ATE400647T1 - C-terminale modifikation von polypeptiden - Google Patents
C-terminale modifikation von polypeptidenInfo
- Publication number
- ATE400647T1 ATE400647T1 AT05774367T AT05774367T ATE400647T1 AT E400647 T1 ATE400647 T1 AT E400647T1 AT 05774367 T AT05774367 T AT 05774367T AT 05774367 T AT05774367 T AT 05774367T AT E400647 T1 ATE400647 T1 AT E400647T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptides
- trypsin
- xaa2
- terminal modification
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04019237 | 2004-08-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE400647T1 true ATE400647T1 (de) | 2008-07-15 |
Family
ID=34926160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05774367T ATE400647T1 (de) | 2004-08-13 | 2005-08-12 | C-terminale modifikation von polypeptiden |
Country Status (10)
Country | Link |
---|---|
US (2) | US20080064079A1 (de) |
EP (1) | EP1778839B1 (de) |
JP (1) | JP4538501B2 (de) |
CN (1) | CN101010425B (de) |
AT (1) | ATE400647T1 (de) |
CA (1) | CA2569707C (de) |
DE (1) | DE602005008071D1 (de) |
ES (1) | ES2309785T3 (de) |
HK (1) | HK1110888A1 (de) |
WO (1) | WO2006015879A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005046113A1 (de) * | 2005-09-27 | 2007-03-29 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen |
DE102006031962A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
DE102006031955A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
JP5770161B2 (ja) | 2009-04-06 | 2015-08-26 | ノヴォ ノルディスク アー/エス | 血小板への第viii因子タンパク質の標的送達 |
AU2010317994B2 (en) | 2009-11-13 | 2014-03-06 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
MY180661A (en) | 2009-11-13 | 2020-12-04 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
EP2533813B1 (de) | 2010-02-11 | 2016-06-01 | F.Hoffmann-La Roche Ag | Proteinkonjugate für trypsinvermittelte Pegylierung durch Transamidierung und Methoden |
US20140148384A1 (en) | 2010-08-30 | 2014-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
BR112014004726A2 (pt) | 2011-08-29 | 2017-04-04 | Sanofi Aventis Deutschland | combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
EP3229828B1 (de) | 2014-12-12 | 2023-04-05 | Sanofi-Aventis Deutschland GmbH | Insulin-glargin/lixisenatid-fixierte verhältnisformulierung |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
TW202015723A (zh) | 2018-05-18 | 2020-05-01 | 美商百歐維拉提夫治療公司 | 治療a型血友病的方法 |
EP3650541A1 (de) | 2018-11-08 | 2020-05-13 | BioPharma Translationsinstitut Dessau Forschungs GmbH | Trypsin-mutante zur c- und n-terminalen modifizierung von polypeptiden |
US20220235344A1 (en) * | 2018-12-19 | 2022-07-28 | Biopharma Translationsinstitut Dessau Forschungs Gmbh | Trypsin variants with improved enzymatic properties |
AU2020399194A1 (en) | 2019-12-10 | 2022-07-28 | Sanofi | A method of forming a conjugate of a sulfonamide and a polypeptide |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9001705D0 (sv) * | 1990-05-11 | 1990-05-11 | Medscand Ab | Saett foer diagnostik av virusbaerande tumoerer genom immunoassay |
US5580751A (en) * | 1990-09-14 | 1996-12-03 | Carlsberg A/S | Process for the preparation of C-terminally amidated peptides |
AU6171594A (en) | 1993-02-04 | 1994-08-29 | Genentech Inc. | Serine protease variants having peptide ligase activity |
US6187579B1 (en) * | 1993-10-28 | 2001-02-13 | Carlsberg A/S | Customized proteases |
US5958783A (en) | 1994-07-25 | 1999-09-28 | Roche Diagnostics Gmbh | Metal complexes with a charged linker |
US5985627A (en) | 1997-02-28 | 1999-11-16 | Carlsberg Laboratory | Modified carboxypeptidase |
DE10049673A1 (de) * | 2000-10-07 | 2002-04-25 | Univ Leipzig | Verfahren zur Herstellung von Peptiden, Peptidmimetika und Proteinen |
CN1354253A (zh) * | 2001-12-24 | 2002-06-19 | 南京医科大学 | 淡色库蚊胰蛋白酶基因 |
-
2005
- 2005-08-12 AT AT05774367T patent/ATE400647T1/de active
- 2005-08-12 WO PCT/EP2005/008809 patent/WO2006015879A1/en active IP Right Grant
- 2005-08-12 JP JP2007524304A patent/JP4538501B2/ja active Active
- 2005-08-12 ES ES05774367T patent/ES2309785T3/es active Active
- 2005-08-12 DE DE602005008071T patent/DE602005008071D1/de active Active
- 2005-08-12 CN CN2005800273012A patent/CN101010425B/zh active Active
- 2005-08-12 EP EP05774367A patent/EP1778839B1/de active Active
- 2005-08-12 CA CA2569707A patent/CA2569707C/en active Active
-
2007
- 2007-02-09 US US11/704,561 patent/US20080064079A1/en not_active Abandoned
-
2008
- 2008-01-25 HK HK08101041.9A patent/HK1110888A1/xx unknown
-
2013
- 2013-01-14 US US13/741,206 patent/US8927230B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN101010425A (zh) | 2007-08-01 |
WO2006015879A1 (en) | 2006-02-16 |
US8927230B2 (en) | 2015-01-06 |
HK1110888A1 (en) | 2008-07-25 |
JP2008508871A (ja) | 2008-03-27 |
CA2569707C (en) | 2013-09-24 |
EP1778839B1 (de) | 2008-07-09 |
US20080064079A1 (en) | 2008-03-13 |
JP4538501B2 (ja) | 2010-09-08 |
US20130177940A1 (en) | 2013-07-11 |
ES2309785T3 (es) | 2008-12-16 |
CA2569707A1 (en) | 2006-02-16 |
EP1778839A1 (de) | 2007-05-02 |
DE602005008071D1 (de) | 2008-08-21 |
CN101010425B (zh) | 2010-05-26 |
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