ATE407677T1 - Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung - Google Patents
Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlungInfo
- Publication number
- ATE407677T1 ATE407677T1 AT97934905T AT97934905T ATE407677T1 AT E407677 T1 ATE407677 T1 AT E407677T1 AT 97934905 T AT97934905 T AT 97934905T AT 97934905 T AT97934905 T AT 97934905T AT E407677 T1 ATE407677 T1 AT E407677T1
- Authority
- AT
- Austria
- Prior art keywords
- propargyl
- tumors
- 10dam
- deazaaminopterin
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2190896P | 1996-07-17 | 1996-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407677T1 true ATE407677T1 (de) | 2008-09-15 |
Family
ID=21806781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97934905T ATE407677T1 (de) | 1996-07-17 | 1997-07-16 | Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung |
Country Status (10)
Country | Link |
---|---|
US (1) | US6028071A (de) |
EP (2) | EP2258702A3 (de) |
JP (2) | JP2001505537A (de) |
AT (1) | ATE407677T1 (de) |
CA (1) | CA2260266C (de) |
DE (1) | DE69738981D1 (de) |
DK (1) | DK0944389T3 (de) |
ES (1) | ES2313737T3 (de) |
PT (1) | PT944389E (de) |
WO (1) | WO1998002163A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2780808B1 (fr) * | 1998-07-03 | 2001-08-10 | Thomson Csf | Dispositif a emission de champ et procedes de fabrication |
US20040053836A1 (en) * | 2002-04-22 | 2004-03-18 | Philipp Mayer-Kuckuk | Method for modulating the production of a selected protein in vivo |
US8263354B2 (en) | 2004-05-30 | 2012-09-11 | Sloan-Kettering Institute For Cancer Research | Methods for assessing cancer for increased sensitivity to 10-propargyl-10-deazaaminopterin |
US20080188479A1 (en) | 2004-05-30 | 2008-08-07 | Sloan-Kettering Institute For Cancer Research | Methods to Treat Cancer with 10-propargyl-10-deazaaminopterin and Methods for Assessing Cancer for Increased Sensitivity to 10-propargyl-10-deazaaminopterin |
WO2005117891A1 (en) * | 2004-05-30 | 2005-12-15 | Sloan-Kettering Institute For Cancer Research | Treatment of t-cell lymphoma using 10-propargyl-10-deazaaminopterin |
US20100248249A1 (en) * | 2007-08-17 | 2010-09-30 | Allos Therapeutics, Inc. | Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels |
US9901578B2 (en) | 2007-08-17 | 2018-02-27 | Allos Therapeutics, Inc. | Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer |
CN102753175A (zh) * | 2010-02-02 | 2012-10-24 | 艾洛斯治疗学有限公司 | 10-炔丙基-10-去氮杂氨基蝶呤之光学纯非对映体以及使用所述非对映体的方法 |
DK2575466T3 (en) * | 2010-06-02 | 2015-07-20 | Allos Therapeutics Inc | Methods of treating methotrexate resistant disorders of 10-propargyl-10-deazaaminopterin |
WO2012061469A2 (en) | 2010-11-02 | 2012-05-10 | Sicor Inc. | Crystalline forms of pralatrexate |
WO2013096800A1 (en) | 2011-12-21 | 2013-06-27 | Plus Chemicals S.A. | Processes and intermediates for preparing pralatrexate |
WO2013164856A1 (en) * | 2012-05-04 | 2013-11-07 | Avra Laboratories Private Limited | A process for preparing intermediates of 10-propargyl-10-deazaaminopterin (pralatrexate) synthesis and the intermediates thereof |
WO2013177713A1 (en) * | 2012-05-31 | 2013-12-05 | Alphora Research Inc. | Process for preparation of an antifolate agent |
WO2014016740A2 (en) | 2012-07-23 | 2014-01-30 | Fresenius Kabi Oncology Ltd. | Improved process for the preparation of pralatrexate |
WO2014020553A1 (en) | 2012-08-03 | 2014-02-06 | Fresenius Kabi Oncology Ltd. | Salts of pralatrexate |
US9783542B2 (en) * | 2012-11-02 | 2017-10-10 | Hetero Research Foundation | Process for pralatrexate |
WO2014187274A1 (zh) * | 2013-05-24 | 2014-11-27 | 苏州明锐医药科技有限公司 | 普拉曲沙及其中间体的制备方法 |
CN103588775B (zh) * | 2013-11-12 | 2016-08-17 | 连云港恒运医药科技有限公司 | 普拉曲沙降解杂质及其制备方法 |
US11439643B2 (en) | 2015-06-16 | 2022-09-13 | Acrotech Biopharma Inc. | Combination therapy using belinostat and pralatrexate to treat lymphoma |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4393064A (en) * | 1976-03-05 | 1983-07-12 | Sri International | Process and composition for treatment of leukemia and process for preparing the same |
US5354751A (en) * | 1992-03-03 | 1994-10-11 | Sri International | Heteroaroyl 10-deazaamino-pterine compounds and use for rheumatoid arthritis |
-
1997
- 1997-07-16 US US09/214,984 patent/US6028071A/en not_active Expired - Lifetime
- 1997-07-16 EP EP10179892A patent/EP2258702A3/de not_active Withdrawn
- 1997-07-16 CA CA2260266A patent/CA2260266C/en not_active Expired - Lifetime
- 1997-07-16 ES ES97934905T patent/ES2313737T3/es not_active Expired - Lifetime
- 1997-07-16 EP EP97934905A patent/EP0944389B1/de not_active Expired - Lifetime
- 1997-07-16 JP JP50613398A patent/JP2001505537A/ja not_active Withdrawn
- 1997-07-16 PT PT97934905T patent/PT944389E/pt unknown
- 1997-07-16 DE DE69738981T patent/DE69738981D1/de not_active Expired - Lifetime
- 1997-07-16 WO PCT/US1997/011982 patent/WO1998002163A1/en active Application Filing
- 1997-07-16 AT AT97934905T patent/ATE407677T1/de active
- 1997-07-16 DK DK97934905T patent/DK0944389T3/da active
-
2008
- 2008-11-19 JP JP2008295509A patent/JP5271677B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT944389E (pt) | 2008-12-03 |
EP2258702A3 (de) | 2011-11-30 |
WO1998002163A1 (en) | 1998-01-22 |
DK0944389T3 (da) | 2008-11-17 |
ES2313737T3 (es) | 2009-03-01 |
CA2260266C (en) | 2011-01-18 |
EP0944389B1 (de) | 2008-09-10 |
CA2260266A1 (en) | 1998-01-22 |
EP0944389A4 (de) | 2001-04-04 |
JP2009091361A (ja) | 2009-04-30 |
JP5271677B2 (ja) | 2013-08-21 |
US6028071A (en) | 2000-02-22 |
EP0944389A1 (de) | 1999-09-29 |
EP2258702A2 (de) | 2010-12-08 |
JP2001505537A (ja) | 2001-04-24 |
DE69738981D1 (de) | 2008-10-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE407677T1 (de) | Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung | |
IL136690A0 (en) | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas | |
IL191890A0 (en) | Tissue inhibitor metalloproteinase type three (timp-3) and compositions thereof | |
TR199802421T2 (xx) | Doku yenilenmesini d�zenleyen maddeler. | |
DE69329559D1 (de) | Verwendung von mannosephosphaten zur behandlung von fibrotischen störungen | |
DE69434313D1 (de) | Superoxiddismutase memetika | |
MX9704030A (es) | 1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos. | |
BR9813318A (pt) | Processo de tratamento de tumores e degeneração macular em paciente humano ou veterinário, composição farmacêutica para tratamento de tumores e degeneração macular em um paciente humano ou veterinário | |
PL302304A1 (en) | Peptides of body organs protecting action, method of obtaining them and their application in therapy | |
ATE79536T1 (de) | Tamoxifen zur topischen verwendung. | |
ZA878249B (en) | Method and therapeutic compositions for the treatment of bleeding disorders | |
ATE291918T1 (de) | Kombinationstherapie zur behandlung von tumoren | |
EP0588477A3 (en) | Medicinal composition comprising tcf-ii | |
ATE251462T1 (de) | Verfahren zur behandlung von narbengewebe | |
ATE25969T1 (de) | 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten. | |
DE60139150D1 (de) | Zusammensetzungen und verfahren zur therapie und diagnose von lungenkrebs | |
ATA57894A (de) | Mittel zur behandlung von osteoporose | |
DE69732851D1 (de) | Verwendung von dextrinsulfat zur behandlung von sehr vasculären tumoren | |
DE19780958D2 (de) | Verwendung von Cytokinen und cytotoxischen Substanzen in einem neuen Verfahren zur Tumorbehandlung | |
DE58904510D1 (de) | Optisch reines dexniguldipin und dessen derivate zur behandlung von tumorerkrankungen. | |
ATE68742T1 (de) | Zusammensetzungen, bestimmt zur holzbehandlung und verfahren zur holzbehandlung. | |
BG102009A (en) | Method for the treatment of manic and two-pole disease |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0944389 Country of ref document: EP |