ATE403678T1 - Peptide, bestehend aus zwei funktionellen pth- domänen, die durch ein linkermolekül verknüpft sind, und derivate davon - Google Patents

Peptide, bestehend aus zwei funktionellen pth- domänen, die durch ein linkermolekül verknüpft sind, und derivate davon

Info

Publication number: ATE403678T1
Authority: AT; Austria
Prior art keywords: pth; derivatives; functional; linker molecule; peptides consisting
Prior art date: 1998-12-31

Application number

AT99968197T

Other languages

English (en)

Inventor

Thomas Gardella

Henry M Kronenberg

John T Potts Jr

Harald Jueppner

Original Assignee

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-31

Filing date

1999-12-30

Publication date

2008-08-15

1999-12-30 Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE403678T1 publication Critical patent/ATE403678T1/de

Links

102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
102000003982 Parathyroid hormone Human genes 0.000 abstract 6
108090000445 Parathyroid hormone Proteins 0.000 abstract 6
239000000199 parathyroid hormone Substances 0.000 abstract 6
229960001319 parathyroid hormone Drugs 0.000 abstract 6
238000000034 method Methods 0.000 abstract 2
239000000556 agonist Substances 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
230000011664 signaling Effects 0.000 abstract 1
OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical group C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT99968197T 1998-12-31 1999-12-30 Peptide, bestehend aus zwei funktionellen pth- domänen, die durch ein linkermolekül verknüpft sind, und derivate davon ATE403678T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11457798P	1998-12-31	1998-12-31

Publications (1)

Publication Number	Publication Date
ATE403678T1 true ATE403678T1 (de)	2008-08-15

Family

ID=22356116

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99968197T ATE403678T1 (de)	1998-12-31	1999-12-30	Peptide, bestehend aus zwei funktionellen pth- domänen, die durch ein linkermolekül verknüpft sind, und derivate davon

Country Status (7)

Country	Link
US (1)	US20080058505A1 (de)
EP (1)	EP1147133B1 (de)
JP (1)	JP2002533115A (de)
AT (1)	ATE403678T1 (de)
AU (1)	AU2486800A (de)
DE (1)	DE69939275D1 (de)
WO (1)	WO2000039278A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4486258B2 (ja)	1998-11-25	2010-06-23	ザ・ジェネラル・ホスピタル・コーポレイション	ヒト副甲状腺ホルモンの改変、調製および使用
EP1141237B1 (de)	1998-12-31	2005-11-02	The General Hospital Corporation	Pth rezeptor und testverfahren unter verwendung desselben
AU2001271935B2 (en) *	2000-07-10	2006-09-14	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Multiple antigenic peptides immunogenic against streptococcus pneumoniae
CA2454275C (en)	2001-07-23	2012-10-23	The General Hospital Corporation	Conformationally constrained parathyroid hormone (pth) analogs
ATE401345T1 (de) *	2002-08-06	2008-08-15	Aplagen Gmbh	Synthetische mimetika von physiologischen bindungsmolekülen
US8088734B2 (en) *	2003-01-21	2012-01-03	Unigene Laboratories Inc.	Oral delivery of peptides
EP2187902B1 (de)	2007-08-01	2013-04-17	The General Hospital Corporation	Screeningverfahren mit g-protein-gekoppelten rezeptoren und entsprechende zusammensetzungen
EP2411038B1 (de)	2009-03-27	2016-12-28	Van Andel Research Institute	Parathryoidhormonpeptide und parathyroidhormonbezogene proteinpeptide sowie anwendungsverfahren dafür
RU2604809C2 (ru)	2010-05-13	2016-12-10	Дзе Дженерал Хоспитал Корпорейшн	Аналоги паратиреоидного гормона и их применение
US20140221282A1 (en) *	2011-05-25	2014-08-07	Astrazeneca Pharmaceuticals Lp	Long duration dual hormone conjugates
US20200354428A9 (en) *	2013-06-23	2020-11-12	Wisconsin Alumni Research Foundation	Analogues of parathyroid hormone (1-34) that function as agonists of the parathyroid hormone receptor-1 and display modified activity profiles
WO2016065052A1 (en)	2014-10-22	2016-04-28	Extend Biosciences, Inc.	Insulin vitamin d conjugates
JP6946182B2 (ja)	2014-10-22	2021-10-06	エクステンドバイオサイエンシズインコーポレーテッドＥｘｔｅｎｄＢｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ	治療用ビタミンｄコンジュゲート

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4086196A (en) *	1975-03-28	1978-04-25	Armour Pharmaceutical Company	Parathyroid hormone
US4675189A (en) *	1980-11-18	1987-06-23	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble active polypeptides
US4736866B1 (en) *	1984-06-22	1988-04-12		Transgenic non-human mammals
IL78342A (en) *	1985-04-04	1991-06-10	Gen Hospital Corp	Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
US4761406A (en) *	1985-06-06	1988-08-02	The Procter & Gamble Company	Regimen for treating osteoporosis
US5527772A (en) *	1987-10-20	1996-06-18	Holick; Michael F.	Regulation of cell proliferation and differentiation using peptides
US5434246A (en) *	1992-03-19	1995-07-18	Takeda Chemical Industries, Ltd.	Parathyroid hormone derivatives
US5814603A (en) *	1992-06-12	1998-09-29	Affymax Technologies N.V.	Compounds with PTH activity
US5977070A (en) *	1992-07-14	1999-11-02	Piazza; Christin Teresa	Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
AU672790B2 (en) *	1992-07-15	1996-10-17	Novartis Ag	Variants of parathyroid hormone and its fragments
CA2126299C (en) *	1994-06-20	2000-12-12	Gordon E. Willick	Parathyroid hormone analogues for the treatment of osteoporosis
EP1123401A1 (de) *	1998-10-22	2001-08-16	The General Hospital Corporation	Bioaktive peptide und peptid-derivate von parathyroidhormon (pth) und parathyroidhormon verwandte peptide (pthrp)
JP4486258B2 (ja) *	1998-11-25	2010-06-23	ザ・ジェネラル・ホスピタル・コーポレイション	ヒト副甲状腺ホルモンの改変、調製および使用
DE69938064T2 (de) *	1998-11-25	2009-01-15	The General Hospital Corp., Boston	Aminoterminal modifizierte parathyroidhormon (pth) analoge
AU4217299A (en) *	1998-11-30	2000-06-19	General Hospital Corporation, The	Pth1r and pth3r receptors, methods and uses thereof

1999
- 1999-12-30 EP EP99968197A patent/EP1147133B1/de not_active Expired - Lifetime
- 1999-12-30 AU AU24868/00A patent/AU2486800A/en not_active Abandoned
- 1999-12-30 AT AT99968197T patent/ATE403678T1/de not_active IP Right Cessation
- 1999-12-30 WO PCT/US1999/031108 patent/WO2000039278A2/en active Application Filing
- 1999-12-30 JP JP2000591171A patent/JP2002533115A/ja active Pending
- 1999-12-30 DE DE69939275T patent/DE69939275D1/de not_active Expired - Fee Related
2007
- 2007-06-18 US US11/812,346 patent/US20080058505A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2000039278A8 (en)	2001-01-11
WO2000039278A2 (en)	2000-07-06
EP1147133B1 (de)	2008-08-06
US20080058505A1 (en)	2008-03-06
DE69939275D1 (de)	2008-09-18
AU2486800A (en)	2000-07-31
JP2002533115A (ja)	2002-10-08
EP1147133A4 (de)	2003-02-12
EP1147133A2 (de)	2001-10-24

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Legal Events

Date	Code	Title	Description
2009-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties