ATE394386T1 - 2-phenylpyran-4-on-derivate als selektive cox-2 inhibitoren - Google Patents
2-phenylpyran-4-on-derivate als selektive cox-2 inhibitorenInfo
- Publication number
- ATE394386T1 ATE394386T1 AT04710358T AT04710358T ATE394386T1 AT E394386 T1 ATE394386 T1 AT E394386T1 AT 04710358 T AT04710358 T AT 04710358T AT 04710358 T AT04710358 T AT 04710358T AT E394386 T1 ATE394386 T1 AT E394386T1
- Authority
- AT
- Austria
- Prior art keywords
- phenylpyran
- derivatives
- inhibitors
- selective cox
- cox
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200300355A ES2213485B1 (es) | 2003-02-13 | 2003-02-13 | Derivados de la 2-fenilpiran-4-ona. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE394386T1 true ATE394386T1 (de) | 2008-05-15 |
Family
ID=32865136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04710358T ATE394386T1 (de) | 2003-02-13 | 2004-02-12 | 2-phenylpyran-4-on-derivate als selektive cox-2 inhibitoren |
Country Status (8)
Country | Link |
---|---|
US (1) | US7582676B2 (de) |
EP (1) | EP1592680B9 (de) |
JP (1) | JP2006517560A (de) |
CN (1) | CN100436438C (de) |
AT (1) | ATE394386T1 (de) |
DE (1) | DE602004013542D1 (de) |
ES (2) | ES2213485B1 (de) |
WO (1) | WO2004072058A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
ES2214129B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4304728A (en) * | 1979-04-05 | 1981-12-08 | Lilly Industries Limited | 6-Substituted pyranone compounds and their use as pharmaceuticals |
US6486194B2 (en) | 1993-06-24 | 2002-11-26 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
US5585504A (en) | 1994-09-16 | 1996-12-17 | Merck & Co., Inc. | Process of making cox-2 inhibitors having a lactone bridge |
GB2294879A (en) | 1994-10-19 | 1996-05-15 | Merck & Co Inc | Cylcooxygenase-2 Inhibitors |
US6231888B1 (en) | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
ES2125161B1 (es) | 1996-03-21 | 1999-11-16 | Grupo Farmaceutico Almirall S | Nuevos derivados de 2-(3h)-oxazolona. |
CZ291463B6 (cs) | 1996-05-17 | 2003-03-12 | Merck And Co., Inc. | Farmaceutický prostředek |
DE69724788T2 (de) | 1996-07-18 | 2004-08-05 | Merck Frosst Canada & Co., Halifax | Substituierte pyridine als selektive cyclooxygenase inhibitoren |
US6307047B1 (en) | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
ES2231757T3 (es) | 1997-09-05 | 2005-05-16 | Glaxo Group Limited | Composiciones farmaceutica que comprenden derivados de 2,3-diaril-pirazolo (1,5-b) piridazina. |
ES2131015B1 (es) | 1997-09-12 | 2000-03-01 | Almirall Prodesfarma Sa | Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas. |
US5994379A (en) | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
KR100295206B1 (ko) * | 1998-08-22 | 2001-07-12 | 서경배 | 디아릴벤조피란유도체및이를함유하는시클로옥시게네이즈-2저해제조성물 |
ATE272628T1 (de) * | 1998-09-09 | 2004-08-15 | Inflazyme Pharm Ltd | Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen |
TW587079B (en) * | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
ES2154561B1 (es) * | 1998-09-25 | 2001-12-01 | Almirall Prodesfarma Sa | Derivados de 2-fenilpiran-4-ona. |
US6303972B1 (en) * | 1998-11-25 | 2001-10-16 | Micron Technology, Inc. | Device including a conductive layer protected against oxidation |
CZ300766B6 (cs) * | 1999-04-14 | 2009-08-05 | Pacific Corporation | Deriváty 4,5-Diaryl-3(2H)-furanonu, zpusob jejich prípravy a jejich použití |
NZ515711A (en) | 1999-06-24 | 2004-01-30 | Pharmacia Corp | Combination of tumors necrocis factor (TNF) antagonists and COX-2 inhibitors for the treatment of inflammation |
DE60006057T2 (de) | 1999-12-03 | 2004-05-27 | Pfizer Products Inc., Groton | Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
PE20011333A1 (es) * | 2000-03-16 | 2002-01-16 | Almirall Prodesfarma Ag | Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2 |
CA2412651A1 (en) | 2000-05-22 | 2001-11-29 | Dr. Reddy's Research Foundation | Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them |
WO2001091856A2 (en) | 2000-06-01 | 2001-12-06 | Pharmacia Corporation | Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation |
JP2004505060A (ja) | 2000-07-27 | 2004-02-19 | ファルマシア・コーポレーション | 炎症関連心臓血管障害を防止するかまたは治療するためのアルドステロンアンタゴニストおよびシクロオキシゲナーゼ−2阻害剤併用療法 |
WO2002055502A1 (en) | 2001-01-02 | 2002-07-18 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine derivatives useful as cyclooxygenase inhibitor |
WO2003006451A1 (en) | 2001-07-10 | 2003-01-23 | Almirall Prodesfarma S.A. | 4-phenylpyran-2-one derivatives |
EP1492773B1 (de) | 2002-04-05 | 2009-02-04 | Cadila Healthcare Ltd. | 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen |
ES2214129B1 (es) | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
ES2214130B1 (es) | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
-
2003
- 2003-02-13 ES ES200300355A patent/ES2213485B1/es not_active Expired - Fee Related
-
2004
- 2004-02-12 JP JP2006501815A patent/JP2006517560A/ja active Pending
- 2004-02-12 DE DE602004013542T patent/DE602004013542D1/de not_active Expired - Fee Related
- 2004-02-12 ES ES04710358T patent/ES2303938T4/es not_active Expired - Lifetime
- 2004-02-12 EP EP04710358A patent/EP1592680B9/de not_active Expired - Lifetime
- 2004-02-12 AT AT04710358T patent/ATE394386T1/de not_active IP Right Cessation
- 2004-02-12 WO PCT/EP2004/001295 patent/WO2004072058A1/en active IP Right Grant
- 2004-02-12 US US10/544,361 patent/US7582676B2/en not_active Expired - Fee Related
- 2004-02-12 CN CNB2004800087372A patent/CN100436438C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7582676B2 (en) | 2009-09-01 |
DE602004013542D1 (en) | 2008-06-19 |
JP2006517560A (ja) | 2006-07-27 |
EP1592680B9 (de) | 2009-03-25 |
EP1592680B1 (de) | 2008-05-07 |
WO2004072058A1 (en) | 2004-08-26 |
CN1768049A (zh) | 2006-05-03 |
ES2303938T4 (es) | 2009-06-05 |
EP1592680A1 (de) | 2005-11-09 |
ES2213485A1 (es) | 2004-08-16 |
US20060142380A1 (en) | 2006-06-29 |
CN100436438C (zh) | 2008-11-26 |
ES2213485B1 (es) | 2005-12-16 |
ES2303938T3 (es) | 2008-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |