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(en)
*
|
|
1886-02-16 |
|
Haemon h |
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(en)
*
|
1960-08-30 |
1964-05-19 |
Teves Kg Alfred |
Process for the manufacture of cast iron having an eutectic graphite formation
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(en)
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1961-10-12 |
1966-08-23 |
Merck & Co Inc |
Compositions and method of using (3-amino-pyrazinoyl) guanidines
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NL6409714A
(de)
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1962-10-30 |
1965-10-01 |
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NL299929A
(de)
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1962-10-30 |
|
|
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(en)
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1964-03-31 |
1967-04-25 |
Merck & Co Inc |
3-aminopyrazinoic acid derivatives and process for their preparation
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BE639386A
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1962-10-30 |
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NL6409716A
(de)
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1962-10-30 |
1965-10-01 |
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DK109779C
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1962-10-30 |
1968-07-01 |
Merck & Co Inc |
Fremgangsmåde til fremstilling af 3-aminopyrazinamidoguanidinforbindelser eller syreadditionssalte heraf.
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1963-11-15 |
1966-09-20 |
Merck & Co Inc |
N-(3-aminopyrazinoyl) benzamidines and process for preparing
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(en)
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1963-12-23 |
1966-03-15 |
Merck & Co Inc |
Amino-pyrazinoyl guanidines
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DE1245967B
(de)
|
1964-03-31 |
1967-08-03 |
Merck &. Co., Inc., Rahway, N.J. (V. St. A.) |
Verfahren zur Herstellung von S.S-Diamino-o-chlor-pyrazincarbonsäurealkylestern
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NL6501301A
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1964-04-03 |
1965-10-04 |
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(en)
*
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1964-09-08 |
1966-05-03 |
Merck & Co Inc |
Synthesis of 3-amino, 5-chloro, 6-substituted-pyrazinoates
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DE1281818B
(de)
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1965-07-17 |
1968-10-31 |
Rheinische Kalksteinwerke |
Verfahren zum gleichzeitigen Mahlen mehrerer Rohstoffe unterschiedlicher Mahlbarkeit
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(en)
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1965-10-04 |
1966-09-20 |
Merck & Co Inc |
Derivatives of pyrazine and a method for their preparation
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(en)
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1965-10-04 |
1967-09-12 |
Merck & Co Inc |
3-amino-6-halopyrazinonitriles and their syntheses
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US3305552A
(en)
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1965-11-22 |
1967-02-21 |
Merck & Co Inc |
3-aminopyrazinoic acids and process for their preparation
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(en)
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1965-11-22 |
1968-01-02 |
Merck & Co Inc |
Process for the preparation of pteridinones
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FR1525671A
(fr)
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1966-08-25 |
1968-05-17 |
Merck & Co Inc |
Procédé de préparation de (3, 5 - diamino - 6 - halogéno - pyrazinoyl) - guanidines et de (3, 5 - diamino - 6 - halogéno -pyrazinamido) guanidines
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FR1525670A
(fr)
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1966-08-25 |
1968-05-17 |
Merck & Co Inc |
Procédé de fabrication de guanidines substituées
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(en)
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1966-11-17 |
1969-10-14 |
Merck & Co Inc |
3-hydroxy and 3-mercapto-pyrazinoyl-guanidines,corresponding ethers and thioethers and processes for their preparation
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(en)
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1966-11-17 |
1972-05-02 |
Merck & Co Inc |
Lower alkyl 3-hydroxy and 3-mercaptopyrazinoates
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1967-04-13 |
1970-09-08 |
Merck & Co Inc |
Process for the preparation of pyrazinoylguanidines from a pyrazinoic azide and a guanidine
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(en)
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1967-04-27 |
1970-04-21 |
Merck & Co Inc |
3-hydroxy- and 3-mercaptopyrazinamidoguanidines the corresponding ethers and thioethers and processes for their preparation
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(en)
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1967-08-08 |
1970-04-21 |
Merck & Co Inc |
1h - imidazo(4,5-b)pyrazin - 2 - one and processes for their preparation
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(en)
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1967-09-28 |
1969-12-30 |
Merck & Co Inc |
2,4 - diamino - 6 - halopteridines and processes for their preparation
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(en)
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1967-11-07 |
1970-03-31 |
Merck & Co Inc |
Process for preparation of pyrazinoylguanidines
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(en)
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1967-11-14 |
1970-06-02 |
Merck & Co Inc |
2 - (5 - amino - 1h - 1,2,4 - triazol - 3 - yl)- 3-aminopyrazines and processes for their preparation
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(en)
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1968-02-14 |
1970-09-29 |
Merck & Co Inc |
1-(3-aminopyrazinoyl)-4,5,5-trisubstituted biguanide products
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(en)
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1968-04-12 |
1969-08-12 |
Merck & Co Inc |
1h-imidazo(4,5-b)pyrazin-2-ones and processes for their preparation
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1968-04-30 |
1970-04-14 |
Merck & Co Inc |
Process for preparation of pyrazinoyland pyrazinamidoguanidines
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1968-07-03 |
1971-12-07 |
Merck & Co Inc |
Certain halophenoxy alkanamides, hydrazides and derivatives thereof
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1968-07-25 |
1971-04-20 |
Merck & Co Inc |
Process for the preparation of 3-aminopyrazinoylureas
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1968-09-04 |
1970-12-01 |
Merck & Co Inc |
Process for making pyrazinoylthiourea compounds
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1968-11-13 |
1971-01-12 |
Merck & Co Inc |
1-(3 - aminopyrazinoyl) - 3 - substituted-3-thioisosemicarbazides and method for preparation
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1968-11-13 |
1971-01-12 |
Merck & Co Inc |
1-(3-aminopyrazinoyl)semicarbazides,1-(3-aminopyrazinoyl) - thiosemicarbazides,and method for their preparation
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1968-11-25 |
1972-06-06 |
Merck & Co Inc |
Substituted 1-oxoinden-5-yloxy alkanoic acids
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1968-12-18 |
1971-06-22 |
Merck & Co Inc |
Certain aminopyridinecarbonyl guanidines
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1968-12-30 |
1971-03-30 |
Merck & Co Inc |
(3-amino-pyrazinoyl)sulfamides and their preparation
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1969-02-12 |
1971-05-04 |
Merck & Co Inc |
Pyrazinamide derivatives and processes for their preparation
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1969-03-05 |
1971-03-30 |
Merck & Co Inc |
Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides
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1969-03-18 |
1970-12-01 |
Merck & Co Inc |
3-amino-5,6-substituted pyrazinamides
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1970-04-17 |
1972-05-02 |
Merck & Co Inc |
Imidazo(4 5-b)pyrazines
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1970-12-23 |
1975-02-04 |
Merck & Co Inc |
Substituted 2-aminomethyl-4,6-dihalophenols
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1971-03-03 |
1974-02-26 |
Merck & Co Inc |
Methods of treating edema and hypertension using certain 2-aminoethylphenols
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1971-11-12 |
1973-05-10 |
Merck & Co Inc |
Indanyloxytetrazoles
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1971-12-27 |
1976-04-27 |
Merck & Co., Inc. |
3-Amino-5-sulfonylbenzoic acids
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1972-10-13 |
1976-08-24 |
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[1-Oxo-2,3-hydrocarbylene-5-indanyloxy(or thio)]alkanoic acids
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1972-10-13 |
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1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids
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1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids
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1-oxo-2,2-disubstituted-5-indanyloxy(or thio)alkano acids
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11,12-Secoprostaglandins
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11,12-secoprostaglandins
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10-Aza-11,12-secoprostaglandins
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11,12-secoprostaglandins
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1973-04-25 |
1978-05-23 |
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8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins
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8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins
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Merck & Co Inc |
Aryl-oxo-alkanoic acids
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[1-Oxo-2-thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acids and derivatives thereof
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1973-10-11 |
1980-01-08 |
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Tetrazole derivatives of [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy(or thio)]alkanoic acids
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1973-10-12 |
1977-03-15 |
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[1-Hydroxy-5-indanyloxy (or thio)]-alkanoic acids
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1973-10-12 |
1977-01-18 |
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(1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and (3,4-disubstituted-5-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-yloxy) acetic acids and derivatives
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1973-10-12 |
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Merck & Co Inc |
Indanacetic acid compounds
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[1,3-Dioxo-2-substituted and 2,2-disubstituted- indanyloxy (or thio] alkanoic acids
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[1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids
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Pharmaceutical compositions and method of treatment employing 1,3-dioxo-2,2-disubstituted indanyloxy alkanoic acids
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11,12-Secoprostaglandins
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1973-12-13 |
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8-Halo-11,12-secoprostaglandins
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1974-02-20 |
1976-09-07 |
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2-Aminomethyl-6-trihalo-methylphenols
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1974-03-04 |
1975-10-21 |
Merck & Co Inc |
5-Oxo-6-substituted-cyclopent-{8 f{9 -indole-2-carboxylic acids
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1974-04-03 |
1976-01-06 |
Merck & Co., Inc. |
6-Oxo-7-substituted-6H-indeno-[5,4-b]furan(and thiophene)-carboxylic acids
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1974-04-23 |
1976-05-18 |
Merck & Co., Inc. |
Phenoxyacetic acid derivatives as uricosuric agents
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1974-04-25 |
1975-12-23 |
Merck & Co Inc |
Phenol compounds in treating pain, fever and inflammation
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1974-05-03 |
1976-05-11 |
Merck & Co., Inc. |
Aryl-oxo-heptenoic acids
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1974-05-22 |
1976-08-10 |
Merck & Co., Inc. |
[1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids
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AT351182B
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1974-06-25 |
1979-07-10 |
Merck & Co Inc |
Verfahren zur herstellung von neuen 9-thia-, 9-oxothia- und 9-dioxothia- 11,12-secoprosta- glandinen
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PL98342B1
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1974-07-30 |
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Sposob wytwarzania kwasu 1-keto-2-arylo-/lub tienylo/-2-podstawionego-indanyloksy-/lub tio/-5-alkanokarboksylowego
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1974-08-30 |
1977-04-26 |
Merck & Co., Inc. |
Substituted phenoxy-tridecanoic acids
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1974-09-13 |
1976-11-09 |
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16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins
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1974-09-13 |
1977-10-25 |
Merck & Co., Inc. |
11,12-Seco-prostaglandins
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1975-02-24 |
1976-10-05 |
Merck & Co., Inc. |
6-Oxo-7-substituted and 7,7-disubstituted-6H-indeno-[5,4-b]furan (and thiophene) carboxylic acids
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1975-04-04 |
1976-10-13 |
Automob Antipollut & Saf Res Center |
Detection apparatus for oil pressure
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1975-04-09 |
1977-04-19 |
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9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins and processes
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1975-04-23 |
1978-06-27 |
Merck & Co., Inc. |
11,12-Secoprostaglandins
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1975-04-25 |
1978-05-30 |
Merck & Co., Inc. |
3,4-Dihydrospiro-2H-1,3-benzoxazines and their use in treating edema, abnormal electrolyte retention, and inflammation
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1975-06-06 |
1977-11-22 |
Merck & Co., Inc. |
8-Halo-11,12-secoprostaglandins
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1975-06-06 |
1977-11-22 |
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8-Methyl-, phenyl-, or substituted phenyl-11,12-secoprostaglandins
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1975-06-18 |
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Merck & Co., Inc. |
Certain 16-aryloxy-11,12-seco-prostaglandins
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1975-07-09 |
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2,3-Dihydro-6,7-disubstituted-5-(acyl)benzofuran-2-carboxylic acids
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1975-07-09 |
1978-05-02 |
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2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids
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1975-07-09 |
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2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids
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1975-08-01 |
1977-08-23 |
Merck & Co., Inc. |
Antiinflammatory 2-aminomethyl-6-trihalomethylphenols
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1975-11-12 |
1980-05-20 |
Merck & Co., Inc. |
Pyridinyl ureas and pharmaceutical use
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1975-11-25 |
1977-06-14 |
Merck & Co., Inc. |
Substituted 2-aminomethyl-6-iodophenols
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1975-12-09 |
1977-05-24 |
Smithkline Corporation |
7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
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1975-12-15 |
1978-04-18 |
Merck & Co., Inc. |
Pyrazinecarboxamides and processes for preparing same
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1976-02-19 |
1978-01-24 |
Merck & Co., Inc. |
Method of treating autoimmune diseases
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1976-03-22 |
1978-04-18 |
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9-Thia-, 9-oxothia-, and 9-dioxothia-11,12-seco-prostaglandins and processes
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1976-03-22 |
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Merck & Co., Inc. |
9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins
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1976-05-03 |
1977-06-14 |
Merck & Co., Inc. |
Method of treatment with 2-iminothiazolidines and thiazolines
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1976-05-03 |
1980-01-01 |
Merck & Co., Inc. |
Derivatives of 2-iminothiazolidines and thiazolines
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1976-05-24 |
1977-11-22 |
Merck & Co., Inc. |
Certain thiazolidine compounds
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1976-05-24 |
1977-05-10 |
Merck & Co., Inc. |
Novel analogs of prostaglandins with 4-oxo-thiazolidinyl nucleus and method of preparation thereof
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1976-06-15 |
1977-12-19 |
Merck & Co Inc |
2-imino-3-aminothiazolidinen.
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1976-06-15 |
1977-10-18 |
Merck & Co., Inc. |
Dihydro- and tetrahydro- iminothiazines
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1976-06-15 |
1977-05-24 |
Merck & Co., Inc. |
Imidazothiazines
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1976-07-23 |
1978-05-02 |
Merck & Co., Inc. |
(3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens
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1976-07-29 |
1978-09-05 |
Air Products & Chemicals, Inc. |
Allyl esters of n-alkyl-omega-(alkyleneureido) amic acids and their synthesis and use in aqueous emulsion polymer systems
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1976-08-16 |
1978-01-10 |
Merck & Co., Inc. |
Spirobenzoxazinium salts, method of use and compositions thereof as antihypertensive agents
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1976-10-18 |
1978-04-18 |
Merck & Co., Inc. |
6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids
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1976-12-06 |
1978-07-11 |
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5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives
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1976-12-17 |
1979-04-17 |
Merck & Co., Inc. |
Interphenylene 11,12-secoprostaglandins
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1976-12-17 |
1979-11-20 |
Merck & Co., Inc. |
Interphenylene 11,12-secoprostaglandins
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1977-01-24 |
1978-08-08 |
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Inhibition of indoleamine-N-methyl transferase by 2-iminopyridines
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1977-02-17 |
1978-05-02 |
Merck & Co., Inc. |
8-Aza-9-dioxothiaprostanoic acids
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1977-03-04 |
1978-09-19 |
Merck & Co., Inc. |
N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidine and processes for preparing same
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1977-03-04 |
1980-06-17 |
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N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same
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1977-04-04 |
1978-09-05 |
Merck & Co., Inc. |
Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins
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1977-06-17 |
1978-09-19 |
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2,3-Dichloro-4-[(substituted-sulfonyl)-phenoxy]-acetic acids
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1977-06-29 |
1980-04-01 |
Merck & Co., Inc. |
6-Substituted amiloride derivatives
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1977-07-18 |
1979-01-09 |
Merck & Co., Inc. |
Substituted naphthyridinones
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1977-07-18 |
1980-10-21 |
Merck & Co., Inc. |
Substituted naphthyridinones and processes for their preparations
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1977-07-26 |
1985-08-20 |
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Prostaglandin antagonists
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Soluble amide & ester pyrazinoylguanidine sodium channel blockers
|
US7807834B2
(en)
*
|
2005-08-03 |
2010-10-05 |
Parion Sciences, Inc. |
Capped pyrazinoylguanidine sodium channel blockers
|