ATE401958T1 - Vorrichtung und verfahren zur durchführung von wärmetauschenden chemischen reaktionen - Google Patents

Vorrichtung und verfahren zur durchführung von wärmetauschenden chemischen reaktionen

Info

Publication number
ATE401958T1
ATE401958T1 AT04015287T AT04015287T ATE401958T1 AT E401958 T1 ATE401958 T1 AT E401958T1 AT 04015287 T AT04015287 T AT 04015287T AT 04015287 T AT04015287 T AT 04015287T AT E401958 T1 ATE401958 T1 AT E401958T1
Authority
AT
Austria
Prior art keywords
chamber
carrying
heat exchange
out heat
chemical reactions
Prior art date
Application number
AT04015287T
Other languages
English (en)
Inventor
Ronald Chang
Douglas Dority
Lee Christel
Kurt Petersen
Original Assignee
Cepheid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepheid filed Critical Cepheid
Application granted granted Critical
Publication of ATE401958T1 publication Critical patent/ATE401958T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28HEAT EXCHANGE IN GENERAL
    • F28FDETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F13/00Arrangements for modifying heat-transfer, e.g. increasing, decreasing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/0332Cuvette constructions with temperature control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00788Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00873Heat exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00952Sensing operations
    • B01J2219/00954Measured properties
    • B01J2219/00963Pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00952Sensing operations
    • B01J2219/00968Type of sensors
    • B01J2219/0097Optical sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/042Caps; Plugs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0848Specific forms of parts of containers
    • B01L2300/0858Side walls
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28HEAT EXCHANGE IN GENERAL
    • F28DHEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
    • F28D21/00Heat-exchange apparatus not covered by any of the groups F28D1/00 - F28D20/00
    • F28D2021/0019Other heat exchangers for particular applications; Heat exchange systems not otherwise provided for
    • F28D2021/0077Other heat exchangers for particular applications; Heat exchange systems not otherwise provided for for tempering, e.g. with cooling or heating circuits for temperature control of elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00356Holding samples at elevated temperature (incubation)
    • G01N2035/00376Conductive heating, e.g. heated plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0401Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403Sample carriers with closing or sealing means
    • G01N2035/0405Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT04015287T 1999-12-21 2000-12-15 Vorrichtung und verfahren zur durchführung von wärmetauschenden chemischen reaktionen ATE401958T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/468,690 US6660228B1 (en) 1998-03-02 1999-12-21 Apparatus for performing heat-exchanging, chemical reactions

Publications (1)

Publication Number Publication Date
ATE401958T1 true ATE401958T1 (de) 2008-08-15

Family

ID=23860833

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04015287T ATE401958T1 (de) 1999-12-21 2000-12-15 Vorrichtung und verfahren zur durchführung von wärmetauschenden chemischen reaktionen
AT00990945T ATE279260T1 (de) 1999-12-21 2000-12-15 Vorrichtung zur durchführung von wärmetauschenden chemischen reaktionen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00990945T ATE279260T1 (de) 1999-12-21 2000-12-15 Vorrichtung zur durchführung von wärmetauschenden chemischen reaktionen

Country Status (6)

Country Link
US (3) US6660228B1 (de)
EP (2) EP1239964B1 (de)
AT (2) ATE401958T1 (de)
AU (1) AU3075301A (de)
DE (2) DE60039640D1 (de)
WO (1) WO2001045845A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8293064B2 (en) * 1998-03-02 2012-10-23 Cepheid Method for fabricating a reaction vessel
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
US6935997B2 (en) * 2000-09-14 2005-08-30 Rutgers, The State University Of New Jersey Patterning technology for folded sheet structures
US7824857B2 (en) 2003-12-02 2010-11-02 Musc Foundation For Research Development Methods and compositions for diagnosing epithelial cell cancer
US7981616B2 (en) 2004-02-27 2011-07-19 Musc Foundation For Research Development Enhanced detection of RNA using a panel of truncated gene-specific primers for reverse transcription
CA2571642A1 (en) 2004-07-09 2006-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N Identification of markers in lung and breast cancer
WO2006013926A1 (ja) * 2004-08-05 2006-02-09 Universal Bio Research Co., Ltd. 反応容器、反応容器液導入装置、液導入反応測定装置、および液導入装置
US8056881B2 (en) 2004-10-13 2011-11-15 University Of Virginia Patent Foundation Electrostatic actuation for management of flow in micro-total analysis systems (μ-TAS) and related method thereof
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
JP4922185B2 (ja) * 2004-12-22 2012-04-25 ユニバーシティ・オブ・ヴァージニア・パテント・ファウンデーション マイクロデバイスまたはナノスケールデバイスにおける熱用途または非熱用途のためのマイクロ波の使用
CA2609453C (en) * 2005-05-24 2014-07-08 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US8343755B2 (en) * 2005-08-01 2013-01-01 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
CA2620285C (en) 2005-08-23 2016-08-16 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
US20110033922A1 (en) * 2005-10-04 2011-02-10 Landers James P Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof
WO2007047336A2 (en) 2005-10-12 2007-04-26 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US8119352B2 (en) 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
WO2008004695A1 (fr) * 2006-07-07 2008-01-10 Universal Bio Research Co., Ltd. Contenant de réaction et dispositif de réaction
US7548081B1 (en) * 2007-07-31 2009-06-16 Agilent Technologies, Inc. System and method for controlling environmental parameters of a device under test
JP5598766B2 (ja) * 2008-04-10 2014-10-01 デナトール アクティエボラグ 生体試料を保管し調整する装置
JP2012526996A (ja) * 2009-05-15 2012-11-01 ビオメリュー・インコーポレイテッド 試料内の微生物因子の迅速な同定および/または特徴付けのためのシステムおよび方法
US20110081686A1 (en) * 2009-10-01 2011-04-07 Vical Incorporated Reactor for Bulk Manufacture of PCR Amplicons
CN102939543B (zh) * 2010-02-12 2015-06-24 西北大学 用于样本采集、处理和反应的测定卡
WO2011148432A1 (ja) * 2010-05-28 2011-12-01 栄研化学株式会社 ピペット
WO2012012779A2 (en) 2010-07-23 2012-01-26 Beckman Coulter Inc. System and method including analytical units
DE102010048443B4 (de) * 2010-10-15 2015-05-21 Technische Universität Braunschweig Carolo-Wilhelmina Verfahren zur durchführung von zeitaufgelösten untersuchungen an zellproben
KR101420094B1 (ko) 2010-10-27 2014-07-17 (주)바이오니아 다양한 생체시료분석을 위한 전자동실시간정량증폭장비, 다양한 생체시료분석을 위한 자동정제 및 반응준비 장치, 전자동 핵산정제 및 실시간 정량 유전자증폭 방법, 전자동 핵산정제방법, 실시간정량pcr을 이용한 병원균의 전자동 생균수검사방법, 정량면역pcr을 이용한 전자동 항원농도획득방법 및 타겟항원에 라벨링된 부착용 타겟핵산의 정제방법
EP2517791A1 (de) * 2011-04-18 2012-10-31 Vibod GmbH Probenrohr mit verbesserter Klappe
WO2012166913A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
KR101481054B1 (ko) 2011-11-15 2015-01-14 한국기계연구원 핵산 자동 분석 장치
US10022731B2 (en) * 2012-01-31 2018-07-17 Argos Therapeutics, Inc. Centrifuge vessels with a center mound and an internal elongate tube suitable for live cell processing and associated systems and methods
AU2013251488A1 (en) 2012-04-27 2014-11-13 Cepheid Apparatus with heterogeneous processing modules
RU2018103106A (ru) 2012-06-28 2019-02-22 Флюоресентрик, Инк. Устройство для обнаружения химического индикатора
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
CA2879638A1 (en) 2012-08-10 2014-02-13 Streck, Inc. Real-time optical system for polymerase chain reaction
US9274044B2 (en) * 2012-11-28 2016-03-01 Wyatt Technology Corporation Cuvette for light scattering measurements incorporating evaporation inhibition means
WO2014093360A1 (en) 2012-12-10 2014-06-19 Landers James P Frequency-based filtering of mechanical actuation using fluidic device
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
EP3014251A1 (de) 2013-06-28 2016-05-04 Streck Inc. Vorrichtungen für echtzeit-polymerasekettenreaktionen
DE102013114132A1 (de) * 2013-12-16 2015-06-18 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Aufschlussreaktor und Analysegerät zur Bestimmung eines Aufschlussparameters einer Flüssigkeitsprobe
EA039230B1 (ru) 2015-07-24 2021-12-21 Сифиид Система для выполнения молекулярных диагностических анализов
US10758908B2 (en) * 2015-09-03 2020-09-01 Tetracore, Inc. Self-metering of fluid into a reaction chamber
WO2017049230A1 (en) * 2015-09-16 2017-03-23 Fluoresentric, Inc. Apparatus, systems and methods for dynamic flux amplification of samples
CN105400680B (zh) * 2015-12-11 2017-12-15 舟山医院 一种荧光定量pcr仪
TWI713536B (zh) * 2016-06-15 2020-12-21 諾貝爾生物有限公司 用於生物熱反應的封蓋系統及其方法
CN110036285B (zh) * 2016-11-22 2022-09-20 Ta仪器-沃特世有限责任公司 直接热注射热分析
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
SG10201702235TA (en) * 2017-03-20 2018-10-30 Star Array Pte Ltd Apparatus for amplification of nucleic acids
CN209400540U (zh) * 2017-09-21 2019-09-17 贝克顿·迪金森公司 危险污染检测***和收集装置
TWI667999B (zh) * 2018-05-17 2019-08-11 廣達電腦股份有限公司 動態調整螢光成像的方法及裝置
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
US11254979B2 (en) 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
EP4152967A1 (de) 2020-06-01 2023-03-29 Shaheen Innovations Holding Limited System zum screening von infektionskrankheiten
AU2021285406A1 (en) 2020-06-01 2023-01-19 Shaheen Innovations Holding Limited An infectious disease screening device
CN116648625A (zh) 2020-10-30 2023-08-25 塞弗德公司 具有可更换的处理模块和远程监测的诊断测定***
EP4278430A1 (de) 2021-01-13 2023-11-22 Cepheid Verlustbehaftete mechatronische systeme und schätzverfahren
DE102022201532A1 (de) 2022-02-15 2023-08-17 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren zur Kalibrierung eines Analysesystems für Lab-on-Chip-Kartuschen

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1247520A (en) * 1967-10-23 1971-09-22 Ole Rues Container for laboratory use
US3708886A (en) 1970-11-09 1973-01-09 Lyoflo Stopper Corp Lyoflo-stopper
AT381466B (de) * 1977-03-16 1986-10-27 Ballies Uwe Trennroehrchen fuer zentrifugaltrennung
US4192429A (en) 1978-03-02 1980-03-11 Becton, Dickinson And Company Vented vacuum tube and stopper
US4479578A (en) * 1981-04-09 1984-10-30 The West Company Single barrel two-compartment medicament container assembly
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US5038852A (en) 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US4810653A (en) 1987-11-23 1989-03-07 Eastman Kodak Company Cuvette with non-flexing thermally conductive wall
US4902624A (en) 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
CA1329698C (en) 1989-06-12 1994-05-24 Mark Joseph Devaney, Jr. Temperature control device
US5098660A (en) 1990-01-08 1992-03-24 Eastman Kodak Company Transfer apparatus for chemical reaction pack
WO1991016675A1 (en) * 1990-04-06 1991-10-31 Applied Biosystems, Inc. Automated molecular biology laboratory
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
US5376313A (en) 1992-03-27 1994-12-27 Abbott Laboratories Injection molding a plastic assay cuvette having low birefringence
EP0603411B1 (de) 1992-07-01 1998-08-19 KATOH, Keiichi Keramischer apparat zur erwaermung und kuehlung
JPH0634546A (ja) 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
EP0662345B1 (de) 1994-01-06 2000-05-31 Johnson & Johnson Clinical Diagnostics, Inc. Vorrichtung zum Erwärmen einer Flüssigkeitsführenden Kammer von einer Reaktionscuvette
CA2143365A1 (en) 1994-03-14 1995-09-15 Hugh V. Cottingham Nucleic acid amplification method and apparatus
JP2909216B2 (ja) 1994-04-29 1999-06-23 パーキン‐エルマー コーポレイション 核酸増幅生成物のリアルタイム検出装置
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US5721136A (en) 1994-11-09 1998-02-24 Mj Research, Inc. Sealing device for thermal cycling vessels
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
AU738336B2 (en) * 1996-05-20 2001-09-13 Precision System Science Co., Ltd. Control method and apparatus for controlling magnetic particles by a sample distributor
US5945070A (en) * 1996-10-31 1999-08-31 Merck & Co., Inc. Reaction vessel filter for combinatorial chemistry or biological use
US5811296A (en) 1996-12-20 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Blocked compartments in a PCR reaction vessel
US5958349A (en) 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
CA2282623C (en) 1997-02-28 2007-05-22 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
US5786182A (en) 1997-05-02 1998-07-28 Biomerieux Vitek, Inc. Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use
US5882601A (en) * 1997-06-18 1999-03-16 Merck & Co., Ltd. Deflected septum seal access port
WO1999033559A1 (en) 1997-12-24 1999-07-08 Cepheid Integrated fluid manipulation cartridge
WO1999048608A2 (en) 1998-03-23 1999-09-30 Cepheid Multi-site reactor system with dynamic, independent control of individual reaction sites
AU746069B2 (en) 1998-05-19 2002-04-11 Cepheid Multi-channel optical detection system
DE19847759A1 (de) * 1998-10-16 2000-04-20 Dade Behring Marburg Gmbh Auswechselbare Schwingpipettiernadel
US6485692B1 (en) * 1998-12-04 2002-11-26 Symyx Technologies, Inc. Continuous feed parallel reactor
EP1045038A1 (de) 1999-04-08 2000-10-18 Hans-Knöll-Institut Für Naturstoff-Forschung E.V. Thermisches Kreisprozessgerät mit Wärmeblock
US6325114B1 (en) * 2000-02-01 2001-12-04 Incyte Genomics, Inc. Pipetting station apparatus

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DE60039640D1 (de) 2008-09-04
US8303895B2 (en) 2012-11-06
ATE279260T1 (de) 2004-10-15
US6660228B1 (en) 2003-12-09
EP1462176B1 (de) 2008-07-23
DE60014967D1 (de) 2004-11-18
AU3075301A (en) 2001-07-03
EP1239964A1 (de) 2002-09-18
WO2001045845A1 (en) 2001-06-28
US20080286151A1 (en) 2008-11-20
EP1462176A2 (de) 2004-09-29
EP1239964B1 (de) 2004-10-13
DE60014967T2 (de) 2005-10-13
EP1462176A3 (de) 2004-10-13
US20110176971A1 (en) 2011-07-21
US7462323B1 (en) 2008-12-09

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