ATE404519T1 - Hyperforinderivate, ihre verwendung sowie diese enthaltende zubereitungen - Google Patents

Hyperforinderivate, ihre verwendung sowie diese enthaltende zubereitungen

Info

Publication number
ATE404519T1
ATE404519T1 AT03718778T AT03718778T ATE404519T1 AT E404519 T1 ATE404519 T1 AT E404519T1 AT 03718778 T AT03718778 T AT 03718778T AT 03718778 T AT03718778 T AT 03718778T AT E404519 T1 ATE404519 T1 AT E404519T1
Authority
AT
Austria
Prior art keywords
hyperforine
derivatives
preparations containing
adhyperforin
hyperforin
Prior art date
Application number
AT03718778T
Other languages
English (en)
Inventor
Ezio Bombardelli
Paolo Morazzoni
Antonella Riva
Nicola Fuzzati
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of ATE404519T1 publication Critical patent/ATE404519T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Lasers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03718778T 2002-04-23 2003-04-18 Hyperforinderivate, ihre verwendung sowie diese enthaltende zubereitungen ATE404519T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI000872A ITMI20020872A1 (it) 2002-04-23 2002-04-23 Derivati dell'iperforina loro uso e formulazioni che li contengono

Publications (1)

Publication Number Publication Date
ATE404519T1 true ATE404519T1 (de) 2008-08-15

Family

ID=11449767

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03718778T ATE404519T1 (de) 2002-04-23 2003-04-18 Hyperforinderivate, ihre verwendung sowie diese enthaltende zubereitungen

Country Status (19)

Country Link
US (2) USRE43280E1 (de)
EP (1) EP1497250B1 (de)
JP (1) JP4315818B2 (de)
KR (1) KR100944052B1 (de)
CN (1) CN1290816C (de)
AT (1) ATE404519T1 (de)
CA (1) CA2483205C (de)
DE (1) DE60322871D1 (de)
DK (1) DK1497250T3 (de)
ES (1) ES2311697T3 (de)
HK (1) HK1075654A1 (de)
IL (1) IL164763A (de)
IT (1) ITMI20020872A1 (de)
NO (1) NO329176B1 (de)
PL (1) PL205829B1 (de)
PT (1) PT1497250E (de)
RU (1) RU2320636C2 (de)
SI (1) SI1497250T1 (de)
WO (1) WO2003091194A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102772461B (zh) * 2011-05-11 2014-05-14 成都康弘药业集团股份有限公司 药物组合物在制备预防或治疗老年性痴呆的药物中的应用
BR112013030986A2 (pt) * 2011-06-03 2016-12-06 Harvard College análogos de hiperforina, métodos de síntese e usos dos mesmos
ITMI20131012A1 (it) * 2013-06-19 2014-12-20 Indena Spa Derivati dell'iperforina e loro uso nella malattia di alzheimer
US20180071269A1 (en) 2015-08-12 2018-03-15 Tianxin Wang Therapeutical methods, formulations and nutraceutical formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE204759T1 (de) 1998-02-13 2001-09-15 Schwabe Willmar Gmbh & Co Verwendung von hyperforin und hyperforinhaltigen extrakten zur behandlung und prophylaxe von demenzerkrankungen
EP1056705B1 (de) 1998-02-13 2003-10-29 Dr. Willmar Schwabe GmbH & Co. KG Stabile hyperforin-salze, verfahren zu ihrer herstellung und verwendung zur therapie der alzheimerschen krankheit
IT1301679B1 (it) 1998-06-10 2000-07-07 Indena Spa Derivati dell'iperforina, loro uso e formulazioni che licontengono.

Also Published As

Publication number Publication date
USRE43280E1 (en) 2012-03-27
CN1290816C (zh) 2006-12-20
JP2005523917A (ja) 2005-08-11
KR20040111519A (ko) 2004-12-31
DK1497250T3 (da) 2008-12-01
ITMI20020872A1 (it) 2003-10-23
WO2003091194A1 (en) 2003-11-06
PT1497250E (pt) 2008-11-12
ES2311697T3 (es) 2009-02-16
NO20044519L (no) 2004-11-02
ITMI20020872A0 (it) 2002-04-23
EP1497250A1 (de) 2005-01-19
PL205829B1 (pl) 2010-05-31
RU2320636C2 (ru) 2008-03-27
HK1075654A1 (en) 2005-12-23
US20050165117A1 (en) 2005-07-28
RU2004131210A (ru) 2005-04-10
DE60322871D1 (de) 2008-09-25
CA2483205C (en) 2011-07-05
CN1646462A (zh) 2005-07-27
CA2483205A1 (en) 2003-11-06
US7105705B2 (en) 2006-09-12
PL371347A1 (en) 2005-06-13
EP1497250B1 (de) 2008-08-13
AU2003222828A1 (en) 2003-11-10
KR100944052B1 (ko) 2010-02-24
JP4315818B2 (ja) 2009-08-19
SI1497250T1 (sl) 2008-12-31
IL164763A (en) 2010-02-17
IL164763A0 (en) 2005-12-18
NO329176B1 (no) 2010-09-06

Similar Documents

Publication Publication Date Title
NO20053855L (no) 1-fenylalkankarboksylsyrederivater til behandling av neurodegenerative sykdommer.
AU2002233288A1 (en) Combined use of Enzyme Inhibitors and Pharmaceutical Preparations thereof for the Treatment and Prophylaxis of Arteriosclerosis, for the Treatment and Prevention of Allergic Reactions of Type I According to the Gell and Coombs Classification, and for the Treatment and Prevention of Dermatological Diseases Associated with FO
NO20053077L (no) Terapeutiske formuleringer for behandling av beta-amyloid-relaterte sykdommer.
IL154888A (en) Aqueous Pharmaceutical Gel Preparation Containing At least One Vitamin D or One Vitamin D Analog At least One Corticosteroid
WO2004006858A3 (en) Compounds, compositions, and methods employing same
ATE396198T1 (de) 17alpha-alkyl-17beta-oxy-estratriene und zwischenprodukte zu deren herstellung, verwendung der 17alpha-alkyl-17beta-oxy-estratriene zur herstellung von arzneimitteln sowie pharmazeutische präparate
CY1108932T1 (el) Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων
IL167250A (en) Chirale oxazole-arylpropionic acid derivatives, compositions comprising thereof and their use in the preparation of medicaments for the treatment of ppar alpha/ ppar gamma agonists-modulated diseases
MX9708800A (es) Compuestos biciclicos aromaticos.
ZA200501714B (en) Analogues of vitamin d
WO2005027977A3 (en) Diclofenac compositions for the treatment of skin disorders
DE602004014163D1 (de) Pyrimidylpyrrolderivate, die als kinaseinhibitoren wirken
HK1075654A1 (en) Hyperforin derivatives, the use thereof and formulations containing them
WO2003018535A3 (en) Novel aminobenzoephenones
SE0001916D0 (sv) Novel formulation
NO995838L (no) Nye heteroetynylenforbindelser og farmasoeytiske og kosmetiske preparater inneholdende de samme
ATE252383T1 (de) Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure und / oder ihrer physiologisch verträglichen salze zur herstellung eines medikaments zur behandlung von krebserkrankungen
ATE293445T1 (de) Herstellung reiner stereoisomere von tricyclo- (5.2.1.0(2.6) )-dec-9-yl-xanthogenat sowie deren verwendung als arzneimittel
ATE261732T1 (de) Pharmazeutische zusammensetzung, umfassend eukalyptus- und orangenöl
DE60003074D1 (de) Fusidinsäure-derivate
DE60327249D1 (de) Anthranilsäureamide und ihre pharmazeutische verwendung
ATE334675T1 (de) Arzneimittel enthaltend substituierte 2,5- diaminomethyl-1h-pyrrole
HUP0200148A2 (hu) N-(3',4'-dimetoxi-cinnamoil)antranilsav alkalmazása szívkoszorúér-műtéttel kapcsolatos cardiovascularis események megelőzésére vagy mérséklésére
TH48054A3 (th) วิธีการรักษาอาธีโรสเคลอโรซิส โดยใช้ตัวยับยั้ง aP2 และสิ่งผสมรวม
UA37445A (uk) Протизапальний засіб

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1497250

Country of ref document: EP