ATE389653T1 - 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen - Google Patents

4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen

Info

Publication number
ATE389653T1
ATE389653T1 AT04734885T AT04734885T ATE389653T1 AT E389653 T1 ATE389653 T1 AT E389653T1 AT 04734885 T AT04734885 T AT 04734885T AT 04734885 T AT04734885 T AT 04734885T AT E389653 T1 ATE389653 T1 AT E389653T1
Authority
AT
Austria
Prior art keywords
pyrazolo
pyrimidine
substituted derivatives
nhch2c6h5
nhc4h9
Prior art date
Application number
AT04734885T
Other languages
English (en)
Inventor
Francesco Bondavalli
Maurizio Botta
Olga Bruno
Fabrizio Manetti
Silvia Schenone
Fabio Carraro
Original Assignee
Univ Siena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT000264A external-priority patent/ITRM20030264A1/it
Priority claimed from IT000263A external-priority patent/ITRM20030263A1/it
Application filed by Univ Siena filed Critical Univ Siena
Application granted granted Critical
Publication of ATE389653T1 publication Critical patent/ATE389653T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04734885T 2003-05-28 2004-05-26 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen ATE389653T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000264A ITRM20030264A1 (it) 2003-05-28 2003-05-28 Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)-
IT000263A ITRM20030263A1 (it) 2003-05-28 2003-05-28 Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)-

Publications (1)

Publication Number Publication Date
ATE389653T1 true ATE389653T1 (de) 2008-04-15

Family

ID=33492308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04734885T ATE389653T1 (de) 2003-05-28 2004-05-26 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen

Country Status (8)

Country Link
US (1) US7589086B2 (de)
EP (1) EP1638966B1 (de)
JP (1) JP4642766B2 (de)
AT (1) ATE389653T1 (de)
CA (1) CA2527496C (de)
DE (1) DE602004012559T2 (de)
ES (1) ES2304252T3 (de)
WO (2) WO2004106340A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1746099A1 (de) 2004-12-23 2007-01-24 DeveloGen Aktiengesellschaft Mnk1 or Mnk2 Inhibitoren
WO2006071819A1 (en) * 2004-12-28 2006-07-06 Exelixis, Inc. [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
US7558755B2 (en) * 2005-07-13 2009-07-07 Mott Antony R Methods and systems for valuing investments, budgets and decisions
GB0524436D0 (en) * 2005-11-30 2006-01-11 Novartis Ag Organic compounds
EP2004656B1 (de) 2006-04-07 2013-07-10 Boehringer Ingelheim International GmbH Thienopyrimidine mit mnk1/mnk2-hemmender wirkung für pharmazeutische zusammensetzungen
EP1889847A1 (de) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidine zur pharmazeutischen Anwendung
US8466164B2 (en) 2007-09-14 2013-06-18 Universita Degli Studi Di Siena 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof
CA2735361A1 (en) 2008-08-26 2010-03-04 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
AR080328A1 (es) 2010-02-26 2012-03-28 Boehringer Ingelheim Int Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros
MX2012009735A (es) 2010-02-26 2012-09-12 Boehringer Ingelheim Int 4-[cicloalquiloxi (hetero) arilamino] tieno [2,3-d] pirimidinas que tienen actividad inhibitoria de mnk1/mnk2 para composiciones farmaceuticas.
EP2571361A4 (de) * 2010-05-19 2013-11-13 Univ North Carolina Pyrazolopyrimidinverbindungen zur krebsbehandlung
EP2632920A1 (de) 2010-10-27 2013-09-04 Dynamix Pharmaceuticals Ltd. Sulfonamide zur modulation von pkm2
JP2014532060A (ja) 2011-10-03 2014-12-04 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 癌を治療するためのピロロピリミジン化合物
IN2014DN09610A (de) 2012-05-22 2015-07-31 Univ North Carolina
CN103570723B (zh) * 2012-07-27 2016-07-13 广西梧州制药（集团）股份有限公司 吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途
WO2014062774A1 (en) 2012-10-17 2014-04-24 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
WO2014085225A1 (en) 2012-11-27 2014-06-05 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
CA2945129A1 (en) 2014-04-11 2015-10-15 The University Of North Carolina At Chapel Hill Mertk-specific pyrrolopyrimidine compounds
US10709708B2 (en) 2016-03-17 2020-07-14 The University Of North Carolina At Chapel Hill Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58208293A (ja) * 1982-05-20 1983-12-03 Lion Corp １Ｈ−ピラゾロ〔３，４−ｄ〕ピリミジン誘導体及び該化合物を含有する抗腫瘍剤
DE69609602T2 (de) * 1995-04-03 2001-04-12 Novartis Ag Pyrazolderivate und verfahren zu deren herstellung
WO2003029209A2 (en) * 2001-10-02 2003-04-10 Smithkline Beecham Corporation Chemical compounds

Also Published As

Publication number Publication date
WO2004106340A3 (en) 2005-02-17
WO2004106339A2 (en) 2004-12-09
DE602004012559T2 (de) 2009-04-30
WO2004106340A2 (en) 2004-12-09
US7589086B2 (en) 2009-09-15
DE602004012559D1 (de) 2008-04-30
WO2004106339A3 (en) 2005-02-17
US20070010510A1 (en) 2007-01-11
ES2304252T3 (es) 2008-10-01
EP1638966A2 (de) 2006-03-29
CA2527496C (en) 2012-08-14
CA2527496A1 (en) 2004-12-09
JP4642766B2 (ja) 2011-03-02
EP1638966B1 (de) 2008-03-19
JP2007500206A (ja) 2007-01-11

Similar Documents

Publication Publication Date Title
ATE389653T1 (de) 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen
YU83302A (sh) Jedinjenja pirolo (2,3-d) pirimidina kao imunosupresivni agensi
IL160915A0 (en) Indolizines inhibiting kinase proteins
ATE362474T1 (de) Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen
AU2002357773A1 (en) 1,6 naphthyridines useful as inhibitors of syk kinase
DK1278735T3 (da) 2,4-di(hetero-)arylamino(-oxy)-5-substituerede pyrimidiner som antineoplastiske midler
IL163781A0 (en) Purine derivatives as kinase inhibitors
MXPA03010961A (es) Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
WO2007023111A3 (en) P38 map kinase inhibitors and methods for using the same
TW200608977A (en) Substituted 2-alkyl quinazolinone derivatives as parp inhibitors
MXPA05008584A (es) Compuestos heterociclicos utiles como activadores de nurr-1.
MXPA04003886A (es) Tiofen- y tiazolsulfonamidas como agentes antineoplasticos.
WO2002085906A3 (en) Phthalazinones derivatives useful as pde4/7 inhibitors
CY1110319T1 (el) Ενωσεις 7-φενυλ πυραζολοπυριδινης
DK1742950T3 (da) Pyrazolo-[4,3-D]-pyrimidiner
MY136297A (en) Piperazine derivatives having sst1 antagonistic activity
CA2452036A1 (en) 6-'2-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity
EA200301101A1 (ru) Производные пиперазина и их применение в качестве ингибиторов pde4
DE69910574D1 (de) Pyrazolo[1,5-a]triazine als crf antagonisten
TW200635928A (en) 7-Amino-6-heteroaryl-1,2,4-triazolo[1,5-a]pyrimidine and the use thereof for controlling harmful fungi
DK1307463T3 (da) Pyrrolo[2,1-b][1,3]benzothiazepiner og deres anvendelse til fremstillingen af medikamenter med antipsykotisk aktivitet
UY26791A1 (es) Compuestos de pirrol (2,3-d) pirimidina

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1638966

Country of ref document: EP