ATE385253T1 - Nhibitor-resistente hcv ns3 protease - Google Patents
Nhibitor-resistente hcv ns3 proteaseInfo
- Publication number
- ATE385253T1 ATE385253T1 AT03770808T AT03770808T ATE385253T1 AT E385253 T1 ATE385253 T1 AT E385253T1 AT 03770808 T AT03770808 T AT 03770808T AT 03770808 T AT03770808 T AT 03770808T AT E385253 T1 ATE385253 T1 AT E385253T1
- Authority
- AT
- Austria
- Prior art keywords
- protease
- resistant
- inhibitor
- hcv
- nhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
- C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Photolithography (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- External Artificial Organs (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42194302P | 2002-10-29 | 2002-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE385253T1 true ATE385253T1 (de) | 2008-02-15 |
Family
ID=32230287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03770808T ATE385253T1 (de) | 2002-10-29 | 2003-10-24 | Nhibitor-resistente hcv ns3 protease |
Country Status (13)
Country | Link |
---|---|
US (1) | US7208309B2 (de) |
EP (1) | EP1558730B1 (de) |
JP (1) | JP4295222B2 (de) |
AT (1) | ATE385253T1 (de) |
AU (1) | AU2003280239B2 (de) |
CA (1) | CA2498653C (de) |
DE (1) | DE60318954T2 (de) |
DK (1) | DK1558730T3 (de) |
ES (1) | ES2298585T3 (de) |
IL (1) | IL168254A (de) |
MX (1) | MXPA05004276A (de) |
NZ (1) | NZ540292A (de) |
WO (1) | WO2004039970A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050009877A1 (en) * | 2003-05-15 | 2005-01-13 | Henry Lu | Methods of identifying HCV NS5B polymerase inhibitors and their uses |
JP4890254B2 (ja) | 2003-10-27 | 2012-03-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | Hcvns3−ns4aプロテアーゼ耐性突然変異体 |
ES2336009T3 (es) | 2004-01-30 | 2010-04-07 | Medivir Ab | Inhibidores de la ns-3 serina proteasa del vhc. |
US20080207760A1 (en) * | 2005-04-11 | 2008-08-28 | Achillion Pharmaceuticals, Inc. | Pharmaceutical Compositions For and Methods of Inhibiting Hcv |
US7465537B2 (en) * | 2005-05-01 | 2008-12-16 | The Board Of Trustees Of The University Of Arkansas | Compounds and methods for inhibiting hepatitis C virus replication |
US20070128625A1 (en) * | 2005-07-25 | 2007-06-07 | Gilead Sciences, Llc | Drug-resistant mutants of hepatitis C virus |
PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
KR20140098867A (ko) | 2005-11-11 | 2014-08-08 | 버텍스 파마슈티칼스 인코포레이티드 | C형 간염 바이러스 변이체 |
EP2121991A2 (de) | 2006-10-20 | 2009-11-25 | Innogenetics N.V. | Methodik zur analyse von sequenzvariationen innerhalb des hcv-ns3/4a-genombereichs |
US20100143886A1 (en) * | 2007-03-09 | 2010-06-10 | Ludmerer Steven W | In vivo hcv resistance to anti-viral inhibitors |
US8298541B2 (en) * | 2007-03-29 | 2012-10-30 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Live attenuated virus vaccines for La Crosse virus and other Bunyaviridae |
EP2342336B1 (de) | 2008-09-05 | 2016-12-14 | President and Fellows of Harvard College | Kontinuierliche gerichtete evolution von proteinen und nukleinsäuren |
CA2825370A1 (en) | 2010-12-22 | 2012-06-28 | President And Fellows Of Harvard College | Continuous directed evolution |
EP2729490A1 (de) | 2011-07-06 | 2014-05-14 | Gilead Sciences, Inc. | Hcv-genotyp-4-replikons |
US8889848B2 (en) | 2011-07-06 | 2014-11-18 | Gilead Sciences, Inc. | HCV genotype 3 replicons |
EP3097196B1 (de) | 2014-01-20 | 2019-09-11 | President and Fellows of Harvard College | Negativauswahl und stringenzmodulation in systemen der kontinuierlichen evolution |
WO2016077052A2 (en) * | 2014-10-22 | 2016-05-19 | President And Fellows Of Harvard College | Evolution of proteases |
US11299729B2 (en) | 2015-04-17 | 2022-04-12 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
US10392674B2 (en) | 2015-07-22 | 2019-08-27 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
WO2017015559A2 (en) | 2015-07-23 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of bt toxins |
US10612011B2 (en) | 2015-07-30 | 2020-04-07 | President And Fellows Of Harvard College | Evolution of TALENs |
WO2019010164A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | EVOLUTION OF ARNT SYNTHÉTASES |
EP3673059A4 (de) | 2017-08-25 | 2021-09-01 | President And Fellows Of Harvard College | Entwicklung von bont-peptidasen |
WO2019056002A1 (en) | 2017-09-18 | 2019-03-21 | President And Fellows Of Harvard College | CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS |
WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
WO2020205510A1 (en) | 2019-03-29 | 2020-10-08 | Trustees Of Boston University | Chimeric antigen receptor (car) modulation |
WO2022020431A2 (en) | 2020-07-21 | 2022-01-27 | Trustees Of Boston University | Inducible control of gene expression |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843752A (en) * | 1995-05-12 | 1998-12-01 | Schering Corporation | Soluble active hepatitis C virus protease |
IT1277914B1 (it) * | 1995-08-22 | 1997-11-12 | Angeletti P Ist Richerche Bio | Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e |
US5990276A (en) * | 1996-05-10 | 1999-11-23 | Schering Corporation | Synthetic inhibitors of hepatitis C virus NS3 protease |
US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
US6326137B1 (en) * | 1999-06-25 | 2001-12-04 | Schering Corporation | Hepatitis C virus protease-dependent chimeric pestivirus |
US20050074465A1 (en) * | 1999-11-24 | 2005-04-07 | Michael Houghton | HCV fusion proteins with modified NS3 domains |
US6986892B1 (en) * | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
JP2004516039A (ja) * | 2000-12-22 | 2004-06-03 | ベーリンガー インゲルハイム (カナダ) リミテッド | C型肝炎ウイルスからの自己複製rna分子 |
WO2002068933A2 (en) * | 2001-02-28 | 2002-09-06 | The Scripps Research Institute | Small molecule design against drug resistant mutants using directed evolution |
JP4890254B2 (ja) | 2003-10-27 | 2012-03-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | Hcvns3−ns4aプロテアーゼ耐性突然変異体 |
-
2003
- 2003-10-24 CA CA2498653A patent/CA2498653C/en not_active Expired - Lifetime
- 2003-10-24 NZ NZ540292A patent/NZ540292A/en not_active IP Right Cessation
- 2003-10-24 EP EP03770808A patent/EP1558730B1/de not_active Expired - Lifetime
- 2003-10-24 JP JP2004547307A patent/JP4295222B2/ja not_active Expired - Lifetime
- 2003-10-24 WO PCT/CA2003/001636 patent/WO2004039970A1/en active IP Right Grant
- 2003-10-24 ES ES03770808T patent/ES2298585T3/es not_active Expired - Lifetime
- 2003-10-24 AT AT03770808T patent/ATE385253T1/de active
- 2003-10-24 DK DK03770808T patent/DK1558730T3/da active
- 2003-10-24 DE DE60318954T patent/DE60318954T2/de not_active Expired - Lifetime
- 2003-10-24 MX MXPA05004276A patent/MXPA05004276A/es active IP Right Grant
- 2003-10-24 AU AU2003280239A patent/AU2003280239B2/en not_active Expired
- 2003-10-28 US US10/695,140 patent/US7208309B2/en active Active
-
2005
- 2005-04-27 IL IL168254A patent/IL168254A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003280239A1 (en) | 2004-05-25 |
US7208309B2 (en) | 2007-04-24 |
WO2004039970A1 (en) | 2004-05-13 |
MXPA05004276A (es) | 2005-08-03 |
DE60318954T2 (de) | 2009-01-22 |
EP1558730B1 (de) | 2008-01-30 |
DK1558730T3 (da) | 2008-05-26 |
CA2498653A1 (en) | 2004-05-13 |
JP2006503584A (ja) | 2006-02-02 |
EP1558730A1 (de) | 2005-08-03 |
AU2003280239B2 (en) | 2009-03-12 |
ES2298585T3 (es) | 2008-05-16 |
DE60318954D1 (de) | 2008-03-20 |
US20050019753A1 (en) | 2005-01-27 |
JP4295222B2 (ja) | 2009-07-15 |
IL168254A (en) | 2010-11-30 |
CA2498653C (en) | 2010-12-14 |
NZ540292A (en) | 2006-09-29 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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