ATE389631T1 - Verfahren zur herstellung von fexofenadinen - Google Patents

Verfahren zur herstellung von fexofenadinen

Info

Publication number
ATE389631T1
ATE389631T1 AT01947748T AT01947748T ATE389631T1 AT E389631 T1 ATE389631 T1 AT E389631T1 AT 01947748 T AT01947748 T AT 01947748T AT 01947748 T AT01947748 T AT 01947748T AT E389631 T1 ATE389631 T1 AT E389631T1
Authority
AT
Austria
Prior art keywords
sub
compound
formula
alkyl
hereinbefore defined
Prior art date
Application number
AT01947748T
Other languages
English (en)
Inventor
Federico Milla
William Paul Jackson
Original Assignee
Texcontor Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texcontor Ets filed Critical Texcontor Ets
Application granted granted Critical
Publication of ATE389631T1 publication Critical patent/ATE389631T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Catalysts (AREA)
AT01947748T 2000-07-28 2001-07-19 Verfahren zur herstellung von fexofenadinen ATE389631T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0018691.6A GB0018691D0 (en) 2000-07-28 2000-07-28 Process

Publications (1)

Publication Number Publication Date
ATE389631T1 true ATE389631T1 (de) 2008-04-15

Family

ID=9896639

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01947748T ATE389631T1 (de) 2000-07-28 2001-07-19 Verfahren zur herstellung von fexofenadinen

Country Status (9)

Country Link
US (1) US7176318B2 (de)
EP (1) EP1307423B1 (de)
AT (1) ATE389631T1 (de)
AU (1) AU2001269388A1 (de)
DE (1) DE60133288T2 (de)
ES (1) ES2302737T3 (de)
GB (1) GB0018691D0 (de)
PT (1) PT1307423E (de)
WO (1) WO2002010115A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2261209A1 (de) * 2001-06-18 2010-12-15 Dr. Reddy's Laboratories Ltd. Neue Kristalformen von 4-[4-[4- Hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzen Essigsäure und ihre Hydrochlorides
US7700779B2 (en) 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
EP1616861A3 (de) * 2004-06-15 2006-02-08 Dipharma S.p.A. Verfahren zur Herstellung von Keto-Verbindungen
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US8367704B2 (en) 2008-02-12 2013-02-05 Yuhan Corporation Process for preparation of 2-methyl-2′ phenylpropionic acid derivatives and novel intermediate compounds
CN102070490B (zh) * 2009-11-21 2014-07-30 浙江华海药业股份有限公司 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法
CN102070512B (zh) * 2009-11-21 2014-11-19 浙江华海药业股份有限公司 一种高纯度非索非那定及其中间体的合成路线与制备方法
ITMI20120589A1 (it) * 2012-04-12 2013-10-13 Chemelectiva S R L Intermedi utili per la sintesi di fexofenadina, processo per la loro preparazione e per la preparazione di fexofenadina
US20130237709A1 (en) * 2012-03-02 2013-09-12 Chemelectiva S.R.L. Intermediates useful for the synthesis of fexofenadine, processes for their preparation and for the preparation of fexofenadine
ES2738630T3 (es) 2015-01-22 2020-01-24 Sanofi Aventis Deutschland Procedimiento para la producción de 2-[4-(ciclopropanocarbonil)fenil]-2-metil-propanonitrilo
PL3365327T3 (pl) * 2015-10-22 2020-05-18 Sanofi-Aventis Deutschland Gmbh Sposób wytwarzania feksofenadyny i związki pośrednie stosowane w tym sposobie
CN107782804B (zh) * 2016-08-25 2020-11-13 人福普克药业（武汉）有限公司 检测盐酸非索非那定样品中有关物质的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5499135A (en) * 1990-12-24 1996-03-12 Alcatel N.V. Optical amplifier
DK1026147T3 (da) * 1993-06-24 2004-03-22 Albany Molecular Res Inc Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater
EP2261207A1 (de) * 1993-06-25 2010-12-15 Aventisub II Inc. Zwischenprodukte zur Herstellung antihistaminischer 4-Diphenylmethyl-/Diphenylmethoxy- Piperidinderivate
IT1271417B (it) 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
JPH08237203A (ja) * 1995-02-23 1996-09-13 Fujitsu Ltd 光フィルタアレイ、光送信機及び光送信システム
US6101200A (en) * 1997-12-24 2000-08-08 Nortel Networks Corporation Laser module allowing simultaneous wavelength and power control
US6134253A (en) * 1998-02-19 2000-10-17 Jds Uniphase Corporation Method and apparatus for monitoring and control of laser emission wavelength
FR2776302B1 (fr) 1998-03-19 2002-04-12 Hoechst Marion Roussel Inc Nouveau procede de preparation de la fexofenadine
JP3197869B2 (ja) * 1998-03-31 2001-08-13 アンリツ株式会社 波長可変レーザ光源装置
US6018536A (en) * 1998-11-20 2000-01-25 Sarnoff Corporation Multiple-wavelength mode-locked laser

Also Published As

Publication number Publication date
US7176318B2 (en) 2007-02-13
ES2302737T3 (es) 2008-08-01
DE60133288D1 (de) 2008-04-30
US20030166682A1 (en) 2003-09-04
EP1307423B1 (de) 2008-03-19
DE60133288T2 (de) 2009-04-16
EP1307423A1 (de) 2003-05-07
WO2002010115A1 (en) 2002-02-07
GB0018691D0 (en) 2000-09-20
AU2001269388A1 (en) 2002-02-13
PT1307423E (pt) 2008-06-09

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