl carrier protein reductase of Staphylococcus aureus, FAB I |
US6294669B1 (en) | 1996-09-20 | 2001-09-25 | Meiji Seika Kaisha Ltd. | Crystalline substance of cefditoren pivoxyl and the production of the same |
US6521408B1 (en) | 1997-09-25 | 2003-02-18 | National Institute Of Agrobiological Sciences | Method for assessing a function of a gene |
DE19641437A1 (de) | 1996-10-08 | 1998-04-09 | Basf Ag | 1,3-Bis-(N-lactamyl)propane und deren pharmazeutische und kosmetische Verwendung |
DE19652239A1 (de) | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
SI9600371B (sl) | 1996-12-18 | 2005-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Etilidenski derivati tricikličnih karbapenemov |
WO1998043969A1 (en) * | 1997-03-31 | 1998-10-08 | Dupont Pharmaceuticals Company | Indazoles of cyclic ureas useful as hiv protease inhibitors |
ATE389417T1 (de) | 1997-04-01 | 2008-04-15 | Borody Thomas J | Verfahren und zusammensetzungen zur behandlung entzündlicher darmerkrankungen |
US6406880B1 (en) | 1997-05-02 | 2002-06-18 | Integrated Research Technology, Llc | Betaines as adjuvants to susceptibility testing and antimicrobial therapy |
US6184363B1 (en) | 1997-06-13 | 2001-02-06 | Northwestern University | Inhibitors of β-lactamases and uses therefor |
US6207679B1 (en) | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
WO1998058928A1 (fr) | 1997-06-23 | 1998-12-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Agent prophylactique ou therapeutique contre des maladies attribuables a une infection par des helicobacters |
AUPO758297A0 (en) | 1997-06-27 | 1997-07-24 | Rowe, James Baber | Control of acidic gut syndrome |
US6198000B1 (en) | 1997-07-07 | 2001-03-06 | Pfizer Inc. | Intermediates useful in the synthesis of quinoline antibiotics |
CA2298480A1 (en) | 1997-07-25 | 1999-02-04 | Tsumura & Co. | Pyridylacrylamide derivatives and nephritis remedies and tgf-.beta. inhibitors containing the same |
HN1998000106A (es) | 1997-08-01 | 1999-01-08 | Pfizer Prod Inc | Composiciones parenterales de alatroflaxacino |
US5932743A (en) * | 1997-08-21 | 1999-08-03 | American Home Products Corporation | Methods for the solid phase synthesis of substituted indole compounds |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
US6432444B1 (en) | 1997-10-31 | 2002-08-13 | New Horizons Diagnostics Corp | Use of bacterial phage associated lysing enzymes for treating dermatological infections |
DE19881833B4 (de) | 1997-10-31 | 2007-05-10 | Syngenta Participations Ag | Transgene Pflanzen |
SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
DE19753298A1 (de) | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
WO1999034832A1 (fr) | 1998-01-07 | 1999-07-15 | Meiji Seika Kaisha Ltd. | Compositions de cephalosporine amorphes, stables du point de vue cristallographique et procede de preparation de ces compositions |
US6184380B1 (en) | 1999-01-25 | 2001-02-06 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
PA8466701A1 (es) | 1998-01-21 | 2000-09-29 | Pfizer Prod Inc | Comprimido de mesilato de trovafloxacino |
US6204279B1 (en) | 1998-06-03 | 2001-03-20 | Microcide Pharmaceuticals, Inc. | Peptidomimetic efflux pump inhibitors |
RU2241489C2 (ru) | 1998-02-27 | 2004-12-10 | Биора Биоэкс Аб | Композиции матриксных протеинов для залечивания ран |
US6350738B1 (en) | 1998-03-06 | 2002-02-26 | Brigham Young University | Steroid derived antibiotics |
DE19820801A1 (de) | 1998-05-09 | 1999-11-25 | Gruenenthal Gmbh | Orale Arzneiformen mit reproduzierbarer Wirkstofffreisetzung von Gatifloxacin oder pharmazeutisch verwendbaren Salzen oder Hydraten |
DE19821039A1 (de) | 1998-05-11 | 1999-11-18 | Bayer Ag | Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan |
US6399629B1 (en) | 1998-06-01 | 2002-06-04 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
US6428579B1 (en) | 1998-07-01 | 2002-08-06 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
US6423741B1 (en) | 1998-07-10 | 2002-07-23 | Council Of Scientific And Industrial Research | Anti-microbial composition and method for producing the same |
GB9815567D0 (en) | 1998-07-18 | 1998-09-16 | Glaxo Group Ltd | Antiviral compound |
JP3531648B2 (ja) | 1998-08-04 | 2004-05-31 | 武田シェリング・プラウ アニマルヘルス株式会社 | β−ラクタム抗生物質の安定化製剤 |
BRPI9906735B8 (pt) | 1998-08-21 | 2021-05-25 | Kyorin Seiyaku Kk | 'composição farmacêutica líquida aquosa e método para prevenção de precipitações de cristais e para prevenção da coloração de gatifloxacina.' |
US6461607B1 (en) | 1998-08-24 | 2002-10-08 | Ganeden Biotech, Inc. | Probiotic, lactic acid-producing bacteria and uses thereof |
US6518487B1 (en) | 1998-09-23 | 2003-02-11 | Pioneer Hi-Bred International, Inc. | Cyclin D polynucleotides, polypeptides and uses thereof |
US6395746B1 (en) | 1998-09-30 | 2002-05-28 | Alcon Manufacturing, Ltd. | Methods of treating ophthalmic, otic and nasal infections and attendant inflammation |
US6509327B1 (en) | 1998-09-30 | 2003-01-21 | Alcon Manufacturing, Ltd. | Compositions and methods for treating otic, ophthalmic and nasal infections |
TW526202B (en) | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
US6515113B2 (en) | 1999-02-18 | 2003-02-04 | The Regents Of The University Of California | Phthalamide lanthanide complexes for use as luminescent markers |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6461829B1 (en) | 1999-03-03 | 2002-10-08 | The Trustees Of Princeton University | Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrates analogs and methods for discovering new antibiotics |
US6495161B1 (en) | 1999-03-09 | 2002-12-17 | Vivorx, Inc. | Cytoprotective biocompatible containment systems for biologically active materials and methods of making same |
US6239113B1 (en) | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
JP2003502282A (ja) | 1999-04-08 | 2003-01-21 | ザ ゼネラル ホスピタル コーポレーション | ヒト転移性細胞の作用因子源から離れた意図された移動 |
CO5180550A1 (es) * | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
US6290946B1 (en) | 1999-05-13 | 2001-09-18 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders and antibacterial agents |
US6514535B2 (en) | 1999-05-21 | 2003-02-04 | Noveon Ip Holdings Corp. | Bioadhesive hydrogels with functionalized degradable crosslinks |
AR024077A1 (es) * | 1999-05-25 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
CO5370679A1 (es) * | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
US6239141B1 (en) | 1999-06-04 | 2001-05-29 | Pfizer Inc. | Trovafloxacin oral suspensions |
CO5180605A1 (es) * | 1999-06-23 | 2002-07-30 | Smithkline Beecham Corp | Compuestos de indol |
CA2282066C (en) | 1999-06-29 | 2010-09-07 | Smithkline Beecham Corporation | Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
US6500459B1 (en) | 1999-07-21 | 2002-12-31 | Harinderpal Chhabra | Controlled onset and sustained release dosage forms and the preparation thereof |
US6346391B1 (en) * | 1999-07-22 | 2002-02-12 | Trustees Of Tufts College | Methods of reducing microbial resistance to drugs |
JP2003507437A (ja) | 1999-08-26 | 2003-02-25 | ガネデン バイオテック, インコーポレイテッド | 抗真菌薬剤、抗細菌薬剤、および抗ウイルス薬剤のためのキャリアであるエミュー油の使用 |
US6221859B1 (en) | 1999-08-27 | 2001-04-24 | Merck & Co., Inc. | Carbapenem antibacterial compositions and methods of the treatment |
US6174878B1 (en) | 1999-08-31 | 2001-01-16 | Alcon Laboratories, Inc. | Topical use of kappa opioid agonists to treat otic pain |
JP2003509350A (ja) | 1999-09-11 | 2003-03-11 | ザ、プロクター、エンド、ギャンブル、カンパニー | 注加可能な液体賦形剤 |
DK1142573T3 (da) | 1999-09-17 | 2006-04-10 | Daiichi Asubio Pharma Co Ltd | Farmaceutiske præparater omfattende faropenem-natrium og en diaminacetatforbindelse til forbedring af absorption i mave-tarm-kanalen |
US6500463B1 (en) | 1999-10-01 | 2002-12-31 | General Mills, Inc. | Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles |
ATE332130T1 (de) | 1999-10-08 | 2006-07-15 | Affinium Pharm Inc | Fab-i-hemmer |
US6846819B1 (en) * | 1999-10-08 | 2005-01-25 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
US6730684B1 (en) * | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
US6762201B1 (en) * | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
ATE294578T1 (de) | 1999-10-08 | 2005-05-15 | Affinium Pharm Inc | Fab i hemmer |
CA2323008C (en) * | 1999-10-11 | 2005-07-12 | Pfizer Inc. | Pharmaceutically active compounds |
DE60014143T2 (de) | 1999-10-19 | 2006-03-02 | Sato Pharmaceutical Co., Ltd. | Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur |
US6951729B1 (en) | 1999-10-27 | 2005-10-04 | Affinium Pharmaceuticals, Inc. | High throughput screening method for biological agents affecting fatty acid biosynthesis |
ATE461692T1 (de) | 1999-10-29 | 2010-04-15 | Novartis Ag | Trockenpulverzusammensetzungen mit verbesserter dispersität |
US6531291B1 (en) | 1999-11-10 | 2003-03-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof |
US6514986B2 (en) | 2000-11-22 | 2003-02-04 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US6656703B1 (en) | 1999-12-29 | 2003-12-02 | Millennium Pharamaceuticals, Inc. | High throughput screen for inhibitors of fatty acid biosynthesis in bacteria |
US6372752B1 (en) * | 2000-02-07 | 2002-04-16 | Genzyme Corporation | Inha inhibitors and methods of use thereof |
WO2001072317A1 (en) | 2000-03-28 | 2001-10-04 | Council Of Scientific And Industrial Research | Formulation comprising thymol useful in the treatment of drug resistant bacterial infections |
CN1438981A (zh) | 2000-04-21 | 2003-08-27 | 罗迪亚/奇莱克斯公司 | 制备r-1-(芳氧基)丙-2-醇的方法 |
US6203955B1 (en) * | 2000-04-28 | 2001-03-20 | Toshiba Tec Kabushiki Kaisha | Developing agent and image forming apparatus |
US20050043321A1 (en) | 2000-07-26 | 2005-02-24 | Vyden John K. | Method for treating atopic disorders |
US6288239B1 (en) | 2000-09-19 | 2001-09-11 | Board Of Trustees Operating Michigan State University | 5-trityloxymethyl-oxazolidinones and process for the preparation thereof |
US6821746B2 (en) | 2000-10-06 | 2004-11-23 | Affinium Pharmaceuticals, Inc. | Methods of screening for FabK antagonists and agonists |
US7048926B2 (en) * | 2000-10-06 | 2006-05-23 | Affinium Pharmaceuticals, Inc. | Methods of agonizing and antagonizing FabK |
WO2002042273A2 (en) | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
WO2002048097A1 (en) | 2000-12-12 | 2002-06-20 | Corvas International, Inc. | Compounds, compositions and methods for treatment of parasitic infections |
US6388070B1 (en) | 2001-01-05 | 2002-05-14 | Orchid Chemicals & Pharmaceuticals Ltd. | Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds |
US6495158B1 (en) | 2001-01-19 | 2002-12-17 | Lec Tec Corporation | Acne patch |
US7049310B2 (en) | 2001-04-06 | 2006-05-23 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
US6503906B1 (en) | 2002-02-21 | 2003-01-07 | Ren-Jin Lee | Method for optimizing ciprofloxacin treatment of anthrax-exposed patients according to the patient's characteristics |
ES2518316T3 (es) * | 2002-12-06 | 2014-11-05 | Debiopharm International Sa | Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia |
DE602004016831D1 (de) * | 2003-03-17 | 2008-11-13 | Affinium Pharm Inc | Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend |
WO2007053131A2 (en) | 2004-06-04 | 2007-05-10 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as antibiotic agents |
JP2009518399A (ja) | 2005-12-05 | 2009-05-07 | アフィニウム ファーマシューティカルズ, インク. | Fabi阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物 |
CA2658506C (en) | 2006-07-20 | 2016-01-26 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as fab 1 inhibitors |
US8263613B2 (en) | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
-
2002
- 2002-04-03 US US10/474,315 patent/US7049310B2/en not_active Expired - Lifetime
- 2002-04-03 ES ES02807262T patent/ES2320984T3/es not_active Expired - Lifetime
- 2002-04-03 DK DK02807262T patent/DK1560584T3/da active
- 2002-04-03 AT AT02807262T patent/ATE420640T1/de not_active IP Right Cessation
- 2002-04-03 AU AU2002367773A patent/AU2002367773A1/en not_active Abandoned
- 2002-04-03 CA CA002444597A patent/CA2444597A1/en not_active Abandoned
- 2002-04-03 EP EP02807262A patent/EP1560584B1/de not_active Expired - Lifetime
- 2002-04-03 DE DE60230934T patent/DE60230934D1/de not_active Expired - Lifetime
- 2002-04-03 WO PCT/US2002/010332 patent/WO2003088897A2/en active Search and Examination
- 2002-04-03 JP JP2003585650A patent/JP4387804B2/ja not_active Expired - Lifetime
- 2002-04-04 MY MYPI20021219A patent/MY138285A/en unknown
- 2002-04-04 AR ARP020101249A patent/AR035812A1/es active IP Right Grant
-
2005
- 2005-11-22 US US11/284,660 patent/US7250424B2/en not_active Expired - Lifetime
-
2007
- 2007-06-25 US US11/767,967 patent/US7741339B2/en not_active Expired - Lifetime
-
2010
- 2010-04-12 US US12/758,227 patent/US8153652B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1560584A2 (de) | 2005-08-10 |
EP1560584B1 (de) | 2009-01-14 |
US7741339B2 (en) | 2010-06-22 |
JP2005519984A (ja) | 2005-07-07 |
MY138285A (en) | 2009-05-29 |
WO2003088897A2 (en) | 2003-10-30 |
US20060116394A1 (en) | 2006-06-01 |
EP1560584A4 (de) | 2005-10-12 |
US20090221699A1 (en) | 2009-09-03 |
US20110098277A1 (en) | 2011-04-28 |
US20040147580A1 (en) | 2004-07-29 |
US7049310B2 (en) | 2006-05-23 |
WO2003088897A3 (en) | 2005-06-09 |
DE60230934D1 (de) | 2009-03-05 |
US8153652B2 (en) | 2012-04-10 |
AR035812A1 (es) | 2004-07-14 |
ES2320984T3 (es) | 2009-06-01 |
AU2002367773A8 (en) | 2003-11-03 |
US7250424B2 (en) | 2007-07-31 |
CA2444597A1 (en) | 2002-10-06 |
AU2002367773A1 (en) | 2003-11-03 |
JP4387804B2 (ja) | 2009-12-24 |
DK1560584T3 (da) | 2009-05-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE420640T1 (de) | Fab-i-inhibitoren | |
CY2015028I1 (el) | Ενας αναστολεας ν-ακυλοσφιγγοσινο γλυκοζυλοτρανσφερασης | |
DE60234125D1 (de) | E inhibitoren | |
PT1370553E (pt) | Inibidores de rhoquinase | |
ATE285821T1 (de) | Fab i inhibitoren | |
ATE333454T1 (de) | Metalloproteinaseinhibitoren | |
EE200300439A (et) | Metalloproteinaasi inhibiitorid | |
DE60218138D1 (de) | Rho-kinase inhibitoren | |
DE60219846D1 (de) | Gewebedistraktor | |
PT1411764E (pt) | Cerca | |
DE60227839D1 (de) | Martensitische nanoverbundstähle | |
EE200300452A (et) | Metalloproteinaasi inhibiitorid | |
DE60227475D1 (de) | Halbleiterbauelement | |
DE60225790D1 (de) | Halbleiterbauelement | |
DE50208029D1 (de) | Kugelgelenk | |
DE60129205D1 (de) | Mittelspannungskabelendverschluss | |
NO20013535L (no) | Nöytrofil-funksjons-inhibitorer | |
ITMI20010954A0 (it) | Procedimento di iodurazione | |
DE60229395D1 (de) | Altung | |
DE50115802D1 (de) | Dafür | |
DE10295006D2 (de) | Bauwerksabdichtung | |
DE10196706D2 (de) | Nagelfeile | |
SE0100694D0 (sv) | DHFR inhibitors | |
DOP2001000307A (es) | Inhibidores de thrombin | |
SE0103266D0 (sv) | Skär |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |