ATE407685T1 - Verbindungen und methoden zur behandlung von hautverletzungen - Google Patents
Verbindungen und methoden zur behandlung von hautverletzungenInfo
- Publication number
- ATE407685T1 ATE407685T1 AT01984214T AT01984214T ATE407685T1 AT E407685 T1 ATE407685 T1 AT E407685T1 AT 01984214 T AT01984214 T AT 01984214T AT 01984214 T AT01984214 T AT 01984214T AT E407685 T1 ATE407685 T1 AT E407685T1
- Authority
- AT
- Austria
- Prior art keywords
- skin
- appearance
- compounds
- methods
- subject
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/986—Milk; Derivatives thereof, e.g. butter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Obesity (AREA)
- Birds (AREA)
- Endocrinology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPQ8786A AUPQ878600A0 (en) | 2000-07-13 | 2000-07-13 | Compositions and methods for the treatment of intact skin |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407685T1 true ATE407685T1 (de) | 2008-09-15 |
Family
ID=3822850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01984214T ATE407685T1 (de) | 2000-07-13 | 2001-07-13 | Verbindungen und methoden zur behandlung von hautverletzungen |
Country Status (9)
Country | Link |
---|---|
US (1) | US7410946B2 (de) |
EP (1) | EP1303284B1 (de) |
JP (1) | JP2004502788A (de) |
AT (1) | ATE407685T1 (de) |
AU (1) | AUPQ878600A0 (de) |
CA (1) | CA2415701A1 (de) |
DE (1) | DE60135755D1 (de) |
NZ (1) | NZ523533A (de) |
WO (1) | WO2002005828A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030134780A1 (en) * | 2001-10-05 | 2003-07-17 | Procyte Corporation | Skin care compositions containing peptide copper complexes and retinol, retinol derivatives, or a mixture thereof |
WO2003047543A1 (en) * | 2001-10-05 | 2003-06-12 | Procyte Corporation | Methods for the treatment of hyperpigmentation of skin |
AUPS282002A0 (en) * | 2002-06-06 | 2002-06-27 | Gropep Limited | Metalloproteinase inhibitors |
WO2004004671A1 (en) * | 2002-07-02 | 2004-01-15 | Procyte Corporation | Compositions containing peptide copper complexes and soft tissue fillers |
ATE493966T1 (de) * | 2003-05-07 | 2011-01-15 | Snow Brand Milk Products Co Ltd | Mittel zur förderung der hautkollagenproduktion |
IL157814A (en) | 2003-09-08 | 2007-12-03 | Lev Bar Ltd | Cosmetic composition comprising camel milk or components thereof |
WO2005049054A1 (en) * | 2003-11-21 | 2005-06-02 | Beta Peptide Pty Ltd | Compositions and methods for the treatment of skin damage |
DE102005002486A1 (de) * | 2005-01-18 | 2006-07-27 | Henkel Kgaa | Tensidhaltiges Reinigungsmittel mit speziellen Proteinen |
EP1865920A1 (de) * | 2005-04-04 | 2007-12-19 | Bioartificial Gel Technologies Inc. | Verhütung und behandlung von strahlenbedingter dermatitis |
US20070004036A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for keratinocyte culture |
US20070128685A1 (en) * | 2005-07-01 | 2007-06-07 | Rodolfo Faudoa | Methods and compositions for cell culture |
US20070003541A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for therapeutics |
US8435224B2 (en) | 2005-09-12 | 2013-05-07 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds |
JP5399072B2 (ja) | 2005-09-12 | 2014-01-29 | アベラ ファーマスーティカルズ インコーポレイテッド | ジメチルスルホキシド(dmso)若しくは関連化合物、又はそれに関連する臭気を除去するシステム |
US8480797B2 (en) | 2005-09-12 | 2013-07-09 | Abela Pharmaceuticals, Inc. | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors |
EP1937286B1 (de) | 2005-09-12 | 2016-03-09 | Abela Pharmaceuticals, Inc. | Zusammensetzungen aus dimethylsulfoxid (dmso) |
US9284274B2 (en) | 2005-12-07 | 2016-03-15 | Ramot At Tel-Aviv University Ltd. | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof |
US7776339B2 (en) * | 2006-01-11 | 2010-08-17 | Active Organics, Lp | Extract of R. miehei |
JP2008255020A (ja) * | 2007-04-02 | 2008-10-23 | Fujifilm Corp | 抗老化皮膚外用剤 |
BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
US9284252B2 (en) | 2009-06-09 | 2016-03-15 | Sepal Pharma Ltd. | Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders |
AU2010258223B2 (en) * | 2009-06-09 | 2014-12-04 | Ramot At Tel-Aviv University Ltd. | Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders |
US8100186B2 (en) * | 2009-07-15 | 2012-01-24 | Enventure Global Technology, L.L.C. | Expansion system for expandable tubulars and method of expanding thereof |
KR20120093993A (ko) | 2009-10-30 | 2012-08-23 | 아벨라 파마슈티칼스, 인코포레이티드 | 퇴행성 관절염 치료를 위한 디메틸설폭사이드 및 메틸설포닐메탄 제제 |
AU2012210013C1 (en) * | 2011-01-26 | 2017-06-01 | Megmilk Snow Brand Co., Ltd. | Sense-improving agent |
US20140234433A1 (en) * | 2013-02-15 | 2014-08-21 | Nicholas V. Perricone | Topical Composition for Stimulating Epidermis and Dermis Layers of the Skin |
CN104547309A (zh) * | 2014-12-25 | 2015-04-29 | 湖南炎帝生物工程有限公司 | 一种祛黄褐斑的中药组合物及其制备方法与应用 |
CN105396124A (zh) * | 2015-11-30 | 2016-03-16 | 吉林省宝沪生物科技有限公司 | 一种治疗紫外线致表皮角朊细胞凋亡的药物 |
RU2632707C1 (ru) * | 2016-12-07 | 2017-10-09 | Лариса Валентиновна Гладских | Способ профилактики реинфицирования травмированной поверхности кожи у пациентов при проведении косметической процедуры пилинга |
CN106906180A (zh) | 2016-12-28 | 2017-06-30 | 里程 | 一种具有生物活化作用的复合添加剂及其制备方法和用途 |
CN107397862A (zh) * | 2017-08-24 | 2017-11-28 | 王小军 | 一种治疗坏疽性脓皮症的中药 |
CN111704652B (zh) * | 2020-06-02 | 2022-04-22 | 昆明医科大学 | 一种抗光损伤皮肤保护活性多肽om-gl15及其应用 |
CN112221021B (zh) * | 2020-11-02 | 2023-02-07 | 中南大学湘雅三医院 | 一种皮肤科智能激光祛斑控制*** |
KR102627823B1 (ko) * | 2021-05-11 | 2024-01-19 | 충북대학교 산학협력단 | 우유로부터 유래된 엑소좀을 유효성분으로 포함하는 흉터 생성 억제용 조성물 |
CN113312790A (zh) * | 2021-06-16 | 2021-08-27 | 中国医学科学院放射医学研究所 | 一种辐射剂量的分析方法、装置、存储介质及电子设备 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3959491A (en) * | 1974-10-29 | 1976-05-25 | Stiefel Laboratories, Inc. | Stable human skin cosmetic composition containing milk |
WO1992000994A1 (en) | 1990-07-13 | 1992-01-23 | Gropep Pty. Ltd. | Growth-promoting agent |
US6319522B1 (en) * | 1990-07-13 | 2001-11-20 | Gropep Limited | Growth-promoting agent |
AUPN271295A0 (en) | 1995-05-02 | 1995-05-25 | Gropep Pty Ltd | Method of treatment |
AU5833994A (en) * | 1993-01-26 | 1994-08-15 | Horse Vitality Ltd. | Pharmaceutical and dermocosmetic compositions containing equine colostrum |
US5435997A (en) * | 1994-02-08 | 1995-07-25 | Burns; Michael J. | Topical agent and method for the treatment of pseudofolliculitis barbae |
AUPM534794A0 (en) | 1994-04-28 | 1994-05-19 | Gropep Pty Ltd | Modified milk growth factor |
JPH08133943A (ja) * | 1994-11-04 | 1996-05-28 | Kyodo Nyugyo Kk | 美肌剤 |
JP4051475B2 (ja) * | 1996-03-15 | 2008-02-27 | バイオイコール アーゲー | 成長因子複合体の抽出方法 |
DE19649891C2 (de) | 1996-12-02 | 1998-12-10 | Mk Produktkontor Gmbh | Verwendung von antioxidativen Zusammensetzungen mit Süßmolkekonzentrat |
ES2139525B1 (es) * | 1997-11-17 | 2000-10-16 | Sanchez Pedro Cuevas | Empleo de derivados del lactosuero como citoprotectores y cicatrizantes. |
JP3643691B2 (ja) * | 1998-02-05 | 2005-04-27 | 株式会社ノエビア | 皮膚外用剤 |
JP4762383B2 (ja) * | 1998-03-12 | 2011-08-31 | キユーピー株式会社 | 線維芽細胞増殖剤 |
FR2781151B1 (fr) * | 1998-07-17 | 2001-11-23 | Jean Noel Thorel | Produits cosmetiques ou dermo-pharmaceutiques, d'origine laitiere |
JP3907856B2 (ja) * | 1998-11-17 | 2007-04-18 | 株式会社ナリス化粧品 | 化粧料 |
JP2000178165A (ja) * | 1998-12-16 | 2000-06-27 | Shiseido Co Ltd | 皮膚外用剤 |
-
2000
- 2000-07-13 AU AUPQ8786A patent/AUPQ878600A0/en not_active Abandoned
-
2001
- 2001-07-13 EP EP01984214A patent/EP1303284B1/de not_active Expired - Lifetime
- 2001-07-13 JP JP2002511760A patent/JP2004502788A/ja active Pending
- 2001-07-13 WO PCT/AU2001/000854 patent/WO2002005828A1/en active IP Right Grant
- 2001-07-13 DE DE60135755T patent/DE60135755D1/de not_active Expired - Lifetime
- 2001-07-13 AT AT01984214T patent/ATE407685T1/de not_active IP Right Cessation
- 2001-07-13 CA CA002415701A patent/CA2415701A1/en not_active Abandoned
- 2001-07-13 NZ NZ523533A patent/NZ523533A/en not_active IP Right Cessation
- 2001-07-13 US US10/332,705 patent/US7410946B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20040081673A1 (en) | 2004-04-29 |
WO2002005828A1 (en) | 2002-01-24 |
EP1303284A4 (de) | 2004-05-12 |
EP1303284B1 (de) | 2008-09-10 |
JP2004502788A (ja) | 2004-01-29 |
CA2415701A1 (en) | 2002-01-24 |
DE60135755D1 (de) | 2008-10-23 |
US7410946B2 (en) | 2008-08-12 |
AUPQ878600A0 (en) | 2000-08-03 |
NZ523533A (en) | 2006-09-29 |
EP1303284A1 (de) | 2003-04-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE407685T1 (de) | Verbindungen und methoden zur behandlung von hautverletzungen | |
TW200509956A (en) | Compositions and methods for treatment of rosacea | |
BR0309890A (pt) | Composição farmacêutica contendo plasma sanguìneo, ou soro sanguìneo utilizada no tratamento de lesões, bem como seu método e processo de aplicação | |
BR0008926A (pt) | Utilização de um extrato de uva, rico ouenriquecido em polifenóis e processo detratamento cosmético do corpo humano | |
DE59907752D1 (de) | Verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien | |
DE60222137D1 (de) | Zuckerderivate von hydromorphon, dihydromorphin und dihydroisomorphin, zusammensetzungen davon und verwendung zur vorbeugung und behandlung von schmerzen | |
WO2006040688A3 (en) | Inhibitors of acetylcholinesterase for treating skin diseases | |
ATE422357T1 (de) | Verwendung von allopurinol zur behandlung von bluthochdruck | |
TW200505473A (en) | Compositions and methods for treatment of psoriasis | |
DE60124715D1 (de) | Er produktion von beta-endorphin | |
EP1952799A3 (de) | Kosmetische Zubereitung mit Hyaluronsäure und Saponinen zur Behandlung von Hautalterungserscheinungen | |
DE60312505D1 (de) | Injektion aus ixeris sonchifolia zur behandlung von kardiozerebralen gefässerkrankungen und funduserkrankungen sowie herstellungsverfahren dafür | |
DE60218843D1 (de) | Verfahren zur identifizierung von mitteln zur behandlung von diabetes | |
DE60237039D1 (de) | Verfahren zur behandlung von rosacea und telangiectasia | |
ATE216251T1 (de) | Myrteextrakt enthaltendes haarpflegemittel, verfahren zur herstellung und verwendung insbesondere für eine antischuppenbehandlung | |
WO1999056666A8 (en) | The treatment of sexual dysfunction in certain patient groups | |
HUP0401913A2 (hu) | Bromhidrosis kezelésére és megelőzésére szolgáló gyógyszerkészítmény | |
DE60206280D1 (de) | Verwendung von extrakten aus ginkgo biloba zur herstellung eines medikaments zur behandlung von sarcopenia | |
ATE294582T1 (de) | Verwendung von alpha-1-adrenorezeptor- antagonisten zur herstellung eines medikaments für die vorbeugung und die behandlung von krebs | |
DE69920015D1 (de) | Verfahren zur induktion der herstellung von wachstumsfaktoren | |
ATE492285T1 (de) | Verwendung von kahalalide verbindungen zur herstellung eines arzneimittels zur behandlung von psoriasis | |
ATE448796T1 (de) | Arzneimittel zur behandlung von tumoren und deren metastasen unter verwendung eines bindemoleküls gegen das bone-sialoprotein | |
DE602004016292D1 (de) | Verwendung einer zusammensetzung mit vitamin k1-oxid oder einem derivat daraus zur behandlung und/oder vorbeugung von hautverletzungen bei säugern | |
BG105924A (en) | Composition for the treatment of psoriasis | |
WO2004087090A3 (en) | Cosmetic process using transdermal systems applied to acupuncture points of the face and/or the neck |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |