ATE411805T1 - Organo-phosphorverbindungen zur aktivierung von gamma/delta-t-zellen - Google Patents
Organo-phosphorverbindungen zur aktivierung von gamma/delta-t-zellenInfo
- Publication number
- ATE411805T1 ATE411805T1 AT02776913T AT02776913T ATE411805T1 AT E411805 T1 ATE411805 T1 AT E411805T1 AT 02776913 T AT02776913 T AT 02776913T AT 02776913 T AT02776913 T AT 02776913T AT E411805 T1 ATE411805 T1 AT E411805T1
- Authority
- AT
- Austria
- Prior art keywords
- delta
- gamma
- activation
- cells
- organo
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 2
- 150000002903 organophosphorus compounds Chemical class 0.000 title abstract 2
- 101100453077 Botryococcus braunii HDR gene Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65746—Esters of oxyacids of phosphorus the molecule containing more than one cyclic phosphorus atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/098—Esters of polyphosphoric acids or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Virology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2001134705 DE10134705A1 (de) | 2001-07-20 | 2001-07-20 | Organo-Phosphorverbindungen zur Aktivierung von gamma/delta-T-Zellen |
DE2001135395 DE10135395A1 (de) | 2001-07-25 | 2001-07-25 | Organo-Phosphorverbindungen zur Aktivierung von gamma/delta-T-Zellen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE411805T1 true ATE411805T1 (de) | 2008-11-15 |
Family
ID=26009714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02776913T ATE411805T1 (de) | 2001-07-20 | 2002-07-18 | Organo-phosphorverbindungen zur aktivierung von gamma/delta-t-zellen |
Country Status (13)
Country | Link |
---|---|
US (3) | US7399756B2 (de) |
EP (1) | EP1408984B1 (de) |
JP (1) | JP4607451B2 (de) |
KR (1) | KR100906018B1 (de) |
CN (1) | CN1533279A (de) |
AT (1) | ATE411805T1 (de) |
AU (1) | AU2002339423B2 (de) |
CA (1) | CA2453817C (de) |
DE (1) | DE50212935D1 (de) |
DK (1) | DK1408984T3 (de) |
ES (1) | ES2315411T3 (de) |
PT (1) | PT1408984E (de) |
WO (1) | WO2003009855A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10201458A1 (de) * | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
KR100906018B1 (ko) * | 2001-07-20 | 2009-07-06 | 바이오에이전시 아게 | 감마/델타 t세포 활성화를 위한 유기-인 화합물 |
FR2833266B1 (fr) * | 2001-12-11 | 2004-10-22 | Mayoly Spindler Lab | Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2 |
FR2836483B1 (fr) * | 2002-02-22 | 2006-09-15 | Innate Pharma | Procedes de production de lymphocytes gamma delta t |
GB0212666D0 (en) * | 2002-05-31 | 2002-07-10 | Secr Defence | Immunogenic sequences |
EP1426052B1 (de) * | 2002-12-02 | 2009-09-02 | Innate Pharma | Interleukin-2 und Gamma Delta T Zellaktivator enthaltende Zusammensetzungen und deren Verwendungen |
EA014685B1 (ru) | 2003-04-25 | 2010-12-30 | Джилид Сайэнс, Инк. | Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе |
EP1689758A2 (de) * | 2003-12-02 | 2006-08-16 | Innate Pharma | Neue klasse von aktivatoren von gamma-delta-t-zellen und deren verwendung |
US20100291118A1 (en) * | 2003-12-02 | 2010-11-18 | Innate Pharma | Class of Gamma Delta T Cells Activators and Use Thereof |
US20070134273A1 (en) * | 2004-02-10 | 2007-06-14 | Francois Romagne | Composition and method for the treatment of carcinoma |
AU2005235271A1 (en) * | 2004-04-26 | 2005-11-03 | Innate Pharma | Adjuvant composition and methods for its use |
ATE505196T1 (de) | 2004-07-27 | 2011-04-15 | Gilead Sciences Inc | Nukleosid phosphonat konjugate als anti hiv mittel |
WO2006067635A2 (en) * | 2004-12-20 | 2006-06-29 | Innate Pharma S.A. | USE OF Ϝδ T LYMPHOCYTE ACTIVATORS AS VACCINE ADJUVANT |
WO2006103568A2 (en) * | 2005-03-22 | 2006-10-05 | Innate Pharma | NEW CLASS OF Ϝδ T CELLS ACTIVATORS AND USE THEREOF |
GB2443591B (en) * | 2005-09-07 | 2010-04-28 | Secr Defence | Adjuvanted vaccine |
EP1933848A2 (de) * | 2005-10-06 | 2008-06-25 | Innate Pharma | Phosphoantigen-salze von organischen basen und verfahren zu ihrer kristallisation |
WO2008012538A2 (en) * | 2006-07-25 | 2008-01-31 | The Secretary Of State For Defence | Live vaccine strains of francisella |
US20100029674A1 (en) | 2006-11-17 | 2010-02-04 | Innate Pharma, S.A. | Methods of Using Phosphoantigen for the Treatment of Cancer |
EP2123285A1 (de) | 2008-05-21 | 2009-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nucleosid-Phosphorantigene zur Verwendung in der VGAMMA9VDELTA2-T-Zellen-vermittelten Therapie |
US20100093667A1 (en) | 2008-07-08 | 2010-04-15 | Gilead Sciences, Inc. | Salts of hiv inhibitor compounds |
WO2010029062A1 (en) * | 2008-09-10 | 2010-03-18 | Innate Pharma | Novel polymorphic form of chdmapp, method of preparation thereof, and pharmaceutical composition comprising same |
GB0901411D0 (en) * | 2009-01-29 | 2009-03-11 | Secr Defence | Treatment |
GB0901423D0 (en) * | 2009-01-29 | 2009-03-11 | Secr Defence | Treatment |
GB0906234D0 (en) | 2009-04-14 | 2009-05-20 | Secr Defence | Vaccine |
US10814006B2 (en) | 2015-07-14 | 2020-10-27 | University Of Iowa Research Foundation | Fluorescent prodrugs |
SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
CN109651429A (zh) * | 2017-10-11 | 2019-04-19 | 清华大学 | 高效稳定的Vγ9Vδ2 T细胞的小分子激动剂 |
CN111465383A (zh) | 2017-12-11 | 2020-07-28 | 宝洁公司 | 包括含有膦酸根基团和阴离子基团的聚合物的口腔护理组合物 |
MX2020005973A (es) | 2017-12-11 | 2022-04-29 | Procter & Gamble | Composiciones para el cuidado bucal que comprenden polimeros que contienen grupo fosfono-fosfato y anionico. |
CN111372554A (zh) | 2017-12-11 | 2020-07-03 | 宝洁公司 | 包含多价阳离子和含膦酰基-磷酸根聚合物的组合物 |
CN111372657A (zh) * | 2017-12-11 | 2020-07-03 | 宝洁公司 | 含有膦酰基-磷酸根的化合物和聚合物 |
WO2019118417A1 (en) | 2017-12-11 | 2019-06-20 | The Procter & Gamble Company | Phosphono-phosphate and anionic group containing polymers |
WO2019118418A1 (en) | 2017-12-11 | 2019-06-20 | The Procter & Gamble Company | Method of making phosphono-phosphate containing compounds |
US11926641B2 (en) | 2018-03-19 | 2024-03-12 | University Of Iowa Research Foundation | Phosphonamidate butyrophilin ligands |
EP3856206A1 (de) | 2018-09-27 | 2021-08-04 | Phosphogam, Inc. | Verfahren und zusammensetzungen zur expansion und verwendung allogener gamma-/delta-t-zellen |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639653A (en) * | 1993-07-19 | 1997-06-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy | Method for proliferating Vγ2Vδ2 T cells |
FR2715660A1 (fr) | 1994-01-28 | 1995-08-04 | Centre Nat Rech Scient | Composés organo-phosphorés activateurs des lymphocytes Tgammadelta, procédé pour préparer et/ou isoler et/ou caractériser ces composés, compositions et utilisations pharmaceutiques. |
WO1997043437A2 (en) * | 1996-05-15 | 1997-11-20 | The University Of Sheffield | Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors |
DE19828450A1 (de) | 1998-06-26 | 1999-12-30 | Hassan Jomaa | Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien |
FR2782721B1 (fr) | 1998-09-01 | 2000-11-03 | Inst Nat Sante Rech Med | Nouveaux composes phosphohalohydrines, procede de fabrication et applications |
ATE317007T1 (de) * | 1998-09-22 | 2006-02-15 | Bioagency Ag | Gene des 1-desoxy-d-xylulose-biosynthesewegs |
DE19854310A1 (de) | 1998-11-25 | 2000-06-29 | Hassan Jomaa | Verwendung von Phosphonoameisensäurederivaten zur therapeutischen und prophylaktischen Behandlung von Infektionen |
US6534050B1 (en) * | 1999-01-21 | 2003-03-18 | Chugai Seiyaku Kabushiki Kaisha | 2-methyl-3-butenyl-1-pyrophosphoric acid salts and agents for treating lymphocytes |
FR2791981B1 (fr) | 1999-04-06 | 2001-07-20 | Inst Nat Sante Rech Med | Composes inhibant selectivement les lymphocytes tgamma9delta2, et leurs applications |
JP2003500073A (ja) * | 1999-05-21 | 2003-01-07 | ヨマー、ファルマカ、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング | イソプレノイドの濃度を変更するためのデオキシ−d−キシルロースホスフェート生合成経路の遺伝子の使用 |
AU7729000A (en) | 1999-09-30 | 2001-04-30 | National Jewish Medical And Research Center | Modulation of gammadelta t cells to regulate airway hyperresponsiveness |
DE10027821A1 (de) | 2000-06-05 | 2001-12-06 | Adelbert Bacher | Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg |
US6841717B2 (en) | 2000-08-07 | 2005-01-11 | Monsanto Technology, L.L.C. | Methyl-D-erythritol phosphate pathway genes |
DE10201458A1 (de) * | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
DE10119905A1 (de) | 2001-04-23 | 2002-10-24 | Jomaa Pharmaka Gmbh | Inaktivierung von Genen des MEP-Wegs |
KR100906018B1 (ko) * | 2001-07-20 | 2009-07-06 | 바이오에이전시 아게 | 감마/델타 t세포 활성화를 위한 유기-인 화합물 |
EP1470217A1 (de) | 2001-10-31 | 2004-10-27 | Université Libre de Bruxelles | Herstellung und verwendung dendritischer zellen |
-
2002
- 2002-07-18 KR KR1020047000770A patent/KR100906018B1/ko not_active IP Right Cessation
- 2002-07-18 AT AT02776913T patent/ATE411805T1/de active
- 2002-07-18 US US10/484,143 patent/US7399756B2/en not_active Expired - Fee Related
- 2002-07-18 CN CNA028145585A patent/CN1533279A/zh active Pending
- 2002-07-18 ES ES02776913T patent/ES2315411T3/es not_active Expired - Lifetime
- 2002-07-18 CA CA2453817A patent/CA2453817C/en not_active Expired - Fee Related
- 2002-07-18 DK DK02776913T patent/DK1408984T3/da active
- 2002-07-18 DE DE50212935T patent/DE50212935D1/de not_active Expired - Lifetime
- 2002-07-18 EP EP02776913A patent/EP1408984B1/de not_active Expired - Lifetime
- 2002-07-18 JP JP2003515247A patent/JP4607451B2/ja not_active Expired - Fee Related
- 2002-07-18 WO PCT/EP2002/007986 patent/WO2003009855A2/de active IP Right Grant
- 2002-07-18 PT PT02776913T patent/PT1408984E/pt unknown
- 2002-07-18 AU AU2002339423A patent/AU2002339423B2/en not_active Ceased
-
2008
- 2008-06-11 US US12/137,241 patent/US7871992B2/en not_active Expired - Fee Related
-
2011
- 2011-01-17 US US13/007,852 patent/US20110112054A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PT1408984E (pt) | 2008-12-26 |
ES2315411T3 (es) | 2009-04-01 |
US7871992B2 (en) | 2011-01-18 |
EP1408984B1 (de) | 2008-10-22 |
US20060030546A1 (en) | 2006-02-09 |
CA2453817C (en) | 2011-09-20 |
US20080249067A1 (en) | 2008-10-09 |
AU2002339423B2 (en) | 2007-03-15 |
AU2002339423C1 (en) | 2003-02-17 |
CN1533279A (zh) | 2004-09-29 |
JP2005508305A (ja) | 2005-03-31 |
DE50212935D1 (de) | 2008-12-04 |
WO2003009855A2 (de) | 2003-02-06 |
CA2453817A1 (en) | 2003-02-06 |
JP4607451B2 (ja) | 2011-01-05 |
WO2003009855A3 (de) | 2003-11-06 |
US20110112054A1 (en) | 2011-05-12 |
KR100906018B1 (ko) | 2009-07-06 |
KR20040030814A (ko) | 2004-04-09 |
US7399756B2 (en) | 2008-07-15 |
DK1408984T3 (da) | 2009-02-09 |
EP1408984A2 (de) | 2004-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE411805T1 (de) | Organo-phosphorverbindungen zur aktivierung von gamma/delta-t-zellen | |
CY1108655T1 (el) | ΘΕΙΟΖΟΛΙΔΙΝ-4-ΟΝΕΣ ΓΙΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΠΡΩΤΕΪΝΩΝ hYAK3 | |
CY1116385T1 (el) | Αντινοηματικη διαμορφωση της εκφρασης της απολιποπρωτεινης β | |
TR200002965T2 (tr) | Enfeksiyonların terapötik ve profilaktik tedavisi için organofosforlu terkiplerin kullanımı | |
ATE364698T1 (de) | Neues, physiologisch aktives peptid und dessen verwendung | |
DE60325209D1 (de) | Diarylharnstoffderivate, die sich zur behandlung von proteinkinaseabhängigen krankheiten eignen | |
BR0315689A (pt) | Alvo para terapia de dano cognitivo | |
PT1140944E (pt) | Derivados de epotilona e sua utilizacao como agentes antitumorais | |
CY1115745T1 (el) | Συνθεσεις και μεθοδοι για αντιμετωπιση ή προληψη σχετιζομενης με οξαλικα νοσου | |
CY1112055T1 (el) | Συνθεσεις και μεθοδοι για την διαγνωση και θεραπευτικη αγωγη ογκου πνευμονα | |
BR0107943A (pt) | Sìtios de entrada de ribossoma internos sintéticos e métodos de identificar os mesmos | |
ATE478082T1 (de) | Phosphonate, monophosphonamidate, bisphosphonamidate zur behandlung von virenerkrankungen | |
TR200500221T2 (tr) | Farmasötik Maddeler Olarak Bisiklik Amino Asitler | |
BR0116452A (pt) | Composto, composição farmacêutica, uso de um composto | |
ATE453653T1 (de) | Platinkomplexe zur behandlung von tumoren | |
HUP0302384A2 (hu) | Sejtek bioenergia metabolizmusában szerepet játszó biokémiai vegyületeket tartalmazó készítmények és alkalmazásuk | |
EA200900802A1 (ru) | Способы и композиции для лечения амилоидных заболеваний | |
DE60120691D1 (de) | Zusammensetzungen zur verwendung bei der behandlung der osteoporose und/oder der entzündlichen gelenkerkrankungen | |
EA200500934A1 (ru) | Соединения, модулирующие активность киназного белка множественных линий, и способы лечения нейродегенеративных и воспалительных заболеваний | |
WO2003105753A3 (en) | METHODS AND COMPOSITIONS FOR GRAFTING FUNCTIONAL LOOPS INTO A PROTEIN | |
PT1140113E (pt) | Utilizacao de bisfosfonatos para profilaxia e tratamento de processos infecciosos | |
ATE290857T1 (de) | Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen | |
ATE222896T1 (de) | Substituierte thiazoline und ihre verwendung zur bekämpfung von tierischen schädlingen | |
ATE225805T1 (de) | Hundecoronavirus s gen und verwendung davon | |
ATE267194T1 (de) | Medikamente geeignet zur behandlung von proliferativen erkrankungen |