ATE398134T1 - Neue analoga von nitrobenzylthioinosin - Google Patents

Neue analoga von nitrobenzylthioinosin

Info

Publication number
ATE398134T1
ATE398134T1 AT03724994T AT03724994T ATE398134T1 AT E398134 T1 ATE398134 T1 AT E398134T1 AT 03724994 T AT03724994 T AT 03724994T AT 03724994 T AT03724994 T AT 03724994T AT E398134 T1 ATE398134 T1 AT E398134T1
Authority
AT
Austria
Prior art keywords
nitrobenzylthioinosine
new
new analogue
analogue
analogs
Prior art date
Application number
AT03724994T
Other languages
English (en)
Inventor
Claudia Puetz
Corinna Sundermann
Bernd Sundermann
Adriaan Ijzerman
Reynier Tromp
Frijtag Drabbe Kuenzel Jac Von
Original Assignee
Gruenenthal Gmbh
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh, Univ Leiden filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of ATE398134T1 publication Critical patent/ATE398134T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03724994T 2002-04-10 2003-04-10 Neue analoga von nitrobenzylthioinosin ATE398134T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02076420A EP1352910A1 (de) 2002-04-10 2002-04-10 Neue Analoga von Nitrobenzylthioinosine

Publications (1)

Publication Number Publication Date
ATE398134T1 true ATE398134T1 (de) 2008-07-15

Family

ID=28051821

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03724994T ATE398134T1 (de) 2002-04-10 2003-04-10 Neue analoga von nitrobenzylthioinosin

Country Status (8)

Country Link
US (1) US7358235B2 (de)
EP (2) EP1352910A1 (de)
JP (1) JP2005526106A (de)
AT (1) ATE398134T1 (de)
AU (1) AU2003227593A1 (de)
DE (1) DE60321554D1 (de)
ES (1) ES2307931T3 (de)
WO (1) WO2003084975A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2294400T3 (es) * 2004-06-29 2008-04-01 Grunenthal Gmbh Nuevos analogos de notrobenciltioinosina.
WO2009034411A1 (en) 2007-09-12 2009-03-19 Centre National De La Recherche Scientifique Perharidines as cdk inhibitors
EP3097092B1 (de) 2014-01-20 2020-08-26 Cleave Biosciences, Inc. Kondensierte pyrimidine als inhibitoren des p97-komplexes
ES2837484T3 (es) 2016-02-04 2021-06-30 Univ Johns Hopkins Rapadocinas, inhibidores del transportador de nucleósidos equilibrativo 1 y usos de los mismos
WO2017136731A1 (en) 2016-02-04 2017-08-10 The Johns Hopkins University Rapaglutins, novel inhibitors of glut and use thereof
WO2018140734A1 (en) * 2017-01-27 2018-08-02 Academia Sinica Compound with analgesic effect for use in prevention and treatment of pain
ES2686909B1 (es) * 2017-03-22 2019-08-16 Consejo Superior Investigacion Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2524284A1 (de) * 1966-12-21 1976-10-28 Boehringer Mannheim Gmbh Adenosin-derivate und verfahren zu ihrer herstellung
US3948886A (en) * 1972-03-13 1976-04-06 Icn Pharmaceuticals, Inc. 6-Substituted purine 3',5'-cyclic nucleotides
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
EP0416011A4 (en) * 1988-05-16 1991-05-22 Us Commerce Chemotherapeutic composition for aids
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
DE69324244T2 (de) * 1992-01-06 1999-09-30 The Wellcome Foundation Ltd., Greenford Therapeutische nukleoside der 2',3'-dideoxy-3'-fluor -purin reihe
FR2685918B1 (fr) * 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
AU7292096A (en) * 1995-11-14 1997-06-05 Pharmacia & Upjohn S.P.A. Aryl and heteroaryl purine compounds
US5780450A (en) * 1995-11-21 1998-07-14 Alcon Laboratories, Inc. Use of adenosine uptake inhibitors for treating retinal or optic nerve head damage
US5801159A (en) * 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
AU3080899A (en) * 1998-03-11 1999-09-27 Lipitek International, Inc. Novel nucleoside analogs and uses in treating disease
CZ20022353A3 (cs) * 2000-01-07 2003-02-12 Universitaire Instelling Antwerpen Deriváty purinu, způsob jejich přípravy a jejich použití

Also Published As

Publication number Publication date
EP1492803A1 (de) 2005-01-05
DE60321554D1 (de) 2008-07-24
EP1352910A1 (de) 2003-10-15
EP1492803B1 (de) 2008-06-11
AU2003227593A1 (en) 2003-10-20
JP2005526106A (ja) 2005-09-02
ES2307931T3 (es) 2008-12-01
US7358235B2 (en) 2008-04-15
US20050096293A1 (en) 2005-05-05
WO2003084975A1 (en) 2003-10-16

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